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Protein

Reticulon

Gene

RTN4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
ReticulonUniRule annotation
Gene namesi
Name:RTN4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4324HelicalUniRule annotationAdd
BLAST
Transmembranei129 – 15022HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ53SY1.
PeptideAtlasiQ53SY1.
PRIDEiQ53SY1.

Expressioni

Gene expression databases

BgeeiENSG00000115310.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337838.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 187187ReticulonInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reticulon domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
HOGENOMiHOG000015254.
HOVERGENiHBG000838.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53SY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VDLLYWRDIK KTGVVFGASL FLLLSLTVFS IVSVTAYIAL ALLSVTISFR
60 70 80 90 100
IYKGVIQAIQ KSDEGHPFRA YLESEVAISE ELVQKYSNSA LGHVNCTIKE
110 120 130 140 150
LRRLFLVDDL VDSLKFAVLM WVFTYVGALF NGLTLLILAL ISLFSVPVIY
160 170 180
ERHQAQIDHY LGLANKNVKD AMAKIQAKIP GLKRKAE
Length:187
Mass (Da):20,937
Last modified:May 24, 2005 - v1
Checksum:iA161F7A143C4607C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013414 Genomic DNA. Translation: AAY24239.1.
UniGeneiHs.637850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013414 Genomic DNA. Translation: AAY24239.1.
UniGeneiHs.637850.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000337838.

Proteomic databases

PaxDbiQ53SY1.
PeptideAtlasiQ53SY1.
PRIDEiQ53SY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
HOGENOMiHOG000015254.
HOVERGENiHBG000838.

Miscellaneous databases

ChiTaRSiRTN4. human.

Gene expression databases

BgeeiENSG00000115310.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53SY1_HUMAN
AccessioniPrimary (citable) accession number: Q53SY1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.