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Protein

Phospholipase A1 member A

Gene

PLA1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166NucleophileBy similarity1
Active sitei190Charge relay systemPROSITE-ProRule annotation1
Active sitei260Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • phosphatidylcholine 1-acylhydrolase activity Source: ProtInc
  • phosphatidylserine 1-acylhydrolase activity Source: Reactome

GO - Biological processi

  • lipid catabolic process Source: UniProtKB-KW
  • lipid metabolic process Source: ProtInc
  • phosphatidylserine acyl-chain remodeling Source: Reactome
  • phosphatidylserine metabolic process Source: ProtInc

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1482801 Acyl chain remodelling of PS

Protein family/group databases

ESTHERihuman-PLA1A Phospholipase

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 member A (EC:3.1.1.-)
Alternative name(s):
Phosphatidylserine-specific phospholipase A1
Short name:
PS-PLA1
Gene namesi
Name:PLA1A
Synonyms:NMD, PSPLA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144837.8
HGNCiHGNC:17661 PLA1A
MIMi607460 gene
neXtProtiNX_Q53H76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51365
OpenTargetsiENSG00000144837
PharmGKBiPA134955851

Polymorphism and mutation databases

BioMutaiPLA1A
DMDMi124015212

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000027333026 – 456Phospholipase A1 member AAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi245 ↔ 258By similarity
Disulfide bondi282 ↔ 293By similarity
Disulfide bondi296 ↔ 304By similarity
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ53H76
PeptideAtlasiQ53H76
PRIDEiQ53H76
ProteomicsDBi62497
62498 [Q53H76-2]
62499 [Q53H76-3]

PTM databases

iPTMnetiQ53H76
PhosphoSitePlusiQ53H76

Expressioni

Tissue specificityi

Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.1 Publication

Gene expression databases

BgeeiENSG00000144837
CleanExiHS_PLA1A
ExpressionAtlasiQ53H76 baseline and differential
GenevisibleiQ53H76 HS

Organism-specific databases

HPAiHPA059740

Interactioni

Protein-protein interaction databases

BioGridi119500, 2 interactors
IntActiQ53H76, 1 interactor
STRINGi9606.ENSP00000273371

Structurei

3D structure databases

ProteinModelPortaliQ53H76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni374 – 456Involved in the recognition of diacyl-phospholipidsAdd BLAST83

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ4N Eukaryota
ENOG4110U23 LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000059578
HOVERGENiHBG082148
InParanoidiQ53H76
KOiK13618
OMAiAPYCVHH
OrthoDBiEOG091G0680
PhylomeDBiQ53H76
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00821 TAGLIPASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53H76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPGPWESCF WVGGLILWLS VGSSGDAPPT PQPKCADFQS ANLFEGTDLK
60 70 80 90 100
VQFLLFVPSN PSCGQLVEGS SDLQNSGFNA TLGTKLIIHG FRVLGTKPSW
110 120 130 140 150
IDTFIRTLLR ATNANVIAVD WIYGSTGVYF SAVKNVIKLS LEISLFLNKL
160 170 180 190 200
LVLGVSESSI HIIGVSLGAH VGGMVGQLFG GQLGQITGLD PAGPEYTRAS
210 220 230 240 250
VEERLDAGDA LFVEAIHTDT DNLGIRIPVG HVDYFVNGGQ DQPGCPTFFY
260 270 280 290 300
AGYSYLICDH MRAVHLYISA LENSCPLMAF PCASYKAFLA GRCLDCFNPF
310 320 330 340 350
LLSCPRIGLV EQGGVKIEPL PKEVKVYLLT TSSAPYCMHH SLVEFHLKEL
360 370 380 390 400
RNKDTNIEVT FLSSNITSSS KITIPKQQRY GKGIIAHATP QCQINQVKFK
410 420 430 440 450
FQSSNRVWKK DRTTIIGKFC TALLPVNDRE KMVCLPEPVN LQASVTVSCD

LKIACV
Length:456
Mass (Da):49,715
Last modified:January 23, 2007 - v2
Checksum:iCF09D725FD75820B
GO
Isoform 2 (identifier: Q53H76-2) [UniParc]FASTAAdd to basket
Also known as: DeltaC

The sequence of this isoform differs from the canonical sequence as follows:
     374-376: IPK → MYT
     377-456: Missing.

Show »
Length:376
Mass (Da):40,784
Checksum:iE4F6460C73D8F775
GO
Isoform 3 (identifier: Q53H76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-151: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):47,890
Checksum:i3F34DC5D33A8E8C9
GO
Isoform 4 (identifier: Q53H76-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,285
Checksum:i1C9E49C66DE3EB7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213V → T in BAD96425 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03012623S → I. Corresponds to variant dbSNP:rs1128293Ensembl.1
Natural variantiVAR_030127110R → H1 PublicationCorresponds to variant dbSNP:rs61733987Ensembl.1
Natural variantiVAR_030128284S → N. Corresponds to variant dbSNP:rs2692622Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449441 – 173Missing in isoform 4. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_022507136 – 151Missing in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_022508374 – 376IPK → MYT in isoform 2. 1 Publication3
Alternative sequenceiVSP_022509377 – 456Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37591 mRNA Translation: AAC99994.1
AF035268 mRNA Translation: AAC98921.1
AF035269 mRNA Translation: AAC98922.1
AK301880 mRNA Translation: BAG63314.1
AK313519 mRNA Translation: BAG36299.1
AK222705 mRNA Translation: BAD96425.1
AC073352 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79557.1
BC047703 mRNA Translation: AAH47703.1
CCDSiCCDS2991.1 [Q53H76-1]
CCDS56268.1 [Q53H76-3]
CCDS56269.1 [Q53H76-4]
RefSeqiNP_001193889.1, NM_001206960.1 [Q53H76-3]
NP_001193890.1, NM_001206961.1 [Q53H76-4]
NP_056984.1, NM_015900.3 [Q53H76-1]
XP_016862061.1, XM_017006572.1 [Q53H76-4]
UniGeneiHs.437451

Genome annotation databases

EnsembliENST00000273371; ENSP00000273371; ENSG00000144837 [Q53H76-1]
ENST00000488919; ENSP00000420625; ENSG00000144837 [Q53H76-4]
ENST00000495992; ENSP00000417326; ENSG00000144837 [Q53H76-3]
GeneIDi51365
KEGGihsa:51365
UCSCiuc003ecu.4 human [Q53H76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPLA1A_HUMAN
AccessioniPrimary (citable) accession number: Q53H76
Secondary accession number(s): B2R8V2
, B4DXA2, O95991, Q86WX6, Q9UPD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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