Q53H82 (LACB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-lactamase-like protein 2
EC=3.-.-.-

Gene names

Name:	LACTB2
ORF Names:	CGI-83

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Beta-lactamase-like protein 2		PRO_0000315743
Sites
	Metal binding	77	1	Zinc 1 By similarity
	Metal binding	79	1	Zinc 1 By similarity
	Metal binding	81	1	Zinc 2 By similarity
	Metal binding	82	1	Zinc 2 By similarity
	Metal binding	145	1	Zinc 1 By similarity
	Metal binding	164	1	Zinc 1 By similarity
	Metal binding	164	1	Zinc 2 By similarity
	Metal binding	199	1	Zinc 2 By similarity
Amino acid modifications
	Modified residue	102	1	N6-acetyllysine By similarity
	Modified residue	247	1	N6-acetyllysine Ref.5
Experimental info
	Sequence conflict	268	1	L → P in BAD96419. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q53H82 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: F569C7DFB070D52C	FASTA	288	32,806
	10 20 30 40 50 60 MAAVLQRVER LSNRVVRVLG CNPGPMTLQG TNTYLVGTGP RRILIDTGEP AIPEYISCLK 70 80 90 100 110 120 QALTEFNTAI QEIVVTHWHR DHSGGIGDIC KSINNDTTYC IKKLPRNPQR EEIIGNGEQQ 130 140 150 160 170 180 YVYLKDGDVI KTEGATLRVL YTPGHTDDHM ALLLEEENAI FSGDCILGEG TTVFEDLYDY 190 200 210 220 230 240 MNSLKELLKI KADIIYPGHG PVIHNAEAKI QQYISHRNIR EQQILTLFRE NFEKSFTVME 250 260 270 280 LVKIIYKNTP ENLHEMAKHN LLLHLKKLEK EGKIFSNTDP DKKWKAHL

References

[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-247, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151841 mRNA. Translation: AAD34078.1. AK222699 mRNA. Translation: BAD96419.1. CH471068 Genomic DNA. Translation: EAW86969.1. BC000878 mRNA. Translation: AAH00878.1.
IPI	IPI00006952.
PIR	T44603.
RefSeq	NP_057111.1. NM_016027.2.
UniGene	Hs.118554.
3D structure databases
ProteinModelPortal	Q53H82.
SMR	Q53H82. Positions 11-285.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q53H82. 1 interaction.
STRING	Q53H82.
Polymorphism databases
DMDM	166223244.
2D gel databases
REPRODUCTION-2DPAGE	IPI00006952.
Proteomic databases
PeptideAtlas	Q53H82.
PRIDE	Q53H82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276590; ENSP00000276590; ENSG00000147592.
GeneID	51110.
KEGG	hsa:51110.
UCSC	uc003xyp.1. human.
Organism-specific databases
CTD	51110.
GeneCards	GC08M071549.
H-InvDB	HIX0007578. HIX0020880.
HGNC	HGNC:18512. LACTB2.
HPA	HPA044391.
neXtProt	NX_Q53H82.
PharmGKB	PA134952605.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13917.
GeneTree	ENSGT00390000001710.
HOGENOM	HBG324401.
HOVERGEN	HBG099837.
InParanoid	Q53H82.
OMA	HKEEIIG.
OrthoDB	EOG476K0W.
PhylomeDB	Q53H82.
Gene expression databases
ArrayExpress	Q53H82.
Bgee	Q53H82.
CleanEx	HS_LACTB2.
Genevestigator	Q53H82.
Family and domain databases
InterPro	IPR001279. Beta-lactamas-like. [Graphical view]
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	53861.

Entry information

Entry name

LACB2_HUMAN

Accession

Primary (citable) accession number: Q53H82
Secondary accession number(s): Q9Y392

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.