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Q53RD9

- FBLN7_HUMAN

UniProt

Q53RD9 - FBLN7_HUMAN

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Protein

Fibulin-7

Gene

FBLN7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibulin-7
Short name:
FIBL-7
Gene namesi
Name:FBLN7
Synonyms:TM14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26740. FBLN7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. focal adhesion Source: UniProtKB
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 439415Fibulin-7PRO_0000313655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 121By similarity
Disulfide bondi107 ↔ 134By similarity
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi140 ↔ 151By similarity
Disulfide bondi145 ↔ 160By similarity
Disulfide bondi162 ↔ 171By similarity
Disulfide bondi228 ↔ 244By similarity
Disulfide bondi240 ↔ 253By similarity
Disulfide bondi255 ↔ 268By similarity
Disulfide bondi274 ↔ 287By similarity
Disulfide bondi281 ↔ 296By similarity
Disulfide bondi301 ↔ 318By similarity
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ53RD9.
PRIDEiQ53RD9.

PTM databases

PhosphoSiteiQ53RD9.

Expressioni

Gene expression databases

BgeeiQ53RD9.
CleanExiHS_FBLN7.
ExpressionAtlasiQ53RD9. baseline and differential.
GenevestigatoriQ53RD9.

Organism-specific databases

HPAiHPA034992.

Interactioni

Subunit structurei

Interacts with heparin, FBLN1, FN1 and DSPP. Preferentially binds dental mesenchyme cells and odontoblasts but not dental epithelial cells or nondental cells. Binding requires a heparan sulfate-containing receptor on the cell surface as well as an integrin By similarity.By similarity

Protein-protein interaction databases

BioGridi126208. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ53RD9.
SMRiQ53RD9. Positions 136-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 13658SushiPROSITE-ProRule annotationAdd
BLAST
Domaini136 – 17237EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini224 – 26946EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini270 – 31950EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili28 – 5326Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the fibulin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG240186.
GeneTreeiENSGT00750000117722.
HOGENOMiHOG000089983.
HOVERGENiHBG107003.
InParanoidiQ53RD9.
KOiK17342.
OMAiQHCSCEA.
OrthoDBiEOG74XS6C.
PhylomeDBiQ53RD9.
TreeFamiTF330076.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q53RD9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPSSPRALF LLLLILACPE PRASQNCLSK QQLLSAIRQL QQLLKGQETR
60 70 80 90 100
FAEGIRHMKS RLAALQNSVG RVGPDALPVS CPALNTPADG RKFGSKYLVD
110 120 130 140 150
HEVHFTCNPG FRLVGPSSVV CLPNGTWTGE QPHCRGISEC SSQPCQNGGT
160 170 180 190 200
CVEGVNQYRC ICPPGRTGNR CQHQAQTAAP EGSVAGDSAF SRAPRCAQVE
210 220 230 240 250
RAQHCSCEAG FHLSGAAGDS VCQDVNECEL YGQEGRPRLC MHACVNTPGS
260 270 280 290 300
YRCTCPGGYR TLADGKSCED VDECVGLQPV CPQGTTCINT GGSFQCVSPE
310 320 330 340 350
CPEGSGNVSY VKTSPFQCER NPCPMDSRPC RHLPKTISFH YLSLPSNLKT
360 370 380 390 400
PITLFRMATA SAPGRAGPNS LRFGIVGGNS RGHFVMQRSD RQTGDLILVQ
410 420 430
NLEGPQTLEV DVDMSEYLDR SFQANHVSKV TIFVSPYDF
Length:439
Mass (Da):47,376
Last modified:May 24, 2005 - v1
Checksum:i905C12B76B78E2EE
GO
Isoform 2 (identifier: Q53RD9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-223: Missing.

Show »
Length:393
Mass (Da):42,801
Checksum:i309F379792EC9ED6
GO
Isoform 3 (identifier: Q53RD9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:382
Mass (Da):40,980
Checksum:i000F84ED82599AFA
GO
Isoform 4 (identifier: Q53RD9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-269: Missing.

Show »
Length:305
Mass (Da):33,326
Checksum:i8A8246ACAF379DDD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191V → M.1 Publication
Corresponds to variant rs35586251 [ dbSNP | Ensembl ].
VAR_037689

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5757Missing in isoform 3. 1 PublicationVSP_030084Add
BLAST
Alternative sequencei136 – 269134Missing in isoform 4. 1 PublicationVSP_030085Add
BLAST
Alternative sequencei178 – 22346Missing in isoform 2. 1 PublicationVSP_030086Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094759 mRNA. Translation: BAC04416.1.
AC092645 Genomic DNA. Translation: AAY14854.1.
CH471245 Genomic DNA. Translation: EAW52100.1.
BC035784 mRNA. Translation: AAH35784.1.
BC126986 mRNA. Translation: AAI26987.1.
BC126987 mRNA. Translation: AAI26988.1.
CR933697 mRNA. Translation: CAI46168.1.
CCDSiCCDS2095.1. [Q53RD9-1]
CCDS46391.1. [Q53RD9-2]
RefSeqiNP_001121637.1. NM_001128165.1. [Q53RD9-2]
NP_694946.2. NM_153214.2. [Q53RD9-1]
UniGeneiHs.437696.

Genome annotation databases

EnsembliENST00000331203; ENSP00000331411; ENSG00000144152. [Q53RD9-1]
ENST00000409450; ENSP00000387000; ENSG00000144152. [Q53RD9-2]
ENST00000409667; ENSP00000386822; ENSG00000144152. [Q53RD9-4]
GeneIDi129804.
KEGGihsa:129804.
UCSCiuc002tho.1. human. [Q53RD9-1]
uc010fki.1. human. [Q53RD9-2]
uc010fkj.1. human. [Q53RD9-4]

Polymorphism databases

DMDMi74726569.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094759 mRNA. Translation: BAC04416.1 .
AC092645 Genomic DNA. Translation: AAY14854.1 .
CH471245 Genomic DNA. Translation: EAW52100.1 .
BC035784 mRNA. Translation: AAH35784.1 .
BC126986 mRNA. Translation: AAI26987.1 .
BC126987 mRNA. Translation: AAI26988.1 .
CR933697 mRNA. Translation: CAI46168.1 .
CCDSi CCDS2095.1. [Q53RD9-1 ]
CCDS46391.1. [Q53RD9-2 ]
RefSeqi NP_001121637.1. NM_001128165.1. [Q53RD9-2 ]
NP_694946.2. NM_153214.2. [Q53RD9-1 ]
UniGenei Hs.437696.

3D structure databases

ProteinModelPortali Q53RD9.
SMRi Q53RD9. Positions 136-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126208. 5 interactions.

PTM databases

PhosphoSitei Q53RD9.

Polymorphism databases

DMDMi 74726569.

Proteomic databases

PaxDbi Q53RD9.
PRIDEi Q53RD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331203 ; ENSP00000331411 ; ENSG00000144152 . [Q53RD9-1 ]
ENST00000409450 ; ENSP00000387000 ; ENSG00000144152 . [Q53RD9-2 ]
ENST00000409667 ; ENSP00000386822 ; ENSG00000144152 . [Q53RD9-4 ]
GeneIDi 129804.
KEGGi hsa:129804.
UCSCi uc002tho.1. human. [Q53RD9-1 ]
uc010fki.1. human. [Q53RD9-2 ]
uc010fkj.1. human. [Q53RD9-4 ]

Organism-specific databases

CTDi 129804.
GeneCardsi GC02P112895.
H-InvDB HIX0002376.
HGNCi HGNC:26740. FBLN7.
HPAi HPA034992.
MIMi 611551. gene.
neXtProti NX_Q53RD9.
PharmGKBi PA162388107.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240186.
GeneTreei ENSGT00750000117722.
HOGENOMi HOG000089983.
HOVERGENi HBG107003.
InParanoidi Q53RD9.
KOi K17342.
OMAi QHCSCEA.
OrthoDBi EOG74XS6C.
PhylomeDBi Q53RD9.
TreeFami TF330076.

Miscellaneous databases

GenomeRNAii 129804.
NextBioi 82641.
PROi Q53RD9.
SOURCEi Search...

Gene expression databases

Bgeei Q53RD9.
CleanExi HS_FBLN7.
ExpressionAtlasi Q53RD9. baseline and differential.
Genevestigatori Q53RD9.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00084. Sushi. 1 hit.
[Graphical view ]
SMARTi SM00032. CCP. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 2 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-119.
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Ovary.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-176 (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiFBLN7_HUMAN
AccessioniPrimary (citable) accession number: Q53RD9
Secondary accession number(s): A0JNV1
, A0JNV2, Q5H9P5, Q8N9G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3