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Protein

Arp2/3 complex 34 kDa subunit

Gene

ARPC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Arp2/3 complex 34 kDa subunitUniRule annotation
Gene namesi
Name:ARPC2Imported
ORF Names:hCG_16304Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasmcytoskeleton UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24999.

PTM / Processingi

Proteomic databases

MaxQBiQ53R19.

Expressioni

Gene expression databases

BgeeiENSG00000163466.
ExpressionAtlasiQ53R19. baseline and differential.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ53R19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
HOVERGENiHBG050580.
KOiK05758.
OMAiVFIQEFV.
OrthoDBiEOG091G0BUH.

Family and domain databases

Gene3Di3.30.1460.20. 2 hits.
InterProiView protein in InterPro
IPR007188. ARPC2.
IPR034666. ARPC2/4.
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiView protein in Pfam
PF04045. P34-Arc. 1 hit.
SUPFAMiSSF69645. SSF69645. 2 hits.

Sequencei

Sequence statusi: Complete.

Q53R19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Length:300
Mass (Da):34,333
Last modified:May 24, 2005 - v1
Checksum:i3BA57121BE9A05F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097483 Genomic DNA. Translation: AAX93213.1.
HM005676 mRNA. Translation: AEE61273.1.
AK290268 mRNA. Translation: BAF82957.1.
CH471063 Genomic DNA. Translation: EAW70591.1.
CH471063 Genomic DNA. Translation: EAW70593.1.
RefSeqiNP_005722.1. NM_005731.3.
NP_690601.1. NM_152862.2.
UniGeneiHs.529303.

Genome annotation databases

GeneIDi10109.
KEGGihsa:10109.
UCSCiuc002vhd.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ53R19_HUMAN
AccessioniPrimary (citable) accession number: Q53R19
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.