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Protein

Protein TSSC1

Gene

EIPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ53HC9.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TSSC1
Alternative name(s):
EARP-interacting proteinBy similarity
Endosome-associated recycling protein-interacting proteinBy similarity
Tumor-suppressing STF cDNA 1 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein
Gene namesi
Name:EIPR1By similarity
Synonyms:TSSC1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12383. TSSC1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi7260.
OpenTargetsiENSG00000032389.
PharmGKBiPA37051.

Polymorphism and mutation databases

BioMutaiTSSC1.
DMDMi84029603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512981 – 387Protein TSSC1Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ53HC9.
MaxQBiQ53HC9.
PaxDbiQ53HC9.
PeptideAtlasiQ53HC9.
PRIDEiQ53HC9.

2D gel databases

OGPiO43179.

PTM databases

iPTMnetiQ53HC9.
PhosphoSitePlusiQ53HC9.

Expressioni

Gene expression databases

BgeeiENSG00000032389.
CleanExiHS_TSSC1.
ExpressionAtlasiQ53HC9. baseline and differential.
GenevisibleiQ53HC9. HS.

Organism-specific databases

HPAiHPA031231.
HPA031232.
HPA031233.

Interactioni

Subunit structurei

Interacts with EARP complex components VPS50 and VPS51, and SNAP29.By similarity

Protein-protein interaction databases

BioGridi113111. 32 interactors.
IntActiQ53HC9. 17 interactors.
STRINGi9606.ENSP00000371559.

Structurei

3D structure databases

ProteinModelPortaliQ53HC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 48WD 1Add BLAST45
Repeati55 – 101WD 2Add BLAST47
Repeati124 – 164WD 3Add BLAST41
Repeati172 – 214WD 4Add BLAST43
Repeati219 – 258WD 5Add BLAST40
Repeati263 – 302WD 6Add BLAST40
Repeati338 – 379WD 7Add BLAST42

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1007. Eukaryota.
ENOG410XRIE. LUCA.
GeneTreeiENSGT00730000111137.
HOGENOMiHOG000264967.
HOVERGENiHBG052937.
InParanoidiQ53HC9.
PhylomeDBiQ53HC9.
TreeFamiTF105847.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53HC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD
60 70 80 90 100
ENNIINKNVL LHQAGEIWHI SASPADRGVL TTCYNRTSDS KVLTCAAVWR
110 120 130 140 150
MPKELESGSH ESPDDSSSTA QTLELLCHLD NTAHGNMACV VWEPMGDGKK
160 170 180 190 200
IISLADNHIL LWDLQESSSQ AVLASSASLE GKGQLKFTSG RWSPHHNCTQ
210 220 230 240 250
VATANDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK QYYLASCGDD
260 270 280 290 300
CKVKFWDTRN VTEPVKTLEE HSHWVWNVRY NHSHDQLVLT GSSDSRVILS
310 320 330 340 350
NMVSISSEPF GHLVDDDDIS DQEDHRSEEK SKEPLQDNVI ATYEEHEDSV
360 370 380
YAVDWSSADP WLFASLSYDG RLVINRVPRA LKYHILL
Length:387
Mass (Da):43,603
Last modified:December 20, 2005 - v2
Checksum:i7B1CCD35B7C38780
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58N → S in BAD96372 (Ref. 2) Curated1
Sequence conflicti214T → A in BAD96372 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019952 mRNA. Translation: AAC51911.1.
AK222652 mRNA. Translation: BAD96372.1.
AC019118 Genomic DNA. Translation: AAY24338.1.
AC073502 Genomic DNA. Translation: AAY24193.1.
CH471053 Genomic DNA. Translation: EAX01070.1.
CH471053 Genomic DNA. Translation: EAX01071.1.
BC002485 mRNA. Translation: AAH02485.1.
CCDSiCCDS1651.1.
RefSeqiNP_003301.1. NM_003310.3.
UniGeneiHs.502770.

Genome annotation databases

EnsembliENST00000382125; ENSP00000371559; ENSG00000032389.
GeneIDi7260.
KEGGihsa:7260.
UCSCiuc002qxj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019952 mRNA. Translation: AAC51911.1.
AK222652 mRNA. Translation: BAD96372.1.
AC019118 Genomic DNA. Translation: AAY24338.1.
AC073502 Genomic DNA. Translation: AAY24193.1.
CH471053 Genomic DNA. Translation: EAX01070.1.
CH471053 Genomic DNA. Translation: EAX01071.1.
BC002485 mRNA. Translation: AAH02485.1.
CCDSiCCDS1651.1.
RefSeqiNP_003301.1. NM_003310.3.
UniGeneiHs.502770.

3D structure databases

ProteinModelPortaliQ53HC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113111. 32 interactors.
IntActiQ53HC9. 17 interactors.
STRINGi9606.ENSP00000371559.

PTM databases

iPTMnetiQ53HC9.
PhosphoSitePlusiQ53HC9.

Polymorphism and mutation databases

BioMutaiTSSC1.
DMDMi84029603.

2D gel databases

OGPiO43179.

Proteomic databases

EPDiQ53HC9.
MaxQBiQ53HC9.
PaxDbiQ53HC9.
PeptideAtlasiQ53HC9.
PRIDEiQ53HC9.

Protocols and materials databases

DNASUi7260.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382125; ENSP00000371559; ENSG00000032389.
GeneIDi7260.
KEGGihsa:7260.
UCSCiuc002qxj.3. human.

Organism-specific databases

CTDi7260.
DisGeNETi7260.
GeneCardsiTSSC1.
HGNCiHGNC:12383. TSSC1.
HPAiHPA031231.
HPA031232.
HPA031233.
MIMi608998. gene.
neXtProtiNX_Q53HC9.
OpenTargetsiENSG00000032389.
PharmGKBiPA37051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1007. Eukaryota.
ENOG410XRIE. LUCA.
GeneTreeiENSGT00730000111137.
HOGENOMiHOG000264967.
HOVERGENiHBG052937.
InParanoidiQ53HC9.
PhylomeDBiQ53HC9.
TreeFamiTF105847.

Enzyme and pathway databases

SignaLinkiQ53HC9.

Miscellaneous databases

GeneWikiiTSSC1.
GenomeRNAii7260.
PROiQ53HC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000032389.
CleanExiHS_TSSC1.
ExpressionAtlasiQ53HC9. baseline and differential.
GenevisibleiQ53HC9. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSSC1_HUMAN
AccessioniPrimary (citable) accession number: Q53HC9
Secondary accession number(s): D6W4Y1
, O43179, Q53S19, Q53SG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.