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Protein
Submitted name:

Putative uncharacterized protein MSH2

Gene

MSH2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATPase activity Source: Ensembl
  2. ATP binding Source: InterPro
  3. centromeric DNA binding Source: Ensembl
  4. damaged DNA binding Source: Ensembl
  5. mismatched DNA binding Source: Ensembl

GO - Biological processi

  1. B cell differentiation Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. determination of adult lifespan Source: Ensembl
  4. double-strand break repair Source: Ensembl
  5. germ cell development Source: Ensembl
  6. intra-S DNA damage checkpoint Source: Ensembl
  7. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. isotype switching Source: Ensembl
  10. male gonad development Source: Ensembl
  11. mismatch repair Source: Ensembl
  12. negative regulation of DNA recombination Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. oxidative phosphorylation Source: Ensembl
  15. response to UV-B Source: Ensembl
  16. response to X-ray Source: Ensembl
  17. somatic hypermutation of immunoglobulin genes Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein MSH2Imported
Gene namesi
Name:MSH2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. MutSalpha complex Source: Ensembl
  2. MutSbeta complex Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ53RU4.
ExpressionAtlasiQ53RU4. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000196498.
HOVERGENiHBG006399.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
[Graphical view]
SMARTiSM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q53RU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQPKETLQ LESAAEVGFV RFFQGMPEKP TTTVRLFDRG DFYTAHGEDA
60 70 80 90 100
LLAAREVFKT QGVIKYMGPA GAKNLQSVVL SKMNFESFVK DLLLVRQYRV
110 120 130 140 150
EVYKNRAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSASIGVVGV
160 170 180 190 200
KMSAVDGQRQ VGVGYVDSIQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECV
210 220 230 240 250
LPGGETAGDM GKLRQIIQRG GILITERKKA DFSTKDIYQD LNRLLKGKKG
260 270 280 290 300
EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LTTFDFSQYM
310 320 330 340 350
KLDIAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTPQGQR LVNQWIKQPL
360 370 380 390 400
MDKNRIEERL NLVEAFVEDA ELRQTLQEDL LRRFPDLNRL AKKFQRQAAN
410 420 430 440 450
LQDCYRLYQG INQLPNVIQA LEKHEGKHQK LLLAVFVTPL TDLRSDFSKF
460 470 480 490 500
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREIMNDLEK KMQSTLISAA
510 520 530 540 550
RDLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK
560 570 580
FTNSKLTSLN EEYTKNKTEY EEAQDAIVKE IVNISS
Length:586
Mass (Da):66,276
Last modified:May 24, 2005 - v1
Checksum:iE6E1425FBB365120
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei586 – 5861Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079775 Genomic DNA. Translation: AAY15096.1.
UniGeneiHs.597656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079775 Genomic DNA. Translation: AAY15096.1.
UniGeneiHs.597656.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000196498.
HOVERGENiHBG006399.

Miscellaneous databases

ChiTaRSiMSH2. human.

Gene expression databases

BgeeiQ53RU4.
ExpressionAtlasiQ53RU4. baseline and differential.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
[Graphical view]
SMARTiSM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-295P2."
    Elliott G., Doebber A., Belter E., Haakenson W.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ53RU4_HUMAN
AccessioniPrimary (citable) accession number: Q53RU4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: March 4, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.