Reviewed, UniProtKB/Swiss-Prot Q53I51 (CDA_CRYNE)

Names and origin

Protein names

Recommended name:
    Chitin deacetylase
    EC=3.5.1.41

Gene names

Name:	MP 84
Ordered Locus Names:	CND03580, CNBD2750

Organism

Cryptococcus neoformans (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

5207 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.
Catalytic activity	Chitin + H2O = chitosan + acetate.
Sequence similarities	Belongs to the polysaccharide deacetylase family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	chitin deacetylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 39	21	By similarity		PRO_0000024828
	Chain	40 – 410	371	Chitin deacetylase		PRO_0000024829
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Glycosylation	279	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	22	1	P → H in strain: B-3501A and CAP 67.
	Natural variant	219	1	M → L in strain: B-3501A and CAP 67.

Sequences

	Sequence		Length	Mass (Da)
	Q53I51-1 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 73338AC415E2771A	FASTA	410	43,971
	10 20 30 40 50 60 MYGHLSLSTL SLLAVVAAAP FPESWLQPRD SDVSQLFRRG APDPKASDYL SYYPSPGSTP 70 80 90 100 110 120 NVSTIPQAWL DKLATVQLPN VSVATANDGR PTYPNNENDG DSEICSFTDQ CYVEDDLYSP 130 140 150 160 170 180 PGEKVWALSF DDGPTDVSPA LYDYLAQNNI SSSATHFMIG GNIITSPQSV LIAIEAGGHL 190 200 210 220 230 240 AVHTWSHPYM TTLTNEQVVA ELGWTMQALS DLNGGRIPMY WRPPYGDVDN RVRAIAKGVF 250 260 270 280 290 300 GLVTVLWDSD TNDWAISDQP DQYSVASVEA YFDTLVTGNR TQGLLLLEHE LDNNTVEVFE 310 320 330 340 350 360 TEYPKAVANG WSVKNVADAF SMKWYLNSGK GNDDVVTTMS VAGTLTTAKP THTSTSVASA 370 380 390 400 410 TATSSASVTD SAGVSIASAA SSQESSSWPI ANRPSLFVIA CGLALAAIMV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of two novel cryptococcal mannoproteins recognized by immune sera." Biondo C., Messina L., Bombaci M., Mancuso G., Midiri A., Beninati C., Cusumano V., Gerace E., Papasergi S., Teti G. Infect. Immun. 73:7348-7355(2005) [PubMed: 16239533] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CAP 67.
[2]	"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W. Science 307:1321-1324(2005) [PubMed: 15653466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A and JEC21.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ938050 mRNA. Translation: CAI79614.1. AE017344 Genomic DNA. Translation: AAW42893.1. AAEY01000020 Genomic DNA. Translation: EAL21220.1.
RefSeq	XP_570200.1. XP_775867.1.
UniGene	Fne.244 Fne.6371
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3257267. 4935664.
GenomeReviews	Gene locus CND03580 in contig AE017344_GR. Gene locus CNBD2750 in contig CM000043_GR.
KEGG	cnb:CNBD2750. cne:CND03580.
Phylogenomic databases
HOGENOM	Q53I51.
OMA	SATHFMI.
Enzyme and pathway databases
BRENDA	3.5.1.41. 2772.
Family and domain databases
InterPro	IPR002509. Polysac_deacetylase. [Graphical view]
Gene3D	G3DSA:3.20.20.370. Polysac_deacetylase. 1 hit.
Pfam	PF01522. Polysacc_deac_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDA_CRYNE

Accession

Primary (citable) accession number: Q53I51
Secondary accession number(s): Q55U29, Q5KIB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	November 3, 2009
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)