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Q53RU4

- Q53RU4_HUMAN

UniProt

Q53RU4 - Q53RU4_HUMAN

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Protein
Submitted name:

Putative uncharacterized protein MSH2

Gene
MSH2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATPase activity Source: Ensembl
  2. ATP binding Source: InterPro
  3. centromeric DNA binding Source: Ensembl
  4. damaged DNA binding Source: Ensembl
  5. mismatched DNA binding Source: Ensembl

GO - Biological processi

  1. B cell differentiation Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. determination of adult lifespan Source: Ensembl
  4. double-strand break repair Source: Ensembl
  5. germ cell development Source: Ensembl
  6. intra-S DNA damage checkpoint Source: Ensembl
  7. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. isotype switching Source: Ensembl
  10. male gonad development Source: Ensembl
  11. mismatch repair Source: Ensembl
  12. negative regulation of DNA recombination Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. oxidative phosphorylation Source: Ensembl
  15. response to UV-B Source: Ensembl
  16. response to X-ray Source: Ensembl
  17. somatic hypermutation of immunoglobulin genes Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein MSH2Imported
Gene namesi
Name:MSH2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. MutSalpha complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ53RU4.
BgeeiQ53RU4.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000196498.
HOVERGENiHBG006399.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
[Graphical view]
SMARTiSM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q53RU4-1 [UniParc]FASTAAdd to Basket

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MAVQPKETLQ LESAAEVGFV RFFQGMPEKP TTTVRLFDRG DFYTAHGEDA    50
LLAAREVFKT QGVIKYMGPA GAKNLQSVVL SKMNFESFVK DLLLVRQYRV 100
EVYKNRAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSASIGVVGV 150
KMSAVDGQRQ VGVGYVDSIQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECV 200
LPGGETAGDM GKLRQIIQRG GILITERKKA DFSTKDIYQD LNRLLKGKKG 250
EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LTTFDFSQYM 300
KLDIAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTPQGQR LVNQWIKQPL 350
MDKNRIEERL NLVEAFVEDA ELRQTLQEDL LRRFPDLNRL AKKFQRQAAN 400
LQDCYRLYQG INQLPNVIQA LEKHEGKHQK LLLAVFVTPL TDLRSDFSKF 450
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREIMNDLEK KMQSTLISAA 500
RDLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK 550
FTNSKLTSLN EEYTKNKTEY EEAQDAIVKE IVNISS 586
Length:586
Mass (Da):66,276
Last modified:May 24, 2005 - v1
Checksum:iE6E1425FBB365120
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei586 – 5861Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079775 Genomic DNA. Translation: AAY15096.1.
UniGeneiHs.597656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079775 Genomic DNA. Translation: AAY15096.1 .
UniGenei Hs.597656.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000196498.
HOVERGENi HBG006399.

Miscellaneous databases

ChiTaRSi MSH2. human.

Gene expression databases

ArrayExpressi Q53RU4.
Bgeei Q53RU4.

Family and domain databases

Gene3Di 3.30.420.110. 1 hit.
InterProi IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
[Graphical view ]
SMARTi SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-295P2."
    Elliott G., Doebber A., Belter E., Haakenson W.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ53RU4_HUMAN
AccessioniPrimary (citable) accession number: Q53RU4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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