SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q53T59

- H1BP3_HUMAN

UniProt

Q53T59 - H1BP3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
HCLS1-binding protein 3
Gene
HS1BP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be a modulator of IL-2 signaling By similarity.

GO - Molecular functioni

  1. phosphatidylinositol binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
HCLS1-binding protein 3
Alternative name(s):
HS1-binding protein 3
Short name:
HSP1BP-3
Gene namesi
Name:HS1BP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24979. HS1BP3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392HCLS1-binding protein 3
PRO_0000313802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei3 – 31Phosphoserine1 Publication
Modified residuei139 – 1391Phosphoserine1 Publication
Modified residuei194 – 1941Phosphoserine2 Publications
Modified residuei337 – 3371N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ53T59.
PaxDbiQ53T59.
PeptideAtlasiQ53T59.
PRIDEiQ53T59.

PTM databases

PhosphoSiteiQ53T59.

Expressioni

Gene expression databases

ArrayExpressiQ53T59.
BgeeiQ53T59.
CleanExiHS_HS1BP3.
GenevestigatoriQ53T59.

Organism-specific databases

HPAiHPA035050.

Interactioni

Subunit structurei

Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro By similarity.

Protein-protein interaction databases

BioGridi122141. 2 interactions.
STRINGi9606.ENSP00000305193.

Structurei

3D structure databases

ProteinModelPortaliQ53T59.
SMRiQ53T59. Positions 20-136.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 142124PX
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi196 – 1994Poly-Glu
Compositional biasi212 – 23726Pro-rich
Add
BLAST
Compositional biasi324 – 35229Pro-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG27752.
HOGENOMiHOG000112839.
HOVERGENiHBG098900.
InParanoidiQ53T59.
OMAiIRDHDTP.
PhylomeDBiQ53T59.
TreeFamiTF335484.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53T59-1 [UniParc]FASTAAdd to Basket

« Hide

MQSPAVLVTS RRLQNAHTGL DLTVPQHQEV RGKMMSGHVE YQILVVTRLA    50
AFKSAKHRPE DVVQFLVSKK YSEIEEFYQK LSSRYAAASL PPLPRKVLFV 100
GESDIRERRA VFNEILRCVS KDAELAGSPE LLEFLGTRSP GAAGLTSRDS 150
SVLDGTDSQT GNDEEAFDFF EEQDQVAEEG PPVQSLKGED AEESLEEEEA 200
LDPLGIMRSK KPKKHPKVAV KAKPSPRLTI FDEEVDPDEG LFGPGRKLSP 250
QDPSEDVSSV DPLKLFDDPD LGGAIPLGDS LLLPAACESG GPTPSLSHRD 300
ASKELFRVEE DLDQILNLGA EPKPKPQLKP KPPVAAKPVI PRKPAVPPKA 350
GPAEAVAGQQ KPQEQIQAMD EMDILQYIQD HDTPAQAAPS LF 392
Length:392
Mass (Da):42,780
Last modified:May 24, 2005 - v1
Checksum:i2A360915F833FAE8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti260 – 2601V → M.2 Publications
Corresponds to variant rs2305458 [ dbSNP | Ensembl ].
VAR_037741
Natural varianti273 – 2731G → R.
Corresponds to variant rs35589938 [ dbSNP | Ensembl ].
VAR_037742
Natural varianti348 – 3481P → R.
Corresponds to variant rs35579164 [ dbSNP | Ensembl ].
VAR_037743
Natural varianti388 – 3881A → T.1 Publication
Corresponds to variant rs3732149 [ dbSNP | Ensembl ].
VAR_037744

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314383 mRNA. Translation: BAG37009.1.
AC012065 Genomic DNA. Translation: AAX93235.1.
CH471053 Genomic DNA. Translation: EAX00814.1.
CH471053 Genomic DNA. Translation: EAX00816.1.
BC050636 mRNA. Translation: AAH50636.1.
CCDSiCCDS1700.1.
RefSeqiNP_071905.3. NM_022460.3.
UniGeneiHs.531785.

Genome annotation databases

EnsembliENST00000304031; ENSP00000305193; ENSG00000118960.
GeneIDi64342.
KEGGihsa:64342.
UCSCiuc002rdw.1. human.

Polymorphism databases

DMDMi74726842.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314383 mRNA. Translation: BAG37009.1 .
AC012065 Genomic DNA. Translation: AAX93235.1 .
CH471053 Genomic DNA. Translation: EAX00814.1 .
CH471053 Genomic DNA. Translation: EAX00816.1 .
BC050636 mRNA. Translation: AAH50636.1 .
CCDSi CCDS1700.1.
RefSeqi NP_071905.3. NM_022460.3.
UniGenei Hs.531785.

3D structure databases

ProteinModelPortali Q53T59.
SMRi Q53T59. Positions 20-136.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122141. 2 interactions.
STRINGi 9606.ENSP00000305193.

PTM databases

PhosphoSitei Q53T59.

Polymorphism databases

DMDMi 74726842.

Proteomic databases

MaxQBi Q53T59.
PaxDbi Q53T59.
PeptideAtlasi Q53T59.
PRIDEi Q53T59.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304031 ; ENSP00000305193 ; ENSG00000118960 .
GeneIDi 64342.
KEGGi hsa:64342.
UCSCi uc002rdw.1. human.

Organism-specific databases

CTDi 64342.
GeneCardsi GC02M020760.
HGNCi HGNC:24979. HS1BP3.
HPAi HPA035050.
MIMi 609359. gene.
neXtProti NX_Q53T59.
PharmGKBi PA162391602.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27752.
HOGENOMi HOG000112839.
HOVERGENi HBG098900.
InParanoidi Q53T59.
OMAi IRDHDTP.
PhylomeDBi Q53T59.
TreeFami TF335484.

Miscellaneous databases

ChiTaRSi HS1BP3. human.
GenomeRNAii 64342.
NextBioi 66275.
PROi Q53T59.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q53T59.
Bgeei Q53T59.
CleanExi HS_HS1BP3.
Genevestigatori Q53T59.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
[Graphical view ]
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-260.
    Tissue: Uterus.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-260 AND THR-388.
    Tissue: Brain.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-337, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiH1BP3_HUMAN
AccessioniPrimary (citable) accession number: Q53T59
Secondary accession number(s): B2RAW2
, D6W529, Q86VC2, Q8N367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi