Reviewed, UniProtKB/Swiss-Prot Q53HC9 (TSSC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein TSSC1
Alternative name(s):
    Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein
    Tumor-suppressing STF cDNA 1 protein

Gene names

Name:

TSSC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 5 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DEGS1	O15121	1	EBI-1055422,EBI-1052713
MOBKL1B	Q9H8S9	1	EBI-1055422,EBI-748229

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Protein TSSC1		PRO_0000051298
Regions
	Repeat	132 – 172	41	WD 1
	Repeat	182 – 222	41	WD 2
	Repeat	226 – 266	41	WD 3
	Repeat	270 – 310	41	WD 4
	Repeat	345 – 385	41	WD 5
Experimental info
	Sequence conflict	58	1	N → S in BAD96372. Ref.2
	Sequence conflict	214	1	T → A in BAD96372. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q53HC9-1 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 7B1CCD35B7C38780	FASTA	387	43,603
	10 20 30 40 50 60 MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD ENNIINKNVL 70 80 90 100 110 120 LHQAGEIWHI SASPADRGVL TTCYNRTSDS KVLTCAAVWR MPKELESGSH ESPDDSSSTA 130 140 150 160 170 180 QTLELLCHLD NTAHGNMACV VWEPMGDGKK IISLADNHIL LWDLQESSSQ AVLASSASLE 190 200 210 220 230 240 GKGQLKFTSG RWSPHHNCTQ VATANDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK 250 260 270 280 290 300 QYYLASCGDD CKVKFWDTRN VTEPVKTLEE HSHWVWNVRY NHSHDQLVLT GSSDSRVILS 310 320 330 340 350 360 NMVSISSEPF GHLVDDDDIS DQEDHRSEEK SKEPLQDNVI ATYEEHEDSV YAVDWSSADP 370 380 WLFASLSYDG RLVINRVPRA LKYHILL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes." Hu R.-J., Lee M.P., Connors T.D., Johnson L.A., Burn T.C., Su K., Landes G.M., Feinberg A.P. Genomics 46:9-17(1997) [PubMed: 9403053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF019952 mRNA. Translation: AAC51911.1. AK222652 mRNA. Translation: BAD96372.1. AC019118 Genomic DNA. Translation: AAY24338.1. AC073502 Genomic DNA. Translation: AAY24193.1. BC002485 mRNA. Translation: AAH02485.1.
IPI	IPI00019550.
RefSeq	NP_003301.1.
UniGene	Hs.502770
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q53HC9. 8 interactions.
2-D gel databases
OGP	O43179.
Proteomic databases
PeptideAtlas	Q53HC9.
PRIDE	Q53HC9.
Genome annotation databases
Ensembl	ENSG00000032389. Homo sapiens. [Contig view]
GeneID	7260.
KEGG	hsa:7260.
Organism-specific databases
GeneCards	GC02M003171.
HGNC	HGNC:12383. TSSC1.
MIM	608998. gene.
PharmGKB	PA37051.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q53HC9.
HOVERGEN	Q53HC9.
Gene expression databases
ArrayExpress	Q53HC9.
Bgee	Q53HC9.
CleanEx	HS_TSSC1.
GermOnline	ENSG00000032389. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_region. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 3 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	28385.
SOURCE	Search...

Entry information

Entry name

TSSC1_HUMAN

Accession

Primary (citable) accession number: Q53HC9
Secondary accession number(s): O43179, Q53S19, Q53SG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	June 16, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)