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Protein

Protein LBH

Gene

LBH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LBHCurated
Short name:
hLBH1 Publication
Alternative name(s):
Limb bud and heart development protein homologCurated
Gene namesi
Name:LBHImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000213626.11
HGNCiHGNC:29532 LBH
MIMi611763 gene
neXtProtiNX_Q53QV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi81606
OpenTargetsiENSG00000213626
PharmGKBiPA162393798

Polymorphism and mutation databases

BioMutaiLBH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003248021 – 105Protein LBHAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53QV2
MaxQBiQ53QV2
PaxDbiQ53QV2
PeptideAtlasiQ53QV2
PRIDEiQ53QV2
ProteomicsDBi62511

PTM databases

iPTMnetiQ53QV2
PhosphoSitePlusiQ53QV2

Expressioni

Tissue specificityi

Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.1 Publication

Developmental stagei

Expressed in heart of 25 and 17 weeks embryos.1 Publication

Gene expression databases

BgeeiENSG00000213626
CleanExiHS_LBH
ExpressionAtlasiQ53QV2 baseline and differential
GenevisibleiQ53QV2 HS

Organism-specific databases

HPAiHPA034669

Interactioni

Protein-protein interaction databases

BioGridi123543, 5 interactors
IntActiQ53QV2, 1 interactor
STRINGi9606.ENSP00000378733

Structurei

3D structure databases

ProteinModelPortaliQ53QV2
SMRiQ53QV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 104LBHSequence analysisAdd BLAST87

Sequence similaritiesi

Belongs to the LBH family.Curated

Phylogenomic databases

eggNOGiENOG410IYIC Eukaryota
ENOG4111VQ7 LUCA
GeneTreeiENSGT00390000009189
HOGENOMiHOG000074061
HOVERGENiHBG105431
InParanoidiQ53QV2
PhylomeDBiQ53QV2
TreeFamiTF332770

Family and domain databases

InterProiView protein in InterPro
IPR013294 LBH
IPR038990 LBH_dom
PfamiView protein in Pfam
PF15317 Lbh, 1 hit
PIRSFiPIRSF008130 LBH, 1 hit
PRINTSiPR01881 LBHPROTEIN

Sequencei

Sequence statusi: Complete.

Q53QV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIYFPIHCP DYLRSAKMTE VMMNTQPMEE IGLSPRKDGL SYQIFPDPSD
60 70 80 90 100
FDRCCKLKDR LPSIVVEPTE GEVESGELRW PPEEFLVQED EQDNCEETAK

ENKEQ
Length:105
Mass (Da):12,217
Last modified:May 24, 2005 - v1
Checksum:i384F05E5F3329CFF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54C → R in ABK30936 (PubMed:17390236).Curated1
Sequence conflicti54C → R in CAB66638 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF025586 mRNA Translation: ABK30936.1
AL136703 mRNA Translation: CAB66638.1
AK314598 mRNA Translation: BAG37169.1
AK223541 mRNA Translation: BAD97261.1
AC104698 Genomic DNA Translation: AAY24349.1
BC109376 mRNA Translation: AAI09377.1
BC126434 mRNA Translation: AAI26435.1
BC130415 mRNA Translation: AAI30416.1
CCDSiCCDS33173.1
RefSeqiNP_112177.2, NM_030915.3
UniGeneiHs.567598
Hs.593113

Genome annotation databases

EnsembliENST00000395323; ENSP00000378733; ENSG00000213626
GeneIDi81606
KEGGihsa:81606
UCSCiuc002rne.3 human

Similar proteinsi

Entry informationi

Entry nameiLBH_HUMAN
AccessioniPrimary (citable) accession number: Q53QV2
Secondary accession number(s): B2RBC2, Q9H0Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 24, 2005
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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