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Protein

Kelch-like protein 26

Gene

KLHL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 26
Gene namesi
Name:KLHL26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25623. KLHL26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55295.
OpenTargetsiENSG00000167487.
PharmGKBiPA143485524.

Polymorphism and mutation databases

BioMutaiKLHL26.
DMDMi109892505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002426882 – 615Kelch-like protein 26Add BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ53HC5.
MaxQBiQ53HC5.
PaxDbiQ53HC5.
PeptideAtlasiQ53HC5.
PRIDEiQ53HC5.

PTM databases

iPTMnetiQ53HC5.
PhosphoSitePlusiQ53HC5.

Expressioni

Gene expression databases

BgeeiENSG00000167487.
CleanExiHS_KLHL26.
ExpressionAtlasiQ53HC5. baseline and differential.
GenevisibleiQ53HC5. HS.

Organism-specific databases

HPAiHPA023074.

Interactioni

Protein-protein interaction databases

BioGridi120582. 21 interactors.
IntActiQ53HC5. 6 interactors.
MINTiMINT-1379006.
STRINGi9606.ENSP00000300976.

Structurei

3D structure databases

ProteinModelPortaliQ53HC5.
SMRiQ53HC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 130BTBPROSITE-ProRule annotationAdd BLAST68
Domaini165 – 266BACKAdd BLAST102
Repeati310 – 361Kelch 1Add BLAST52
Repeati362 – 413Kelch 2Add BLAST52
Repeati414 – 460Kelch 3Add BLAST47
Repeati461 – 508Kelch 4Add BLAST48
Repeati510 – 559Kelch 5Add BLAST50
Repeati561 – 608Kelch 6Add BLAST48

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ53HC5.
KOiK10463.
OMAiVETCLHI.
OrthoDBiEOG091G03RZ.
PhylomeDBiQ53HC5.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030588. KLHL26.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF56. PTHR24412:SF56. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53HC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESGGSSGG AGGGGAFGAG PGPERPNSTA DKNGALKCTF SAPSHSTSLL
60 70 80 90 100
QGLATLRAQG QLLDVVLTIN REAFPAHKVV LAACSDYFRA MFTGGMREAS
110 120 130 140 150
QDVIELKGVS ARGLRHIIDF AYSAEVTLDL DCVQDVLGAA VFLQMLPVVE
160 170 180 190 200
LCEEFLKAAM SVETCLNIGQ MATTFSLASL RESVDAFTFR HFLQIAEEED
210 220 230 240 250
FLRLPLERLV FFLQSNRLQS CAEIDLFRAA VRWLQHDPAR RPRASHVLCH
260 270 280 290 300
IRFPLMQSSE LVDSVQTLDI MVEDVLCRQY LLEAFNYQVL PFRQHEMQSP
310 320 330 340 350
RTAVRSDVPS LVTFGGTPYT DSDRSVSSKV YQLPEPGARH FRELTEMEVG
360 370 380 390 400
CSHTCVAVLD NFVYVAGGQH LQYRSGEGAV DACYRYDPHL NRWLRLQAMQ
410 420 430 440 450
ESRIQFQLNV LCGMVYATGG RNRAGSLASV ERYCPRRNEW GYACSLKRRT
460 470 480 490 500
WGHAGAASGG RLYISGGYGI SVEDKKALHC YDPVADQWEF KAPMSEPRVL
510 520 530 540 550
HAMVGAGGRI YALGGRMDHV DRCFDVLAVE YYVPETDQWT SVSPMRAGQS
560 570 580 590 600
EAGCCLLERK IYIVGGYNWR LNNVTGIVQV YNTDTDEWER DLHFPESFAG
610
IACAPVLLPR AGTRR
Length:615
Mass (Da):68,139
Last modified:June 27, 2006 - v2
Checksum:i1583474AF5A45E8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti521D → G in BAD96376 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026861542V → M.1 PublicationCorresponds to variant rs17852384dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001940 mRNA. Translation: BAA91990.1.
AK222656 mRNA. Translation: BAD96376.1.
BC026319 mRNA. Translation: AAH26319.1.
CCDSiCCDS12384.1.
RefSeqiNP_060786.1. NM_018316.2.
UniGeneiHs.250632.

Genome annotation databases

EnsembliENST00000300976; ENSP00000300976; ENSG00000167487.
GeneIDi55295.
KEGGihsa:55295.
UCSCiuc002njz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001940 mRNA. Translation: BAA91990.1.
AK222656 mRNA. Translation: BAD96376.1.
BC026319 mRNA. Translation: AAH26319.1.
CCDSiCCDS12384.1.
RefSeqiNP_060786.1. NM_018316.2.
UniGeneiHs.250632.

3D structure databases

ProteinModelPortaliQ53HC5.
SMRiQ53HC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120582. 21 interactors.
IntActiQ53HC5. 6 interactors.
MINTiMINT-1379006.
STRINGi9606.ENSP00000300976.

PTM databases

iPTMnetiQ53HC5.
PhosphoSitePlusiQ53HC5.

Polymorphism and mutation databases

BioMutaiKLHL26.
DMDMi109892505.

Proteomic databases

EPDiQ53HC5.
MaxQBiQ53HC5.
PaxDbiQ53HC5.
PeptideAtlasiQ53HC5.
PRIDEiQ53HC5.

Protocols and materials databases

DNASUi55295.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300976; ENSP00000300976; ENSG00000167487.
GeneIDi55295.
KEGGihsa:55295.
UCSCiuc002njz.2. human.

Organism-specific databases

CTDi55295.
DisGeNETi55295.
GeneCardsiKLHL26.
HGNCiHGNC:25623. KLHL26.
HPAiHPA023074.
neXtProtiNX_Q53HC5.
OpenTargetsiENSG00000167487.
PharmGKBiPA143485524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ53HC5.
KOiK10463.
OMAiVETCLHI.
OrthoDBiEOG091G03RZ.
PhylomeDBiQ53HC5.
TreeFamiTF328485.

Miscellaneous databases

GenomeRNAii55295.
PROiQ53HC5.

Gene expression databases

BgeeiENSG00000167487.
CleanExiHS_KLHL26.
ExpressionAtlasiQ53HC5. baseline and differential.
GenevisibleiQ53HC5. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030588. KLHL26.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF56. PTHR24412:SF56. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH26_HUMAN
AccessioniPrimary (citable) accession number: Q53HC5
Secondary accession number(s): Q8TAP0, Q9NUX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.