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Q53RU4

- Q53RU4_HUMAN

UniProt

Q53RU4 - Q53RU4_HUMAN

Protein
Submitted name:

Putative uncharacterized protein MSH2

Gene

MSH2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity Source: Ensembl
    2. ATP binding Source: InterPro
    3. centromeric DNA binding Source: Ensembl
    4. damaged DNA binding Source: Ensembl
    5. mismatched DNA binding Source: Ensembl

    GO - Biological processi

    1. B cell differentiation Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. determination of adult lifespan Source: Ensembl
    4. double-strand break repair Source: Ensembl
    5. germ cell development Source: Ensembl
    6. intra-S DNA damage checkpoint Source: Ensembl
    7. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. isotype switching Source: Ensembl
    10. male gonad development Source: Ensembl
    11. mismatch repair Source: Ensembl
    12. negative regulation of DNA recombination Source: Ensembl
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. oxidative phosphorylation Source: Ensembl
    15. response to UV-B Source: Ensembl
    16. response to X-ray Source: Ensembl
    17. somatic hypermutation of immunoglobulin genes Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized protein MSH2Imported
    Gene namesi
    Name:MSH2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. MutSalpha complex Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ53RU4.
    BgeeiQ53RU4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000196498.
    HOVERGENiHBG006399.

    Family and domain databases

    Gene3Di3.30.420.110. 1 hit.
    InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    [Graphical view]
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    [Graphical view]
    SMARTiSM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q53RU4-1 [UniParc]FASTAAdd to Basket

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    MAVQPKETLQ LESAAEVGFV RFFQGMPEKP TTTVRLFDRG DFYTAHGEDA    50
    LLAAREVFKT QGVIKYMGPA GAKNLQSVVL SKMNFESFVK DLLLVRQYRV 100
    EVYKNRAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSASIGVVGV 150
    KMSAVDGQRQ VGVGYVDSIQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECV 200
    LPGGETAGDM GKLRQIIQRG GILITERKKA DFSTKDIYQD LNRLLKGKKG 250
    EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LTTFDFSQYM 300
    KLDIAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTPQGQR LVNQWIKQPL 350
    MDKNRIEERL NLVEAFVEDA ELRQTLQEDL LRRFPDLNRL AKKFQRQAAN 400
    LQDCYRLYQG INQLPNVIQA LEKHEGKHQK LLLAVFVTPL TDLRSDFSKF 450
    QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREIMNDLEK KMQSTLISAA 500
    RDLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK 550
    FTNSKLTSLN EEYTKNKTEY EEAQDAIVKE IVNISS 586
    Length:586
    Mass (Da):66,276
    Last modified:May 24, 2005 - v1
    Checksum:iE6E1425FBB365120
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei586 – 5861Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079775 Genomic DNA. Translation: AAY15096.1.
    UniGeneiHs.597656.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079775 Genomic DNA. Translation: AAY15096.1 .
    UniGenei Hs.597656.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000196498.
    HOVERGENi HBG006399.

    Miscellaneous databases

    ChiTaRSi MSH2. human.

    Gene expression databases

    ArrayExpressi Q53RU4.
    Bgeei Q53RU4.

    Family and domain databases

    Gene3Di 3.30.420.110. 1 hit.
    InterProi IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    [Graphical view ]
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    [Graphical view ]
    SMARTi SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of Homo sapiens BAC clone RP11-295P2."
      Elliott G., Doebber A., Belter E., Haakenson W.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Waterston R.H.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Waterston R.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Wilson R.K.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ53RU4_HUMAN
    AccessioniPrimary (citable) accession number: Q53RU4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.