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Protein

Kelch-like protein 26

Gene

KLHL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 26
Gene namesi
Name:KLHL26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25623. KLHL26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485524.

Polymorphism and mutation databases

BioMutaiKLHL26.
DMDMi109892505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 615614Kelch-like protein 26PRO_0000242688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ53HC5.
MaxQBiQ53HC5.
PaxDbiQ53HC5.
PRIDEiQ53HC5.

PTM databases

iPTMnetiQ53HC5.
PhosphoSiteiQ53HC5.

Expressioni

Gene expression databases

BgeeiQ53HC5.
CleanExiHS_KLHL26.
ExpressionAtlasiQ53HC5. baseline and differential.
GenevisibleiQ53HC5. HS.

Organism-specific databases

HPAiHPA023074.

Interactioni

Protein-protein interaction databases

BioGridi120582. 21 interactions.
IntActiQ53HC5. 6 interactions.
MINTiMINT-1379006.
STRINGi9606.ENSP00000300976.

Structurei

3D structure databases

ProteinModelPortaliQ53HC5.
SMRiQ53HC5. Positions 40-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13068BTBPROSITE-ProRule annotationAdd
BLAST
Domaini165 – 266102BACKAdd
BLAST
Repeati310 – 36152Kelch 1Add
BLAST
Repeati362 – 41352Kelch 2Add
BLAST
Repeati414 – 46047Kelch 3Add
BLAST
Repeati461 – 50848Kelch 4Add
BLAST
Repeati510 – 55950Kelch 5Add
BLAST
Repeati561 – 60848Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ53HC5.
KOiK10463.
OMAiVETCLHI.
OrthoDBiEOG7Z0JVW.
PhylomeDBiQ53HC5.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030588. KLHL26.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF56. PTHR24412:SF56. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53HC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESGGSSGG AGGGGAFGAG PGPERPNSTA DKNGALKCTF SAPSHSTSLL
60 70 80 90 100
QGLATLRAQG QLLDVVLTIN REAFPAHKVV LAACSDYFRA MFTGGMREAS
110 120 130 140 150
QDVIELKGVS ARGLRHIIDF AYSAEVTLDL DCVQDVLGAA VFLQMLPVVE
160 170 180 190 200
LCEEFLKAAM SVETCLNIGQ MATTFSLASL RESVDAFTFR HFLQIAEEED
210 220 230 240 250
FLRLPLERLV FFLQSNRLQS CAEIDLFRAA VRWLQHDPAR RPRASHVLCH
260 270 280 290 300
IRFPLMQSSE LVDSVQTLDI MVEDVLCRQY LLEAFNYQVL PFRQHEMQSP
310 320 330 340 350
RTAVRSDVPS LVTFGGTPYT DSDRSVSSKV YQLPEPGARH FRELTEMEVG
360 370 380 390 400
CSHTCVAVLD NFVYVAGGQH LQYRSGEGAV DACYRYDPHL NRWLRLQAMQ
410 420 430 440 450
ESRIQFQLNV LCGMVYATGG RNRAGSLASV ERYCPRRNEW GYACSLKRRT
460 470 480 490 500
WGHAGAASGG RLYISGGYGI SVEDKKALHC YDPVADQWEF KAPMSEPRVL
510 520 530 540 550
HAMVGAGGRI YALGGRMDHV DRCFDVLAVE YYVPETDQWT SVSPMRAGQS
560 570 580 590 600
EAGCCLLERK IYIVGGYNWR LNNVTGIVQV YNTDTDEWER DLHFPESFAG
610
IACAPVLLPR AGTRR
Length:615
Mass (Da):68,139
Last modified:June 27, 2006 - v2
Checksum:i1583474AF5A45E8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti521 – 5211D → G in BAD96376 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti542 – 5421V → M.1 Publication
Corresponds to variant rs17852384 [ dbSNP | Ensembl ].
VAR_026861

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001940 mRNA. Translation: BAA91990.1.
AK222656 mRNA. Translation: BAD96376.1.
BC026319 mRNA. Translation: AAH26319.1.
CCDSiCCDS12384.1.
RefSeqiNP_060786.1. NM_018316.1.
UniGeneiHs.250632.

Genome annotation databases

EnsembliENST00000300976; ENSP00000300976; ENSG00000167487.
GeneIDi55295.
KEGGihsa:55295.
UCSCiuc002njz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001940 mRNA. Translation: BAA91990.1.
AK222656 mRNA. Translation: BAD96376.1.
BC026319 mRNA. Translation: AAH26319.1.
CCDSiCCDS12384.1.
RefSeqiNP_060786.1. NM_018316.1.
UniGeneiHs.250632.

3D structure databases

ProteinModelPortaliQ53HC5.
SMRiQ53HC5. Positions 40-588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120582. 21 interactions.
IntActiQ53HC5. 6 interactions.
MINTiMINT-1379006.
STRINGi9606.ENSP00000300976.

PTM databases

iPTMnetiQ53HC5.
PhosphoSiteiQ53HC5.

Polymorphism and mutation databases

BioMutaiKLHL26.
DMDMi109892505.

Proteomic databases

EPDiQ53HC5.
MaxQBiQ53HC5.
PaxDbiQ53HC5.
PRIDEiQ53HC5.

Protocols and materials databases

DNASUi55295.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300976; ENSP00000300976; ENSG00000167487.
GeneIDi55295.
KEGGihsa:55295.
UCSCiuc002njz.2. human.

Organism-specific databases

CTDi55295.
GeneCardsiKLHL26.
HGNCiHGNC:25623. KLHL26.
HPAiHPA023074.
neXtProtiNX_Q53HC5.
PharmGKBiPA143485524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ53HC5.
KOiK10463.
OMAiVETCLHI.
OrthoDBiEOG7Z0JVW.
PhylomeDBiQ53HC5.
TreeFamiTF328485.

Miscellaneous databases

GenomeRNAii55295.
NextBioi59496.
PROiQ53HC5.

Gene expression databases

BgeeiQ53HC5.
CleanExiHS_KLHL26.
ExpressionAtlasiQ53HC5. baseline and differential.
GenevisibleiQ53HC5. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030588. KLHL26.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF56. PTHR24412:SF56. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-542.
    Tissue: Brain.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKLH26_HUMAN
AccessioniPrimary (citable) accession number: Q53HC5
Secondary accession number(s): Q8TAP0, Q9NUX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: March 16, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.