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Q53S87

- Q53S87_HUMAN

UniProt

Q53S87 - Q53S87_HUMAN

Protein

Signal transducer and activator of transcription

Gene

STAT4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. cytokine-mediated signaling pathway Source: Ensembl
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. protein phosphorylation Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ActivatorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Enzyme and pathway databases

    SignaLinkiQ53S87.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcriptionUniRule annotation
    Gene namesi
    Name:STAT4Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Cytoplasm UniRule annotation
    Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, NucleusUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Proteomic databases

    PRIDEiQ53S87.

    Expressioni

    Gene expression databases

    ArrayExpressiQ53S87.
    BgeeiQ53S87.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.UniRule annotation
    Contains 1 SH2 domain.UniRule annotation

    Keywords - Domaini

    SH2 domainUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG055669.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q53S87-1 [UniParc]FASTAAdd to Basket

    « Hide

    GKFHGNPMHV AVVISNCLRE ERRILAAANM PVQGPLEKSL QSSSVSERQR    50
    NVEHKVAAIK NSVQMTEQDT KYLEDLQDEF DYRYKTIQTM DQSDKNSAMV 100
    NQEVLTLQEM LNSLDFKRKE ALSKMTQIIH ETDLLMNTML IEELQDWKRR 150
    QQIACIGGPL HNGLDQLQNC FTLLAESLFQ LRRQLEKLEE QSTKMTYEGD 200
    PIPMQRTHML ERVTFLIYNL FKNSFVVERQ PCMPTHPQRP LVLKTLIQFT 250
    VKLRLLIKLP ELNYQVKVKA SIDKNVSTLS NRRFVLCGTN VKAMSIEESS 300
    NGSLSVEFRH LQPKEMKSSA GGKGNEGCHM VTEELHSITF ETQICLYGLT 350
    IDLETSSLPV VMISNVSQLP NAWASIIWYN VSTNDSQNLV FFNNPPPATL 400
    SQLLEVMSWQ FSSYVGRGLN SDQLHMLAEK LTVQSSYSDG HLTWAKFCKE 450
    HLPGKSFTFW TWLEAILDLI KKHILPLWID GYVMGFVSKE KERLLLKDKM 500
    PGTFLLRFSE SHLGGITFTW VDHSESGEVR FHSVEPYNKG RLSALPFADI 550
    LRDYKVIMAE NIPENPLKYL YPDIPKDKAF GKHYSSQPCE VSRPTERGDK 600
    GYVPSVFIPI STIRSDSTEP HSPSDLLPMS PSVYAVLREN LSPTTIETAM 650
    KSPYSAE 657
    Length:657
    Mass (Da):74,997
    Last modified:May 24, 2005 - v1
    Checksum:i68E4BE3B6A751756
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067945 Genomic DNA. Translation: AAY24184.1.
    UniGeneiHs.735572.
    Hs.80642.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067945 Genomic DNA. Translation: AAY24184.1 .
    UniGenei Hs.735572.
    Hs.80642.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q53S87.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG055669.

    Enzyme and pathway databases

    SignaLinki Q53S87.

    Gene expression databases

    ArrayExpressi Q53S87.
    Bgeei Q53S87.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of Homo sapiens BAC clone RP11-629B4."
      Hawkins M., Abbott A., Elliott G., Doebber A., Isak A., Falk A.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Waterston R.H.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Waterston R.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Wilson R.K.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ53S87_HUMAN
    AccessioniPrimary (citable) accession number: Q53S87
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.