Q53RD9 (FBLN7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibulin-7
Short name=FIBL-7

Gene names

Name:	FBLN7
Synonyms:	TM14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation By similarity.
Subunit structure	Interacts with heparin, FBLN1, FN1 and DSPP. Preferentially binds dental mesenchyme cells and odontoblasts but not dental epithelial cells or nondental cells. Binding requires a heparan sulfate-containing receptor on the cell surface as well as an integrin By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the fibulin family. Contains 3 EGF-like domains. Contains 1 Sushi (CCP/SCR) domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil EGF-like domain Repeat Signal Sushi
Ligand	Calcium Heparin-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q53RD9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q53RD9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     178-223: Missing.

Isoform 3 (identifier: Q53RD9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Isoform 4 (identifier: Q53RD9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     136-269: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 439	415	Fibulin-7		PRO_0000313655
Regions
	Domain	79 – 136	58	Sushi
	Domain	136 – 172	37	EGF-like 1; calcium-binding Potential
	Domain	224 – 269	46	EGF-like 2; calcium-binding Potential
	Domain	270 – 319	50	EGF-like 3; calcium-binding Potential
	Coiled coil	28 – 53	26	Potential
Amino acid modifications
	Glycosylation	124	1	N-linked (GlcNAc...) Potential
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
	Disulfide bond	81 ↔ 121		By similarity
	Disulfide bond	107 ↔ 134		By similarity
	Disulfide bond	140 ↔ 151		By similarity
	Disulfide bond	145 ↔ 160		By similarity
	Disulfide bond	162 ↔ 171		By similarity
	Disulfide bond	228 ↔ 244		By similarity
	Disulfide bond	240 ↔ 253		By similarity
	Disulfide bond	255 ↔ 268		By similarity
	Disulfide bond	274 ↔ 287		By similarity
	Disulfide bond	281 ↔ 296		By similarity
	Disulfide bond	301 ↔ 318		By similarity
Natural variations
	Alternative sequence	1 – 57	57	Missing in isoform 3.		VSP_030084
	Alternative sequence	136 – 269	134	Missing in isoform 4.		VSP_030085
	Alternative sequence	178 – 223	46	Missing in isoform 2.		VSP_030086
	Natural variant	119	1	V → M. Ref.1 Corresponds to variant rs35586251 [ dbSNP | Ensembl ].		VAR_037689

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 905C12B76B78E2EE	FASTA	439	47,376
	10 20 30 40 50 60 MVPSSPRALF LLLLILACPE PRASQNCLSK QQLLSAIRQL QQLLKGQETR FAEGIRHMKS 70 80 90 100 110 120 RLAALQNSVG RVGPDALPVS CPALNTPADG RKFGSKYLVD HEVHFTCNPG FRLVGPSSVV 130 140 150 160 170 180 CLPNGTWTGE QPHCRGISEC SSQPCQNGGT CVEGVNQYRC ICPPGRTGNR CQHQAQTAAP 190 200 210 220 230 240 EGSVAGDSAF SRAPRCAQVE RAQHCSCEAG FHLSGAAGDS VCQDVNECEL YGQEGRPRLC 250 260 270 280 290 300 MHACVNTPGS YRCTCPGGYR TLADGKSCED VDECVGLQPV CPQGTTCINT GGSFQCVSPE 310 320 330 340 350 360 CPEGSGNVSY VKTSPFQCER NPCPMDSRPC RHLPKTISFH YLSLPSNLKT PITLFRMATA 370 380 390 400 410 420 SAPGRAGPNS LRFGIVGGNS RGHFVMQRSD RQTGDLILVQ NLEGPQTLEV DVDMSEYLDR 430 SFQANHVSKV TIFVSPYDF
	Isoform 2 [UniParc]. Checksum: 309F379792EC9ED6	FASTA	393	42,801
	10 20 30 40 50 60 MVPSSPRALF LLLLILACPE PRASQNCLSK QQLLSAIRQL QQLLKGQETR FAEGIRHMKS 70 80 90 100 110 120 RLAALQNSVG RVGPDALPVS CPALNTPADG RKFGSKYLVD HEVHFTCNPG FRLVGPSSVV 130 140 150 160 170 180 CLPNGTWTGE QPHCRGISEC SSQPCQNGGT CVEGVNQYRC ICPPGRTGNR CQHQAQTDVN 190 200 210 220 230 240 ECELYGQEGR PRLCMHACVN TPGSYRCTCP GGYRTLADGK SCEDVDECVG LQPVCPQGTT 250 260 270 280 290 300 CINTGGSFQC VSPECPEGSG NVSYVKTSPF QCERNPCPMD SRPCRHLPKT ISFHYLSLPS 310 320 330 340 350 360 NLKTPITLFR MATASAPGRA GPNSLRFGIV GGNSRGHFVM QRSDRQTGDL ILVQNLEGPQ 370 380 390 TLEVDVDMSE YLDRSFQANH VSKVTIFVSP YDF
	Isoform 3 [UniParc]. Checksum: 000F84ED82599AFA	FASTA	382	40,980
	10 20 30 40 50 60 MKSRLAALQN SVGRVGPDAL PVSCPALNTP ADGRKFGSKY LVDHEVHFTC NPGFRLVGPS 70 80 90 100 110 120 SVVCLPNGTW TGEQPHCRGI SECSSQPCQN GGTCVEGVNQ YRCICPPGRT GNRCQHQAQT 130 140 150 160 170 180 AAPEGSVAGD SAFSRAPRCA QVERAQHCSC EAGFHLSGAA GDSVCQDVNE CELYGQEGRP 190 200 210 220 230 240 RLCMHACVNT PGSYRCTCPG GYRTLADGKS CEDVDECVGL QPVCPQGTTC INTGGSFQCV 250 260 270 280 290 300 SPECPEGSGN VSYVKTSPFQ CERNPCPMDS RPCRHLPKTI SFHYLSLPSN LKTPITLFRM 310 320 330 340 350 360 ATASAPGRAG PNSLRFGIVG GNSRGHFVMQ RSDRQTGDLI LVQNLEGPQT LEVDVDMSEY 370 380 LDRSFQANHV SKVTIFVSPY DF
	Isoform 4 [UniParc]. Checksum: 8A8246ACAF379DDD	FASTA	305	33,326
	10 20 30 40 50 60 MVPSSPRALF LLLLILACPE PRASQNCLSK QQLLSAIRQL QQLLKGQETR FAEGIRHMKS 70 80 90 100 110 120 RLAALQNSVG RVGPDALPVS CPALNTPADG RKFGSKYLVD HEVHFTCNPG FRLVGPSSVV 130 140 150 160 170 180 CLPNGTWTGE QPHCRDVDEC VGLQPVCPQG TTCINTGGSF QCVSPECPEG SGNVSYVKTS 190 200 210 220 230 240 PFQCERNPCP MDSRPCRHLP KTISFHYLSL PSNLKTPITL FRMATASAPG RAGPNSLRFG 250 260 270 280 290 300 IVGGNSRGHF VMQRSDRQTG DLILVQNLEG PQTLEVDVDM SEYLDRSFQA NHVSKVTIFV SPYDF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-119. Tissue: Brain.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Tissue: Ovary.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-176 (ISOFORM 3). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK094759 mRNA. Translation: BAC04416.1. AC092645 Genomic DNA. Translation: AAY14854.1. CH471245 Genomic DNA. Translation: EAW52100.1. BC035784 mRNA. Translation: AAH35784.1. BC126986 mRNA. Translation: AAI26987.1. BC126987 mRNA. Translation: AAI26988.1. CR933697 mRNA. Translation: CAI46168.1.
IPI	IPI00167710. IPI00815808. IPI00877764. IPI00878589.
RefSeq	NP_001121637.1. NM_001128165.1. NP_694946.2. NM_153214.2.
UniGene	Hs.437696.
3D structure databases
HSSP	HSSP built from PDB template 1Z6C based on UniProtKB P07225.
ProteinModelPortal	Q53RD9.
ModBase	Search...
PTM databases
PhosphoSite	Q53RD9.
Polymorphism databases
DMDM	74726569.
Proteomic databases
PaxDb	Q53RD9.
PRIDE	Q53RD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331203; ENSP00000331411; ENSG00000144152. ENST00000409450; ENSP00000387000; ENSG00000144152. ENST00000409667; ENSP00000386822; ENSG00000144152.
GeneID	129804.
KEGG	hsa:129804.
UCSC	uc002tho.1. human. uc010fki.1. human. uc010fkj.1. human.
Organism-specific databases
CTD	129804.
GeneCards	GC02P112895.
H-InvDB	HIX0002376.
HGNC	HGNC:26740. FBLN7.
HPA	HPA034992.
MIM	611551. gene.
neXtProt	NX_Q53RD9.
PharmGKB	PA162388107.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240186.
HOGENOM	HOG000089983.
HOVERGEN	HBG107003.
InParanoid	Q53RD9.
OMA	QHCSCEA.
OrthoDB	EOG4QRH40.
PhylomeDB	Q53RD9.
Gene expression databases
ArrayExpress	Q53RD9.
Bgee	Q53RD9.
CleanEx	HS_FBLN7.
Genevestigator	Q53RD9.
Family and domain databases
InterPro	IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00008. EGF. 1 hit. PF07645. EGF_CA. 2 hits. PF00084. Sushi. 1 hit. [Graphical view]
SMART	SM00032. CCP. 1 hit. SM00181. EGF. 1 hit. SM00179. EGF_CA. 2 hits. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 2 hits. PS01187. EGF_CA. 2 hits. PS50923. SUSHI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	129804.
NextBio	82641.
SOURCE	Search...

Entry information

Entry name

FBLN7_HUMAN

Accession

Primary (citable) accession number: Q53RD9
Secondary accession number(s): A0JNV1 , A0JNV2, Q5H9P5, Q8N9G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.