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Protein

Receptor protein serine/threonine kinase

Gene

ACVR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. activin receptor activity, type I Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: Ensembl
  4. transforming growth factor beta receptor activity, type I Source: Ensembl

GO - Biological processi

  1. acute inflammatory response Source: Ensembl
  2. cellular response to glucocorticoid stimulus Source: Ensembl
  3. determination of left/right symmetry Source: Ensembl
  4. gastrulation with mouth forming second Source: Ensembl
  5. germ cell development Source: Ensembl
  6. heart development Source: Ensembl
  7. in utero embryonic development Source: Ensembl
  8. mesoderm formation Source: Ensembl
  9. neural crest cell migration Source: Ensembl
  10. patterning of blood vessels Source: Ensembl
  11. pharyngeal system development Source: Ensembl
  12. regulation of skeletal muscle tissue development Source: Ensembl
  13. smooth muscle cell differentiation Source: Ensembl
  14. transforming growth factor beta receptor signaling pathway Source: Ensembl
  15. urogenital system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ53SF4.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:ACVR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. activin receptor complex Source: Ensembl
  2. apical part of cell Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ53SF4.

Expressioni

Gene expression databases

BgeeiQ53SF4.
ExpressionAtlasiQ53SF4. baseline and differential.

Interactioni

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG054502.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53SF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LAVMHSQSTN QLDVGNNPRV GTKRYMAPEV LDETIQVDCF DSYKRVDIWA
60 70 80 90 100
FGLVLWEVAR RMVSNGIVED YKPPFYDVVP NDPSFEDMRK VVCVDQQRPN
110 120 130 140 150
IPNRWFSDPT LTSLAKLMKE CWYQNPSARL TALRIKKTLT KIDNSLDKLK

TDC
Length:153
Mass (Da):17,701
Last modified:May 24, 2005 - v1
Checksum:iBE38E7E8AE08AA3B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019186 Genomic DNA. Translation: AAY15094.1.
UniGeneiHs.470316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019186 Genomic DNA. Translation: AAY15094.1.
UniGeneiHs.470316.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ53SF4.

Proteomic databases

PRIDEiQ53SF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG054502.

Enzyme and pathway databases

SignaLinkiQ53SF4.

Miscellaneous databases

ChiTaRSiACVR1. human.

Gene expression databases

BgeeiQ53SF4.
ExpressionAtlasiQ53SF4. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-301K6."
    Kozlowicz A., Elliott G., Grewal N.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ53SF4_HUMAN
AccessioniPrimary (citable) accession number: Q53SF4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: February 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.