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Protein

Protein unc-50 homolog

Gene

UNC50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-50 homolog
Alternative name(s):
Periodontal ligament-specific protein 22
Short name:
PDLs22
Protein GMH1 homolog
Short name:
hGMH1
Uncoordinated-like protein
Gene namesi
Name:UNC50
Synonyms:UNCL
ORF Names:HSD-23, HSD23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16046. UNC50.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence analysisAdd
BLAST
Topological domaini104 – 11512LumenalSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Topological domaini137 – 16327CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 1873LumenalSequence analysis
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 22214CytoplasmicSequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Topological domaini244 – 25916LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984566.

Polymorphism and mutation databases

BioMutaiUNC50.
DMDMi160358938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Protein unc-50 homologPRO_0000308961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ53HI1.
MaxQBiQ53HI1.
PaxDbiQ53HI1.
PRIDEiQ53HI1.

PTM databases

iPTMnetiQ53HI1.
PhosphoSiteiQ53HI1.

Expressioni

Tissue specificityi

Present in periodontal ligament fibroblasts (at protein level).1 Publication

Gene expression databases

BgeeiQ53HI1.
CleanExiHS_UNC50.
ExpressionAtlasiQ53HI1. baseline and differential.
GenevisibleiQ53HI1. HS.

Organism-specific databases

HPAiHPA027009.

Interactioni

Protein-protein interaction databases

BioGridi117456. 3 interactions.
IntActiQ53HI1. 4 interactions.
MINTiMINT-6167138.
STRINGi9606.ENSP00000350409.

Structurei

3D structure databases

ProteinModelPortaliQ53HI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-50 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3012. Eukaryota.
ENOG410XT05. LUCA.
GeneTreeiENSGT00390000018553.
HOVERGENiHBG053013.
InParanoidiQ53HI1.
OrthoDBiEOG74BJSN.
PhylomeDBiQ53HI1.
TreeFamiTF105624.

Family and domain databases

InterProiIPR007881. UNC-50.
[Graphical view]
PANTHERiPTHR12841. PTHR12841. 1 hit.
PfamiPF05216. UNC-50. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53HI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSTSVNSL VQGNGVLNSR DAARHTAGAK RYKYLRRLFR FRQMDFEFAA
60 70 80 90 100
WQMLYLFTSP QRVYRNFHYR KQTKDQWARD DPAFLVLLSI WLCVSTIGFG
110 120 130 140 150
FVLDMGFFET IKLLLWVVLI DCVGVGLLIA TLMWFISNKY LVKRQSRDYD
160 170 180 190 200
VEWGYAFDVH LNAFYPLLVI LHFIQLFFIN HVILTDTFIG YLVGNTLWLV
210 220 230 240 250
AVGYYIYVTF LGYSALPFLK NTVILLYPFA PLILLYGLSL ALGWNFTHTL

CSFYKYRVK
Length:259
Mass (Da):30,373
Last modified:November 13, 2007 - v2
Checksum:iF0BAF2594B84330B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341Y → C in AAP20057 (Ref. 4) Curated
Sequence conflicti66 – 661N → S in BAD96319 (Ref. 6) Curated
Sequence conflicti115 – 1151L → P in AAH39078 (PubMed:15489334).Curated
Sequence conflicti119 – 1191L → F in BAD96319 (Ref. 6) Curated
Sequence conflicti173 – 1731F → L in AAK08987 (Ref. 1) Curated
Sequence conflicti173 – 1731F → L in CAB45714 (PubMed:11230166).Curated
Sequence conflicti173 – 1731F → L in CAG38495 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017215 mRNA. Translation: AAK08987.1.
AF077038 mRNA. Translation: AAD27771.1.
AL080115 mRNA. Translation: CAB45714.1.
AY251534 mRNA. Translation: AAP20057.1.
CR533464 mRNA. Translation: CAG38495.1.
AK222599 mRNA. Translation: BAD96319.1.
AC010134 Genomic DNA. Translation: AAX93232.1.
AC064860 Genomic DNA. Translation: AAY14975.1.
CH471127 Genomic DNA. Translation: EAX01900.1.
CH471127 Genomic DNA. Translation: EAX01901.1.
CH471127 Genomic DNA. Translation: EAX01902.1.
BC017019 mRNA. Translation: AAH17019.1.
BC025992 mRNA. Translation: AAH25992.1.
BC039078 mRNA. Translation: AAH39078.1.
BC091481 mRNA. Translation: AAH91481.1.
CCDSiCCDS2035.1.
PIRiT12451.
RefSeqiNP_054763.2. NM_014044.5.
UniGeneiHs.13370.

Genome annotation databases

EnsembliENST00000357765; ENSP00000350409; ENSG00000115446.
GeneIDi25972.
KEGGihsa:25972.
UCSCiuc002szc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017215 mRNA. Translation: AAK08987.1.
AF077038 mRNA. Translation: AAD27771.1.
AL080115 mRNA. Translation: CAB45714.1.
AY251534 mRNA. Translation: AAP20057.1.
CR533464 mRNA. Translation: CAG38495.1.
AK222599 mRNA. Translation: BAD96319.1.
AC010134 Genomic DNA. Translation: AAX93232.1.
AC064860 Genomic DNA. Translation: AAY14975.1.
CH471127 Genomic DNA. Translation: EAX01900.1.
CH471127 Genomic DNA. Translation: EAX01901.1.
CH471127 Genomic DNA. Translation: EAX01902.1.
BC017019 mRNA. Translation: AAH17019.1.
BC025992 mRNA. Translation: AAH25992.1.
BC039078 mRNA. Translation: AAH39078.1.
BC091481 mRNA. Translation: AAH91481.1.
CCDSiCCDS2035.1.
PIRiT12451.
RefSeqiNP_054763.2. NM_014044.5.
UniGeneiHs.13370.

3D structure databases

ProteinModelPortaliQ53HI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117456. 3 interactions.
IntActiQ53HI1. 4 interactions.
MINTiMINT-6167138.
STRINGi9606.ENSP00000350409.

PTM databases

iPTMnetiQ53HI1.
PhosphoSiteiQ53HI1.

Polymorphism and mutation databases

BioMutaiUNC50.
DMDMi160358938.

Proteomic databases

EPDiQ53HI1.
MaxQBiQ53HI1.
PaxDbiQ53HI1.
PRIDEiQ53HI1.

Protocols and materials databases

DNASUi25972.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357765; ENSP00000350409; ENSG00000115446.
GeneIDi25972.
KEGGihsa:25972.
UCSCiuc002szc.5. human.

Organism-specific databases

CTDi25972.
GeneCardsiUNC50.
H-InvDBHIX0002299.
HGNCiHGNC:16046. UNC50.
HPAiHPA027009.
neXtProtiNX_Q53HI1.
PharmGKBiPA134984566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3012. Eukaryota.
ENOG410XT05. LUCA.
GeneTreeiENSGT00390000018553.
HOVERGENiHBG053013.
InParanoidiQ53HI1.
OrthoDBiEOG74BJSN.
PhylomeDBiQ53HI1.
TreeFamiTF105624.

Miscellaneous databases

ChiTaRSiUNC50. human.
GenomeRNAii25972.
NextBioi47606.
PROiQ53HI1.

Gene expression databases

BgeeiQ53HI1.
CleanExiHS_UNC50.
ExpressionAtlasiQ53HI1. baseline and differential.
GenevisibleiQ53HI1. HS.

Family and domain databases

InterProiIPR007881. UNC-50.
[Graphical view]
PANTHERiPTHR12841. PTHR12841. 1 hit.
PfamiPF05216. UNC-50. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Yu L.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "A new spermatogenesis-related gene."
    Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Coronary artery.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung, Placenta and Testis.
  10. "UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein."
    Fitzgerald J., Kennedy D., Viseshakul N., Cohen B.N., Mattick J., Bateman J.F., Forsayeth J.R.
    Brain Res. 877:110-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  11. "Isolation and characterization of cultured human periodontal ligament fibroblast-specific cDNAs."
    Park J.-C., Kim Y.-B., Kim H.-J., Jang H.-S., Kim H.-S., Kim B.-O., Han K.-Y.
    Biochem. Biophys. Res. Commun. 282:1145-1153(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  12. "A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p."
    Chantalat S., Courbeyrette R., Senic-Matuglia F., Jackson C.L., Goud B., Peyroche A.
    Mol. Biol. Cell 14:2357-2371(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "Expression of UNCL during development of periodontal tissue and response of periodontal ligament fibroblasts to mechanical stress in vivo and in vitro."
    Kim H.-J., Choi Y.S., Jeong M.-J., Kim B.-O., Lim S.-H., Kim D.K., Kim C.K., Park J.-C.
    Cell Tissue Res. 327:25-31(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUNC50_HUMAN
AccessioniPrimary (citable) accession number: Q53HI1
Secondary accession number(s): D3DVH4
, Q53S98, Q53TD6, Q5U5U2, Q6X7B9, Q9UQF4, Q9Y4S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 13, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.