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Protein

Laccase-18

Gene

LAC18

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Copper 1By similarity1
Metal bindingi89Copper 2By similarity1
Metal bindingi132Copper 2By similarity1
Metal bindingi134Copper 3By similarity1
Metal bindingi488Copper 4Sequence analysis1
Metal bindingi491Copper 1By similarity1
Metal bindingi493Copper 3By similarity1
Metal bindingi550Copper 3By similarity1
Metal bindingi551Copper 4Sequence analysis1
Metal bindingi552Copper 2By similarity1
Metal bindingi556Copper 4Sequence analysis1
Metal bindingi561Copper 4Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-18 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 18
Diphenol oxidase 18
Urishiol oxidase 18
Gene namesi
Name:LAC18
Ordered Locus Names:Os11g0264000, LOC_Os11g16260
ORF Names:OsJ_032226
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000029190330 – 595Laccase-18Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Glycosylationi402N-linked (GlcNAc...)Sequence analysis1
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi470N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ53LU4.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os11g16260.1.

Structurei

3D structure databases

ProteinModelPortaliQ53LU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 153Plastocyanin-like 1Add BLAST117
Domaini162 – 316Plastocyanin-like 2Add BLAST155
Domaini429 – 571Plastocyanin-like 3Add BLAST143

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
InParanoidiQ53LU4.
OMAiHHTNATA.
OrthoDBiEOG093605N6.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53LU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLSTAASL FCVVVAATAL AMAVVGGEAA VVEQTFMVHE MNVTHLCNTT
60 70 80 90 100
KIYVVNGRFP GPTVDVTEGD TVVVHVINRL PHGLTIHWHG VRQMRSCWAD
110 120 130 140 150
GAGYVTECPI HPGGEKTYRF NVTGQVGTLW WHAHVTCLRA TINGAFIIRP
160 170 180 190 200
RNGKYPFLTP AKDVPIIIGE WWELDLIELD RRMLDGNFDD NPLSATINGK
210 220 230 240 250
LGDLSNCSST VEESFVLDVK RGESYLLRVI NTALFSEYYF KVAGHTFTVV
260 270 280 290 300
GADGNYLTPY KTDMVTVAPG EAIDVLMFTD APPAYYHMVA LANQPPPPDL
310 320 330 340 350
QIPQLTSRGL IRYAGAAMDS NNLPMPMPVM PDQHNTMPSY YFRRNLTGLA
360 370 380 390 400
LPEQQQRHRV PAHVDERLLI TLGLGSICRG GNTTTCKRGR SPETVVVATM
410 420 430 440 450
NNVSFHHTNA TALLEHYYDG RPEGVYTEDF PVRPPRPFNY TDRELIPAGP
460 470 480 490 500
LEAALEPTAK AMRLRRFRYN ASVEIVFQST TLLQSDSNPM HLHGYDVFVL
510 520 530 540 550
AQGLGNFDPK RDVEKFNYHN PQLRNTVQVP RGGWAAVRFL ADNPGMWYLH
560 570 580 590
CHFEFHIIMG MATAFIVEDG PTPETSLPPP PPEFKRCGTN GLSQP
Length:595
Mass (Da):66,189
Last modified:May 24, 2005 - v1
Checksum:iED20952A25B72CAF
GO

Sequence cautioni

The sequence BAF28013 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138197 Genomic DNA. Translation: AAX96096.1.
DP000010 Genomic DNA. Translation: ABA92481.1.
AP008217 Genomic DNA. Translation: BAF28013.2. Sequence problems.
AP014967 Genomic DNA. Translation: BAT13514.1.
CM000148 Genomic DNA. Translation: EAZ18017.1.
RefSeqiXP_015616738.1. XM_015761252.1.

Genome annotation databases

EnsemblPlantsiOS11T0264000-00; OS11T0264000-00; OS11G0264000.
GeneIDi4350236.
GrameneiOS11T0264000-00; OS11T0264000-00; OS11G0264000.
KEGGiosa:4350236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138197 Genomic DNA. Translation: AAX96096.1.
DP000010 Genomic DNA. Translation: ABA92481.1.
AP008217 Genomic DNA. Translation: BAF28013.2. Sequence problems.
AP014967 Genomic DNA. Translation: BAT13514.1.
CM000148 Genomic DNA. Translation: EAZ18017.1.
RefSeqiXP_015616738.1. XM_015761252.1.

3D structure databases

ProteinModelPortaliQ53LU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os11g16260.1.

Proteomic databases

PaxDbiQ53LU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS11T0264000-00; OS11T0264000-00; OS11G0264000.
GeneIDi4350236.
GrameneiOS11T0264000-00; OS11T0264000-00; OS11G0264000.
KEGGiosa:4350236.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
InParanoidiQ53LU4.
OMAiHHTNATA.
OrthoDBiEOG093605N6.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC18_ORYSJ
AccessioniPrimary (citable) accession number: Q53LU4
Secondary accession number(s): A0A0N7KSR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.