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Q53H96 (P5CR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyrroline-5-carboxylate reductase 3

Short name=P5C reductase 3
Short name=P5CR 3
EC=1.5.1.2
Alternative name(s):
Pyrroline-5-carboxylate reductase-like protein
Gene names
Name:PYCRL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Subunit structure

Homodecamer; composed of 5 homodimers By similarity.

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Sequence caution

The sequence BAD96405.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAD96405.1 differs from that shown. Reason: Chimeric cDNA.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Coding sequence diversityPolymorphism
   LigandNADP
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-proline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyrroline-5-carboxylate reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 274273Pyrroline-5-carboxylate reductase 3
PRO_0000324561

Amino acid modifications

Modified residue21N-acetylalanine Ref.6

Natural variations

Natural variant571R → Q.
Corresponds to variant rs11549789 [ dbSNP | Ensembl ].
VAR_039828
Natural variant1051V → M.
Corresponds to variant rs2242089 [ dbSNP | Ensembl ].
VAR_039829
Natural variant1501N → K. Ref.1
Corresponds to variant rs2242090 [ dbSNP | Ensembl ].
VAR_039830

Sequences

Sequence LengthMass (Da)Tools
Q53H96 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: 846FD9B60183B048

FASTA27428,649
        10         20         30         40         50         60 
MAAAEPSPRR VGFVGAGRMA GAIAQGLIRA GKVEAQHILA SAPTDRNLCH FQALGCRTTH 

        70         80         90        100        110        120 
SNQEVLQSCL LVIFATKPHV LPAVLAEVAP VVTTEHILVS VAAGVSLSTL EELLPPNTRV 

       130        140        150        160        170        180 
LRVLPNLPCV VQEGAIVMAR GRHVGSSETN LLQHLLEACG RCEEVPEAYV DIHTGLSGSG 

       190        200        210        220        230        240 
VAFVCAFSEA LAEGAVKMGM PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT 

       250        260        270 
TIYGLHALEQ GGLRAATMSA VEAATCRAKE LSRK 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-150.
Tissue: Thyroid.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-264.
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-274.
Tissue: Amygdala.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001500 mRNA. Translation: BAG50927.1.
AK023914 mRNA. Translation: BAB14721.1.
BC007993 mRNA. Translation: AAH07993.1.
AK222685 mRNA. Translation: BAD96405.1. Sequence problems.
AL833857 mRNA. Translation: CAD38716.1.
RefSeqNP_075566.2. NM_023078.3.
UniGeneHs.165186.

3D structure databases

ProteinModelPortalQ53H96.
SMRQ53H96. Positions 11-271.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122418. 16 interactions.
IntActQ53H96. 4 interactions.
STRING9606.ENSP00000220966.

PTM databases

PhosphoSiteQ53H96.

Polymorphism databases

DMDM172046829.

Proteomic databases

PaxDbQ53H96.
PeptideAtlasQ53H96.
PRIDEQ53H96.

Protocols and materials databases

DNASU65263.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000220966; ENSP00000220966; ENSG00000104524.
GeneID65263.
KEGGhsa:65263.

Organism-specific databases

CTD65263.
GeneCardsGC08M144686.
H-InvDBHIX0007842.
HGNCHGNC:25846. PYCRL.
HPAHPA053776.
neXtProtNX_Q53H96.
PharmGKBPA134889043.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0345.
HOGENOMHOG000230247.
HOVERGENHBG053399.
KOK00286.
OrthoDBEOG7N0C5N.
PhylomeDBQ53H96.

Enzyme and pathway databases

UniPathwayUPA00098; UER00361.

Gene expression databases

ArrayExpressQ53H96.
BgeeQ53H96.
CleanExHS_PYCRL.
GenevestigatorQ53H96.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERPTHR11645. PTHR11645. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
PIRSFPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00112. proC. 1 hit.
PROSITEPS00521. P5CR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi65263.
NextBio67386.
PROQ53H96.

Entry information

Entry nameP5CR3_HUMAN
AccessionPrimary (citable) accession number: Q53H96
Secondary accession number(s): B3KMB5 expand/collapse secondary AC list , Q8N3N9, Q96HX4, Q9H896
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: April 16, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM