Q53HC9 (TSSC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TSSC1

Alternative name(s):
Tumor-suppressing STF cDNA 1 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein

Gene names

Name:

TSSC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 5 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Protein TSSC1		PRO_0000051298
Regions
	Repeat	132 – 172	41	WD 1
	Repeat	182 – 222	41	WD 2
	Repeat	226 – 266	41	WD 3
	Repeat	270 – 310	41	WD 4
	Repeat	345 – 385	41	WD 5
Amino acid modifications
	Modified residue	320	1	Phosphoserine Ref.6
Experimental info
	Sequence conflict	58	1	N → S in BAD96372. Ref.2
	Sequence conflict	214	1	T → A in BAD96372. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q53HC9 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 7B1CCD35B7C38780	FASTA	387	43,603
	10 20 30 40 50 60 MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD ENNIINKNVL 70 80 90 100 110 120 LHQAGEIWHI SASPADRGVL TTCYNRTSDS KVLTCAAVWR MPKELESGSH ESPDDSSSTA 130 140 150 160 170 180 QTLELLCHLD NTAHGNMACV VWEPMGDGKK IISLADNHIL LWDLQESSSQ AVLASSASLE 190 200 210 220 230 240 GKGQLKFTSG RWSPHHNCTQ VATANDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK 250 260 270 280 290 300 QYYLASCGDD CKVKFWDTRN VTEPVKTLEE HSHWVWNVRY NHSHDQLVLT GSSDSRVILS 310 320 330 340 350 360 NMVSISSEPF GHLVDDDDIS DQEDHRSEEK SKEPLQDNVI ATYEEHEDSV YAVDWSSADP 370 380 WLFASLSYDG RLVINRVPRA LKYHILL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes." Hu R.-J., Lee M.P., Connors T.D., Johnson L.A., Burn T.C., Su K., Landes G.M., Feinberg A.P. Genomics 46:9-17(1997) [PubMed: 9403053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF019952 mRNA. Translation: AAC51911.1. AK222652 mRNA. Translation: BAD96372.1. AC019118 Genomic DNA. Translation: AAY24338.1. AC073502 Genomic DNA. Translation: AAY24193.1. CH471053 Genomic DNA. Translation: EAX01070.1. CH471053 Genomic DNA. Translation: EAX01071.1. BC002485 mRNA. Translation: AAH02485.1.
IPI	IPI00019550.
RefSeq	NP_003301.1. NM_003310.2.
UniGene	Hs.502770.
3D structure databases
ProteinModelPortal	Q53HC9.
SMR	Q53HC9. Positions 176-385.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53HC9.
PTM databases
PhosphoSite	Q53HC9.
Polymorphism databases
DMDM	84029603.
2D gel databases
OGP	O43179.
Proteomic databases
PeptideAtlas	Q53HC9.
PRIDE	Q53HC9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382125; ENSP00000371559; ENSG00000032389.
GeneID	7260.
KEGG	hsa:7260.
UCSC	uc002qxj.1. human.
Organism-specific databases
CTD	7260.
GeneCards	GC02M003171.
H-InvDB	HIX0001791.
HGNC	HGNC:12383. TSSC1.
HPA	HPA031231. HPA031232. HPA031233.
MIM	608998. gene.
neXtProt	NX_Q53HC9.
PharmGKB	PA37051.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18917.
GeneTree	ENSGT00570000079069.
HOVERGEN	HBG052937.
OrthoDB	EOG4C5CJP.
PhylomeDB	Q53HC9.
Gene expression databases
ArrayExpress	Q53HC9.
Bgee	Q53HC9.
CleanEx	HS_TSSC1.
Genevestigator	Q53HC9.
GermOnline	ENSG00000032389. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 3 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	28385.
SOURCE	Search...

Entry information

Entry name

TSSC1_HUMAN

Accession

Primary (citable) accession number: Q53HC9
Secondary accession number(s): D6W4Y1 , O43179, Q53S19, Q53SG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.