Q53S46 (Q53S46_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Growth differentiation factor 8 EMBL EAX10880.1

Submitted name:
Myostatin EMBL ABI48371.1
Submitted name:
Putative uncharacterized protein GDF8 EMBL AAY24188.1
Submitted name:
cDNA FLJ75269, highly similar to Homo sapiens myostatin (GDF8) mRNA EMBL BAF84213.1

Gene names

Name:	GDF8 EMBL AAY24188.1
ORF Names:	hCG_24799 EMBL EAX10880.1

Organism

Homo sapiens (Human) EMBL AAY24188.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS001111
Molecular function	Growth factor SAAS SAAS001111 RuleBase RU000354
PTM	Disulfide bond SAAS SAAS001111
Gene Ontology (GO)
Biological_process	negative regulation of muscle hypertrophy Inferred from electronic annotation. Source: Compara negative regulation of skeletal muscle tissue growth Inferred from electronic annotation. Source: Compara ovulation cycle process Inferred from electronic annotation. Source: Compara response to electrical stimulus Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to gravity Inferred from electronic annotation. Source: Compara response to heat Inferred from electronic annotation. Source: Compara response to muscle activity Inferred from electronic annotation. Source: Compara response to testosterone stimulus Inferred from electronic annotation. Source: Compara skeletal muscle atrophy Inferred from electronic annotation. Source: Compara skeletal muscle tissue regeneration Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q53S46 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: EBFF6129725E6AFA	FASTA	375	42,750
	10 20 30 40 50 60 MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS SRIEAIKIQI 70 80 90 100 110 120 LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHATTETIIT 130 140 150 160 170 180 MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK VVKAQLWIYL RPVETPTTVF VQILRLIKPM 190 200 210 220 230 240 KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT 250 260 270 280 290 300 FPGPGEDGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA 310 320 330 340 350 360 PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII 370 YGKIPAMVVD RCGCS

References

[1]	"The sequence of Homo sapiens BAC clone RP11-612D17." Maupin R., Nguyen C., Wedgeworth P., Dignan G. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The sequence of the human genome." Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H. , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X. Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	Waterston R.H. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Waterston R. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	Wilson R.K. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth." Saunders M.A., Good J.M., Lawrence E.C., Ferrell R.E., Li W.H., Nachman M.W. Am. J. Hum. Genet. 79:1089-1097(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: AFRAM_A03 EMBL ABI48371.1, AFRAM_A05 EMBL ABI48373.1, AFRAM_A08 EMBL ABI48376.1, AFRAM_A10 EMBL ABI48378.1, AFRAM_B03 EMBL ABI48380.1, AFRAM_B05 EMBL ABI48381.1, AFRAM_B06 EMBL ABI48382.1, AFRAM_B09 EMBL ABI48384.1, AFRAM_B12 EMBL ABI48387.1, AFRAM_C02 EMBL ABI48388.1, AFRAM_C05 EMBL ABI48391.1, AFRAM_C06 EMBL ABI48392.1, AFRAM_C07 EMBL ABI48393.1, AFRAM_C09 EMBL ABI48395.1, AFRAM_D10 EMBL ABI48403.1, AFRAM_D11 EMBL ABI48404.1, AFRAM_E02 EMBL ABI48406.1, AFRAM_E07 EMBL ABI48410.1, AFRAM_E08 EMBL ABI48411.1, AFRAM_E10 EMBL ABI48413.1, AFRAM_E11 EMBL ABI48414.1, AFRAM_E12 EMBL ABI48415.1, AFRAM_F01 EMBL ABI48416.1, AFRAM_F02 EMBL ABI48417.1, AFRAM_F06 EMBL ABI48420.1, AFRAM_F09 EMBL ABI48423.1, AFRAM_F10 EMBL ABI48424.1, AFRAM_G01 EMBL ABI48425.1, AFRAM_G03 EMBL ABI48427.1, AFRAM_G05 EMBL ABI48428.1, AFRAM_G07 EMBL ABI48430.1, AFRAM_G10 EMBL ABI48433.1, AFRAM_G11 EMBL ABI48434.1, AFRAM_H01 EMBL ABI48436.1, AFRAM_H06 EMBL ABI48440.1, AFRAM_H09 EMBL ABI48443.1, AFRAM_H10 EMBL ABI48444.1, EURO_A04 EMBL ABI48445.1, EURO_A05 EMBL ABI48446.1, EURO_A09 EMBL ABI48447.1, EURO_A10 EMBL ABI48448.1, EURO_B01 EMBL ABI48449.1, EURO_B03 EMBL ABI48450.1, EURO_B04 EMBL ABI48451.1, EURO_B06 EMBL ABI48453.1, EURO_B07 EMBL ABI48454.1, EURO_B09 EMBL ABI48456.1, EURO_B10 EMBL ABI48457.1, EURO_B11 EMBL ABI48458.1, EURO_C01 EMBL ABI48459.1, EURO_C02 EMBL ABI48460.1, EURO_C04 EMBL ABI48461.1, EURO_C05 EMBL ABI48462.1, EURO_C06 EMBL ABI48463.1, EURO_C07 EMBL ABI48464.1, EURO_C09 EMBL ABI48466.1, EURO_C10 EMBL ABI48467.1, EURO_C11 EMBL ABI48468.1, EURO_C12 EMBL ABI48469.1, EURO_D01 EMBL ABI48470.1, EURO_D04 EMBL ABI48471.1, EURO_D05 EMBL ABI48472.1, EURO_D06 EMBL ABI48473.1, EURO_D07 EMBL ABI48474.1, EURO_D08 EMBL ABI48475.1, EURO_D09 EMBL ABI48476.1, EURO_D10 EMBL ABI48477.1, EURO_D11 EMBL ABI48478.1, EURO_E01 EMBL ABI48479.1, EURO_E03 EMBL ABI48480.1, EURO_E04 EMBL ABI48481.1, EURO_E05 EMBL ABI48482.1, EURO_E08 EMBL ABI48483.1, EURO_E09 EMBL ABI48484.1, EURO_E10 EMBL ABI48485.1, EURO_E12 EMBL ABI48486.1, EURO_F01 EMBL ABI48487.1, EURO_F02 EMBL ABI48488.1, EURO_F03 EMBL ABI48489.1, EURO_F04 EMBL ABI48490.1, EURO_F05 EMBL ABI48491.1, EURO_F07 EMBL ABI48492.1, EURO_F08 EMBL ABI48493.1, EURO_F09 EMBL ABI48494.1, EURO_F10 EMBL ABI48495.1, EURO_G02 EMBL ABI48496.1, EURO_G04 EMBL ABI48497.1, EURO_G05 EMBL ABI48498.1, EURO_G06 EMBL ABI48499.1, EURO_G07 EMBL ABI48500.1, EURO_G09 EMBL ABI48502.1, EURO_G10 EMBL ABI48503.1, EURO_G11 EMBL ABI48504.1, EURO_H01 EMBL ABI48506.1, EURO_H02 EMBL ABI48507.1, EURO_H04 EMBL ABI48509.1, EURO_H05 EMBL ABI48510.1, EURO_H07 EMBL ABI48511.1, EURO_H09 EMBL ABI48512.1, EURO_H10 EMBL ABI48513.1 and EURO_H11 EMBL ABI48514.1.
[8]	"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Pericardium EMBL BAF84213.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC073120 Genomic DNA. Translation: AAY24188.1. DQ927048 Genomic DNA. Translation: ABI48371.1. DQ927050 Genomic DNA. Translation: ABI48373.1. DQ927053 Genomic DNA. Translation: ABI48376.1. DQ927055 Genomic DNA. Translation: ABI48378.1. DQ927057 Genomic DNA. Translation: ABI48380.1. DQ927058 Genomic DNA. Translation: ABI48381.1. DQ927059 Genomic DNA. Translation: ABI48382.1. DQ927061 Genomic DNA. Translation: ABI48384.1. DQ927064 Genomic DNA. Translation: ABI48387.1. DQ927065 Genomic DNA. Translation: ABI48388.1. DQ927068 Genomic DNA. Translation: ABI48391.1. DQ927069 Genomic DNA. Translation: ABI48392.1. DQ927070 Genomic DNA. Translation: ABI48393.1. DQ927072 Genomic DNA. Translation: ABI48395.1. DQ927080 Genomic DNA. Translation: ABI48403.1. DQ927081 Genomic DNA. Translation: ABI48404.1. DQ927083 Genomic DNA. Translation: ABI48406.1. DQ927087 Genomic DNA. Translation: ABI48410.1. DQ927088 Genomic DNA. Translation: ABI48411.1. DQ927090 Genomic DNA. Translation: ABI48413.1. DQ927091 Genomic DNA. Translation: ABI48414.1. DQ927092 Genomic DNA. Translation: ABI48415.1. DQ927093 Genomic DNA. Translation: ABI48416.1. DQ927094 Genomic DNA. Translation: ABI48417.1. DQ927097 Genomic DNA. Translation: ABI48420.1. DQ927100 Genomic DNA. Translation: ABI48423.1. DQ927101 Genomic DNA. Translation: ABI48424.1. DQ927102 Genomic DNA. Translation: ABI48425.1. DQ927104 Genomic DNA. Translation: ABI48427.1. DQ927105 Genomic DNA. Translation: ABI48428.1. DQ927107 Genomic DNA. Translation: ABI48430.1. DQ927110 Genomic DNA. Translation: ABI48433.1. DQ927111 Genomic DNA. Translation: ABI48434.1. DQ927113 Genomic DNA. Translation: ABI48436.1. DQ927117 Genomic DNA. Translation: ABI48440.1. DQ927120 Genomic DNA. Translation: ABI48443.1. DQ927121 Genomic DNA. Translation: ABI48444.1. DQ927122 Genomic DNA. Translation: ABI48445.1. DQ927123 Genomic DNA. Translation: ABI48446.1. DQ927124 Genomic DNA. Translation: ABI48447.1. DQ927125 Genomic DNA. Translation: ABI48448.1. DQ927126 Genomic DNA. Translation: ABI48449.1. DQ927127 Genomic DNA. Translation: ABI48450.1. DQ927128 Genomic DNA. Translation: ABI48451.1. DQ927130 Genomic DNA. Translation: ABI48453.1. DQ927131 Genomic DNA. Translation: ABI48454.1. DQ927133 Genomic DNA. Translation: ABI48456.1. DQ927134 Genomic DNA. Translation: ABI48457.1. DQ927135 Genomic DNA. Translation: ABI48458.1. DQ927136 Genomic DNA. Translation: ABI48459.1. DQ927137 Genomic DNA. Translation: ABI48460.1. DQ927138 Genomic DNA. Translation: ABI48461.1. DQ927139 Genomic DNA. Translation: ABI48462.1. DQ927140 Genomic DNA. Translation: ABI48463.1. DQ927141 Genomic DNA. Translation: ABI48464.1. DQ927143 Genomic DNA. Translation: ABI48466.1. DQ927144 Genomic DNA. Translation: ABI48467.1. DQ927145 Genomic DNA. Translation: ABI48468.1. DQ927146 Genomic DNA. Translation: ABI48469.1. DQ927147 Genomic DNA. Translation: ABI48470.1. DQ927148 Genomic DNA. Translation: ABI48471.1. DQ927149 Genomic DNA. Translation: ABI48472.1. DQ927150 Genomic DNA. Translation: ABI48473.1. DQ927151 Genomic DNA. Translation: ABI48474.1. DQ927152 Genomic DNA. Translation: ABI48475.1. DQ927153 Genomic DNA. Translation: ABI48476.1. DQ927154 Genomic DNA. Translation: ABI48477.1. DQ927155 Genomic DNA. Translation: ABI48478.1. DQ927156 Genomic DNA. Translation: ABI48479.1. DQ927157 Genomic DNA. Translation: ABI48480.1. DQ927158 Genomic DNA. Translation: ABI48481.1. DQ927159 Genomic DNA. Translation: ABI48482.1. DQ927160 Genomic DNA. Translation: ABI48483.1. DQ927161 Genomic DNA. Translation: ABI48484.1. DQ927162 Genomic DNA. Translation: ABI48485.1. DQ927163 Genomic DNA. Translation: ABI48486.1. DQ927164 Genomic DNA. Translation: ABI48487.1. DQ927165 Genomic DNA. Translation: ABI48488.1. DQ927166 Genomic DNA. Translation: ABI48489.1. DQ927167 Genomic DNA. Translation: ABI48490.1. DQ927168 Genomic DNA. Translation: ABI48491.1. DQ927169 Genomic DNA. Translation: ABI48492.1. DQ927170 Genomic DNA. Translation: ABI48493.1. DQ927171 Genomic DNA. Translation: ABI48494.1. DQ927172 Genomic DNA. Translation: ABI48495.1. DQ927173 Genomic DNA. Translation: ABI48496.1. DQ927174 Genomic DNA. Translation: ABI48497.1. DQ927175 Genomic DNA. Translation: ABI48498.1. DQ927176 Genomic DNA. Translation: ABI48499.1. DQ927177 Genomic DNA. Translation: ABI48500.1. DQ927179 Genomic DNA. Translation: ABI48502.1. DQ927180 Genomic DNA. Translation: ABI48503.1. DQ927181 Genomic DNA. Translation: ABI48504.1. DQ927183 Genomic DNA. Translation: ABI48506.1. DQ927184 Genomic DNA. Translation: ABI48507.1. DQ927186 Genomic DNA. Translation: ABI48509.1. DQ927187 Genomic DNA. Translation: ABI48510.1. DQ927188 Genomic DNA. Translation: ABI48511.1. DQ927189 Genomic DNA. Translation: ABI48512.1. DQ927190 Genomic DNA. Translation: ABI48513.1. DQ927191 Genomic DNA. Translation: ABI48514.1. AK291524 mRNA. Translation: BAF84213.1. CH471058 Genomic DNA. Translation: EAX10880.1.
IPI	IPI00023751.
RefSeq	NP_005250.1. NM_005259.2.
UniGene	Hs.41565.
3D structure databases
ProteinModelPortal	Q53S46.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53S46.
Proteomic databases
PRIDE	Q53S46.
Protocols and materials databases
DNASU	2660.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2660.
KEGG	hsa:2660.
Organism-specific databases
CTD	2660.
PharmGKB	PA162396253.
Phylogenomic databases
HOVERGEN	HBG000217.
KO	K05497.
OMA	DLLMQVE.
PhylomeDB	Q53S46.
Gene expression databases
ArrayExpress	Q53S46.
Bgee	Q53S46.
Family and domain databases
InterPro	IPR015616. GDF_8. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit. PTHR11848:SF13. PTHR11848:SF13. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2660.
NextBio	10500.

Entry information

Entry name

Q53S46_HUMAN

Accession

Primary (citable) accession number: Q53S46

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.