Unreviewed, UniProtKB/TrEMBL Q53HM4 (Q53HM4_HUMAN)

Names and origin

Protein names	Submitted name:     Ras homolog gene family, member A variant EMBL BAD96276.1
Organism	Homo sapiens (Human) EMBL BAD96276.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Ontologies

Keywords
Cellular component	Membrane Spearmint SPM003578
Ligand	GTP-binding Spearmint SPM003578 RuleBase RU003312V0 Nucleotide-binding
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: Compara cell morphogenesis Inferred from electronic annotation. Source: Compara cell-matrix adhesion Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptosis Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara skeletal muscle tissue development Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro stress fiber assembly Inferred from electronic annotation. Source: Compara
Cellular component	nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD96276.1

Sequences

	Sequence		Length	Mass (Da)
	Q53HM4-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: D05CF9B6C7B24005	FASTA	193	21,756
	10 20 30 40 50 60 MAAIRKKLVI VGDGACGKTC LLTVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT 70 80 90 100 110 120 AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 130 140 150 160 170 180 LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ 190 ARRGKKKSGC LVL

References

[1]	"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides." Maruyama K., Sugano S. Gene 138:171-174(1994) [PubMed: 8125298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adipose tissue EMBL BAD96276.1.
[2]	"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library." Suzuki Y., Yoshitomo K., Maruyama K., Suyama A., Sugano S. Gene 200:149-156(1997) [PubMed: 9373149] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adipose tissue EMBL BAD96276.1.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adipose tissue EMBL BAD96276.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK222556 mRNA. Translation: BAD96276.1.
IPI	IPI00478231.
UniGene	Hs.247077 Hs.709788
3D structure databases
SMR	Q53HM4. Positions 2-181.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53HM4.
Genome annotation databases
Ensembl	ENST00000418115; ENSP00000400175; ENSG00000067560; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:667. RHOA.
Phylogenomic databases
HOVERGEN	Q53HM4.
PhylomeDB	Q53HM4.
Gene expression databases
ArrayExpress	Q53HM4.
Bgee	Q53HM4.
Family and domain databases
InterPro	IPR003578. GTPase_Rho. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q53HM4_HUMAN

Accession

Primary (citable) accession number: Q53HM4

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.