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Protein

Ankyrin repeat domain-containing protein 39

Gene

ANKRD39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 39
Gene namesi
Name:ANKRD39
ORF Names:HSPC200
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28640. ANKRD39.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672606.

Polymorphism and mutation databases

BioMutaiANKRD39.
DMDMi74740664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Ankyrin repeat domain-containing protein 39PRO_0000244366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei153 – 1531PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53RE8.
MaxQBiQ53RE8.
PaxDbiQ53RE8.
PeptideAtlasiQ53RE8.
PRIDEiQ53RE8.

PTM databases

iPTMnetiQ53RE8.
PhosphoSiteiQ53RE8.

Expressioni

Gene expression databases

BgeeiENSG00000213337.
CleanExiHS_ANKRD39.
GenevisibleiQ53RE8. HS.

Organism-specific databases

HPAiHPA042678.

Interactioni

Protein-protein interaction databases

BioGridi119400. 5 interactions.
STRINGi9606.ENSP00000377170.

Structurei

3D structure databases

ProteinModelPortaliQ53RE8.
SMRiQ53RE8. Positions 4-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 5930ANK 1Add
BLAST
Repeati63 – 9230ANK 2Add
BLAST
Repeati96 – 12530ANK 3Add
BLAST
Repeati129 – 15830ANK 4Add
BLAST

Sequence similaritiesi

Belongs to the ANKRD39 family.Curated
Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129826.
HOGENOMiHOG000158359.
HOVERGENiHBG080852.
InParanoidiQ53RE8.
OMAiRVKHFIQ.
OrthoDBiEOG091G0ZJL.
PhylomeDBiQ53RE8.
TreeFamiTF326597.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53RE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPRPCADG PCCSHPSAVL GVQQTLEEMD FERGIWSAAL NGDLGRVKHL
60 70 80 90 100
IQKAEDPSQP DSAGYTALHY ASRNGHYAVC QFLLESGAKC DAQTHGGATA
110 120 130 140 150
LHRASYCGHT EIARLLLSHG SNPRVVDDDG MTSLHKAAER GHGDICSLLL
160 170 180
QHSPALKAIR DRKARLACDL LPCNSDLRDL LSS
Length:183
Mass (Da):19,651
Last modified:May 24, 2005 - v1
Checksum:i11C13234A456CD63
GO

Sequence cautioni

The sequence AAF36120 differs from that shown. Reason: Frameshift at position 172. Curated
The sequence BAD92604 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → L in AAF36120 (PubMed:11042152).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131A → T.1 Publication
Corresponds to variant rs17852947 [ dbSNP | Ensembl ].
VAR_026905

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151034 mRNA. Translation: AAF36120.1. Frameshift.
AB209367 mRNA. Translation: BAD92604.1. Different initiation.
AC092636 Genomic DNA. Translation: AAY14966.1.
BC031303 mRNA. Translation: AAH31303.1.
CCDSiCCDS2028.1.
RefSeqiNP_057550.3. NM_016466.5.
UniGeneiHs.709507.

Genome annotation databases

EnsembliENST00000393537; ENSP00000377170; ENSG00000213337.
ENST00000443120; ENSP00000398321; ENSG00000213337.
GeneIDi51239.
KEGGihsa:51239.
UCSCiuc002sxd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151034 mRNA. Translation: AAF36120.1. Frameshift.
AB209367 mRNA. Translation: BAD92604.1. Different initiation.
AC092636 Genomic DNA. Translation: AAY14966.1.
BC031303 mRNA. Translation: AAH31303.1.
CCDSiCCDS2028.1.
RefSeqiNP_057550.3. NM_016466.5.
UniGeneiHs.709507.

3D structure databases

ProteinModelPortaliQ53RE8.
SMRiQ53RE8. Positions 4-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119400. 5 interactions.
STRINGi9606.ENSP00000377170.

PTM databases

iPTMnetiQ53RE8.
PhosphoSiteiQ53RE8.

Polymorphism and mutation databases

BioMutaiANKRD39.
DMDMi74740664.

Proteomic databases

EPDiQ53RE8.
MaxQBiQ53RE8.
PaxDbiQ53RE8.
PeptideAtlasiQ53RE8.
PRIDEiQ53RE8.

Protocols and materials databases

DNASUi51239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393537; ENSP00000377170; ENSG00000213337.
ENST00000443120; ENSP00000398321; ENSG00000213337.
GeneIDi51239.
KEGGihsa:51239.
UCSCiuc002sxd.5. human.

Organism-specific databases

CTDi51239.
GeneCardsiANKRD39.
H-InvDBHIX0200253.
HGNCiHGNC:28640. ANKRD39.
HPAiHPA042678.
neXtProtiNX_Q53RE8.
PharmGKBiPA142672606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129826.
HOGENOMiHOG000158359.
HOVERGENiHBG080852.
InParanoidiQ53RE8.
OMAiRVKHFIQ.
OrthoDBiEOG091G0ZJL.
PhylomeDBiQ53RE8.
TreeFamiTF326597.

Miscellaneous databases

GenomeRNAii51239.
PROiQ53RE8.

Gene expression databases

BgeeiENSG00000213337.
CleanExiHS_ANKRD39.
GenevisibleiQ53RE8. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR39_HUMAN
AccessioniPrimary (citable) accession number: Q53RE8
Secondary accession number(s): Q59FU2, Q8N5X5, Q9P0S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.