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Protein

Akirin-2

Gene

AKIRIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Immunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Akirin-2
Gene namesi
Name:AKIRIN2
Synonyms:C6orf166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21407. AKIRIN2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55122.
OpenTargetsiENSG00000135334.
PharmGKBiPA162376195.

Polymorphism and mutation databases

BioMutaiAKIRIN2.
DMDMi71152385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895551 – 203Akirin-2Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53H80.
MaxQBiQ53H80.
PaxDbiQ53H80.
PeptideAtlasiQ53H80.
PRIDEiQ53H80.

PTM databases

iPTMnetiQ53H80.
PhosphoSitePlusiQ53H80.

Expressioni

Tissue specificityi

Widely expressed with the highest expression in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000135334.
CleanExiHS_AKIRIN2.
GenevisibleiQ53H80. HS.

Interactioni

Subunit structurei

Interacts with YWHAB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SPG21Q9NZD83EBI-742928,EBI-742688

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120430. 20 interactors.
IntActiQ53H80. 7 interactors.
STRINGi9606.ENSP00000257787.

Structurei

3D structure databases

ProteinModelPortaliQ53H80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 27Nuclear localization signal6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 56Ala-richAdd BLAST29

Sequence similaritiesi

Belongs to the akirin family.Curated

Phylogenomic databases

eggNOGiKOG4330. Eukaryota.
ENOG4111J00. LUCA.
GeneTreeiENSGT00390000007905.
HOGENOMiHOG000231406.
HOVERGENiHBG055078.
InParanoidiQ53H80.
OMAiRAQMGTI.
OrthoDBiEOG091G0PVD.
PhylomeDBiQ53H80.
TreeFamiTF317123.

Family and domain databases

InterProiIPR024132. Akirin.
[Graphical view]
PANTHERiPTHR13293. PTHR13293. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53H80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPTSAAASP LSAAAATAAS
60 70 80 90 100
FSAAAASPQK YLRMEPSPFG DVSSRLTTEQ ILYNIKQEYK RMQKRRHLET
110 120 130 140 150
SFQQTDPCCT SDAQPHAFLL SGPASPGTSS AASSPLKKEQ PLFTLRQVGM
160 170 180 190 200
ICERLLKERE EKVREEYEEI LNTKLAEQYD AFVKFTHDQI MRRYGEQPAS

YVS
Length:203
Mass (Da):22,496
Last modified:July 19, 2005 - v2
Checksum:i33AA93AF94DE80A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171L → S in BAD96421 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222701 mRNA. Translation: BAD96421.1.
AL133211 Genomic DNA. Translation: CAI21541.1.
BC000764 mRNA. Translation: AAH00764.1.
BC003042 mRNA. Translation: AAH03042.1.
BC005051 mRNA. Translation: AAH05051.1.
CCDSiCCDS5013.1.
RefSeqiNP_060534.1. NM_018064.3.
UniGeneiHs.485915.

Genome annotation databases

EnsembliENST00000257787; ENSP00000257787; ENSG00000135334.
GeneIDi55122.
KEGGihsa:55122.
UCSCiuc003pmk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222701 mRNA. Translation: BAD96421.1.
AL133211 Genomic DNA. Translation: CAI21541.1.
BC000764 mRNA. Translation: AAH00764.1.
BC003042 mRNA. Translation: AAH03042.1.
BC005051 mRNA. Translation: AAH05051.1.
CCDSiCCDS5013.1.
RefSeqiNP_060534.1. NM_018064.3.
UniGeneiHs.485915.

3D structure databases

ProteinModelPortaliQ53H80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120430. 20 interactors.
IntActiQ53H80. 7 interactors.
STRINGi9606.ENSP00000257787.

PTM databases

iPTMnetiQ53H80.
PhosphoSitePlusiQ53H80.

Polymorphism and mutation databases

BioMutaiAKIRIN2.
DMDMi71152385.

Proteomic databases

EPDiQ53H80.
MaxQBiQ53H80.
PaxDbiQ53H80.
PeptideAtlasiQ53H80.
PRIDEiQ53H80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257787; ENSP00000257787; ENSG00000135334.
GeneIDi55122.
KEGGihsa:55122.
UCSCiuc003pmk.4. human.

Organism-specific databases

CTDi55122.
DisGeNETi55122.
GeneCardsiAKIRIN2.
H-InvDBHIX0006057.
HGNCiHGNC:21407. AKIRIN2.
MIMi615165. gene.
neXtProtiNX_Q53H80.
OpenTargetsiENSG00000135334.
PharmGKBiPA162376195.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4330. Eukaryota.
ENOG4111J00. LUCA.
GeneTreeiENSGT00390000007905.
HOGENOMiHOG000231406.
HOVERGENiHBG055078.
InParanoidiQ53H80.
OMAiRAQMGTI.
OrthoDBiEOG091G0PVD.
PhylomeDBiQ53H80.
TreeFamiTF317123.

Miscellaneous databases

ChiTaRSiAKIRIN2. human.
GeneWikiiC6orf166.
GenomeRNAii55122.
PROiQ53H80.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135334.
CleanExiHS_AKIRIN2.
GenevisibleiQ53H80. HS.

Family and domain databases

InterProiIPR024132. Akirin.
[Graphical view]
PANTHERiPTHR13293. PTHR13293. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAKIR2_HUMAN
AccessioniPrimary (citable) accession number: Q53H80
Secondary accession number(s): Q9BQB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.