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Q53RD9 (FBLN7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibulin-7

Short name=FIBL-7
Gene names
Name:FBLN7
Synonyms:TM14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation By similarity.

Subunit structure

Interacts with heparin, FBLN1, FN1 and DSPP. Preferentially binds dental mesenchyme cells and odontoblasts but not dental epithelial cells or nondental cells. Binding requires a heparan sulfate-containing receptor on the cell surface as well as an integrin By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the fibulin family.

Contains 3 EGF-like domains.

Contains 1 Sushi (CCP/SCR) domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
EGF-like domain
Repeat
Signal
Sushi
   LigandCalcium
Heparin-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q53RD9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q53RD9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     178-223: Missing.
Isoform 3 (identifier: Q53RD9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
Isoform 4 (identifier: Q53RD9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     136-269: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 439415Fibulin-7
PRO_0000313655

Regions

Domain79 – 13658Sushi
Domain136 – 17237EGF-like 1; calcium-binding Potential
Domain224 – 26946EGF-like 2; calcium-binding Potential
Domain270 – 31950EGF-like 3; calcium-binding Potential
Coiled coil28 – 5326 Potential

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation3071N-linked (GlcNAc...) Potential
Disulfide bond81 ↔ 121 By similarity
Disulfide bond107 ↔ 134 By similarity
Disulfide bond140 ↔ 151 By similarity
Disulfide bond145 ↔ 160 By similarity
Disulfide bond162 ↔ 171 By similarity
Disulfide bond228 ↔ 244 By similarity
Disulfide bond240 ↔ 253 By similarity
Disulfide bond255 ↔ 268 By similarity
Disulfide bond274 ↔ 287 By similarity
Disulfide bond281 ↔ 296 By similarity
Disulfide bond301 ↔ 318 By similarity

Natural variations

Alternative sequence1 – 5757Missing in isoform 3.
VSP_030084
Alternative sequence136 – 269134Missing in isoform 4.
VSP_030085
Alternative sequence178 – 22346Missing in isoform 2.
VSP_030086
Natural variant1191V → M. Ref.1
Corresponds to variant rs35586251 [ dbSNP | Ensembl ].
VAR_037689

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 905C12B76B78E2EE

FASTA43947,376
        10         20         30         40         50         60 
MVPSSPRALF LLLLILACPE PRASQNCLSK QQLLSAIRQL QQLLKGQETR FAEGIRHMKS 

        70         80         90        100        110        120 
RLAALQNSVG RVGPDALPVS CPALNTPADG RKFGSKYLVD HEVHFTCNPG FRLVGPSSVV 

       130        140        150        160        170        180 
CLPNGTWTGE QPHCRGISEC SSQPCQNGGT CVEGVNQYRC ICPPGRTGNR CQHQAQTAAP 

       190        200        210        220        230        240 
EGSVAGDSAF SRAPRCAQVE RAQHCSCEAG FHLSGAAGDS VCQDVNECEL YGQEGRPRLC 

       250        260        270        280        290        300 
MHACVNTPGS YRCTCPGGYR TLADGKSCED VDECVGLQPV CPQGTTCINT GGSFQCVSPE 

       310        320        330        340        350        360 
CPEGSGNVSY VKTSPFQCER NPCPMDSRPC RHLPKTISFH YLSLPSNLKT PITLFRMATA 

       370        380        390        400        410        420 
SAPGRAGPNS LRFGIVGGNS RGHFVMQRSD RQTGDLILVQ NLEGPQTLEV DVDMSEYLDR 

       430 
SFQANHVSKV TIFVSPYDF 

« Hide

Isoform 2 [UniParc].

Checksum: 309F379792EC9ED6
Show »

FASTA39342,801
Isoform 3 [UniParc].

Checksum: 000F84ED82599AFA
Show »

FASTA38240,980
Isoform 4 [UniParc].

Checksum: 8A8246ACAF379DDD
Show »

FASTA30533,326

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-119.
Tissue: Brain.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
Tissue: Ovary.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-176 (ISOFORM 3).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK094759 mRNA. Translation: BAC04416.1.
AC092645 Genomic DNA. Translation: AAY14854.1.
CH471245 Genomic DNA. Translation: EAW52100.1.
BC035784 mRNA. Translation: AAH35784.1.
BC126986 mRNA. Translation: AAI26987.1.
BC126987 mRNA. Translation: AAI26988.1.
CR933697 mRNA. Translation: CAI46168.1.
RefSeqNP_001121637.1. NM_001128165.1.
NP_694946.2. NM_153214.2.
UniGeneHs.437696.

3D structure databases

ProteinModelPortalQ53RD9.
SMRQ53RD9. Positions 37-338.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ53RD9.

Polymorphism databases

DMDM74726569.

Proteomic databases

PaxDbQ53RD9.
PRIDEQ53RD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331203; ENSP00000331411; ENSG00000144152. [Q53RD9-1]
ENST00000409450; ENSP00000387000; ENSG00000144152. [Q53RD9-2]
ENST00000409667; ENSP00000386822; ENSG00000144152. [Q53RD9-4]
GeneID129804.
KEGGhsa:129804.
UCSCuc002tho.1. human. [Q53RD9-1]
uc010fki.1. human. [Q53RD9-2]
uc010fkj.1. human. [Q53RD9-4]

Organism-specific databases

CTD129804.
GeneCardsGC02P112895.
H-InvDBHIX0002376.
HGNCHGNC:26740. FBLN7.
HPAHPA034992.
MIM611551. gene.
neXtProtNX_Q53RD9.
PharmGKBPA162388107.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240186.
HOGENOMHOG000089983.
HOVERGENHBG107003.
InParanoidQ53RD9.
KOK17342.
OMAQHCSCEA.
OrthoDBEOG74XS6C.
PhylomeDBQ53RD9.
TreeFamTF330076.

Gene expression databases

ArrayExpressQ53RD9.
BgeeQ53RD9.
CleanExHS_FBLN7.
GenevestigatorQ53RD9.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00084. Sushi. 1 hit.
[Graphical view]
SMARTSM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 2 hits.
[Graphical view]
SUPFAMSSF57535. SSF57535. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi129804.
NextBio82641.
PROQ53RD9.
SOURCESearch...

Entry information

Entry nameFBLN7_HUMAN
AccessionPrimary (citable) accession number: Q53RD9
Secondary accession number(s): A0JNV1 expand/collapse secondary AC list , A0JNV2, Q5H9P5, Q8N9G0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM