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Q53S87

- Q53S87_HUMAN

UniProt

Q53S87 - Q53S87_HUMAN

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Protein

Signal transducer and activator of transcription

Gene

STAT4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. cytokine-mediated signaling pathway Source: Ensembl
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. protein phosphorylation Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

SignaLinkiQ53S87.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:STAT4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Cytoplasm UniRule annotation
Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PRIDEiQ53S87.

Expressioni

Gene expression databases

BgeeiQ53S87.
ExpressionAtlasiQ53S87. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

HOVERGENiHBG055669.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53S87 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GKFHGNPMHV AVVISNCLRE ERRILAAANM PVQGPLEKSL QSSSVSERQR
60 70 80 90 100
NVEHKVAAIK NSVQMTEQDT KYLEDLQDEF DYRYKTIQTM DQSDKNSAMV
110 120 130 140 150
NQEVLTLQEM LNSLDFKRKE ALSKMTQIIH ETDLLMNTML IEELQDWKRR
160 170 180 190 200
QQIACIGGPL HNGLDQLQNC FTLLAESLFQ LRRQLEKLEE QSTKMTYEGD
210 220 230 240 250
PIPMQRTHML ERVTFLIYNL FKNSFVVERQ PCMPTHPQRP LVLKTLIQFT
260 270 280 290 300
VKLRLLIKLP ELNYQVKVKA SIDKNVSTLS NRRFVLCGTN VKAMSIEESS
310 320 330 340 350
NGSLSVEFRH LQPKEMKSSA GGKGNEGCHM VTEELHSITF ETQICLYGLT
360 370 380 390 400
IDLETSSLPV VMISNVSQLP NAWASIIWYN VSTNDSQNLV FFNNPPPATL
410 420 430 440 450
SQLLEVMSWQ FSSYVGRGLN SDQLHMLAEK LTVQSSYSDG HLTWAKFCKE
460 470 480 490 500
HLPGKSFTFW TWLEAILDLI KKHILPLWID GYVMGFVSKE KERLLLKDKM
510 520 530 540 550
PGTFLLRFSE SHLGGITFTW VDHSESGEVR FHSVEPYNKG RLSALPFADI
560 570 580 590 600
LRDYKVIMAE NIPENPLKYL YPDIPKDKAF GKHYSSQPCE VSRPTERGDK
610 620 630 640 650
GYVPSVFIPI STIRSDSTEP HSPSDLLPMS PSVYAVLREN LSPTTIETAM

KSPYSAE
Length:657
Mass (Da):74,997
Last modified:May 24, 2005 - v1
Checksum:i68E4BE3B6A751756
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC067945 Genomic DNA. Translation: AAY24184.1.
UniGeneiHs.735572.
Hs.80642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC067945 Genomic DNA. Translation: AAY24184.1 .
UniGenei Hs.735572.
Hs.80642.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q53S87.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG055669.

Enzyme and pathway databases

SignaLinki Q53S87.

Gene expression databases

Bgeei Q53S87.
ExpressionAtlasi Q53S87. baseline and differential.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-629B4."
    Hawkins M., Abbott A., Elliott G., Doebber A., Isak A., Falk A.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ53S87_HUMAN
AccessioniPrimary (citable) accession number: Q53S87
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.