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Protein

Coiled-coil domain-containing protein 92

Gene

CCDC92

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 92
Alternative name(s):
Limkain beta-2
Gene namesi
Name:CCDC92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000119242.8.
HGNCiHGNC:29563. CCDC92.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119242.
PharmGKBiPA144596459.

Polymorphism and mutation databases

BioMutaiCCDC92.
DMDMi125863297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745001 – 331Coiled-coil domain-containing protein 92Add BLAST331

Proteomic databases

MaxQBiQ53HC0.
PaxDbiQ53HC0.
PeptideAtlasiQ53HC0.
PRIDEiQ53HC0.

PTM databases

iPTMnetiQ53HC0.
PhosphoSitePlusiQ53HC0.

Expressioni

Gene expression databases

BgeeiENSG00000119242.
CleanExiHS_CCDC92.
ExpressionAtlasiQ53HC0. baseline and differential.
GenevisibleiQ53HC0. HS.

Organism-specific databases

HPAiHPA038560.
HPA057580.

Interactioni

Subunit structurei

Interacts with CEP164.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123180. 34 interactors.
CORUMiQ53HC0.
IntActiQ53HC0. 19 interactors.
MINTiMINT-1415043.
STRINGi9606.ENSP00000238156.

Structurei

3D structure databases

ProteinModelPortaliQ53HC0.
SMRiQ53HC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili18 – 44Sequence analysisAdd BLAST27
Coiled coili76 – 152Sequence analysisAdd BLAST77

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIA1. Eukaryota.
ENOG410ZQ07. LUCA.
GeneTreeiENSGT00430000031027.
HOGENOMiHOG000294136.
HOVERGENiHBG081052.
InParanoidiQ53HC0.
KOiK16452.
OMAiPHFSSYS.
OrthoDBiEOG091G0W9R.
PhylomeDBiQ53HC0.
TreeFamiTF329066.

Family and domain databases

InterProiView protein in InterPro
IPR033224. CCDC92.
PANTHERiPTHR14882:SF4. PTHR14882:SF4. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53HC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPHFSSYD EGPLDVSMAA TNLENQLHSA QKNLLFLQRE HASTLKGLHS
60 70 80 90 100
EIRRLQQHCT DLTYELTVKS SEQTGDGTSK SSELKKRCEE LEAQLKVKEN
110 120 130 140 150
ENAELLKELE QKNAMITVLE NTIKEREKKY LEELKAKSHK LTLLSSELEQ
160 170 180 190 200
RASTIAYLTS QLHAAKKKLM SSSGTSDASP SGSPVLASYK PAPPKDKLPE
210 220 230 240 250
TPRRRMKKSL SAPLHPEFEE VYRFGAESRK LLLREPVDAM PDPTPFLLAR
260 270 280 290 300
ESAEVHLIKE RPLVIPPIAS DRSGEQHSPA REKPHKAHVG VAHRIHHATP
310 320 330
PQAQPEVKTL AVDQVNGGKV VRKHSGTDRT V
Length:331
Mass (Da):36,961
Last modified:February 6, 2007 - v2
Checksum:i840D062480338500
GO
Isoform 2 (identifier: Q53HC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Note: No experimental confirmation available.
Show »
Length:314
Mass (Da):35,110
Checksum:iD611C978B87B27A9
GO

Sequence cautioni

The sequence BAD96381 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03030170S → C. Corresponds to variant dbSNP:rs11057401Ensembl.1
Natural variantiVAR_050765253A → T1 PublicationCorresponds to variant dbSNP:rs35935939Ensembl.1
Natural variantiVAR_030302281R → H. Corresponds to variant dbSNP:rs17886730Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569061 – 17Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015292 mRNA. Translation: BAB82436.1.
AK026124 mRNA. Translation: BAB15366.1.
AK054680 mRNA. Translation: BAG51412.1.
AK125866 mRNA. Translation: BAG54259.1.
AK222661 mRNA. Translation: BAD96381.1. Different initiation.
AC068790 Genomic DNA. No translation available.
AC079315 Genomic DNA. No translation available.
BC017186 mRNA. Translation: AAH17186.1.
CCDSiCCDS76619.1. [Q53HC0-2]
CCDS9256.1. [Q53HC0-1]
RefSeqiNP_001291886.1. NM_001304957.1. [Q53HC0-1]
NP_001291887.1. NM_001304958.1. [Q53HC0-1]
NP_001291888.1. NM_001304959.1. [Q53HC0-1]
NP_001291889.1. NM_001304960.1. [Q53HC0-1]
NP_001291890.1. NM_001304961.1. [Q53HC0-2]
NP_079416.1. NM_025140.2. [Q53HC0-1]
XP_005253681.1. XM_005253624.2. [Q53HC0-1]
XP_016875473.1. XM_017019984.1. [Q53HC0-1]
UniGeneiHs.114111.
Hs.713131.

Genome annotation databases

EnsembliENST00000238156; ENSP00000238156; ENSG00000119242. [Q53HC0-1]
ENST00000545135; ENSP00000439526; ENSG00000119242. [Q53HC0-2]
ENST00000545891; ENSP00000440024; ENSG00000119242. [Q53HC0-2]
ENST00000614047; ENSP00000479437; ENSG00000275035. [Q53HC0-2]
ENST00000631749; ENSP00000487695; ENSG00000275035. [Q53HC0-2]
ENST00000632401; ENSP00000488830; ENSG00000275035. [Q53HC0-1]
GeneIDi80212.
KEGGihsa:80212.
UCSCiuc001ufv.2. human. [Q53HC0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCD92_HUMAN
AccessioniPrimary (citable) accession number: Q53HC0
Secondary accession number(s): B3KNQ0, Q9H697
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations