Q53R41 (FAKD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FAST kinase domain-containing protein 1

Gene names

Name:	FASTKD1
Synonyms:	KIAA1800

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	847 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the FAST kinase family. Contains 1 RAP domain.
Caution	It is uncertain whether Met-1 or Met-15 is the initiator.
Sequence caution	The sequence AAH32687.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB15168.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular respiration Inferred from sequence or structural similarity PubMed 20869947. Source: UniProtKB protein phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	mitochondrion Inferred from direct assay PubMed 20869947. Source: UniProtKB
Molecular_function	protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q53R41-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q53R41-2)

The sequence of this isoform differs from the canonical sequence as follows:
     649-692: ILSPSRSARVQFHLMELNRSVCLECPEFQIPWFHDRFCQQYNKG → S

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 847	847	FAST kinase domain-containing protein 1		PRO_0000284710
Regions
	Domain	777 – 837	61	RAP
Amino acid modifications
	Modified residue	360	1	N6-acetyllysine Ref.5
Natural variations
	Alternative sequence	649 – 692	44	ILSPS…QYNKG → S in isoform 2.		VSP_024617
	Natural variant	384	1	E → Q. Corresponds to variant rs12618227 [ dbSNP | Ensembl ].		VAR_031806
	Natural variant	446	1	C → G. Corresponds to variant rs35106223 [ dbSNP | Ensembl ].		VAR_031807
	Natural variant	467	1	M → V. Ref.1 Ref.3 Corresponds to variant rs2253680 [ dbSNP | Ensembl ].		VAR_031808
Experimental info
	Sequence conflict	213	1	V → M in BAB85043. Ref.1
	Sequence conflict	228	1	V → A in BAB85043. Ref.1
	Sequence conflict	288	1	M → T in BAB15168. Ref.1
	Sequence conflict	293	1	L → P in BAB85043. Ref.1
	Sequence conflict	756	1	E → EMPWESNIEIVGSRLPPGAE RIALEFLDSKA in BAB47429. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 5026A635048EB0B3	FASTA	847	97,411
	10 20 30 40 50 60 MKKTPVFLES LVTNMLRLRA ICPFSWRVFQ FRPISCEPLI IQMNKCTDEE QMFGFIERNK 70 80 90 100 110 120 AILSEKQVGC AFDMLWKLQK QKTSLLKNAE YVRDHPQFLT LHNLATNKFK LMNDDTLVNV 130 140 150 160 170 180 LYVTQQFAGE AHDPLVEALV TEAWRRLERF DIKLLSEFSS CLADQHLYFS PLMGKIADIV 190 200 210 220 230 240 HRNLETTQDL SSLSVLMVNI SSLISRHFQQ QLVNKTELLF DTIDSSEVNV AKSIAKFLRN 250 260 270 280 290 300 VRYRYQPLLE RCNNVFLSNV DHLDLDSISK ILSVYKFLQF NSFEFIIMAK KKLTEMIPLC 310 320 330 340 350 360 NHPASFVKLF VALGPIAGPE EKKQLKSTML LMSEDLTGEQ ALAVLGAMGD MESRNSCLIK 370 380 390 400 410 420 RVTSVLHKHL DGYKPLELLK ITQELTFLHF QRKEFFAKLR ELLLSYLKNS FIPTEVSVLV 430 440 450 460 470 480 RAISLLPSPH LDEVGISRIE AVLPQCDLNN LSSFATSVLR WIQHDHMYLD NMTAKQLKLL 490 500 510 520 530 540 QKLDHYGRQR LQHSNSLDLL RKELKSLKGN TFPESLLEEM IATLQHFMDD INYINVGEIA 550 560 570 580 590 600 SFISSTDYLS TLLLDRIASV AVQQIEKIHP FTIPAIIRPF SVLNYDPPQR DEFLGTCVQH 610 620 630 640 650 660 LNSYLGILDP FILVFLGFSL ATLEYFPEDL LKAIFNIKFL ARLDSQLEIL SPSRSARVQF 670 680 690 700 710 720 HLMELNRSVC LECPEFQIPW FHDRFCQQYN KGIGGMDGTQ QQIFKMLAEV LGGINCVKAS 730 740 750 760 770 780 VLTPYYHKVD FECILDKRKK PLPYGSHNIA LGQLPEMPWE SNIEIVGSRL PPGAERIALE 790 800 810 820 830 840 FLDSKALCRN IPHMKGKSAM KKRHLEILGY RVIQISQFEW NSMALSTKDA RMDYLRECIF GEVKSCL
	Isoform 2 [UniParc]. Checksum: 1026298B7060A369	FASTA	804	92,204
	10 20 30 40 50 60 MKKTPVFLES LVTNMLRLRA ICPFSWRVFQ FRPISCEPLI IQMNKCTDEE QMFGFIERNK 70 80 90 100 110 120 AILSEKQVGC AFDMLWKLQK QKTSLLKNAE YVRDHPQFLT LHNLATNKFK LMNDDTLVNV 130 140 150 160 170 180 LYVTQQFAGE AHDPLVEALV TEAWRRLERF DIKLLSEFSS CLADQHLYFS PLMGKIADIV 190 200 210 220 230 240 HRNLETTQDL SSLSVLMVNI SSLISRHFQQ QLVNKTELLF DTIDSSEVNV AKSIAKFLRN 250 260 270 280 290 300 VRYRYQPLLE RCNNVFLSNV DHLDLDSISK ILSVYKFLQF NSFEFIIMAK KKLTEMIPLC 310 320 330 340 350 360 NHPASFVKLF VALGPIAGPE EKKQLKSTML LMSEDLTGEQ ALAVLGAMGD MESRNSCLIK 370 380 390 400 410 420 RVTSVLHKHL DGYKPLELLK ITQELTFLHF QRKEFFAKLR ELLLSYLKNS FIPTEVSVLV 430 440 450 460 470 480 RAISLLPSPH LDEVGISRIE AVLPQCDLNN LSSFATSVLR WIQHDHMYLD NMTAKQLKLL 490 500 510 520 530 540 QKLDHYGRQR LQHSNSLDLL RKELKSLKGN TFPESLLEEM IATLQHFMDD INYINVGEIA 550 560 570 580 590 600 SFISSTDYLS TLLLDRIASV AVQQIEKIHP FTIPAIIRPF SVLNYDPPQR DEFLGTCVQH 610 620 630 640 650 660 LNSYLGILDP FILVFLGFSL ATLEYFPEDL LKAIFNIKFL ARLDSQLESI GGMDGTQQQI 670 680 690 700 710 720 FKMLAEVLGG INCVKASVLT PYYHKVDFEC ILDKRKKPLP YGSHNIALGQ LPEMPWESNI 730 740 750 760 770 780 EIVGSRLPPG AERIALEFLD SKALCRNIPH MKGKSAMKKR HLEILGYRVI QISQFEWNSM 790 800 ALSTKDARMD YLRECIFGEV KSCL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-847 (ISOFORM 1), VARIANT VAL-467. Tissue: Mammary gland.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-847 (ISOFORM 1), VARIANT VAL-467. Tissue: Eye.
[4]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 142-847 (ISOFORM 1). Tissue: Brain.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-360, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK025554 mRNA. Translation: BAB15168.1. Different initiation. AK055892 mRNA. Translation: BAB71037.1. AK074302 mRNA. Translation: BAB85043.1. AC093899 Genomic DNA. Translation: AAY24118.1. BC032687 mRNA. Translation: AAH32687.1. Different initiation. AB058703 mRNA. Translation: BAB47429.1.
IPI	IPI00289061. IPI00300186.
RefSeq	NP_078898.3. NM_024622.3.
UniGene	Hs.529276.
3D structure databases
ProteinModelPortal	Q53R41.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q53R41. 1 interaction.
STRING	9606.ENSP00000400513.
PTM databases
PhosphoSite	Q53R41.
Polymorphism databases
DMDM	74726532.
Proteomic databases
PaxDb	Q53R41.
PRIDE	Q53R41.
Protocols and materials databases
DNASU	79675.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000453153; ENSP00000400513; ENSG00000138399. ENST00000453929; ENSP00000403229; ENSG00000138399.
GeneID	79675.
KEGG	hsa:79675.
UCSC	uc002uev.4. human. uc002uex.4. human.
Organism-specific databases
CTD	79675.
GeneCards	GC02M170386.
H-InvDB	HIX0002572.
HGNC	HGNC:26150. FASTKD1.
HPA	HPA043719.
neXtProt	NX_Q53R41.
PharmGKB	PA145148834.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39093.
HOGENOM	HOG000293293.
HOVERGEN	HBG099520.
InParanoid	Q53R41.
OMA	GYRVIQI.
OrthoDB	EOG4FJ88B.
Gene expression databases
ArrayExpress	Q53R41.
Bgee	Q53R41.
CleanEx	HS_FASTKD1.
Genevestigator	Q53R41.
Family and domain databases
InterPro	IPR013579. FAST_2. IPR010622. FAST_Leu-rich. IPR013584. RAP. [Graphical view]
Pfam	PF06743. FAST_1. 1 hit. PF08368. FAST_2. 1 hit. PF08373. RAP. 1 hit. [Graphical view]
SMART	SM00952. RAP. 1 hit. [Graphical view]
PROSITE	PS51286. RAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79675.
NextBio	68914.

Entry information

Entry name

FAKD1_HUMAN

Accession

Primary (citable) accession number: Q53R41
Secondary accession number(s): Q8N583 , Q8TEA9, Q96JM5, Q96N71, Q9H6T4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.