Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 177

Gene

TMEM177

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 177
Gene namesi
Name:TMEM177
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28143. TMEM177.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144120.
PharmGKBiPA162405985.

Polymorphism and mutation databases

BioMutaiTMEM177.
DMDMi74727288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002826461 – 311Transmembrane protein 177Add BLAST311

Proteomic databases

EPDiQ53S58.
MaxQBiQ53S58.
PaxDbiQ53S58.
PeptideAtlasiQ53S58.
PRIDEiQ53S58.

PTM databases

iPTMnetiQ53S58.
PhosphoSitePlusiQ53S58.

Expressioni

Gene expression databases

BgeeiENSG00000144120.
CleanExiHS_TMEM177.
ExpressionAtlasiQ53S58. baseline and differential.
GenevisibleiQ53S58. HS.

Organism-specific databases

HPAiHPA053816.

Interactioni

Protein-protein interaction databases

BioGridi123307. 33 interactors.
IntActiQ53S58. 1 interactor.
STRINGi9606.ENSP00000272521.

Structurei

3D structure databases

ProteinModelPortaliQ53S58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM177 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGW5. Eukaryota.
ENOG4111JNC. LUCA.
GeneTreeiENSGT00390000010354.
HOGENOMiHOG000154617.
HOVERGENiHBG108578.
InParanoidiQ53S58.
OMAiPYTTRRD.
OrthoDBiEOG091G0JOG.
PhylomeDBiQ53S58.
TreeFamiTF328369.

Family and domain databases

InterProiIPR026620. TMEM177.
[Graphical view]
PANTHERiPTHR21824. PTHR21824. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53S58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLWRTAA FVQRHRTGLL VGSCAGLFGV PISYHLFPDP VVQWLYQYWP
60 70 80 90 100
QGQPAPLPPQ LQSLFQEVLQ DIGVPSGHCY KPFTTFTFQP VSAGFPRLPA
110 120 130 140 150
GAVVGIPASF LGDLVINTNH PVVIHGHTVD WRSPAGARLR ASLTLSREAQ
160 170 180 190 200
KFALAREVVY LESSTTAVHA LLAPACLAGT WALGVGAKYT LGLHAGPMNL
210 220 230 240 250
RAAFSLVAAV AGFVAYAFSQ DSLTHAVESW LDRRTASLSA AYACGGVEFY
260 270 280 290 300
EKLLSGNLAL RSLLGKDGEK LYTPSGNIVP RHLFRIKHLP YTTRRDSVLQ
310
MWRGMLNPGR S
Length:311
Mass (Da):33,760
Last modified:May 24, 2005 - v1
Checksum:iFC9697323D148426
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03142129G → A.Corresponds to variant rs11684353dbSNPEnsembl.1
Natural variantiVAR_03142232I → V.1 PublicationCorresponds to variant rs13011768dbSNPEnsembl.1
Natural variantiVAR_031423267D → E.1 PublicationCorresponds to variant rs1983406dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069154 Genomic DNA. Translation: AAY24148.1.
BC004404 mRNA. Translation: AAH04404.1.
CCDSiCCDS2128.1.
RefSeqiNP_001098668.1. NM_001105198.1.
NP_001098669.1. NM_001105199.1.
NP_085054.2. NM_030577.2.
UniGeneiHs.439991.

Genome annotation databases

EnsembliENST00000272521; ENSP00000272521; ENSG00000144120.
ENST00000401466; ENSP00000385966; ENSG00000144120.
ENST00000424086; ENSP00000402661; ENSG00000144120.
GeneIDi80775.
KEGGihsa:80775.
UCSCiuc002tmc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069154 Genomic DNA. Translation: AAY24148.1.
BC004404 mRNA. Translation: AAH04404.1.
CCDSiCCDS2128.1.
RefSeqiNP_001098668.1. NM_001105198.1.
NP_001098669.1. NM_001105199.1.
NP_085054.2. NM_030577.2.
UniGeneiHs.439991.

3D structure databases

ProteinModelPortaliQ53S58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123307. 33 interactors.
IntActiQ53S58. 1 interactor.
STRINGi9606.ENSP00000272521.

PTM databases

iPTMnetiQ53S58.
PhosphoSitePlusiQ53S58.

Polymorphism and mutation databases

BioMutaiTMEM177.
DMDMi74727288.

Proteomic databases

EPDiQ53S58.
MaxQBiQ53S58.
PaxDbiQ53S58.
PeptideAtlasiQ53S58.
PRIDEiQ53S58.

Protocols and materials databases

DNASUi80775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272521; ENSP00000272521; ENSG00000144120.
ENST00000401466; ENSP00000385966; ENSG00000144120.
ENST00000424086; ENSP00000402661; ENSG00000144120.
GeneIDi80775.
KEGGihsa:80775.
UCSCiuc002tmc.1. human.

Organism-specific databases

CTDi80775.
GeneCardsiTMEM177.
HGNCiHGNC:28143. TMEM177.
HPAiHPA053816.
neXtProtiNX_Q53S58.
OpenTargetsiENSG00000144120.
PharmGKBiPA162405985.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGW5. Eukaryota.
ENOG4111JNC. LUCA.
GeneTreeiENSGT00390000010354.
HOGENOMiHOG000154617.
HOVERGENiHBG108578.
InParanoidiQ53S58.
OMAiPYTTRRD.
OrthoDBiEOG091G0JOG.
PhylomeDBiQ53S58.
TreeFamiTF328369.

Miscellaneous databases

ChiTaRSiTMEM177. human.
GenomeRNAii80775.
PROiQ53S58.

Gene expression databases

BgeeiENSG00000144120.
CleanExiHS_TMEM177.
ExpressionAtlasiQ53S58. baseline and differential.
GenevisibleiQ53S58. HS.

Family and domain databases

InterProiIPR026620. TMEM177.
[Graphical view]
PANTHERiPTHR21824. PTHR21824. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTM177_HUMAN
AccessioniPrimary (citable) accession number: Q53S58
Secondary accession number(s): Q9BT20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.