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Q53H96

- P5CR3_HUMAN

UniProt

Q53H96 - P5CR3_HUMAN

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Protein
Pyrroline-5-carboxylate reductase 3
Gene
PYCRL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathwayi

GO - Molecular functioni

  1. pyrroline-5-carboxylate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00361.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroline-5-carboxylate reductase 3 (EC:1.5.1.2)
Short name:
P5C reductase 3
Short name:
P5CR 3
Alternative name(s):
Pyrroline-5-carboxylate reductase-like protein
Gene namesi
Name:PYCRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:25846. PYCRL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 274273Pyrroline-5-carboxylate reductase 3
PRO_0000324561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ53H96.
PaxDbiQ53H96.
PeptideAtlasiQ53H96.
PRIDEiQ53H96.

PTM databases

PhosphoSiteiQ53H96.

Expressioni

Gene expression databases

ArrayExpressiQ53H96.
BgeeiQ53H96.
CleanExiHS_PYCRL.
GenevestigatoriQ53H96.

Organism-specific databases

HPAiHPA053776.

Interactioni

Subunit structurei

Homodecamer; composed of 5 homodimers By similarity.

Protein-protein interaction databases

BioGridi122418. 15 interactions.
IntActiQ53H96. 4 interactions.
STRINGi9606.ENSP00000220966.

Structurei

3D structure databases

ProteinModelPortaliQ53H96.
SMRiQ53H96. Positions 11-271.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0345.
HOGENOMiHOG000230247.
HOVERGENiHBG053399.
KOiK00286.
OrthoDBiEOG7N0C5N.
PhylomeDBiQ53H96.

Family and domain databases

Gene3Di1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01925. P5C_reductase.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view]
PIRSFiPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00112. proC. 1 hit.
PROSITEiPS00521. P5CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53H96-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAEPSPRR VGFVGAGRMA GAIAQGLIRA GKVEAQHILA SAPTDRNLCH    50
FQALGCRTTH SNQEVLQSCL LVIFATKPHV LPAVLAEVAP VVTTEHILVS 100
VAAGVSLSTL EELLPPNTRV LRVLPNLPCV VQEGAIVMAR GRHVGSSETN 150
LLQHLLEACG RCEEVPEAYV DIHTGLSGSG VAFVCAFSEA LAEGAVKMGM 200
PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT TIYGLHALEQ 250
GGLRAATMSA VEAATCRAKE LSRK 274
Length:274
Mass (Da):28,649
Last modified:March 18, 2008 - v2
Checksum:i846FD9B60183B048
GO

Sequence cautioni

The sequence BAD96405.1 differs from that shown. Reason: Chimeric cDNA.
The sequence BAD96405.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571R → Q.
Corresponds to variant rs11549789 [ dbSNP | Ensembl ].
VAR_039828
Natural varianti105 – 1051V → M.
Corresponds to variant rs2242089 [ dbSNP | Ensembl ].
VAR_039829
Natural varianti150 – 1501N → K.1 Publication
Corresponds to variant rs2242090 [ dbSNP | Ensembl ].
VAR_039830

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001500 mRNA. Translation: BAG50927.1.
AK023914 mRNA. Translation: BAB14721.1.
BC007993 mRNA. Translation: AAH07993.1.
AK222685 mRNA. Translation: BAD96405.1. Sequence problems.
AL833857 mRNA. Translation: CAD38716.1.
RefSeqiNP_075566.2. NM_023078.3.
UniGeneiHs.165186.

Genome annotation databases

EnsembliENST00000220966; ENSP00000220966; ENSG00000104524.
GeneIDi65263.
KEGGihsa:65263.

Polymorphism databases

DMDMi172046829.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001500 mRNA. Translation: BAG50927.1 .
AK023914 mRNA. Translation: BAB14721.1 .
BC007993 mRNA. Translation: AAH07993.1 .
AK222685 mRNA. Translation: BAD96405.1 . Sequence problems.
AL833857 mRNA. Translation: CAD38716.1 .
RefSeqi NP_075566.2. NM_023078.3.
UniGenei Hs.165186.

3D structure databases

ProteinModelPortali Q53H96.
SMRi Q53H96. Positions 11-271.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122418. 15 interactions.
IntActi Q53H96. 4 interactions.
STRINGi 9606.ENSP00000220966.

PTM databases

PhosphoSitei Q53H96.

Polymorphism databases

DMDMi 172046829.

Proteomic databases

MaxQBi Q53H96.
PaxDbi Q53H96.
PeptideAtlasi Q53H96.
PRIDEi Q53H96.

Protocols and materials databases

DNASUi 65263.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000220966 ; ENSP00000220966 ; ENSG00000104524 .
GeneIDi 65263.
KEGGi hsa:65263.

Organism-specific databases

CTDi 65263.
GeneCardsi GC08M144686.
H-InvDB HIX0007842.
HGNCi HGNC:25846. PYCRL.
HPAi HPA053776.
neXtProti NX_Q53H96.
PharmGKBi PA134889043.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0345.
HOGENOMi HOG000230247.
HOVERGENi HBG053399.
KOi K00286.
OrthoDBi EOG7N0C5N.
PhylomeDBi Q53H96.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00361 .

Miscellaneous databases

GenomeRNAii 65263.
NextBioi 67386.
PROi Q53H96.

Gene expression databases

ArrayExpressi Q53H96.
Bgeei Q53H96.
CleanExi HS_PYCRL.
Genevestigatori Q53H96.

Family and domain databases

Gene3Di 1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_01925. P5C_reductase.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view ]
PANTHERi PTHR11645. PTHR11645. 1 hit.
Pfami PF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view ]
PIRSFi PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00112. proC. 1 hit.
PROSITEi PS00521. P5CR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-150.
    Tissue: Thyroid.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-264.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-274.
    Tissue: Amygdala.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiP5CR3_HUMAN
AccessioniPrimary (citable) accession number: Q53H96
Secondary accession number(s): B3KMB5
, Q8N3N9, Q96HX4, Q9H896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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