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Protein

Ankyrin repeat domain-containing protein SOWAHC

Gene

SOWAHC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein SOWAHC
Alternative name(s):
Ankyrin repeat domain-containing protein 57
Protein sosondowah homolog C
Gene namesi
Name:SOWAHC
Synonyms:ANKRD57, C2orf26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000198142.4
HGNCiHGNC:26149 SOWAHC
neXtProtiNX_Q53LP3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198142
PharmGKBiPA134882354

Polymorphism and mutation databases

BioMutaiSOWAHC
DMDMi74740628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743401 – 525Ankyrin repeat domain-containing protein SOWAHCAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53LP3
MaxQBiQ53LP3
PaxDbiQ53LP3
PeptideAtlasiQ53LP3
PRIDEiQ53LP3

PTM databases

iPTMnetiQ53LP3
PhosphoSitePlusiQ53LP3

Expressioni

Gene expression databases

BgeeiENSG00000198142
CleanExiHS_ANKRD57
GenevisibleiQ53LP3 HS

Organism-specific databases

HPAiHPA056131

Interactioni

Protein-protein interaction databases

BioGridi122402, 6 interactors
IntActiQ53LP3, 3 interactors
STRINGi9606.ENSP00000365830

Structurei

3D structure databases

ProteinModelPortaliQ53LP3
SMRiQ53LP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati301 – 330ANK 1Add BLAST30
Repeati340 – 370ANK 2Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 180Pro-richAdd BLAST94
Compositional biasi438 – 443Poly-His6

Sequence similaritiesi

Belongs to the SOWAH family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063547
HOGENOMiHOG000116317
HOVERGENiHBG079715
InParanoidiQ53LP3
OMAiIHTTPSF
OrthoDBiEOG091G0F4O
PhylomeDBiQ53LP3
TreeFamiTF331362

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q53LP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPAEWGPE AALGPEAVLR FLAERGGRAL HAELVQHFRG ALGGEPEQRA
60 70 80 90 100
RARAHFKELV NAVATVRVDP ADGAKYVHLK KRFCEGPSEP SGDPPRIQVT
110 120 130 140 150
AEPEAPDGPA GPEARDRLPD AAAPESLPGQ GRELGEGEPP APAHWPPLSA
160 170 180 190 200
GARRKNSRRD VQPLPRTPAP GPSEDLELPP HGCEEADRGS SLVGATAQRP
210 220 230 240 250
ARQNLRDLVM GSSPQLKRSV CPGGSSPGSS SGGGRGRGGG DSDSASVASS
260 270 280 290 300
SAEEESSGGG SVTLDPLEHA WMLSASDGKW DSLEGLLTCE PGLLVKRDFI
310 320 330 340 350
TGFTCLHWAA KHGRQELLAM LVNFANKHQL PVNIDARTSG GYTALHLAAM
360 370 380 390 400
HGHVEVVKLL VGAYDADVDI RDYSGKKASQ YLSRSIAEEI KNLVGALDEG
410 420 430 440 450
DGESAAGSGG GRWRLSKVLP SHLITYKLSH ALEDGGDHHH HHHSAEGWVG
460 470 480 490 500
GKAKDPGRKA SGSSSGRIKP RLNKIRFRTQ IVHTTPSFRD PEQPLEGRGE
510 520
EGVGEERPVK GHSPFTLRPK SNVFG
Length:525
Mass (Da):55,672
Last modified:May 24, 2005 - v1
Checksum:i6E90B5E911D41B02
GO

Sequence cautioni

The sequence BAB15161 differs from that shown. Reason: Frameshift at position 311.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307H → R in BAB15161 (PubMed:14702039).Curated1
Sequence conflicti318L → V in BAB15161 (PubMed:14702039).Curated1
Sequence conflicti334I → M in BAB15161 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025523 mRNA Translation: BAB15161.1 Frameshift.
AC140485 Genomic DNA Translation: AAY24143.1
AC011753 Genomic DNA Translation: AAY24292.1
BC036652 mRNA Translation: AAH36652.2
CCDSiCCDS33270.1
RefSeqiNP_075392.2, NM_023016.3
UniGeneiHs.355455

Genome annotation databases

EnsembliENST00000356454; ENSP00000365830; ENSG00000198142
GeneIDi65124
KEGGihsa:65124
UCSCiuc002tfb.4 human

Similar proteinsi

Entry informationi

Entry nameiSWAHC_HUMAN
AccessioniPrimary (citable) accession number: Q53LP3
Secondary accession number(s): Q8NE15, Q9H6U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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