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Protein
Submitted name:

Inducible T-cell co-stimulator

Gene

ICOS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Inducible T-cell co-stimulatorImported
Submitted name:
Inducible T-cell co-stimulator, isoform CRA_bImported
Submitted name:
Putative uncharacterized protein ICOSImported
Submitted name:
cDNA, FLJ95906, Homo sapiens inducible T-cell co-stimulator (ICOS), mRNAImported
Gene namesi
Name:ICOSImported
ORF Names:hCG_1642889Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei141 – 164HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500878069920 – 199Sequence analysisAdd BLAST180

Expressioni

Gene expression databases

BgeeiENSG00000163600.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319476.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 134IGvInterPro annotationAdd BLAST112

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410J005. Eukaryota.
ENOG41117EH. LUCA.
HOVERGENiHBG052079.
KOiK06713.
OMAiLFCFQVE.
OrthoDBiEOG091G0IRJ.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF15910. V-set_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53QY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ
60 70 80 90 100
FKMQLLKGGQ ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD
110 120 130 140 150
HSHANYYFCN LSIFDPPPFK VTLTGGYLHI YESQLCCQLK FWLPIGCAAF
160 170 180 190
VVVCILGCIL ICWLTKKKYS SSVHDPNGEY MFMRAVNTAK KSRLTDVTL
Length:199
Mass (Da):22,625
Last modified:May 24, 2005 - v1
Checksum:i214EC741C9BDC9FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103880 Genomic DNA. Translation: AAX93073.1.
EF064727 Genomic DNA. Translation: ABK41910.1.
AK314985 mRNA. Translation: BAG37484.1.
CH471063 Genomic DNA. Translation: EAW70356.1.
RefSeqiNP_036224.1. NM_012092.3.
UniGeneiHs.56247.

Genome annotation databases

GeneIDi29851.
KEGGihsa:29851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103880 Genomic DNA. Translation: AAX93073.1.
EF064727 Genomic DNA. Translation: ABK41910.1.
AK314985 mRNA. Translation: BAG37484.1.
CH471063 Genomic DNA. Translation: EAW70356.1.
RefSeqiNP_036224.1. NM_012092.3.
UniGeneiHs.56247.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319476.

Protocols and materials databases

DNASUi29851.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29851.
KEGGihsa:29851.

Organism-specific databases

CTDi29851.
PharmGKBiPA29599.

Phylogenomic databases

eggNOGiENOG410J005. Eukaryota.
ENOG41117EH. LUCA.
HOVERGENiHBG052079.
KOiK06713.
OMAiLFCFQVE.
OrthoDBiEOG091G0IRJ.

Miscellaneous databases

GenomeRNAii29851.

Gene expression databases

BgeeiENSG00000163600.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF15910. V-set_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53QY6_HUMAN
AccessioniPrimary (citable) accession number: Q53QY6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.