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Protein

Protein unc-50 homolog

Gene

UNC50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-50 homolog
Alternative name(s):
Periodontal ligament-specific protein 22
Short name:
PDLs22
Protein GMH1 homolog
Short name:
hGMH1
Uncoordinated-like protein
Gene namesi
Name:UNC50
Synonyms:UNCL
ORF Names:HSD-23, HSD23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115446.11
HGNCiHGNC:16046 UNC50
MIMi617826 gene
neXtProtiNX_Q53HI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 115LumenalSequence analysisAdd BLAST12
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 163CytoplasmicSequence analysisAdd BLAST27
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 187LumenalSequence analysis3
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 222CytoplasmicSequence analysisAdd BLAST14
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 259LumenalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25972
OpenTargetsiENSG00000115446
PharmGKBiPA134984566

Polymorphism and mutation databases

BioMutaiUNC50
DMDMi160358938

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003089611 – 259Protein unc-50 homologAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ53HI1
MaxQBiQ53HI1
PaxDbiQ53HI1
PeptideAtlasiQ53HI1
PRIDEiQ53HI1

PTM databases

iPTMnetiQ53HI1
PhosphoSitePlusiQ53HI1

Expressioni

Tissue specificityi

Present in periodontal ligament fibroblasts (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000115446
CleanExiHS_UNC50
ExpressionAtlasiQ53HI1 baseline and differential
GenevisibleiQ53HI1 HS

Organism-specific databases

HPAiHPA027009

Interactioni

Protein-protein interaction databases

BioGridi117456, 5 interactors
IntActiQ53HI1, 7 interactors
MINTiQ53HI1
STRINGi9606.ENSP00000350409

Structurei

3D structure databases

ProteinModelPortaliQ53HI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-50 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3012 Eukaryota
ENOG410XT05 LUCA
GeneTreeiENSGT00390000018553
HOVERGENiHBG053013
InParanoidiQ53HI1
PhylomeDBiQ53HI1
TreeFamiTF105624

Family and domain databases

InterProiView protein in InterPro
IPR007881 UNC-50
PANTHERiPTHR12841 PTHR12841, 1 hit
PfamiView protein in Pfam
PF05216 UNC-50, 1 hit

Sequencei

Sequence statusi: Complete.

Q53HI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSTSVNSL VQGNGVLNSR DAARHTAGAK RYKYLRRLFR FRQMDFEFAA
60 70 80 90 100
WQMLYLFTSP QRVYRNFHYR KQTKDQWARD DPAFLVLLSI WLCVSTIGFG
110 120 130 140 150
FVLDMGFFET IKLLLWVVLI DCVGVGLLIA TLMWFISNKY LVKRQSRDYD
160 170 180 190 200
VEWGYAFDVH LNAFYPLLVI LHFIQLFFIN HVILTDTFIG YLVGNTLWLV
210 220 230 240 250
AVGYYIYVTF LGYSALPFLK NTVILLYPFA PLILLYGLSL ALGWNFTHTL

CSFYKYRVK
Length:259
Mass (Da):30,373
Last modified:November 13, 2007 - v2
Checksum:iF0BAF2594B84330B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Y → C in AAP20057 (Ref. 4) Curated1
Sequence conflicti66N → S in BAD96319 (Ref. 6) Curated1
Sequence conflicti115L → P in AAH39078 (PubMed:15489334).Curated1
Sequence conflicti119L → F in BAD96319 (Ref. 6) Curated1
Sequence conflicti173F → L in AAK08987 (Ref. 1) Curated1
Sequence conflicti173F → L in CAB45714 (PubMed:11230166).Curated1
Sequence conflicti173F → L in CAG38495 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017215 mRNA Translation: AAK08987.1
AF077038 mRNA Translation: AAD27771.1
AL080115 mRNA Translation: CAB45714.1
AY251534 mRNA Translation: AAP20057.1
CR533464 mRNA Translation: CAG38495.1
AK222599 mRNA Translation: BAD96319.1
AC010134 Genomic DNA Translation: AAX93232.1
AC064860 Genomic DNA Translation: AAY14975.1
CH471127 Genomic DNA Translation: EAX01900.1
CH471127 Genomic DNA Translation: EAX01901.1
CH471127 Genomic DNA Translation: EAX01902.1
BC017019 mRNA Translation: AAH17019.1
BC025992 mRNA Translation: AAH25992.1
BC039078 mRNA Translation: AAH39078.1
BC091481 mRNA Translation: AAH91481.1
CCDSiCCDS2035.1
PIRiT12451
RefSeqiNP_054763.2, NM_014044.6
UniGeneiHs.13370

Genome annotation databases

EnsembliENST00000357765; ENSP00000350409; ENSG00000115446
GeneIDi25972
KEGGihsa:25972
UCSCiuc002szc.5 human

Similar proteinsi

Entry informationi

Entry nameiUNC50_HUMAN
AccessioniPrimary (citable) accession number: Q53HI1
Secondary accession number(s): D3DVH4
, Q53S98, Q53TD6, Q5U5U2, Q6X7B9, Q9UQF4, Q9Y4S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 25, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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