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Q53LU4

- LAC18_ORYSJ

UniProt

Q53LU4 - LAC18_ORYSJ

Protein

Laccase-18

Gene

LAC18

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Copper 1By similarity
    Metal bindingi89 – 891Copper 2By similarity
    Metal bindingi132 – 1321Copper 2By similarity
    Metal bindingi134 – 1341Copper 3By similarity
    Metal bindingi488 – 4881Copper 4Sequence Analysis
    Metal bindingi491 – 4911Copper 1By similarity
    Metal bindingi493 – 4931Copper 3By similarity
    Metal bindingi550 – 5501Copper 3By similarity
    Metal bindingi551 – 5511Copper 4Sequence Analysis
    Metal bindingi552 – 5521Copper 2By similarity
    Metal bindingi556 – 5561Copper 4Sequence Analysis
    Metal bindingi561 – 5611Copper 4Sequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-18 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 18
    Diphenol oxidase 18
    Urishiol oxidase 18
    Gene namesi
    Name:LAC18
    Ordered Locus Names:Os11g0264000, LOC_Os11g16260
    ORF Names:OsJ_032226
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 11

    Organism-specific databases

    GrameneiQ53LU4.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 595566Laccase-18PRO_0000291903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ53LU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 153117Plastocyanin-like 1Add
    BLAST
    Domaini162 – 316155Plastocyanin-like 2Add
    BLAST
    Domaini429 – 571143Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    OMAiNDINGTE.

    Family and domain databases

    Gene3Di2.60.40.420. 4 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 4 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q53LU4-1 [UniParc]FASTAAdd to Basket

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    MEKLSTAASL FCVVVAATAL AMAVVGGEAA VVEQTFMVHE MNVTHLCNTT    50
    KIYVVNGRFP GPTVDVTEGD TVVVHVINRL PHGLTIHWHG VRQMRSCWAD 100
    GAGYVTECPI HPGGEKTYRF NVTGQVGTLW WHAHVTCLRA TINGAFIIRP 150
    RNGKYPFLTP AKDVPIIIGE WWELDLIELD RRMLDGNFDD NPLSATINGK 200
    LGDLSNCSST VEESFVLDVK RGESYLLRVI NTALFSEYYF KVAGHTFTVV 250
    GADGNYLTPY KTDMVTVAPG EAIDVLMFTD APPAYYHMVA LANQPPPPDL 300
    QIPQLTSRGL IRYAGAAMDS NNLPMPMPVM PDQHNTMPSY YFRRNLTGLA 350
    LPEQQQRHRV PAHVDERLLI TLGLGSICRG GNTTTCKRGR SPETVVVATM 400
    NNVSFHHTNA TALLEHYYDG RPEGVYTEDF PVRPPRPFNY TDRELIPAGP 450
    LEAALEPTAK AMRLRRFRYN ASVEIVFQST TLLQSDSNPM HLHGYDVFVL 500
    AQGLGNFDPK RDVEKFNYHN PQLRNTVQVP RGGWAAVRFL ADNPGMWYLH 550
    CHFEFHIIMG MATAFIVEDG PTPETSLPPP PPEFKRCGTN GLSQP 595
    Length:595
    Mass (Da):66,189
    Last modified:May 24, 2005 - v1
    Checksum:iED20952A25B72CAF
    GO

    Sequence cautioni

    The sequence BAF28013.2 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138197 Genomic DNA. Translation: AAX96096.1.
    DP000010 Genomic DNA. Translation: ABA92481.1.
    AP008217 Genomic DNA. Translation: BAF28013.2. Sequence problems.
    CM000148 Genomic DNA. Translation: EAZ18017.1.
    RefSeqiNP_001067650.2. NM_001074182.2.
    UniGeneiOs.86101.

    Genome annotation databases

    EnsemblPlantsiOS11T0264000-00; OS11T0264000-00; OS11G0264000.
    GeneIDi4350236.
    KEGGiosa:4350236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138197 Genomic DNA. Translation: AAX96096.1 .
    DP000010 Genomic DNA. Translation: ABA92481.1 .
    AP008217 Genomic DNA. Translation: BAF28013.2 . Sequence problems.
    CM000148 Genomic DNA. Translation: EAZ18017.1 .
    RefSeqi NP_001067650.2. NM_001074182.2.
    UniGenei Os.86101.

    3D structure databases

    ProteinModelPortali Q53LU4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS11T0264000-00 ; OS11T0264000-00 ; OS11G0264000 .
    GeneIDi 4350236.
    KEGGi osa:4350236.

    Organism-specific databases

    Gramenei Q53LU4.

    Phylogenomic databases

    eggNOGi COG2132.
    OMAi NDINGTE.

    Family and domain databases

    Gene3Di 2.60.40.420. 4 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 4 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
      The rice chromosomes 11 and 12 sequencing consortia
      BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLAC18_ORYSJ
    AccessioniPrimary (citable) accession number: Q53LU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3