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Protein

Testis-expressed protein 44

Gene

TEX44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 44
Gene namesi
Name:TEX44Imported
Synonyms:C2orf57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000177673.3.
HGNCiHGNC:28563. TEX44.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177673.
PharmGKBiPA162379291.

Polymorphism and mutation databases

BioMutaiC2orf57.
DMDMi74726496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003091821 – 395Testis-expressed protein 44Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ53QW1.
PeptideAtlasiQ53QW1.
PRIDEiQ53QW1.

PTM databases

iPTMnetiQ53QW1.
PhosphoSitePlusiQ53QW1.

Expressioni

Tissue specificityi

Testis. Detected in germ cells at all stages of the seminiferous epithelium, strong expression in elongating spermatids (at protein level) (PubMed:26168773).1 Publication

Gene expression databases

BgeeiENSG00000177673.
CleanExiHS_C2orf57.
GenevisibleiQ53QW1. HS.

Organism-specific databases

HPAiHPA049917.
HPA056433.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CPT1BQ925235EBI-10278496,EBI-10278486

Protein-protein interaction databases

BioGridi127908. 2 interactors.
IntActiQ53QW1. 8 interactors.
STRINGi9606.ENSP00000315557.

Structurei

3D structure databases

ProteinModelPortaliQ53QW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVVR. Eukaryota.
ENOG4111CPU. LUCA.
GeneTreeiENSGT00390000009950.
HOGENOMiHOG000111325.
InParanoidiQ53QW1.
OMAiVWSETTM.
OrthoDBiEOG091G0EFB.
PhylomeDBiQ53QW1.
TreeFamiTF338437.

Family and domain databases

InterProiView protein in InterPro
IPR031460. DUF4678.
PANTHERiPTHR37365. PTHR37365. 1 hit.
PfamiView protein in Pfam
PF15727. DUF4678. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53QW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPGYPLGN VDDSRSKDSP AGEPQGQVPL TADVLAVSSS VASTDWQDID
60 70 80 90 100
QASFKTATPR AISTSGDKDK SAVVPEHGQK TPRKITPLLP SQNPSPLQVS
110 120 130 140 150
MSLQNPAWDR QVQDARTSQS LVVFPSHLLG KDKMSQMASV PEREPESAPS
160 170 180 190 200
APSAELQSTQ HMEAQPVESD ADHVTAGANG QHGPQAASTT KSAEEKAEHP
210 220 230 240 250
KAPHPEAEAL PSDESPVAMG ANVVDSLGDL QTWFFPPPPA GSVSPSPGPH
260 270 280 290 300
EVALGRRPLD SSLYTASEEN SYMRSMTSLL DRGEGSISSL ADILVWSETT
310 320 330 340 350
MGMAIATGFL DSGHSTVADL LHSSGPSLRS VPSLVGSVSS AFSSGLVSGT
360 370 380 390
SSALRTITRV LETVEQRTVE GIRSAMRYLT SHLTPRQAQA DPNYD
Length:395
Mass (Da):41,589
Last modified:May 24, 2005 - v1
Checksum:iEA2BD81DEC8AD50B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03689411V → L. Corresponds to variant dbSNP:rs16828251Ensembl.1
Natural variantiVAR_03689579Q → R. Corresponds to variant dbSNP:rs16828254Ensembl.1
Natural variantiVAR_036896168E → K. Corresponds to variant dbSNP:rs16828257Ensembl.1
Natural variantiVAR_036897261S → P2 PublicationsCorresponds to variant dbSNP:rs10933378Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104634 Genomic DNA. Translation: AAY24071.1.
CH471063 Genomic DNA. Translation: EAW70967.1.
BC024251 mRNA. Translation: AAH24251.1.
BC034405 mRNA. Translation: AAH34405.1.
BC063389 mRNA. Translation: AAH63389.1.
CCDSiCCDS2487.1.
RefSeqiNP_689827.2. NM_152614.2.
UniGeneiHs.98104.

Genome annotation databases

EnsembliENST00000313965; ENSP00000315557; ENSG00000177673.
GeneIDi165100.
KEGGihsa:165100.
UCSCiuc002vrz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTEX44_HUMAN
AccessioniPrimary (citable) accession number: Q53QW1
Secondary accession number(s): Q8N4F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations