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Protein

Coiled-coil domain-containing protein 92

Gene

CCDC92

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 92
Alternative name(s):
Limkain beta-2
Gene namesi
Name:CCDC92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29563. CCDC92.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596459.

Polymorphism and mutation databases

BioMutaiCCDC92.
DMDMi125863297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Coiled-coil domain-containing protein 92PRO_0000274500Add
BLAST

Proteomic databases

MaxQBiQ53HC0.
PaxDbiQ53HC0.
PRIDEiQ53HC0.

PTM databases

iPTMnetiQ53HC0.
PhosphoSiteiQ53HC0.

Expressioni

Gene expression databases

BgeeiQ53HC0.
CleanExiHS_CCDC92.
ExpressionAtlasiQ53HC0. baseline and differential.
GenevisibleiQ53HC0. HS.

Organism-specific databases

HPAiHPA038560.

Interactioni

Subunit structurei

Interacts with CEP164.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP164Q9UPV05EBI-719994,EBI-3937015
CEP76Q8TAP63EBI-719994,EBI-742887
FHL2Q141925EBI-719994,EBI-701903
taxP140793EBI-719994,EBI-9675698From a different organism.
TP53BP2Q13625-33EBI-719994,EBI-10175039
TRIM27P143733EBI-719994,EBI-719493

Protein-protein interaction databases

BioGridi123180. 31 interactions.
IntActiQ53HC0. 14 interactions.
MINTiMINT-1415043.
STRINGi9606.ENSP00000238156.

Structurei

3D structure databases

ProteinModelPortaliQ53HC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili18 – 4427Sequence analysisAdd
BLAST
Coiled coili76 – 15277Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIA1. Eukaryota.
ENOG410ZQ07. LUCA.
GeneTreeiENSGT00430000031027.
HOGENOMiHOG000294136.
HOVERGENiHBG081052.
InParanoidiQ53HC0.
KOiK16452.
OMAiPHFSSYS.
OrthoDBiEOG74BJSJ.
PhylomeDBiQ53HC0.
TreeFamiTF329066.

Family and domain databases

InterProiIPR033224. CCDC92.
[Graphical view]
PANTHERiPTHR14882:SF4. PTHR14882:SF4. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53HC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPHFSSYD EGPLDVSMAA TNLENQLHSA QKNLLFLQRE HASTLKGLHS
60 70 80 90 100
EIRRLQQHCT DLTYELTVKS SEQTGDGTSK SSELKKRCEE LEAQLKVKEN
110 120 130 140 150
ENAELLKELE QKNAMITVLE NTIKEREKKY LEELKAKSHK LTLLSSELEQ
160 170 180 190 200
RASTIAYLTS QLHAAKKKLM SSSGTSDASP SGSPVLASYK PAPPKDKLPE
210 220 230 240 250
TPRRRMKKSL SAPLHPEFEE VYRFGAESRK LLLREPVDAM PDPTPFLLAR
260 270 280 290 300
ESAEVHLIKE RPLVIPPIAS DRSGEQHSPA REKPHKAHVG VAHRIHHATP
310 320 330
PQAQPEVKTL AVDQVNGGKV VRKHSGTDRT V
Length:331
Mass (Da):36,961
Last modified:February 6, 2007 - v2
Checksum:i840D062480338500
GO
Isoform 2 (identifier: Q53HC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Note: No experimental confirmation available.
Show »
Length:314
Mass (Da):35,110
Checksum:iD611C978B87B27A9
GO

Sequence cautioni

The sequence BAD96381.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701S → C.
Corresponds to variant rs11057401 [ dbSNP | Ensembl ].
VAR_030301
Natural varianti253 – 2531A → T.1 Publication
Corresponds to variant rs35935939 [ dbSNP | Ensembl ].
VAR_050765
Natural varianti281 – 2811R → H.
Corresponds to variant rs17886730 [ dbSNP | Ensembl ].
VAR_030302

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717Missing in isoform 2. 1 PublicationVSP_056906Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015292 mRNA. Translation: BAB82436.1.
AK026124 mRNA. Translation: BAB15366.1.
AK054680 mRNA. Translation: BAG51412.1.
AK125866 mRNA. Translation: BAG54259.1.
AK222661 mRNA. Translation: BAD96381.1. Different initiation.
AC068790 Genomic DNA. No translation available.
AC079315 Genomic DNA. No translation available.
BC017186 mRNA. Translation: AAH17186.1.
CCDSiCCDS76619.1. [Q53HC0-2]
CCDS9256.1. [Q53HC0-1]
RefSeqiNP_001291886.1. NM_001304957.1. [Q53HC0-1]
NP_001291887.1. NM_001304958.1. [Q53HC0-1]
NP_001291888.1. NM_001304959.1. [Q53HC0-1]
NP_001291889.1. NM_001304960.1. [Q53HC0-1]
NP_001291890.1. NM_001304961.1. [Q53HC0-2]
NP_079416.1. NM_025140.2. [Q53HC0-1]
XP_005253681.1. XM_005253624.1. [Q53HC0-1]
UniGeneiHs.114111.
Hs.713131.

Genome annotation databases

EnsembliENST00000238156; ENSP00000238156; ENSG00000119242. [Q53HC0-1]
ENST00000545135; ENSP00000439526; ENSG00000119242. [Q53HC0-2]
ENST00000545891; ENSP00000440024; ENSG00000119242. [Q53HC0-2]
ENST00000614047; ENSP00000479437; ENSG00000275035. [Q53HC0-2]
ENST00000631749; ENSP00000487695; ENSG00000275035. [Q53HC0-2]
ENST00000632401; ENSP00000488830; ENSG00000275035. [Q53HC0-1]
GeneIDi80212.
KEGGihsa:80212.
UCSCiuc001ufv.2. human. [Q53HC0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015292 mRNA. Translation: BAB82436.1.
AK026124 mRNA. Translation: BAB15366.1.
AK054680 mRNA. Translation: BAG51412.1.
AK125866 mRNA. Translation: BAG54259.1.
AK222661 mRNA. Translation: BAD96381.1. Different initiation.
AC068790 Genomic DNA. No translation available.
AC079315 Genomic DNA. No translation available.
BC017186 mRNA. Translation: AAH17186.1.
CCDSiCCDS76619.1. [Q53HC0-2]
CCDS9256.1. [Q53HC0-1]
RefSeqiNP_001291886.1. NM_001304957.1. [Q53HC0-1]
NP_001291887.1. NM_001304958.1. [Q53HC0-1]
NP_001291888.1. NM_001304959.1. [Q53HC0-1]
NP_001291889.1. NM_001304960.1. [Q53HC0-1]
NP_001291890.1. NM_001304961.1. [Q53HC0-2]
NP_079416.1. NM_025140.2. [Q53HC0-1]
XP_005253681.1. XM_005253624.1. [Q53HC0-1]
UniGeneiHs.114111.
Hs.713131.

3D structure databases

ProteinModelPortaliQ53HC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123180. 31 interactions.
IntActiQ53HC0. 14 interactions.
MINTiMINT-1415043.
STRINGi9606.ENSP00000238156.

PTM databases

iPTMnetiQ53HC0.
PhosphoSiteiQ53HC0.

Polymorphism and mutation databases

BioMutaiCCDC92.
DMDMi125863297.

Proteomic databases

MaxQBiQ53HC0.
PaxDbiQ53HC0.
PRIDEiQ53HC0.

Protocols and materials databases

DNASUi80212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238156; ENSP00000238156; ENSG00000119242. [Q53HC0-1]
ENST00000545135; ENSP00000439526; ENSG00000119242. [Q53HC0-2]
ENST00000545891; ENSP00000440024; ENSG00000119242. [Q53HC0-2]
ENST00000614047; ENSP00000479437; ENSG00000275035. [Q53HC0-2]
ENST00000631749; ENSP00000487695; ENSG00000275035. [Q53HC0-2]
ENST00000632401; ENSP00000488830; ENSG00000275035. [Q53HC0-1]
GeneIDi80212.
KEGGihsa:80212.
UCSCiuc001ufv.2. human. [Q53HC0-1]

Organism-specific databases

CTDi80212.
GeneCardsiCCDC92.
HGNCiHGNC:29563. CCDC92.
HPAiHPA038560.
neXtProtiNX_Q53HC0.
PharmGKBiPA144596459.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIA1. Eukaryota.
ENOG410ZQ07. LUCA.
GeneTreeiENSGT00430000031027.
HOGENOMiHOG000294136.
HOVERGENiHBG081052.
InParanoidiQ53HC0.
KOiK16452.
OMAiPHFSSYS.
OrthoDBiEOG74BJSJ.
PhylomeDBiQ53HC0.
TreeFamiTF329066.

Miscellaneous databases

ChiTaRSiCCDC92. human.
GenomeRNAii80212.
PROiQ53HC0.

Gene expression databases

BgeeiQ53HC0.
CleanExiHS_CCDC92.
ExpressionAtlasiQ53HC0. baseline and differential.
GenevisibleiQ53HC0. HS.

Family and domain databases

InterProiIPR033224. CCDC92.
[Graphical view]
PANTHERiPTHR14882:SF4. PTHR14882:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Limkain beta 2 associates with the LIM domain of LIM kinase 2 and localizes in the nucleus."
    Miyamoto K., Sumi T., Nakamura T.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Testis.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-253.
    Tissue: Brain.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  6. "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling."
    Chaki M., Airik R., Ghosh A.K., Giles R.H., Chen R., Slaats G.G., Wang H., Hurd T.W., Zhou W., Cluckey A., Gee H.Y., Ramaswami G., Hong C.J., Hamilton B.A., Cervenka I., Ganji R.S., Bryja V., Arts H.H.
    , van Reeuwijk J., Oud M.M., Letteboer S.J., Roepman R., Husson H., Ibraghimov-Beskrovnaya O., Yasunaga T., Walz G., Eley L., Sayer J.A., Schermer B., Liebau M.C., Benzing T., Le Corre S., Drummond I., Janssen S., Allen S.J., Natarajan S., O'Toole J.F., Attanasio M., Saunier S., Antignac C., Koenekoop R.K., Ren H., Lopez I., Nayir A., Stoetzel C., Dollfus H., Massoudi R., Gleeson J.G., Andreoli S.P., Doherty D.G., Lindstrad A., Golzio C., Katsanis N., Pape L., Abboud E.B., Al-Rajhi A.A., Lewis R.A., Omran H., Lee E.Y., Wang S., Sekiguchi J.M., Saunders R., Johnson C.A., Garner E., Vanselow K., Andersen J.S., Shlomai J., Nurnberg G., Nurnberg P., Levy S., Smogorzewska A., Otto E.A., Hildebrandt F.
    Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CEP164, SUBCELLULAR LOCATION.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCCD92_HUMAN
AccessioniPrimary (citable) accession number: Q53HC0
Secondary accession number(s): B3KNQ0, Q9H697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.