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Q53SM6

- Q53SM6_HUMAN

UniProt

Q53SM6 - Q53SM6_HUMAN

Protein
Submitted name:

Putative uncharacterized protein EPAS1

Gene

EPAS1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. blood vessel remodeling Source: Ensembl
    3. cell maturation Source: Ensembl
    4. embryonic placenta development Source: Ensembl
    5. erythrocyte differentiation Source: Ensembl
    6. lung development Source: Ensembl
    7. mitochondrion organization Source: Ensembl
    8. myoblast fate commitment Source: Ensembl
    9. norepinephrine metabolic process Source: Ensembl
    10. regulation of heart rate Source: Ensembl
    11. regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: Ensembl
    12. surfactant homeostasis Source: Ensembl
    13. visual perception Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized protein EPAS1Imported
    Gene namesi
    Name:EPAS1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-KW
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ53SM6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ53SM6.
    BgeeiQ53SM6.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
    Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000234306.
    HOVERGENiHBG060456.

    Family and domain databases

    InterProiIPR011598. bHLH_dom.
    IPR014887. HIF-1_TAD_C.
    IPR021537. HIF_alpha_subunit.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view]
    PfamiPF11413. HIF-1. 1 hit.
    PF08778. HIF-1a_CTAD. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view]
    PRINTSiPR00785. NCTRNSLOCATR.
    SMARTiSM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    TIGRFAMsiTIGR00229. sensory_box. 2 hits.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q53SM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    SSSERRKEKS RDAARCRRSK ETEVFYELAH ELPLPHSVSS HLDKASIMRL    50
    AISFLRTHKL LSSVCSENES EAEADQQMDN LYLKALEGFI AVVTQDGDMI 100
    FLSENISKFM GLTQVELTGH SIFDFTHPCD HEEIRENLSL KNGSGFGKKS 150
    KDMSTERDFF MRMKCTVTNR GRTVNLKSAT WKVLHCTGQV KVYNNCPPHN 200
    SLCGYKEPLL SCLIIMCEPI QHPSHMDIPL DSKTFLSRHS MDMKFTYCDD 250
    RITELIGYHP EELLGRSAYE FYHALDSENM TKSHQNLCTK GQVVSGQYRM 300
    LAKHGGYVWL ETQGTVIYNP RNLQPQCIMC VNYVLSEIEK NDVVFSMDQT 350
    ESLFKPHLMA MNSIFDSSGK GAVSEKSNFL FTKLKEEPEE LAQLAPTPGD 400
    AIISLDFGNQ NFEESSAYGK AILPPSQPWA TELRSHSTQS EAGSLPAFTV 450
    PQAAAPGSTT PSATSSSSSC STPNSPEDYY TSLDNDLKIE VIEKLFAMDT 500
    EAKDQCSTQT DFNELDLETL APYIPMDGED FQLSPICPEE RLLAENPQST 550
    PQHCFSAMTN IFQPLAPVAP HSPFLLDKFQ QQLESKKTEP EHRPMSSIFF 600
    DAGSKASLPP CCGQASTPLS SMGGRSNTQW PPDPPLHFGP TKWAVGDQRT 650
    EFLGAAPLGP PVSPPHVSTF KTRSAKGFGA RGPDVLSPAM VALSNKLKLK 700
    RQLEYEEQAF QDLSGGDPPG GSTSHLMWKR MKNLRGGSCP LMPDKPLSAN 750
    VPNDKFTQNP MRGLGHPLRH LPLPQPPSAI SPGENSKSRF PPQCYATQYQ 800
    DYSLSSAHKV SGMASRLLGP SFESYLLPEL TRYDCEVNVP VLGSSTLLQG 850
    GDLLRALDQA T 861
    Length:861
    Mass (Da):95,371
    Last modified:May 24, 2005 - v1
    Checksum:iDAE13C3B7F57EBDE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC016912 Genomic DNA. Translation: AAY14704.1.
    UniGeneiHs.468410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC016912 Genomic DNA. Translation: AAY14704.1 .
    UniGenei Hs.468410.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q53SM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000234306.
    HOVERGENi HBG060456.

    Miscellaneous databases

    ChiTaRSi EPAS1. human.

    Gene expression databases

    ArrayExpressi Q53SM6.
    Bgeei Q53SM6.

    Family and domain databases

    InterProi IPR011598. bHLH_dom.
    IPR014887. HIF-1_TAD_C.
    IPR021537. HIF_alpha_subunit.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view ]
    Pfami PF11413. HIF-1. 1 hit.
    PF08778. HIF-1a_CTAD. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view ]
    PRINTSi PR00785. NCTRNSLOCATR.
    SMARTi SM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    TIGRFAMsi TIGR00229. sensory_box. 2 hits.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of Homo sapiens BAC clone RP11-480A6."
      Cotton M., Phillips A., Elliott G., Doebber A., Pearman C.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Waterston R.H.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Waterston R.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Wilson R.K.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ53SM6_HUMAN
    AccessioniPrimary (citable) accession number: Q53SM6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.