Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Growth differentiation factor 8

Gene

GDF8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Growth differentiation factor 8Imported
Submitted name:
MyostatinImported
Submitted name:
Putative uncharacterized protein GDF8Imported
Submitted name:
cDNA FLJ75269, highly similar to Homo sapiens myostatin (GDF8) mRNAImported
Gene namesi
Name:GDF8Imported
ORF Names:hCG_24799Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396253.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500878070919 – 375Sequence analysisAdd BLAST357

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000138379.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000260950.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 375TGF_BETA_2InterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOVERGENiHBG000217.
KOiK05497.
OMAiQIFVYIY.
OrthoDBiEOG091G078V.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR015616. GDF_8.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF150. PTHR11848:SF150. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53S46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS
60 70 80 90 100
SRIEAIKIQI LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD
110 120 130 140 150
SSDGSLEDDD YHATTETIIT MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK
160 170 180 190 200
VVKAQLWIYL RPVETPTTVF VQILRLIKPM KDGTRYTGIR SLKLDMNPGT
210 220 230 240 250
GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT FPGPGEDGLN
260 270 280 290 300
PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA
310 320 330 340 350
PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM
360 370
LYFNGKEQII YGKIPAMVVD RCGCS
Length:375
Mass (Da):42,750
Last modified:May 24, 2005 - v1
Checksum:iEBFF6129725E6AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073120 Genomic DNA. Translation: AAY24188.1.
DQ927048 Genomic DNA. Translation: ABI48371.1.
DQ927050 Genomic DNA. Translation: ABI48373.1.
DQ927053 Genomic DNA. Translation: ABI48376.1.
DQ927055 Genomic DNA. Translation: ABI48378.1.
DQ927057 Genomic DNA. Translation: ABI48380.1.
DQ927058 Genomic DNA. Translation: ABI48381.1.
DQ927059 Genomic DNA. Translation: ABI48382.1.
DQ927061 Genomic DNA. Translation: ABI48384.1.
DQ927064 Genomic DNA. Translation: ABI48387.1.
DQ927065 Genomic DNA. Translation: ABI48388.1.
DQ927068 Genomic DNA. Translation: ABI48391.1.
DQ927069 Genomic DNA. Translation: ABI48392.1.
DQ927070 Genomic DNA. Translation: ABI48393.1.
DQ927072 Genomic DNA. Translation: ABI48395.1.
DQ927080 Genomic DNA. Translation: ABI48403.1.
DQ927081 Genomic DNA. Translation: ABI48404.1.
DQ927083 Genomic DNA. Translation: ABI48406.1.
DQ927087 Genomic DNA. Translation: ABI48410.1.
DQ927088 Genomic DNA. Translation: ABI48411.1.
DQ927090 Genomic DNA. Translation: ABI48413.1.
DQ927091 Genomic DNA. Translation: ABI48414.1.
DQ927092 Genomic DNA. Translation: ABI48415.1.
DQ927093 Genomic DNA. Translation: ABI48416.1.
DQ927094 Genomic DNA. Translation: ABI48417.1.
DQ927097 Genomic DNA. Translation: ABI48420.1.
DQ927100 Genomic DNA. Translation: ABI48423.1.
DQ927101 Genomic DNA. Translation: ABI48424.1.
DQ927102 Genomic DNA. Translation: ABI48425.1.
DQ927104 Genomic DNA. Translation: ABI48427.1.
DQ927105 Genomic DNA. Translation: ABI48428.1.
DQ927107 Genomic DNA. Translation: ABI48430.1.
DQ927110 Genomic DNA. Translation: ABI48433.1.
DQ927111 Genomic DNA. Translation: ABI48434.1.
DQ927113 Genomic DNA. Translation: ABI48436.1.
DQ927117 Genomic DNA. Translation: ABI48440.1.
DQ927120 Genomic DNA. Translation: ABI48443.1.
DQ927121 Genomic DNA. Translation: ABI48444.1.
DQ927122 Genomic DNA. Translation: ABI48445.1.
DQ927123 Genomic DNA. Translation: ABI48446.1.
DQ927124 Genomic DNA. Translation: ABI48447.1.
DQ927125 Genomic DNA. Translation: ABI48448.1.
DQ927126 Genomic DNA. Translation: ABI48449.1.
DQ927127 Genomic DNA. Translation: ABI48450.1.
DQ927128 Genomic DNA. Translation: ABI48451.1.
DQ927130 Genomic DNA. Translation: ABI48453.1.
DQ927131 Genomic DNA. Translation: ABI48454.1.
DQ927133 Genomic DNA. Translation: ABI48456.1.
DQ927134 Genomic DNA. Translation: ABI48457.1.
DQ927135 Genomic DNA. Translation: ABI48458.1.
DQ927136 Genomic DNA. Translation: ABI48459.1.
DQ927137 Genomic DNA. Translation: ABI48460.1.
DQ927138 Genomic DNA. Translation: ABI48461.1.
DQ927139 Genomic DNA. Translation: ABI48462.1.
DQ927140 Genomic DNA. Translation: ABI48463.1.
DQ927141 Genomic DNA. Translation: ABI48464.1.
DQ927143 Genomic DNA. Translation: ABI48466.1.
DQ927144 Genomic DNA. Translation: ABI48467.1.
DQ927145 Genomic DNA. Translation: ABI48468.1.
DQ927146 Genomic DNA. Translation: ABI48469.1.
DQ927147 Genomic DNA. Translation: ABI48470.1.
DQ927148 Genomic DNA. Translation: ABI48471.1.
DQ927149 Genomic DNA. Translation: ABI48472.1.
DQ927150 Genomic DNA. Translation: ABI48473.1.
DQ927151 Genomic DNA. Translation: ABI48474.1.
DQ927152 Genomic DNA. Translation: ABI48475.1.
DQ927153 Genomic DNA. Translation: ABI48476.1.
DQ927154 Genomic DNA. Translation: ABI48477.1.
DQ927155 Genomic DNA. Translation: ABI48478.1.
DQ927156 Genomic DNA. Translation: ABI48479.1.
DQ927157 Genomic DNA. Translation: ABI48480.1.
DQ927158 Genomic DNA. Translation: ABI48481.1.
DQ927159 Genomic DNA. Translation: ABI48482.1.
DQ927160 Genomic DNA. Translation: ABI48483.1.
DQ927161 Genomic DNA. Translation: ABI48484.1.
DQ927162 Genomic DNA. Translation: ABI48485.1.
DQ927163 Genomic DNA. Translation: ABI48486.1.
DQ927164 Genomic DNA. Translation: ABI48487.1.
DQ927165 Genomic DNA. Translation: ABI48488.1.
DQ927166 Genomic DNA. Translation: ABI48489.1.
DQ927167 Genomic DNA. Translation: ABI48490.1.
DQ927168 Genomic DNA. Translation: ABI48491.1.
DQ927169 Genomic DNA. Translation: ABI48492.1.
DQ927170 Genomic DNA. Translation: ABI48493.1.
DQ927171 Genomic DNA. Translation: ABI48494.1.
DQ927172 Genomic DNA. Translation: ABI48495.1.
DQ927173 Genomic DNA. Translation: ABI48496.1.
DQ927174 Genomic DNA. Translation: ABI48497.1.
DQ927175 Genomic DNA. Translation: ABI48498.1.
DQ927176 Genomic DNA. Translation: ABI48499.1.
DQ927177 Genomic DNA. Translation: ABI48500.1.
DQ927179 Genomic DNA. Translation: ABI48502.1.
DQ927180 Genomic DNA. Translation: ABI48503.1.
DQ927181 Genomic DNA. Translation: ABI48504.1.
DQ927183 Genomic DNA. Translation: ABI48506.1.
DQ927184 Genomic DNA. Translation: ABI48507.1.
DQ927186 Genomic DNA. Translation: ABI48509.1.
DQ927187 Genomic DNA. Translation: ABI48510.1.
DQ927188 Genomic DNA. Translation: ABI48511.1.
DQ927189 Genomic DNA. Translation: ABI48512.1.
DQ927190 Genomic DNA. Translation: ABI48513.1.
DQ927191 Genomic DNA. Translation: ABI48514.1.
AK291524 mRNA. Translation: BAF84213.1.
CH471058 Genomic DNA. Translation: EAX10880.1.
RefSeqiNP_005250.1. NM_005259.2.
UniGeneiHs.41565.

Genome annotation databases

GeneIDi2660.
KEGGihsa:2660.
UCSCiuc002urp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073120 Genomic DNA. Translation: AAY24188.1.
DQ927048 Genomic DNA. Translation: ABI48371.1.
DQ927050 Genomic DNA. Translation: ABI48373.1.
DQ927053 Genomic DNA. Translation: ABI48376.1.
DQ927055 Genomic DNA. Translation: ABI48378.1.
DQ927057 Genomic DNA. Translation: ABI48380.1.
DQ927058 Genomic DNA. Translation: ABI48381.1.
DQ927059 Genomic DNA. Translation: ABI48382.1.
DQ927061 Genomic DNA. Translation: ABI48384.1.
DQ927064 Genomic DNA. Translation: ABI48387.1.
DQ927065 Genomic DNA. Translation: ABI48388.1.
DQ927068 Genomic DNA. Translation: ABI48391.1.
DQ927069 Genomic DNA. Translation: ABI48392.1.
DQ927070 Genomic DNA. Translation: ABI48393.1.
DQ927072 Genomic DNA. Translation: ABI48395.1.
DQ927080 Genomic DNA. Translation: ABI48403.1.
DQ927081 Genomic DNA. Translation: ABI48404.1.
DQ927083 Genomic DNA. Translation: ABI48406.1.
DQ927087 Genomic DNA. Translation: ABI48410.1.
DQ927088 Genomic DNA. Translation: ABI48411.1.
DQ927090 Genomic DNA. Translation: ABI48413.1.
DQ927091 Genomic DNA. Translation: ABI48414.1.
DQ927092 Genomic DNA. Translation: ABI48415.1.
DQ927093 Genomic DNA. Translation: ABI48416.1.
DQ927094 Genomic DNA. Translation: ABI48417.1.
DQ927097 Genomic DNA. Translation: ABI48420.1.
DQ927100 Genomic DNA. Translation: ABI48423.1.
DQ927101 Genomic DNA. Translation: ABI48424.1.
DQ927102 Genomic DNA. Translation: ABI48425.1.
DQ927104 Genomic DNA. Translation: ABI48427.1.
DQ927105 Genomic DNA. Translation: ABI48428.1.
DQ927107 Genomic DNA. Translation: ABI48430.1.
DQ927110 Genomic DNA. Translation: ABI48433.1.
DQ927111 Genomic DNA. Translation: ABI48434.1.
DQ927113 Genomic DNA. Translation: ABI48436.1.
DQ927117 Genomic DNA. Translation: ABI48440.1.
DQ927120 Genomic DNA. Translation: ABI48443.1.
DQ927121 Genomic DNA. Translation: ABI48444.1.
DQ927122 Genomic DNA. Translation: ABI48445.1.
DQ927123 Genomic DNA. Translation: ABI48446.1.
DQ927124 Genomic DNA. Translation: ABI48447.1.
DQ927125 Genomic DNA. Translation: ABI48448.1.
DQ927126 Genomic DNA. Translation: ABI48449.1.
DQ927127 Genomic DNA. Translation: ABI48450.1.
DQ927128 Genomic DNA. Translation: ABI48451.1.
DQ927130 Genomic DNA. Translation: ABI48453.1.
DQ927131 Genomic DNA. Translation: ABI48454.1.
DQ927133 Genomic DNA. Translation: ABI48456.1.
DQ927134 Genomic DNA. Translation: ABI48457.1.
DQ927135 Genomic DNA. Translation: ABI48458.1.
DQ927136 Genomic DNA. Translation: ABI48459.1.
DQ927137 Genomic DNA. Translation: ABI48460.1.
DQ927138 Genomic DNA. Translation: ABI48461.1.
DQ927139 Genomic DNA. Translation: ABI48462.1.
DQ927140 Genomic DNA. Translation: ABI48463.1.
DQ927141 Genomic DNA. Translation: ABI48464.1.
DQ927143 Genomic DNA. Translation: ABI48466.1.
DQ927144 Genomic DNA. Translation: ABI48467.1.
DQ927145 Genomic DNA. Translation: ABI48468.1.
DQ927146 Genomic DNA. Translation: ABI48469.1.
DQ927147 Genomic DNA. Translation: ABI48470.1.
DQ927148 Genomic DNA. Translation: ABI48471.1.
DQ927149 Genomic DNA. Translation: ABI48472.1.
DQ927150 Genomic DNA. Translation: ABI48473.1.
DQ927151 Genomic DNA. Translation: ABI48474.1.
DQ927152 Genomic DNA. Translation: ABI48475.1.
DQ927153 Genomic DNA. Translation: ABI48476.1.
DQ927154 Genomic DNA. Translation: ABI48477.1.
DQ927155 Genomic DNA. Translation: ABI48478.1.
DQ927156 Genomic DNA. Translation: ABI48479.1.
DQ927157 Genomic DNA. Translation: ABI48480.1.
DQ927158 Genomic DNA. Translation: ABI48481.1.
DQ927159 Genomic DNA. Translation: ABI48482.1.
DQ927160 Genomic DNA. Translation: ABI48483.1.
DQ927161 Genomic DNA. Translation: ABI48484.1.
DQ927162 Genomic DNA. Translation: ABI48485.1.
DQ927163 Genomic DNA. Translation: ABI48486.1.
DQ927164 Genomic DNA. Translation: ABI48487.1.
DQ927165 Genomic DNA. Translation: ABI48488.1.
DQ927166 Genomic DNA. Translation: ABI48489.1.
DQ927167 Genomic DNA. Translation: ABI48490.1.
DQ927168 Genomic DNA. Translation: ABI48491.1.
DQ927169 Genomic DNA. Translation: ABI48492.1.
DQ927170 Genomic DNA. Translation: ABI48493.1.
DQ927171 Genomic DNA. Translation: ABI48494.1.
DQ927172 Genomic DNA. Translation: ABI48495.1.
DQ927173 Genomic DNA. Translation: ABI48496.1.
DQ927174 Genomic DNA. Translation: ABI48497.1.
DQ927175 Genomic DNA. Translation: ABI48498.1.
DQ927176 Genomic DNA. Translation: ABI48499.1.
DQ927177 Genomic DNA. Translation: ABI48500.1.
DQ927179 Genomic DNA. Translation: ABI48502.1.
DQ927180 Genomic DNA. Translation: ABI48503.1.
DQ927181 Genomic DNA. Translation: ABI48504.1.
DQ927183 Genomic DNA. Translation: ABI48506.1.
DQ927184 Genomic DNA. Translation: ABI48507.1.
DQ927186 Genomic DNA. Translation: ABI48509.1.
DQ927187 Genomic DNA. Translation: ABI48510.1.
DQ927188 Genomic DNA. Translation: ABI48511.1.
DQ927189 Genomic DNA. Translation: ABI48512.1.
DQ927190 Genomic DNA. Translation: ABI48513.1.
DQ927191 Genomic DNA. Translation: ABI48514.1.
AK291524 mRNA. Translation: BAF84213.1.
CH471058 Genomic DNA. Translation: EAX10880.1.
RefSeqiNP_005250.1. NM_005259.2.
UniGeneiHs.41565.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000260950.

Protocols and materials databases

DNASUi2660.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2660.
KEGGihsa:2660.
UCSCiuc002urp.4. human.

Organism-specific databases

CTDi2660.
PharmGKBiPA162396253.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOVERGENiHBG000217.
KOiK05497.
OMAiQIFVYIY.
OrthoDBiEOG091G078V.

Miscellaneous databases

GenomeRNAii2660.

Gene expression databases

BgeeiENSG00000138379.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR015616. GDF_8.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF150. PTHR11848:SF150. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53S46_HUMAN
AccessioniPrimary (citable) accession number: Q53S46
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.