Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q53H96

- P5CR3_HUMAN

UniProt

Q53H96 - P5CR3_HUMAN

Protein

Pyrroline-5-carboxylate reductase 3

Gene

PYCRL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

    Pathwayi

    GO - Molecular functioni

    1. pyrroline-5-carboxylate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00098; UER00361.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrroline-5-carboxylate reductase 3 (EC:1.5.1.2)
    Short name:
    P5C reductase 3
    Short name:
    P5CR 3
    Alternative name(s):
    Pyrroline-5-carboxylate reductase-like protein
    Gene namesi
    Name:PYCRL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:25846. PYCRL.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134889043.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 274273Pyrroline-5-carboxylate reductase 3PRO_0000324561Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ53H96.
    PaxDbiQ53H96.
    PeptideAtlasiQ53H96.
    PRIDEiQ53H96.

    PTM databases

    PhosphoSiteiQ53H96.

    Expressioni

    Gene expression databases

    ArrayExpressiQ53H96.
    BgeeiQ53H96.
    CleanExiHS_PYCRL.
    GenevestigatoriQ53H96.

    Organism-specific databases

    HPAiHPA053776.

    Interactioni

    Subunit structurei

    Homodecamer; composed of 5 homodimers.By similarity

    Protein-protein interaction databases

    BioGridi122418. 15 interactions.
    IntActiQ53H96. 4 interactions.
    STRINGi9606.ENSP00000220966.

    Structurei

    3D structure databases

    ProteinModelPortaliQ53H96.
    SMRiQ53H96. Positions 11-271.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0345.
    HOGENOMiHOG000230247.
    HOVERGENiHBG053399.
    KOiK00286.
    OrthoDBiEOG7N0C5N.
    PhylomeDBiQ53H96.

    Family and domain databases

    Gene3Di1.10.3730.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_01925. P5C_reductase.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR029036. P5CR_dimer.
    IPR028939. ProC_N.
    IPR000304. Pyrroline-COOH_reductase.
    [Graphical view]
    PANTHERiPTHR11645. PTHR11645. 1 hit.
    PfamiPF03807. F420_oxidored. 1 hit.
    PF14748. P5CR_dimer. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00112. proC. 1 hit.
    PROSITEiPS00521. P5CR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q53H96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAEPSPRR VGFVGAGRMA GAIAQGLIRA GKVEAQHILA SAPTDRNLCH    50
    FQALGCRTTH SNQEVLQSCL LVIFATKPHV LPAVLAEVAP VVTTEHILVS 100
    VAAGVSLSTL EELLPPNTRV LRVLPNLPCV VQEGAIVMAR GRHVGSSETN 150
    LLQHLLEACG RCEEVPEAYV DIHTGLSGSG VAFVCAFSEA LAEGAVKMGM 200
    PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT TIYGLHALEQ 250
    GGLRAATMSA VEAATCRAKE LSRK 274
    Length:274
    Mass (Da):28,649
    Last modified:March 18, 2008 - v2
    Checksum:i846FD9B60183B048
    GO

    Sequence cautioni

    The sequence BAD96405.1 differs from that shown. Reason: Chimeric cDNA.
    The sequence BAD96405.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571R → Q.
    Corresponds to variant rs11549789 [ dbSNP | Ensembl ].
    VAR_039828
    Natural varianti105 – 1051V → M.
    Corresponds to variant rs2242089 [ dbSNP | Ensembl ].
    VAR_039829
    Natural varianti150 – 1501N → K.1 Publication
    Corresponds to variant rs2242090 [ dbSNP | Ensembl ].
    VAR_039830

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001500 mRNA. Translation: BAG50927.1.
    AK023914 mRNA. Translation: BAB14721.1.
    BC007993 mRNA. Translation: AAH07993.1.
    AK222685 mRNA. Translation: BAD96405.1. Sequence problems.
    AL833857 mRNA. Translation: CAD38716.1.
    RefSeqiNP_075566.2. NM_023078.3.
    UniGeneiHs.165186.

    Genome annotation databases

    EnsembliENST00000220966; ENSP00000220966; ENSG00000104524.
    GeneIDi65263.
    KEGGihsa:65263.

    Polymorphism databases

    DMDMi172046829.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001500 mRNA. Translation: BAG50927.1 .
    AK023914 mRNA. Translation: BAB14721.1 .
    BC007993 mRNA. Translation: AAH07993.1 .
    AK222685 mRNA. Translation: BAD96405.1 . Sequence problems.
    AL833857 mRNA. Translation: CAD38716.1 .
    RefSeqi NP_075566.2. NM_023078.3.
    UniGenei Hs.165186.

    3D structure databases

    ProteinModelPortali Q53H96.
    SMRi Q53H96. Positions 11-271.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122418. 15 interactions.
    IntActi Q53H96. 4 interactions.
    STRINGi 9606.ENSP00000220966.

    PTM databases

    PhosphoSitei Q53H96.

    Polymorphism databases

    DMDMi 172046829.

    Proteomic databases

    MaxQBi Q53H96.
    PaxDbi Q53H96.
    PeptideAtlasi Q53H96.
    PRIDEi Q53H96.

    Protocols and materials databases

    DNASUi 65263.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000220966 ; ENSP00000220966 ; ENSG00000104524 .
    GeneIDi 65263.
    KEGGi hsa:65263.

    Organism-specific databases

    CTDi 65263.
    GeneCardsi GC08M144686.
    H-InvDB HIX0007842.
    HGNCi HGNC:25846. PYCRL.
    HPAi HPA053776.
    neXtProti NX_Q53H96.
    PharmGKBi PA134889043.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0345.
    HOGENOMi HOG000230247.
    HOVERGENi HBG053399.
    KOi K00286.
    OrthoDBi EOG7N0C5N.
    PhylomeDBi Q53H96.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00361 .

    Miscellaneous databases

    GenomeRNAii 65263.
    NextBioi 67386.
    PROi Q53H96.

    Gene expression databases

    ArrayExpressi Q53H96.
    Bgeei Q53H96.
    CleanExi HS_PYCRL.
    Genevestigatori Q53H96.

    Family and domain databases

    Gene3Di 1.10.3730.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_01925. P5C_reductase.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR029036. P5CR_dimer.
    IPR028939. ProC_N.
    IPR000304. Pyrroline-COOH_reductase.
    [Graphical view ]
    PANTHERi PTHR11645. PTHR11645. 1 hit.
    Pfami PF03807. F420_oxidored. 1 hit.
    PF14748. P5CR_dimer. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00112. proC. 1 hit.
    PROSITEi PS00521. P5CR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-150.
      Tissue: Thyroid.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-264.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-274.
      Tissue: Amygdala.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiP5CR3_HUMAN
    AccessioniPrimary (citable) accession number: Q53H96
    Secondary accession number(s): B3KMB5
    , Q8N3N9, Q96HX4, Q9H896
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3