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Protein

Mitogen-activated protein kinase 15

Gene

MPK15

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei139Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 15 (EC:2.7.11.24)
Short name:
MAP kinase 15
Gene namesi
Name:MPK15
Ordered Locus Names:Os11g0271100, LOC_Os11g17080
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397581 – 498Mitogen-activated protein kinase 15Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphothreonineBy similarity1
Modified residuei177PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ53N72
PRIDEiQ53N72

Expressioni

Inductioni

By jasmonic acid (JA) and infection with rice blast fungus (M.grisea).1 Publication

Gene expression databases

ExpressionAtlasiQ53N72 baseline and differential
GenevisibleiQ53N72 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os11g17080.1

Structurei

3D structure databases

ProteinModelPortaliQ53N72
SMRiQ53N72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 304Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 177TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
InParanoidiQ53N72
OMAiPSCKNER
OrthoDBiEOG093605CF

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q53N72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFFTEYGEG NRYKIEEVIG KGSYGVVCSA LDTHTGEKVA IKKINDIFEH
60 70 80 90 100
VSDATRILRE IKLLRLLRHP DIVEIKHILL PPSRREFKDI YVVFELMESD
110 120 130 140 150
LHQVIKANDD LTPEHYQFFL YQLLRGLKYI HTANVFHRDL KPKNILANAD
160 170 180 190 200
CKLKICDFGL ARVAFSDTPT AIFWTDYVAT RWYRAPELCG SFFSKYTPAI
210 220 230 240 250
DIWSIGCIFA ELLTGKPLFP GKNVVHQLDI ITDLLGTPST EAISRIRNEK
260 270 280 290 300
ARRYLSSMRR KKPIPFTQKF PNADPLALRL LERMLSFEPK DRPNAEEALA
310 320 330 340 350
DPYFRNIANV DREPSAQPVT KLEFEFERRR ITKEDIRELI YRDILEYHPN
360 370 380 390 400
MLREYLEGTE SAGFMYPSAV DHFKKQFAYL EEHYAKGSTA APPERQHNSL
410 420 430 440 450
PRPSVLYSDD RPQNTANIAE DLSKCVLGDN TQKMHQGSAS VCANRVPQGG
460 470 480 490
AARPGKVVGS ALRYGNCSTS TAEQYEHRRT DRNPALATNT VSPRGSYP
Length:498
Mass (Da):56,967
Last modified:May 24, 2005 - v1
Checksum:iEBC9F67E62DF299D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135497 Genomic DNA Translation: AAX94956.1
DP000010 Genomic DNA Translation: ABA92667.1
AP014967 Genomic DNA Translation: BAT13563.1
AK068981 mRNA Translation: BAG91195.1
RefSeqiXP_015615372.1, XM_015759886.1
UniGeneiOs.103029

Genome annotation databases

EnsemblPlantsiOs11t0271100-01; Os11t0271100-01; Os11g0271100
GeneIDi4350264
GrameneiOs11t0271100-01; Os11t0271100-01; Os11g0271100
KEGGiosa:4350264

Similar proteinsi

Entry informationi

Entry nameiMPK15_ORYSJ
AccessioniPrimary (citable) accession number: Q53N72
Secondary accession number(s): B7EFP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome