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Protein

Protein LBH

Gene

LBH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.1 Publication

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • regulation of blood coagulation Source: UniProtKB
  • regulation of gene expression Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LBH
Short name:
hLBH
Gene namesi
Name:LBH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29532. LBH.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393798.

Polymorphism and mutation databases

BioMutaiLBH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Protein LBHPRO_0000324802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53QV2.
MaxQBiQ53QV2.
PaxDbiQ53QV2.
PRIDEiQ53QV2.

PTM databases

iPTMnetiQ53QV2.
PhosphoSiteiQ53QV2.

Expressioni

Tissue specificityi

Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.1 Publication

Developmental stagei

Expressed in heart of 25 and 17 weeks embryos.1 Publication

Gene expression databases

BgeeiQ53QV2.
CleanExiHS_LBH.
ExpressionAtlasiQ53QV2. baseline and differential.
GenevisibleiQ53QV2. HS.

Organism-specific databases

HPAiHPA034669.

Interactioni

Protein-protein interaction databases

BioGridi123543. 2 interactions.
IntActiQ53QV2. 1 interaction.
MINTiMINT-4716185.
STRINGi9606.ENSP00000378733.

Structurei

3D structure databases

ProteinModelPortaliQ53QV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LBH family.Curated

Phylogenomic databases

eggNOGiENOG410IYIC. Eukaryota.
ENOG4111VQ7. LUCA.
GeneTreeiENSGT00390000009189.
HOGENOMiHOG000074061.
HOVERGENiHBG105431.
InParanoidiQ53QV2.
OrthoDBiEOG7TQV35.
PhylomeDBiQ53QV2.
TreeFamiTF332770.

Family and domain databases

InterProiIPR013294. LBH.
[Graphical view]
PIRSFiPIRSF008130. LBH. 1 hit.
PRINTSiPR01881. LBHPROTEIN.

Sequencei

Sequence statusi: Complete.

Q53QV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIYFPIHCP DYLRSAKMTE VMMNTQPMEE IGLSPRKDGL SYQIFPDPSD
60 70 80 90 100
FDRCCKLKDR LPSIVVEPTE GEVESGELRW PPEEFLVQED EQDNCEETAK

ENKEQ
Length:105
Mass (Da):12,217
Last modified:May 24, 2005 - v1
Checksum:i384F05E5F3329CFF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541C → R in ABK30936 (PubMed:17390236).Curated
Sequence conflicti54 – 541C → R in CAB66638 (PubMed:11230166).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF025586 mRNA. Translation: ABK30936.1.
AL136703 mRNA. Translation: CAB66638.1.
AK314598 mRNA. Translation: BAG37169.1.
AK223541 mRNA. Translation: BAD97261.1.
AC104698 Genomic DNA. Translation: AAY24349.1.
BC109376 mRNA. Translation: AAI09377.1.
BC126434 mRNA. Translation: AAI26435.1.
BC130415 mRNA. Translation: AAI30416.1.
CCDSiCCDS33173.1.
RefSeqiNP_112177.2. NM_030915.3.
UniGeneiHs.567598.
Hs.593113.

Genome annotation databases

EnsembliENST00000395323; ENSP00000378733; ENSG00000213626.
GeneIDi81606.
KEGGihsa:81606.
UCSCiuc002rne.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF025586 mRNA. Translation: ABK30936.1.
AL136703 mRNA. Translation: CAB66638.1.
AK314598 mRNA. Translation: BAG37169.1.
AK223541 mRNA. Translation: BAD97261.1.
AC104698 Genomic DNA. Translation: AAY24349.1.
BC109376 mRNA. Translation: AAI09377.1.
BC126434 mRNA. Translation: AAI26435.1.
BC130415 mRNA. Translation: AAI30416.1.
CCDSiCCDS33173.1.
RefSeqiNP_112177.2. NM_030915.3.
UniGeneiHs.567598.
Hs.593113.

3D structure databases

ProteinModelPortaliQ53QV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123543. 2 interactions.
IntActiQ53QV2. 1 interaction.
MINTiMINT-4716185.
STRINGi9606.ENSP00000378733.

PTM databases

iPTMnetiQ53QV2.
PhosphoSiteiQ53QV2.

Polymorphism and mutation databases

BioMutaiLBH.

Proteomic databases

EPDiQ53QV2.
MaxQBiQ53QV2.
PaxDbiQ53QV2.
PRIDEiQ53QV2.

Protocols and materials databases

DNASUi81606.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395323; ENSP00000378733; ENSG00000213626.
GeneIDi81606.
KEGGihsa:81606.
UCSCiuc002rne.3. human.

Organism-specific databases

CTDi81606.
GeneCardsiLBH.
HGNCiHGNC:29532. LBH.
HPAiHPA034669.
MIMi611763. gene.
neXtProtiNX_Q53QV2.
PharmGKBiPA162393798.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYIC. Eukaryota.
ENOG4111VQ7. LUCA.
GeneTreeiENSGT00390000009189.
HOGENOMiHOG000074061.
HOVERGENiHBG105431.
InParanoidiQ53QV2.
OrthoDBiEOG7TQV35.
PhylomeDBiQ53QV2.
TreeFamiTF332770.

Miscellaneous databases

ChiTaRSiLBH. human.
GeneWikiiLBH.
GenomeRNAii81606.
PROiQ53QV2.
SOURCEiSearch...

Gene expression databases

BgeeiQ53QV2.
CleanExiHS_LBH.
ExpressionAtlasiQ53QV2. baseline and differential.
GenevisibleiQ53QV2. HS.

Family and domain databases

InterProiIPR013294. LBH.
[Graphical view]
PIRSFiPIRSF008130. LBH. 1 hit.
PRINTSiPR01881. LBHPROTEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway."
    Ai J., Wang Y., Tan K., Deng Y., Luo N., Yuan W., Wang Z., Li Y., Wang Y., Mo X., Zhu C., Yin Z., Liu M., Wu X.
    Mol. Biol. Rep. 35:179-187(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, FUNCTION.
    Tissue: Embryonic heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiLBH_HUMAN
AccessioniPrimary (citable) accession number: Q53QV2
Secondary accession number(s): B2RBC2, Q9H0Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 24, 2005
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.