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Protein

Transmembrane protein 177

Gene

TMEM177

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 177
Gene namesi
Name:TMEM177
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144120.12
HGNCiHGNC:28143 TMEM177
neXtProtiNX_Q53S58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17Mitochondrial matrix1 PublicationAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 166Mitochondrial intermembrane1 PublicationAdd BLAST128
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 197Mitochondrial matrix1 Publication10
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 311Mitochondrial intermembrane1 PublicationAdd BLAST93

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144120
PharmGKBiPA162405985

Polymorphism and mutation databases

BioMutaiTMEM177
DMDMi74727288

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002826461 – 311Transmembrane protein 177Add BLAST311

Proteomic databases

EPDiQ53S58
MaxQBiQ53S58
PaxDbiQ53S58
PeptideAtlasiQ53S58
PRIDEiQ53S58
ProteomicsDBi62533

PTM databases

iPTMnetiQ53S58
PhosphoSitePlusiQ53S58

Expressioni

Gene expression databases

BgeeiENSG00000144120
CleanExiHS_TMEM177
ExpressionAtlasiQ53S58 baseline and differential
GenevisibleiQ53S58 HS

Organism-specific databases

HPAiHPA036689
HPA053816

Interactioni

Subunit structurei

Found in a complex with COX20, COA6, MT-CO2/COX2, COX18, SCO1 and SCO2. Interacts with COX20. Interacts with COX1, MT-CO2/COX2, SCO1 and SCO2 in a COX20-dependent manner.1 Publication

Protein-protein interaction databases

BioGridi123307, 33 interactors
IntActiQ53S58, 1 interactor
STRINGi9606.ENSP00000272521

Structurei

3D structure databases

ProteinModelPortaliQ53S58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM177 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGW5 Eukaryota
ENOG4111JNC LUCA
GeneTreeiENSGT00390000010354
HOGENOMiHOG000154617
HOVERGENiHBG108578
InParanoidiQ53S58
OMAiPRHWFRI
OrthoDBiEOG091G0JOG
PhylomeDBiQ53S58
TreeFamiTF328369

Family and domain databases

InterProiView protein in InterPro
IPR026620 TMEM177
PANTHERiPTHR21824 PTHR21824, 1 hit

Sequencei

Sequence statusi: Complete.

Q53S58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLWRTAA FVQRHRTGLL VGSCAGLFGV PISYHLFPDP VVQWLYQYWP
60 70 80 90 100
QGQPAPLPPQ LQSLFQEVLQ DIGVPSGHCY KPFTTFTFQP VSAGFPRLPA
110 120 130 140 150
GAVVGIPASF LGDLVINTNH PVVIHGHTVD WRSPAGARLR ASLTLSREAQ
160 170 180 190 200
KFALAREVVY LESSTTAVHA LLAPACLAGT WALGVGAKYT LGLHAGPMNL
210 220 230 240 250
RAAFSLVAAV AGFVAYAFSQ DSLTHAVESW LDRRTASLSA AYACGGVEFY
260 270 280 290 300
EKLLSGNLAL RSLLGKDGEK LYTPSGNIVP RHLFRIKHLP YTTRRDSVLQ
310
MWRGMLNPGR S
Length:311
Mass (Da):33,760
Last modified:May 24, 2005 - v1
Checksum:iFC9697323D148426
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03142129G → A. Corresponds to variant dbSNP:rs11684353Ensembl.1
Natural variantiVAR_03142232I → V1 PublicationCorresponds to variant dbSNP:rs13011768Ensembl.1
Natural variantiVAR_031423267D → E1 PublicationCorresponds to variant dbSNP:rs1983406Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069154 Genomic DNA Translation: AAY24148.1
BC004404 mRNA Translation: AAH04404.1
CCDSiCCDS2128.1
RefSeqiNP_001098668.1, NM_001105198.1
NP_001098669.1, NM_001105199.1
NP_085054.2, NM_030577.2
UniGeneiHs.439991

Genome annotation databases

EnsembliENST00000272521; ENSP00000272521; ENSG00000144120
ENST00000401466; ENSP00000385966; ENSG00000144120
ENST00000424086; ENSP00000402661; ENSG00000144120
GeneIDi80775
KEGGihsa:80775
UCSCiuc002tmc.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM177_HUMAN
AccessioniPrimary (citable) accession number: Q53S58
Secondary accession number(s): Q9BT20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 24, 2005
Last modified: June 20, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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