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Protein

Beta-lactamase-like protein 2

Gene

LACTB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Zinc 1By similarity
Metal bindingi79 – 791Zinc 1By similarity
Metal bindingi81 – 811Zinc 2By similarity
Metal bindingi82 – 821Zinc 2By similarity
Metal bindingi145 – 1451Zinc 1By similarity
Metal bindingi164 – 1641Zinc 1By similarity
Metal bindingi164 – 1641Zinc 2By similarity
Metal bindingi199 – 1991Zinc 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase-like protein 2 (EC:3.-.-.-)
Gene namesi
Name:LACTB2
ORF Names:CGI-83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18512. LACTB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952605.

Polymorphism and mutation databases

BioMutaiLACTB2.
DMDMi166223244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Beta-lactamase-like protein 2PRO_0000315743Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021N6-acetyllysineBy similarity
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei273 – 2731N6-succinyllysineBy similarity
Modified residuei282 – 2821N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ53H82.
MaxQBiQ53H82.
PaxDbiQ53H82.
PeptideAtlasiQ53H82.
PRIDEiQ53H82.

2D gel databases

REPRODUCTION-2DPAGEIPI00006952.

PTM databases

iPTMnetiQ53H82.

Expressioni

Gene expression databases

BgeeiQ53H82.
CleanExiHS_LACTB2.
ExpressionAtlasiQ53H82. baseline and differential.
GenevisibleiQ53H82. HS.

Organism-specific databases

HPAiHPA044391.
HPA053040.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-3943430,EBI-747107

Protein-protein interaction databases

BioGridi119299. 20 interactions.
IntActiQ53H82. 2 interactions.
STRINGi9606.ENSP00000276590.

Structurei

Secondary structure

1
288
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 104Combined sources
Beta strandi12 – 198Combined sources
Turni25 – 273Combined sources
Beta strandi32 – 365Combined sources
Beta strandi38 – 458Combined sources
Helixi53 – 6513Combined sources
Beta strandi70 – 745Combined sources
Helixi80 – 834Combined sources
Helixi86 – 927Combined sources
Beta strandi101 – 1033Combined sources
Turni115 – 1184Combined sources
Beta strandi121 – 1233Combined sources
Beta strandi129 – 1324Combined sources
Beta strandi135 – 1417Combined sources
Beta strandi144 – 1463Combined sources
Beta strandi150 – 1545Combined sources
Turni155 – 1584Combined sources
Beta strandi159 – 1635Combined sources
Beta strandi168 – 1703Combined sources
Helixi177 – 19014Combined sources
Beta strandi193 – 2019Combined sources
Helixi206 – 23025Combined sources
Turni231 – 2333Combined sources
Helixi238 – 2458Combined sources
Turni246 – 2483Combined sources
Helixi251 – 2533Combined sources
Helixi254 – 27017Combined sources
Beta strandi273 – 2764Combined sources
Beta strandi284 – 2863Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AD9X-ray2.60A/B/C/D/E/F1-288[»]
ProteinModelPortaliQ53H82.
SMRiQ53H82. Positions 1-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0813. Eukaryota.
COG0491. LUCA.
GeneTreeiENSGT00390000001710.
HOGENOMiHOG000246879.
HOVERGENiHBG099837.
InParanoidiQ53H82.
OMAiHPLAHNQ.
OrthoDBiEOG7XM2ZK.
PhylomeDBiQ53H82.
TreeFamiTF314297.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53H82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVLQRVER LSNRVVRVLG CNPGPMTLQG TNTYLVGTGP RRILIDTGEP
60 70 80 90 100
AIPEYISCLK QALTEFNTAI QEIVVTHWHR DHSGGIGDIC KSINNDTTYC
110 120 130 140 150
IKKLPRNPQR EEIIGNGEQQ YVYLKDGDVI KTEGATLRVL YTPGHTDDHM
160 170 180 190 200
ALLLEEENAI FSGDCILGEG TTVFEDLYDY MNSLKELLKI KADIIYPGHG
210 220 230 240 250
PVIHNAEAKI QQYISHRNIR EQQILTLFRE NFEKSFTVME LVKIIYKNTP
260 270 280
ENLHEMAKHN LLLHLKKLEK EGKIFSNTDP DKKWKAHL
Length:288
Mass (Da):32,806
Last modified:January 15, 2008 - v2
Checksum:iF569C7DFB070D52C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391G → S in BAF82890 (PubMed:14702039).Curated
Sequence conflicti268 – 2681L → P in BAD96419 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151841 mRNA. Translation: AAD34078.1.
AK290201 mRNA. Translation: BAF82890.1.
AK222699 mRNA. Translation: BAD96419.1.
CH471068 Genomic DNA. Translation: EAW86969.1.
BC000878 mRNA. Translation: AAH00878.1.
CCDSiCCDS6208.1.
PIRiT44603.
RefSeqiNP_057111.1. NM_016027.2.
UniGeneiHs.118554.

Genome annotation databases

EnsembliENST00000276590; ENSP00000276590; ENSG00000147592.
ENST00000522447; ENSP00000428801; ENSG00000147592.
GeneIDi51110.
KEGGihsa:51110.
UCSCiuc003xyp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151841 mRNA. Translation: AAD34078.1.
AK290201 mRNA. Translation: BAF82890.1.
AK222699 mRNA. Translation: BAD96419.1.
CH471068 Genomic DNA. Translation: EAW86969.1.
BC000878 mRNA. Translation: AAH00878.1.
CCDSiCCDS6208.1.
PIRiT44603.
RefSeqiNP_057111.1. NM_016027.2.
UniGeneiHs.118554.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AD9X-ray2.60A/B/C/D/E/F1-288[»]
ProteinModelPortaliQ53H82.
SMRiQ53H82. Positions 1-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119299. 20 interactions.
IntActiQ53H82. 2 interactions.
STRINGi9606.ENSP00000276590.

PTM databases

iPTMnetiQ53H82.

Polymorphism and mutation databases

BioMutaiLACTB2.
DMDMi166223244.

2D gel databases

REPRODUCTION-2DPAGEIPI00006952.

Proteomic databases

EPDiQ53H82.
MaxQBiQ53H82.
PaxDbiQ53H82.
PeptideAtlasiQ53H82.
PRIDEiQ53H82.

Protocols and materials databases

DNASUi51110.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276590; ENSP00000276590; ENSG00000147592.
ENST00000522447; ENSP00000428801; ENSG00000147592.
GeneIDi51110.
KEGGihsa:51110.
UCSCiuc003xyp.4. human.

Organism-specific databases

CTDi51110.
GeneCardsiLACTB2.
HGNCiHGNC:18512. LACTB2.
HPAiHPA044391.
HPA053040.
neXtProtiNX_Q53H82.
PharmGKBiPA134952605.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0813. Eukaryota.
COG0491. LUCA.
GeneTreeiENSGT00390000001710.
HOGENOMiHOG000246879.
HOVERGENiHBG099837.
InParanoidiQ53H82.
OMAiHPLAHNQ.
OrthoDBiEOG7XM2ZK.
PhylomeDBiQ53H82.
TreeFamiTF314297.

Miscellaneous databases

GenomeRNAii51110.
PROiQ53H82.

Gene expression databases

BgeeiQ53H82.
CleanExiHS_LACTB2.
ExpressionAtlasiQ53H82. baseline and differential.
GenevisibleiQ53H82. HS.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLACB2_HUMAN
AccessioniPrimary (citable) accession number: Q53H82
Secondary accession number(s): A8K2D6, Q9Y392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.