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Protein

Ankyrin repeat domain-containing protein 39

Gene

ANKRD39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 39
Gene namesi
Name:ANKRD39
ORF Names:HSPC200
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000213337.8
HGNCiHGNC:28640 ANKRD39
neXtProtiNX_Q53RE8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213337
PharmGKBiPA142672606

Polymorphism and mutation databases

BioMutaiANKRD39
DMDMi74740664

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443661 – 183Ankyrin repeat domain-containing protein 39Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53RE8
MaxQBiQ53RE8
PaxDbiQ53RE8
PeptideAtlasiQ53RE8
PRIDEiQ53RE8

PTM databases

iPTMnetiQ53RE8
PhosphoSitePlusiQ53RE8

Expressioni

Gene expression databases

BgeeiENSG00000213337
CleanExiHS_ANKRD39
GenevisibleiQ53RE8 HS

Organism-specific databases

HPAiHPA042678

Interactioni

Protein-protein interaction databases

BioGridi119400, 63 interactors
STRINGi9606.ENSP00000377170

Structurei

3D structure databases

ProteinModelPortaliQ53RE8
SMRiQ53RE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 59ANK 1Add BLAST30
Repeati63 – 92ANK 2Add BLAST30
Repeati96 – 125ANK 3Add BLAST30
Repeati129 – 158ANK 4Add BLAST30

Sequence similaritiesi

Belongs to the ANKRD39 family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00910000144124
HOGENOMiHOG000158359
HOVERGENiHBG080852
InParanoidiQ53RE8
OMAiMEFERGI
OrthoDBiEOG091G0ZJL
PhylomeDBiQ53RE8
TreeFamiTF326597

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequencei

Sequence statusi: Complete.

Q53RE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPRPCADG PCCSHPSAVL GVQQTLEEMD FERGIWSAAL NGDLGRVKHL
60 70 80 90 100
IQKAEDPSQP DSAGYTALHY ASRNGHYAVC QFLLESGAKC DAQTHGGATA
110 120 130 140 150
LHRASYCGHT EIARLLLSHG SNPRVVDDDG MTSLHKAAER GHGDICSLLL
160 170 180
QHSPALKAIR DRKARLACDL LPCNSDLRDL LSS
Length:183
Mass (Da):19,651
Last modified:May 24, 2005 - v1
Checksum:i11C13234A456CD63
GO

Sequence cautioni

The sequence AAF36120 differs from that shown. Reason: Frameshift at position 172.Curated
The sequence BAD92604 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → L in AAF36120 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026905113A → T1 PublicationCorresponds to variant dbSNP:rs17852947Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151034 mRNA Translation: AAF36120.1 Frameshift.
AB209367 mRNA Translation: BAD92604.1 Different initiation.
AC092636 Genomic DNA Translation: AAY14966.1
BC031303 mRNA Translation: AAH31303.1
CCDSiCCDS2028.1
RefSeqiNP_057550.3, NM_016466.5
UniGeneiHs.709507

Genome annotation databases

EnsembliENST00000393537; ENSP00000377170; ENSG00000213337
ENST00000443120; ENSP00000398321; ENSG00000213337
GeneIDi51239
KEGGihsa:51239
UCSCiuc002sxd.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANR39_HUMAN
AccessioniPrimary (citable) accession number: Q53RE8
Secondary accession number(s): Q59FU2, Q8N5X5, Q9P0S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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