Q53RU4 (Q53RU4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein MSH2 EMBL AAY15096.1

Gene names

Name:

MSH2 EMBL AAY15096.1

Organism

Homo sapiens (Human) EMBL AAY15096.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	586 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the DNA mismatch repair MutS family. RuleBase RU003756

Ontologies

Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC B cell differentiation Inferred from electronic annotation. Source: Compara apoptotic process Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: Compara determination of adult lifespan Inferred from electronic annotation. Source: Compara double-strand break repair Inferred from electronic annotation. Source: Compara germ cell development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara intra-S DNA damage checkpoint Inferred from electronic annotation. Source: Compara isotype switching Inferred from electronic annotation. Source: Compara male gonad development Inferred from electronic annotation. Source: Compara mismatch repair Inferred from electronic annotation. Source: Compara negative regulation of DNA recombination Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara oxidative phosphorylation Inferred from electronic annotation. Source: Compara response to UV-B Inferred from electronic annotation. Source: Compara response to X-ray Inferred from electronic annotation. Source: Compara somatic hypermutation of immunoglobulin genes Inferred from electronic annotation. Source: Compara
Cellular_component	MutSalpha complex Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity Inferred from electronic annotation. Source: Compara centromeric DNA binding Inferred from electronic annotation. Source: Compara damaged DNA binding Inferred from electronic annotation. Source: Compara guanine/thymine mispair binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	586	1	EMBL AAY15096.1

Sequences

	Sequence		Length	Mass (Da)
	Q53RU4 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: E6E1425FBB365120	FASTA	586	66,276
	10 20 30 40 50 60 MAVQPKETLQ LESAAEVGFV RFFQGMPEKP TTTVRLFDRG DFYTAHGEDA LLAAREVFKT 70 80 90 100 110 120 QGVIKYMGPA GAKNLQSVVL SKMNFESFVK DLLLVRQYRV EVYKNRAGNK ASKENDWYLA 130 140 150 160 170 180 YKASPGNLSQ FEDILFGNND MSASIGVVGV KMSAVDGQRQ VGVGYVDSIQ RKLGLCEFPD 190 200 210 220 230 240 NDQFSNLEAL LIQIGPKECV LPGGETAGDM GKLRQIIQRG GILITERKKA DFSTKDIYQD 250 260 270 280 290 300 LNRLLKGKKG EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LTTFDFSQYM 310 320 330 340 350 360 KLDIAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTPQGQR LVNQWIKQPL MDKNRIEERL 370 380 390 400 410 420 NLVEAFVEDA ELRQTLQEDL LRRFPDLNRL AKKFQRQAAN LQDCYRLYQG INQLPNVIQA 430 440 450 460 470 480 LEKHEGKHQK LLLAVFVTPL TDLRSDFSKF QEMIETTLDM DQVENHEFLV KPSFDPNLSE 490 500 510 520 530 540 LREIMNDLEK KMQSTLISAA RDLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS 550 560 570 580 TVDIQKNGVK FTNSKLTSLN EEYTKNKTEY EEAQDAIVKE IVNISS

References

[1]	"The sequence of Homo sapiens BAC clone RP11-295P2." Elliott G., Doebber A., Belter E., Haakenson W. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Waterston R.H. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Waterston R. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Wilson R.K. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC079775 Genomic DNA. Translation: AAY15096.1.
IPI	IPI00893933.
UniGene	Hs.597656.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q53RU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000196498.
HOVERGEN	HBG006399.
Gene expression databases
ArrayExpress	Q53RU4.
Bgee	Q53RU4.
Family and domain databases
Gene3D	3.30.420.110. 1 hit.
InterPro	IPR007695. DNA_mismatch_repair_MutS-lik_N. IPR007861. DNA_mismatch_repair_MutS_clamp. IPR007696. DNA_mismatch_repair_MutS_core. IPR007860. DNA_mmatch_repair_MutS_con_dom. [Graphical view]
Pfam	PF01624. MutS_I. 1 hit. PF05188. MutS_II. 1 hit. PF05192. MutS_III. 1 hit. PF05190. MutS_IV. 1 hit. [Graphical view]
SMART	SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF48334. DNA_repair_MutS_domIII. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MSH2. human.

Entry information

Entry name

Q53RU4_HUMAN

Accession

Primary (citable) accession number: Q53RU4

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.