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Protein
Submitted name:

Complement component 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi262MagnesiumCombined sources1
Metal bindingi262ManganeseCombined sources1
Metal bindingi264MagnesiumCombined sources1
Metal bindingi264ManganeseCombined sources1
Metal bindingi337MagnesiumCombined sources1
Metal bindingi337ManganeseCombined sources1
Active sitei507Charge relay systemUniRule annotation1
Active sitei561Charge relay systemUniRule annotation1
Binding sitei644FucoseCombined sources1
Active sitei679Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation
LigandMagnesiumCombined sources, ManganeseCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 2 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500424883221 – 752Sequence analysisAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi117 ↔ 144PROSITE-ProRule annotation
Disulfide bondi177 ↔ 204PROSITE-ProRule annotation
Glycosylationi333N-linked (GlcNAc...)Combined sources1
Disulfide bondi463 ↔ 581Combined sources
Glycosylationi467N-linked (GlcNAc...)Combined sources1
Disulfide bondi492 ↔ 508Combined sources
Disulfide bondi584 ↔ 600Combined sources
Glycosylationi621N-linked (GlcNAc...)Combined sources1
Disulfide bondi638 ↔ 665Combined sources
Disulfide bondi675 ↔ 705Combined sources

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ53HP3.
PeptideAtlasiQ53HP3.
PRIDEiQ53HP3.

Expressioni

Gene expression databases

GenevisibleiQ53HP3. HS.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6QX-ray2.10A244-752[»]
2ODPX-ray1.90A244-752[»]
SMRiQ53HP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 86SushiInterPro annotationAdd BLAST65
Domaini87 – 146SushiInterPro annotationAdd BLAST60
Domaini149 – 206SushiInterPro annotationAdd BLAST58
Domaini254 – 452VWFAInterPro annotationAdd BLAST199
Domaini464 – 744Peptidase S1InterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOVERGENiHBG002567.
KOiK01332.

Family and domain databases

CDDicd00033. CCP. 3 hits.
cd00190. Tryp_SPc. 1 hit.
Gene3Di3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR011360. Compl_C2_B.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
IPR002035. VWF_A.
PfamiView protein in Pfam
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
PF00092. VWA. 1 hit.
PIRSFiPIRSF001154. Compl_C2_B. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00032. CCP. 3 hits.
SM00020. Tryp_SPc. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF57535. SSF57535. 3 hits.
PROSITEiView protein in PROSITE
PS50923. SUSHI. 3 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q53HP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS
60 70 80 90 100
CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY
110 120 130 140 150
TPRLGSYPVG GNVSFECEDG FILRGSPVRQ CRPNGMWDGE TAVCDNGAGH
160 170 180 190 200
CPNPGISLGA VRTGFRFGHG DKVRYRCSSN LVLTGSSERE CQGNGVWSGT
210 220 230 240 250
EPICRQPYSY DFPEDVAPAL GTSFSHMLGA TNLTQKTKES LGRKIQIQRS
260 270 280 290 300
GHLNLYLLLD CSQSVSENDF LIFKESASLM VDRIFSFEIN VSVAIITFAS
310 320 330 340 350
EPKVLMSVLN DNSRDMTEVI SSLENANYKD HENGTGTNTY AALNSVYLMM
360 370 380 390 400
NNQMRLLGME TMAWQEIRHA IILLTDGKSN MGGSPKTAVD HIREILNINQ
410 420 430 440 450
KRNDYLDIYA IGVGKLDVDW RELNELGSKK DGERHAFILQ DTKALHQVFE
460 470 480 490 500
HMLDVSKLTD TICGVGNMSA NASDQERTPW HVTIKPKSQE TCRGALISDQ
510 520 530 540 550
WVLTAAHCFR DGNDHSLWRV NVGDPKSQWG KEFLIEKAVI SPGFDVFAKK
560 570 580 590 600
NQGILEFYGD DIALLKLAQK VKMSTHARPI CLPCTMEANL ALRRPQGSTC
610 620 630 640 650
RDHENELLNK QSVPAHFVAL NGSKLNINLK MGVEWTSCAE VVSQEKTMFP
660 670 680 690 700
NLTDVREVVT DQFLCSGTQE DESPCKGESG GAVFLERRFR FFQVGLVSWG
710 720 730 740 750
LYNPCLGSAD KNSRKRAPRS KVPPPRDFHI NLFRMQPWLR QHLGDVLNFL

PL
Length:752
Mass (Da):83,284
Last modified:May 24, 2005 - v1
Checksum:iB9AF4D3E700CF443
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222537 mRNA. Translation: BAD96257.1.
RefSeqiNP_000054.2. NM_000063.5.
NP_001139375.1. NM_001145903.2.
NP_001269386.1. NM_001282457.1.
UniGeneiHs.408903.

Genome annotation databases

GeneIDi717.
KEGGihsa:717.

Similar proteinsi

Entry informationi

Entry nameiQ53HP3_HUMAN
AccessioniPrimary (citable) accession number: Q53HP3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

3D-structureCombined sources