Q53H80 (AKIR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Akirin-2

Gene names

Name:	AKIRIN2
Synonyms:	C6orf166

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 By similarity.
Subunit structure	Interacts with YWHAB By similarity.
Subcellular location	Nucleus Ref.6.
Tissue specificity	Widely expressed with the highest expression in peripheral blood leukocytes. Ref.6
Miscellaneous	'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.
Sequence similarities	Belongs to the akirin family.

Ontologies

Keywords
Biological process	Immunity Innate immunity Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Developmental protein Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	innate immune response Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	transcriptional repressor complex Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Akirin-2		PRO_0000089555
Regions
	Motif	22 – 27	6	Nuclear localization signal
	Compositional bias	28 – 56	29	Ala-rich
Amino acid modifications
	Modified residue	18	1	Phosphoserine Ref.5 Ref.8
	Modified residue	21	1	Phosphoserine Ref.4 Ref.5 Ref.8 Ref.9
Experimental info
	Sequence conflict	171	1	L → S in BAD96421. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q53H80 [UniParc]. Last modified July 19, 2005. Version 2. Checksum: 33AA93AF94DE80A1	FASTA	203	22,496
	10 20 30 40 50 60 MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPTSAAASP LSAAAATAAS FSAAAASPQK 70 80 90 100 110 120 YLRMEPSPFG DVSSRLTTEQ ILYNIKQEYK RMQKRRHLET SFQQTDPCCT SDAQPHAFLL 130 140 150 160 170 180 SGPASPGTSS AASSPLKKEQ PLFTLRQVGM ICERLLKERE EKVREEYEEI LNTKLAEQYD 190 200 AFVKFTHDQI MRRYGEQPAS YVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung carcinoma.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-21, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in Drosophila and mice." Goto A., Matsushita K., Gesellchen V., El Chamy L., Kuttenkeuler D., Takeuchi O., Hoffmann J.A., Akira S., Boutros M., Reichhart J.-M. Nat. Immunol. 9:97-104(2008) [PubMed: 18066067] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	Erratum Goto A., Matsushita K., Gesellchen V., El Chamy L., Kuttenkeuler D., Takeuchi O., Hoffmann J.A., Akira S., Boutros M., Reichhart J.-M. Nat. Immunol. 9:216-216(2008)
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-21, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK222701 mRNA. Translation: BAD96421.1. AL133211 Genomic DNA. Translation: CAI21541.1. BC000764 mRNA. Translation: AAH00764.1. BC003042 mRNA. Translation: AAH03042.1. BC005051 mRNA. Translation: AAH05051.1.
IPI	IPI00604547.
RefSeq	NP_060534.1. NM_018064.3.
UniGene	Hs.485915.
3D structure databases
ProteinModelPortal	Q53H80.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q53H80. 3 interactions.
STRING	Q53H80.
PTM databases
PhosphoSite	Q53H80.
Polymorphism databases
DMDM	71152385.
Proteomic databases
PRIDE	Q53H80.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257787; ENSP00000257787; ENSG00000135334.
GeneID	55122.
KEGG	hsa:55122.
UCSC	uc003pmk.1. human.
Organism-specific databases
CTD	55122.
GeneCards	GC06M088384.
HGNC	HGNC:21407. AKIRIN2.
neXtProt	NX_Q53H80.
PharmGKB	PA162376195.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG403044.
HOVERGEN	HBG055078.
InParanoid	Q53H80.
OMA	CCASDAQ.
OrthoDB	EOG447FVM.
PhylomeDB	Q53H80.
Gene expression databases
ArrayExpress	Q53H80.
Bgee	Q53H80.
CleanEx	HS_AKIRIN2.
Genevestigator	Q53H80.
GermOnline	ENSG00000135334. Homo sapiens.
Family and domain databases
InterPro	IPR024132. Akirin. [Graphical view]
PANTHER	PTHR13293. PTHR13293. 1 hit.
ProtoNet	Search...
Other
NextBio	58772.

Entry information

Entry name

AKIR2_HUMAN

Accession

Primary (citable) accession number: Q53H80
Secondary accession number(s): Q9BQB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.