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Protein
Submitted name:

Interleukin 8 receptor, beta

Gene

IL8RB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 8 receptor, betaImported
Submitted name:
Putative uncharacterized protein IL8RBImported
Submitted name:
cDNA FLJ78215, highly similar to Homo sapiens interleukin 8 receptor beta (IL8RB) mRNAImported
Submitted name:
cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNAImported
Gene namesi
Name:IL8RBImported
ORF Names:hCG_16291Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 74HelicalSequence analysisAdd BLAST26
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20
Transmembranei130 – 148HelicalSequence analysisAdd BLAST19
Transmembranei160 – 183HelicalSequence analysisAdd BLAST24
Transmembranei218 – 239HelicalSequence analysisAdd BLAST22
Transmembranei251 – 273HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29843.

Expressioni

Gene expression databases

BgeeiENSG00000180871.
ExpressionAtlasiQ53PC4. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 314G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
HOVERGENiHBG106917.
KOiK05050.
OMAiINKHAVV.
OrthoDBiEOG091G0C7W.

Family and domain databases

InterProiView protein in InterPro
IPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53PC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF
60 70 80 90 100
VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT
110 120 130 140 150
LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH
160 170 180 190 200
ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM
210 220 230 240 250
GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM
260 270 280 290 300
RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE
310 320 330 340 350
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG
360
SSSGHTSTTL
Length:360
Mass (Da):40,759
Last modified:May 24, 2005 - v1
Checksum:i564F04A8BCC0A197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124768 Genomic DNA. Translation: AAY24026.1.
AK290906 mRNA. Translation: BAF83595.1.
AK312664 mRNA. Translation: BAG35546.1.
CH471063 Genomic DNA. Translation: EAW70589.1.
RefSeqiNP_001161770.1. NM_001168298.1.
NP_001548.1. NM_001557.3.
XP_005246587.1. XM_005246530.3.
XP_016859479.1. XM_017003990.1.
XP_016859480.1. XM_017003991.1.
XP_016859481.1. XM_017003992.1.
UniGeneiHs.846.

Genome annotation databases

GeneIDi3579.
KEGGihsa:3579.
UCSCiuc002vha.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ53PC4_HUMAN
AccessioniPrimary (citable) accession number: Q53PC4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.