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Q53SM6

- Q53SM6_HUMAN

UniProt

Q53SM6 - Q53SM6_HUMAN

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Protein
Submitted name:

Putative uncharacterized protein EPAS1

Gene

EPAS1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. blood vessel remodeling Source: Ensembl
  3. cell maturation Source: Ensembl
  4. embryonic placenta development Source: Ensembl
  5. erythrocyte differentiation Source: Ensembl
  6. lung development Source: Ensembl
  7. mitochondrion organization Source: Ensembl
  8. myoblast fate commitment Source: Ensembl
  9. norepinephrine metabolic process Source: Ensembl
  10. regulation of heart rate Source: Ensembl
  11. regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: Ensembl
  12. surfactant homeostasis Source: Ensembl
  13. visual perception Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein EPAS1Imported
Gene namesi
Name:EPAS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ53SM6.

Expressioni

Gene expression databases

BgeeiQ53SM6.
ExpressionAtlasiQ53SM6. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ53SM6. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000234306.
HOVERGENiHBG060456.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR014887. HIF-1_TAD_C.
IPR021537. HIF_alpha_subunit.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF11413. HIF-1. 1 hit.
PF08778. HIF-1a_CTAD. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53SM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SSSERRKEKS RDAARCRRSK ETEVFYELAH ELPLPHSVSS HLDKASIMRL
60 70 80 90 100
AISFLRTHKL LSSVCSENES EAEADQQMDN LYLKALEGFI AVVTQDGDMI
110 120 130 140 150
FLSENISKFM GLTQVELTGH SIFDFTHPCD HEEIRENLSL KNGSGFGKKS
160 170 180 190 200
KDMSTERDFF MRMKCTVTNR GRTVNLKSAT WKVLHCTGQV KVYNNCPPHN
210 220 230 240 250
SLCGYKEPLL SCLIIMCEPI QHPSHMDIPL DSKTFLSRHS MDMKFTYCDD
260 270 280 290 300
RITELIGYHP EELLGRSAYE FYHALDSENM TKSHQNLCTK GQVVSGQYRM
310 320 330 340 350
LAKHGGYVWL ETQGTVIYNP RNLQPQCIMC VNYVLSEIEK NDVVFSMDQT
360 370 380 390 400
ESLFKPHLMA MNSIFDSSGK GAVSEKSNFL FTKLKEEPEE LAQLAPTPGD
410 420 430 440 450
AIISLDFGNQ NFEESSAYGK AILPPSQPWA TELRSHSTQS EAGSLPAFTV
460 470 480 490 500
PQAAAPGSTT PSATSSSSSC STPNSPEDYY TSLDNDLKIE VIEKLFAMDT
510 520 530 540 550
EAKDQCSTQT DFNELDLETL APYIPMDGED FQLSPICPEE RLLAENPQST
560 570 580 590 600
PQHCFSAMTN IFQPLAPVAP HSPFLLDKFQ QQLESKKTEP EHRPMSSIFF
610 620 630 640 650
DAGSKASLPP CCGQASTPLS SMGGRSNTQW PPDPPLHFGP TKWAVGDQRT
660 670 680 690 700
EFLGAAPLGP PVSPPHVSTF KTRSAKGFGA RGPDVLSPAM VALSNKLKLK
710 720 730 740 750
RQLEYEEQAF QDLSGGDPPG GSTSHLMWKR MKNLRGGSCP LMPDKPLSAN
760 770 780 790 800
VPNDKFTQNP MRGLGHPLRH LPLPQPPSAI SPGENSKSRF PPQCYATQYQ
810 820 830 840 850
DYSLSSAHKV SGMASRLLGP SFESYLLPEL TRYDCEVNVP VLGSSTLLQG
860
GDLLRALDQA T
Length:861
Mass (Da):95,371
Last modified:May 24, 2005 - v1
Checksum:iDAE13C3B7F57EBDE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC016912 Genomic DNA. Translation: AAY14704.1.
UniGeneiHs.468410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC016912 Genomic DNA. Translation: AAY14704.1 .
UniGenei Hs.468410.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q53SM6. 1 interaction.

Proteomic databases

PRIDEi Q53SM6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000234306.
HOVERGENi HBG060456.

Miscellaneous databases

ChiTaRSi EPAS1. human.

Gene expression databases

Bgeei Q53SM6.
ExpressionAtlasi Q53SM6. baseline and differential.

Family and domain databases

InterProi IPR011598. bHLH_dom.
IPR014887. HIF-1_TAD_C.
IPR021537. HIF_alpha_subunit.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view ]
Pfami PF11413. HIF-1. 1 hit.
PF08778. HIF-1a_CTAD. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view ]
PRINTSi PR00785. NCTRNSLOCATR.
SMARTi SM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsi TIGR00229. sensory_box. 2 hits.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-480A6."
    Cotton M., Phillips A., Elliott G., Doebber A., Pearman C.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ53SM6_HUMAN
AccessioniPrimary (citable) accession number: Q53SM6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.