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Protein

Cordon-bleu protein-like 1

Gene

COBLL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cordon-bleu protein-like 1
Gene namesi
Name:COBLL1
Synonyms:KIAA0977
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000082438.15
HGNCiHGNC:23571 COBLL1
MIMi610318 gene
neXtProtiNX_Q53SF7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi22837
OpenTargetsiENSG00000082438
PharmGKBiPA134990267

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002604931 – 1204Cordon-bleu protein-like 1Add BLAST1204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphothreonineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei298PhosphothreonineCombined sources1
Modified residuei311PhosphoserineCombined sources1
Modified residuei322PhosphothreonineCombined sources1
Modified residuei364PhosphoserineBy similarity1
Modified residuei371PhosphoserineBy similarity1
Modified residuei382PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei538PhosphoserineBy similarity1
Modified residuei548PhosphoserineBy similarity1
Modified residuei551PhosphoserineBy similarity1
Modified residuei639PhosphoserineBy similarity1
Modified residuei660PhosphoserineBy similarity1
Modified residuei862PhosphoserineCombined sources1
Modified residuei889PhosphoserineBy similarity1
Modified residuei890PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei993PhosphoserineCombined sources1
Modified residuei1023PhosphoserineBy similarity1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1197PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ53SF7
PaxDbiQ53SF7
PeptideAtlasiQ53SF7
PRIDEiQ53SF7

PTM databases

iPTMnetiQ53SF7
PhosphoSitePlusiQ53SF7

Expressioni

Gene expression databases

BgeeiENSG00000082438
CleanExiHS_COBLL1
ExpressionAtlasiQ53SF7 baseline and differential
GenevisibleiQ53SF7 HS

Organism-specific databases

HPAiHPA044933
HPA053344

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116511, 29 interactors
CORUMiQ53SF7
IntActiQ53SF7, 22 interactors
STRINGi9606.ENSP00000341360

Structurei

Secondary structure

11204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi185 – 191Combined sources7
Turni192 – 194Combined sources3
Beta strandi195 – 201Combined sources7
Beta strandi203 – 205Combined sources3
Helixi207 – 217Combined sources11
Beta strandi224 – 229Combined sources6
Helixi243 – 246Combined sources4
Beta strandi249 – 255Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAJNMR-A182-259[»]
ProteinModelPortaliQ53SF7
SMRiQ53SF7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53SF7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1157 – 1177WH2PROSITE-ProRule annotationAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 334KKRRAP 16
Motifi398 – 403KKRRAP 26

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIGI Eukaryota
ENOG4111I5R LUCA
GeneTreeiENSGT00530000063608
HOVERGENiHBG105908
InParanoidiQ53SF7
OrthoDBiEOG091G01LF
PhylomeDBiQ53SF7
TreeFamiTF333490

Family and domain databases

InterProiView protein in InterPro
IPR019025 Cordon-bleu_ubiquitin_domain
IPR003124 WH2_dom
PfamiView protein in Pfam
PF09469 Cobl, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53SF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCGRAAEAAA SSRTPGREMG QAVTRRLGAG ARAAPRRAMD GRTPRPQDAP
60 70 80 90 100
ARRKPKAKAP LPPAETKYTD VSSAADSVES TAFIMEQKEN MIDKDVELSV
110 120 130 140 150
VLPGDIIKST TVHGSKPMMD LLIFLCAQYH LNPSSYTIDL LSAEQNHIKF
160 170 180 190 200
KPNTPIGMLE VEKVILKPKM LDKKKPTPII PEKTVRVVIN FKKTQKTIVR
210 220 230 240 250
VSPHASLQEL APIICSKCEF DPLHTLLLKD YQSQEPLDLT KSLNDLGLRE
260 270 280 290 300
LYAMDVNRES CQISQNLDIM KEKENKGFFS FFQRSKKKRD QTASAPATPL
310 320 330 340 350
VNKHRPTFTR SNTISKPYIS NTLPSDAPKK RRAPLPPMPA SQSVPQDLAH
360 370 380 390 400
IQERPASCIV KSMSVDETDK SPCEAGRVRA GSLQLSSMSA GNSSLRRTKR
410 420 430 440 450
KAPSPPSKIP PHQSDENSRV TALQPVDGVP PDSASEANSP EELSSPETFH
460 470 480 490 500
PGLSSQEQCT APKLMEETSV FECPGTPEAA ITSLTSGISS DYSLEEIDEK
510 520 530 540 550
EELSEVPKVE AENISPKSQD IPFVSTDIIN TLKNDPDSAL GNGSGEFSQN
560 570 580 590 600
SMEEKQETKS TDGQEPHSVV YDTSNGKKVV DSIRNLKSLG PNQENVQNEI
610 620 630 640 650
IVYPENTEDN MKNGVKKTEI NVEGVAKNNN IDMEVERPSN SEAHETDTAI
660 670 680 690 700
SYKENHLAAS SVPDQKLNQP SAEKTKDAAI QTTPSCNSFD GKHQDHNLSD
710 720 730 740 750
SKVEECVQTS NNNISTQHSC LSSQDSVNTS REFRSQGTLI IHSEDPLTVK
760 770 780 790 800
DPICAHGNDD LLPPVDRIDK NSTASYLKNY PLYRQDYNPK PKPSNEITRE
810 820 830 840 850
YIPKIGMTTY KIVPPKSLEI SKDWQSETIE YKDDQDMHAL GKKHTHENVK
860 870 880 890 900
ETAIQTEDSA ISESPEEPLP NLKPKPNLRT EHQVPSSVSS PDDAMVSPLK
910 920 930 940 950
PAPKMTRDTG TAPFAPNLEE INNILESKFK SRASNAQAKP SSFFLQMQKR
960 970 980 990 1000
VSGHYVTSAA AKSVHAAPNP APKELTNKEA ERDMLPSPEQ TLSPLSKMPH
1010 1020 1030 1040 1050
SVPQPLVEKT DDDVIGQAPA EASPPPIAPK PVTIPASQVS TQNLKTLKTF
1060 1070 1080 1090 1100
GAPRPYSSSG PSPFALAVVK RSQSFSKERT ESPSASALVQ PPANTEEGKT
1110 1120 1130 1140 1150
HSVNKFVDIP QLGVSDKENN SAHNEQNSQI PTPTDGPSFT VMRQSSLTFQ
1160 1170 1180 1190 1200
SSDPEQMRQS LLTAIRSGEA AAKLKRVTIP SNTISVNGRS RLSHSMSPDA

QDGH
Length:1,204
Mass (Da):131,787
Last modified:November 28, 2006 - v2
Checksum:i6BA6F2ADF3440670
GO
Isoform 2 (identifier: Q53SF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     447-486: ETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTS → A
     595-595: N → NV

Show »
Length:1,166
Mass (Da):127,719
Checksum:i0FBC2D76FA27E9B6
GO
Isoform 3 (identifier: Q53SF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:1,166
Mass (Da):127,935
Checksum:i25D9282A915026E6
GO
Isoform 4 (identifier: Q53SF7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     447-486: ETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTS → A
     595-595: N → NV

Show »
Length:1,128
Mass (Da):123,868
Checksum:iB0BC3812F4BA93E8
GO
Isoform 5 (identifier: Q53SF7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     115-144: SKPMMDLLIFLCAQYHLNPSSYTIDLLSAE → RYAGVNEISGPPLLIPPLKVSVIYVLMFVL
     145-1204: Missing.

Show »
Length:106
Mass (Da):11,516
Checksum:i5922939ACD3632B9
GO

Sequence cautioni

The sequence BAA76821 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43215 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368T → A in AAH71588 (PubMed:15489334).Curated1
Sequence conflicti845T → G in CAB43215 (PubMed:17974005).Curated1
Sequence conflicti947M → T in CAD97877 (PubMed:17974005).Curated1
Sequence conflicti1048K → E in AAH71588 (PubMed:15489334).Curated1
Sequence conflicti1095T → A in CAD97877 (PubMed:17974005).Curated1
Sequence conflicti1151S → G in CAB43215 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0216211 – 38Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_021622115 – 144SKPMM…LLSAE → RYAGVNEISGPPLLIPPLKV SVIYVLMFVL in isoform 5. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_021623145 – 1204Missing in isoform 5. 1 PublicationAdd BLAST1060
Alternative sequenceiVSP_021624447 – 486ETFHP…TSLTS → A in isoform 2 and isoform 4. 3 PublicationsAdd BLAST40
Alternative sequenceiVSP_021625595N → NV in isoform 2 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023194 mRNA Translation: BAA76821.2 Different initiation.
AK225849 mRNA No translation available.
AC019181 Genomic DNA Translation: AAX93068.1
CH471058 Genomic DNA Translation: EAX11340.1
BC006264 mRNA Translation: AAH06264.1
BC071588 mRNA Translation: AAH71588.1
AL049939 mRNA Translation: CAB43215.1 Different initiation.
BX537877 mRNA Translation: CAD97877.2
CCDSiCCDS2223.2 [Q53SF7-3]
CCDS63045.1 [Q53SF7-4]
PIRiT08673
RefSeqiNP_001265387.1, NM_001278458.1
NP_001265389.1, NM_001278460.1
NP_001265390.1, NM_001278461.1 [Q53SF7-4]
NP_055715.3, NM_014900.4 [Q53SF7-3]
UniGeneiHs.470457
Hs.744314

Genome annotation databases

EnsembliENST00000342193; ENSP00000341360; ENSG00000082438 [Q53SF7-3]
ENST00000375458; ENSP00000364607; ENSG00000082438 [Q53SF7-4]
ENST00000392717; ENSP00000376478; ENSG00000082438 [Q53SF7-1]
GeneIDi22837
KEGGihsa:22837
UCSCiuc002ucp.5 human [Q53SF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCOBL1_HUMAN
AccessioniPrimary (citable) accession number: Q53SF7
Secondary accession number(s): A6NMZ3
, Q6IQ33, Q7Z3I6, Q9BRH4, Q9UG88, Q9Y2I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health