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Protein
Submitted name:

Bile salt export pump

Gene

ABCB11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi243 – 250ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Bile salt export pumpImported
Submitted name:
Uncharacterized protein ABCB11Imported
Gene namesi
Name:ABCB11Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:42. ABCB11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 43HelicalSequence analysisAdd BLAST26
Transmembranei108 – 126HelicalSequence analysisAdd BLAST19
Transmembranei146 – 165HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 173ABC transmembrane type-1InterPro annotationAdd BLAST173
Domaini208 – 446ABC transporterInterPro annotationAdd BLAST239

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG008358.
OrthoDBiEOG091G0HVA.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR030278. BSEP.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24221:SF287. PTHR24221:SF287. 1 hit.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q53S60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAGSQIGMIV NSFTNVTVAM IIAFSFSWKL SLVILCFFPF LALSGATQTR
60 70 80 90 100
MLTGFASRDK QALEMVGQIT NEALSNIRTV AGIGKERRFI EALETELEKP
110 120 130 140 150
FKTAIQKANI YGFCFAFAQC IMFIANSASY RYGGYLISNE GLHFSYVFRV
160 170 180 190 200
ISAVVLSATA LGRAFSYTPS YAKAKISAAR FFQLLDRQPP ISVYNTAGEK
210 220 230 240 250
WDNFQGKIDF VDCKFTYPSR PDSQVLNGLS VSISPGQTLA FVGSSGCGKS
260 270 280 290 300
TSIQLLERFY DPDQGKVMID GHDSKKVNVQ FLRSNIGIVS QEPVLFACSI
310 320 330 340 350
MDNIKYGDNT KEIPMERVIA AAKQAQLHDF VMSLPEKYET NVGSQGSQLS
360 370 380 390 400
RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQVA LDKAREGRTC
410 420 430 440 450
IVIAHRLSTI QNADIIAVMA QGVVIEKGTH EELMAQKGAY YKLVTTGSPI

S
Length:451
Mass (Da):49,465
Last modified:May 24, 2005 - v1
Checksum:iECB159B211346084
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069137 Genomic DNA. Translation: AAY24100.1.
UniGeneiHs.658439.

Genome annotation databases

EnsembliENST00000618180; ENSP00000480206; ENSG00000276582.
UCSCiuc032qzp.2. human.

Similar proteinsi

Entry informationi

Entry nameiQ53S60_HUMAN
AccessioniPrimary (citable) accession number: Q53S60
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported