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Protein

Ankyrin repeat domain-containing protein SOWAHC

Gene

SOWAHC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33176-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein SOWAHC
Alternative name(s):
Ankyrin repeat domain-containing protein 57
Protein sosondowah homolog C
Gene namesi
Name:SOWAHC
Synonyms:ANKRD57, C2orf26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26149. SOWAHC.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198142.
PharmGKBiPA134882354.

Polymorphism and mutation databases

BioMutaiSOWAHC.
DMDMi74740628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743401 – 525Ankyrin repeat domain-containing protein SOWAHCAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53LP3.
MaxQBiQ53LP3.
PaxDbiQ53LP3.
PeptideAtlasiQ53LP3.
PRIDEiQ53LP3.

PTM databases

iPTMnetiQ53LP3.
PhosphoSitePlusiQ53LP3.

Expressioni

Gene expression databases

BgeeiENSG00000198142.
CleanExiHS_ANKRD57.
GenevisibleiQ53LP3. HS.

Organism-specific databases

HPAiHPA056131.

Interactioni

Protein-protein interaction databases

BioGridi122402. 5 interactors.
IntActiQ53LP3. 3 interactors.
STRINGi9606.ENSP00000365830.

Structurei

3D structure databases

ProteinModelPortaliQ53LP3.
SMRiQ53LP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati301 – 330ANK 1Add BLAST30
Repeati340 – 370ANK 2Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 180Pro-richAdd BLAST94
Compositional biasi438 – 443Poly-His6

Sequence similaritiesi

Belongs to the SOWAH family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063547.
HOGENOMiHOG000116317.
HOVERGENiHBG079715.
InParanoidiQ53LP3.
OMAiQLKRSVC.
OrthoDBiEOG091G0F4O.
PhylomeDBiQ53LP3.
TreeFamiTF331362.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53LP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPAEWGPE AALGPEAVLR FLAERGGRAL HAELVQHFRG ALGGEPEQRA
60 70 80 90 100
RARAHFKELV NAVATVRVDP ADGAKYVHLK KRFCEGPSEP SGDPPRIQVT
110 120 130 140 150
AEPEAPDGPA GPEARDRLPD AAAPESLPGQ GRELGEGEPP APAHWPPLSA
160 170 180 190 200
GARRKNSRRD VQPLPRTPAP GPSEDLELPP HGCEEADRGS SLVGATAQRP
210 220 230 240 250
ARQNLRDLVM GSSPQLKRSV CPGGSSPGSS SGGGRGRGGG DSDSASVASS
260 270 280 290 300
SAEEESSGGG SVTLDPLEHA WMLSASDGKW DSLEGLLTCE PGLLVKRDFI
310 320 330 340 350
TGFTCLHWAA KHGRQELLAM LVNFANKHQL PVNIDARTSG GYTALHLAAM
360 370 380 390 400
HGHVEVVKLL VGAYDADVDI RDYSGKKASQ YLSRSIAEEI KNLVGALDEG
410 420 430 440 450
DGESAAGSGG GRWRLSKVLP SHLITYKLSH ALEDGGDHHH HHHSAEGWVG
460 470 480 490 500
GKAKDPGRKA SGSSSGRIKP RLNKIRFRTQ IVHTTPSFRD PEQPLEGRGE
510 520
EGVGEERPVK GHSPFTLRPK SNVFG
Length:525
Mass (Da):55,672
Last modified:May 24, 2005 - v1
Checksum:i6E90B5E911D41B02
GO

Sequence cautioni

The sequence BAB15161 differs from that shown. Reason: Frameshift at position 311.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307H → R in BAB15161 (PubMed:14702039).Curated1
Sequence conflicti318L → V in BAB15161 (PubMed:14702039).Curated1
Sequence conflicti334I → M in BAB15161 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025523 mRNA. Translation: BAB15161.1. Frameshift.
AC140485 Genomic DNA. Translation: AAY24143.1.
AC011753 Genomic DNA. Translation: AAY24292.1.
BC036652 mRNA. Translation: AAH36652.2.
CCDSiCCDS33270.1.
RefSeqiNP_075392.2. NM_023016.3.
UniGeneiHs.355455.

Genome annotation databases

EnsembliENST00000356454; ENSP00000365830; ENSG00000198142.
GeneIDi65124.
KEGGihsa:65124.
UCSCiuc002tfb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025523 mRNA. Translation: BAB15161.1. Frameshift.
AC140485 Genomic DNA. Translation: AAY24143.1.
AC011753 Genomic DNA. Translation: AAY24292.1.
BC036652 mRNA. Translation: AAH36652.2.
CCDSiCCDS33270.1.
RefSeqiNP_075392.2. NM_023016.3.
UniGeneiHs.355455.

3D structure databases

ProteinModelPortaliQ53LP3.
SMRiQ53LP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122402. 5 interactors.
IntActiQ53LP3. 3 interactors.
STRINGi9606.ENSP00000365830.

PTM databases

iPTMnetiQ53LP3.
PhosphoSitePlusiQ53LP3.

Polymorphism and mutation databases

BioMutaiSOWAHC.
DMDMi74740628.

Proteomic databases

EPDiQ53LP3.
MaxQBiQ53LP3.
PaxDbiQ53LP3.
PeptideAtlasiQ53LP3.
PRIDEiQ53LP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356454; ENSP00000365830; ENSG00000198142.
GeneIDi65124.
KEGGihsa:65124.
UCSCiuc002tfb.4. human.

Organism-specific databases

CTDi65124.
GeneCardsiSOWAHC.
HGNCiHGNC:26149. SOWAHC.
HPAiHPA056131.
neXtProtiNX_Q53LP3.
OpenTargetsiENSG00000198142.
PharmGKBiPA134882354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063547.
HOGENOMiHOG000116317.
HOVERGENiHBG079715.
InParanoidiQ53LP3.
OMAiQLKRSVC.
OrthoDBiEOG091G0F4O.
PhylomeDBiQ53LP3.
TreeFamiTF331362.

Enzyme and pathway databases

BioCyciZFISH:G66-33176-MONOMER.

Miscellaneous databases

GenomeRNAii65124.
PROiQ53LP3.

Gene expression databases

BgeeiENSG00000198142.
CleanExiHS_ANKRD57.
GenevisibleiQ53LP3. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWAHC_HUMAN
AccessioniPrimary (citable) accession number: Q53LP3
Secondary accession number(s): Q8NE15, Q9H6U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.