Putative uncharacterized protein RASGRP3

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Unreviewed, UniProtKB/TrEMBL Q53SD7 (Q53SD7_HUMAN)

Last modified June 16, 2009. Version 48. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
Putative uncharacterized protein RASGRP3 EMBL AAY15037.1
Submitted name:
RAS guanyl releasing protein 3 (Calcium and DAG-regulated), isoform CRA_b EMBL EAX00433.1

Gene names

Name:	RASGRP3 EMBL AAY15037.1
ORF Names:	hCG_21341 EMBL EAX00433.1

Organism

Homo sapiens (Human) EMBL AAY15037.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	690 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Sequence similarities

Contains 1 N-terminal Ras-GEF domain. Spearmint SPM000651

Contains 1 Ras-GEF domain. Spearmint SPM000651

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Ontologies

Keywords
Ligand	Calcium RuleBase RU000331V1 Metal-binding Spearmint SPM002219 Zinc Spearmint SPM002219
Molecular function	Guanine-nucleotide releasing factor Spearmint SPM000651
Gene Ontology (GO)
Biological process	Ras protein signal transduction Inferred from electronic annotation. Source: Compara regulation of GTPase activity Inferred from electronic annotation. Source: Compara regulation of small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: Compara intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	Ras GTPase binding Inferred from electronic annotation. Source: Compara Ras guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: Compara calcium ion binding Inferred from electronic annotation. Source: InterPro diacylglycerol binding Inferred from electronic annotation. Source: UniProtKB-KW guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q53SD7-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 747BBAA2CCAC2D12
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FASTA

690

78,332

        10         20         30         40         50         60 
MGSSGLGKAA TLDELLCTCI EMFDDNGELD NSYLPRIVLL MHRWYLSSTE LAEKLLCMYR 

        70         80         90        100        110        120 
NATGESCNEF RLKICYFMRY WILKFPAEFN LDLGLIRMTE EFREVASQLG YEKHVSLIDI 

       130        140        150        160        170        180 
SSIPSYDWMR RVTQRKKVSK KGKACLLFDH LEPIELAEHL TFLEHKSFRR ISFTDYQSYV 

       190        200        210        220        230        240 
IHGCLENNPT LERSIALFNG ISKWVQLMVL SKPTPQQRAE VITKFINVAK KLLQLKNFNT 

       250        260        270        280        290        300 
LMAVVGGLSH SSISRLKETH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP 

       310        320        330        340        350        360 
ILGVHLKDLI AVHVIFPDWT EENKVNIVKM HQLSVTLSEL VSLQNASHHL EPNMDLINLL 

       370        380        390        400        410        420 
TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV PLEWALGVMP KPDPTVINKH 

       430        440        450        460        470        480 
IRKLVESVFR NYDHDHDGYI SQEDFESIAA NFPFLDSFCV LDKDQDGLIS KDEMMAYFLR 

       490        500        510        520        530        540 
AKSQLHCKMG PGFIHNFQEM TYLKPTFCEH CAGFLWGIIK QGYKCKDCGA NCHKQCKDLL 

       550        560        570        580        590        600 
VLACRRFARA PSLSSGHGSL PGSPSLPPAQ DEVFEFPGVT AGHRDLDSRA ITLVTGSSRK 

       610        620        630        640        650        660 
ISVRLQRATT SQATQTEPVW SEAGWGDSGS HTFPKMKSKF HDKAAKDKGF AKWENEKPRV 

       670        680        690 
HAGVDVVDRG TEFELDQDEG EETRQDGEDG

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References

[1]	"The sequence of Homo sapiens BAC clone RP11-322P19." Haakenson W., Marquis-Homeyer C. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Waterston R.H. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Waterston R. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Wilson R.K. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AC020594 Genomic DNA. Translation: AAY15037.1. CH471053 Genomic DNA. Translation: EAX00433.1.
IPI	IPI00171874.
RefSeq	NP_001132960.1. NP_733772.1.
UniGene	Hs.143674
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q53SD7.
Genome annotation databases
Ensembl	ENSG00000152689. Homo sapiens. [Contig view]
GeneID	25780.
KEGG	hsa:25780.
Organism-specific databases
HGNC	HGNC:14545. RASGRP3.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q53SD7.
OMA	Q53SD7. FRRISFT.
Gene expression databases
ArrayExpress	Q53SD7.
Bgee	Q53SD7.
Family and domain databases
InterPro	IPR002219. DAG_PE_bd. IPR011992. EF-Hand_type. IPR018248. EF_hand. IPR018247. EF_HAND_1. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. IPR008937. Ras_GEF. IPR000651. RasGef_N. IPR001895. RasGRF_CDC25. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:1.10.840.10. RasGRF_CDC25. 1 hit.
PANTHER	PTHR23113. Ras_GEF. 1 hit.
Pfam	PF00130. C1_1. 1 hit. PF00036. efhand. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. [Graphical view]
SMART	SM00109. C1. 1 hit. SM00054. EFh. 2 hits. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	46931.

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Entry information

Entry name

Q53SD7_HUMAN

Accession

Primary (citable) accession number: Q53SD7

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information