ID   Q53SF4_HUMAN            Unreviewed;       153 AA.
AC   Q53SF4;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=receptor protein serine/threonine kinase {ECO:0000256|ARBA:ARBA00012401};
DE            EC=2.7.11.30 {ECO:0000256|ARBA:ARBA00012401};
DE   Flags: Fragment;
GN   Name=ACVR1 {ECO:0000313|EMBL:AAY15094.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAY15094.1};
RN   [1] {ECO:0000313|EMBL:AAY15094.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kozlowicz A., Elliott G., Grewal N.;
RT   "The sequence of Homo sapiens BAC clone RP11-301K6.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAY15094.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Waterston R.H.;
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAY15094.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Waterston R.;
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAY15094.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|ARBA:ARBA00009605}.
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DR   EMBL; AC019186; AAY15094.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q53SF4; -.
DR   PeptideAtlas; Q53SF4; -.
DR   ChiTaRS; ACVR1; human.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255:SF69; ACTIVIN RECEPTOR TYPE-1; 1.
DR   PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT   DOMAIN          1..146
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAY15094.1"
SQ   SEQUENCE   153 AA;  17701 MW;  BE38E7E8AE08AA3B CRC64;
     LAVMHSQSTN QLDVGNNPRV GTKRYMAPEV LDETIQVDCF DSYKRVDIWA FGLVLWEVAR
     RMVSNGIVED YKPPFYDVVP NDPSFEDMRK VVCVDQQRPN IPNRWFSDPT LTSLAKLMKE
     CWYQNPSARL TALRIKKTLT KIDNSLDKLK TDC
//