##gff-version 3
Q53RT3	UniProtKB	Propeptide	1	190	.	.	.	ID=PRO_0000271170;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16098038;Dbxref=PMID:16098038	
Q53RT3	UniProtKB	Chain	191	326	.	.	.	ID=PRO_0000271171;Note=Retroviral-like aspartic protease 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16098038;Dbxref=PMID:16098038	
Q53RT3	UniProtKB	Propeptide	327	343	.	.	.	ID=PRO_0000271172;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16098038;Dbxref=PMID:16098038	
Q53RT3	UniProtKB	Topological domain	1	55	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q53RT3	UniProtKB	Transmembrane	56	76	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q53RT3	UniProtKB	Topological domain	77	343	.	.	.	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q53RT3	UniProtKB	Domain	207	288	.	.	.	Note=Peptidase A2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00275	
Q53RT3	UniProtKB	Active site	212	212	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10094	
Q53RT3	UniProtKB	Glycosylation	276	276	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q53RT3	UniProtKB	Alternative sequence	1	84	.	.	.	ID=VSP_061434;Note=In isoform 2. Missing	
Q53RT3	UniProtKB	Natural variant	49	49	.	.	.	ID=VAR_051508;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs3796097,PMID:14702039,PMID:15489334	
Q53RT3	UniProtKB	Natural variant	199	199	.	.	.	ID=VAR_084554;Note=In ADLI%3B impairs filaggrin cleavage. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32516568;Dbxref=PMID:32516568	
Q53RT3	UniProtKB	Natural variant	311	311	.	.	.	ID=VAR_084555;Note=In ADLI%3B impairs filaggrin cleavage. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32516568;Dbxref=PMID:32516568	
Q53RT3	UniProtKB	Natural variant	314	314	.	.	.	ID=VAR_084556;Note=In ADLI%3B impairs filaggrin cleavage. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32516568;Dbxref=PMID:32516568	
Q53RT3	UniProtKB	Mutagenesis	212	212	.	.	.	Note=Abolishes production of active form of enzyme. D->A%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16098038;Dbxref=PMID:16098038	
Q53RT3	UniProtKB	Sequence conflict	31	31	.	.	.	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305