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Protein

Phospholipase A1 member A

Gene

PLA1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166NucleophileBy similarity1
Active sitei190Charge relay systemPROSITE-ProRule annotation1
Active sitei260Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • phosphatidylcholine 1-acylhydrolase activity Source: ProtInc

GO - Biological processi

  • lipid catabolic process Source: UniProtKB-KW
  • lipid metabolic process Source: ProtInc
  • phosphatidylserine metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1482801. Acyl chain remodelling of PS.

Protein family/group databases

ESTHERihuman-PLA1A. Phospholipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 member A (EC:3.1.1.-)
Alternative name(s):
Phosphatidylserine-specific phospholipase A1
Short name:
PS-PLA1
Gene namesi
Name:PLA1A
Synonyms:NMD, PSPLA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17661. PLA1A.

Subcellular locationi

GO - Cellular componenti

  • acrosomal membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51365.
OpenTargetsiENSG00000144837.
PharmGKBiPA134955851.

Polymorphism and mutation databases

BioMutaiPLA1A.
DMDMi124015212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000027333026 – 456Phospholipase A1 member AAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi245 ↔ 258By similarity
Disulfide bondi282 ↔ 293By similarity
Disulfide bondi296 ↔ 304By similarity
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ53H76.
PeptideAtlasiQ53H76.
PRIDEiQ53H76.

PTM databases

iPTMnetiQ53H76.
PhosphoSitePlusiQ53H76.

Expressioni

Tissue specificityi

Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.1 Publication

Gene expression databases

BgeeiENSG00000144837.
CleanExiHS_PLA1A.
ExpressionAtlasiQ53H76. baseline and differential.
GenevisibleiQ53H76. HS.

Organism-specific databases

HPAiHPA058981.

Interactioni

Protein-protein interaction databases

BioGridi119500. 2 interactors.
IntActiQ53H76. 1 interactor.
STRINGi9606.ENSP00000273371.

Structurei

3D structure databases

ProteinModelPortaliQ53H76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni374 – 456Involved in the recognition of diacyl-phospholipidsAdd BLAST83

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ4N. Eukaryota.
ENOG4110U23. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000059578.
HOVERGENiHBG082148.
InParanoidiQ53H76.
KOiK13618.
OMAiAPYCVHH.
OrthoDBiEOG091G0680.
PhylomeDBiQ53H76.
TreeFamiTF324997.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53H76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPGPWESCF WVGGLILWLS VGSSGDAPPT PQPKCADFQS ANLFEGTDLK
60 70 80 90 100
VQFLLFVPSN PSCGQLVEGS SDLQNSGFNA TLGTKLIIHG FRVLGTKPSW
110 120 130 140 150
IDTFIRTLLR ATNANVIAVD WIYGSTGVYF SAVKNVIKLS LEISLFLNKL
160 170 180 190 200
LVLGVSESSI HIIGVSLGAH VGGMVGQLFG GQLGQITGLD PAGPEYTRAS
210 220 230 240 250
VEERLDAGDA LFVEAIHTDT DNLGIRIPVG HVDYFVNGGQ DQPGCPTFFY
260 270 280 290 300
AGYSYLICDH MRAVHLYISA LENSCPLMAF PCASYKAFLA GRCLDCFNPF
310 320 330 340 350
LLSCPRIGLV EQGGVKIEPL PKEVKVYLLT TSSAPYCMHH SLVEFHLKEL
360 370 380 390 400
RNKDTNIEVT FLSSNITSSS KITIPKQQRY GKGIIAHATP QCQINQVKFK
410 420 430 440 450
FQSSNRVWKK DRTTIIGKFC TALLPVNDRE KMVCLPEPVN LQASVTVSCD

LKIACV
Length:456
Mass (Da):49,715
Last modified:January 23, 2007 - v2
Checksum:iCF09D725FD75820B
GO
Isoform 2 (identifier: Q53H76-2) [UniParc]FASTAAdd to basket
Also known as: DeltaC

The sequence of this isoform differs from the canonical sequence as follows:
     374-376: IPK → MYT
     377-456: Missing.

Show »
Length:376
Mass (Da):40,784
Checksum:iE4F6460C73D8F775
GO
Isoform 3 (identifier: Q53H76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-151: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):47,890
Checksum:i3F34DC5D33A8E8C9
GO
Isoform 4 (identifier: Q53H76-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,285
Checksum:i1C9E49C66DE3EB7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213V → T in BAD96425 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03012623S → I.Corresponds to variant rs11929241dbSNPEnsembl.1
Natural variantiVAR_030127110R → H.1 PublicationCorresponds to variant rs61733987dbSNPEnsembl.1
Natural variantiVAR_030128284S → N.Corresponds to variant rs2692622dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449441 – 173Missing in isoform 4. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_022507136 – 151Missing in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_022508374 – 376IPK → MYT in isoform 2. 1 Publication3
Alternative sequenceiVSP_022509377 – 456Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37591 mRNA. Translation: AAC99994.1.
AF035268 mRNA. Translation: AAC98921.1.
AF035269 mRNA. Translation: AAC98922.1.
AK301880 mRNA. Translation: BAG63314.1.
AK313519 mRNA. Translation: BAG36299.1.
AK222705 mRNA. Translation: BAD96425.1.
AC073352 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79557.1.
BC047703 mRNA. Translation: AAH47703.1.
CCDSiCCDS2991.1. [Q53H76-1]
CCDS56268.1. [Q53H76-3]
CCDS56269.1. [Q53H76-4]
RefSeqiNP_001193889.1. NM_001206960.1. [Q53H76-3]
NP_001193890.1. NM_001206961.1. [Q53H76-4]
NP_056984.1. NM_015900.3. [Q53H76-1]
XP_016862061.1. XM_017006572.1. [Q53H76-4]
UniGeneiHs.437451.

Genome annotation databases

EnsembliENST00000273371; ENSP00000273371; ENSG00000144837. [Q53H76-1]
ENST00000488919; ENSP00000420625; ENSG00000144837. [Q53H76-4]
ENST00000495992; ENSP00000417326; ENSG00000144837. [Q53H76-3]
GeneIDi51365.
KEGGihsa:51365.
UCSCiuc003ecu.4. human. [Q53H76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37591 mRNA. Translation: AAC99994.1.
AF035268 mRNA. Translation: AAC98921.1.
AF035269 mRNA. Translation: AAC98922.1.
AK301880 mRNA. Translation: BAG63314.1.
AK313519 mRNA. Translation: BAG36299.1.
AK222705 mRNA. Translation: BAD96425.1.
AC073352 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79557.1.
BC047703 mRNA. Translation: AAH47703.1.
CCDSiCCDS2991.1. [Q53H76-1]
CCDS56268.1. [Q53H76-3]
CCDS56269.1. [Q53H76-4]
RefSeqiNP_001193889.1. NM_001206960.1. [Q53H76-3]
NP_001193890.1. NM_001206961.1. [Q53H76-4]
NP_056984.1. NM_015900.3. [Q53H76-1]
XP_016862061.1. XM_017006572.1. [Q53H76-4]
UniGeneiHs.437451.

3D structure databases

ProteinModelPortaliQ53H76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119500. 2 interactors.
IntActiQ53H76. 1 interactor.
STRINGi9606.ENSP00000273371.

Protein family/group databases

ESTHERihuman-PLA1A. Phospholipase.

PTM databases

iPTMnetiQ53H76.
PhosphoSitePlusiQ53H76.

Polymorphism and mutation databases

BioMutaiPLA1A.
DMDMi124015212.

Proteomic databases

PaxDbiQ53H76.
PeptideAtlasiQ53H76.
PRIDEiQ53H76.

Protocols and materials databases

DNASUi51365.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273371; ENSP00000273371; ENSG00000144837. [Q53H76-1]
ENST00000488919; ENSP00000420625; ENSG00000144837. [Q53H76-4]
ENST00000495992; ENSP00000417326; ENSG00000144837. [Q53H76-3]
GeneIDi51365.
KEGGihsa:51365.
UCSCiuc003ecu.4. human. [Q53H76-1]

Organism-specific databases

CTDi51365.
DisGeNETi51365.
GeneCardsiPLA1A.
HGNCiHGNC:17661. PLA1A.
HPAiHPA058981.
MIMi607460. gene.
neXtProtiNX_Q53H76.
OpenTargetsiENSG00000144837.
PharmGKBiPA134955851.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ4N. Eukaryota.
ENOG4110U23. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000059578.
HOVERGENiHBG082148.
InParanoidiQ53H76.
KOiK13618.
OMAiAPYCVHH.
OrthoDBiEOG091G0680.
PhylomeDBiQ53H76.
TreeFamiTF324997.

Enzyme and pathway databases

ReactomeiR-HSA-1482801. Acyl chain remodelling of PS.

Miscellaneous databases

GenomeRNAii51365.
PROiQ53H76.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144837.
CleanExiHS_PLA1A.
ExpressionAtlasiQ53H76. baseline and differential.
GenevisibleiQ53H76. HS.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLA1A_HUMAN
AccessioniPrimary (citable) accession number: Q53H76
Secondary accession number(s): B2R8V2
, B4DXA2, O95991, Q86WX6, Q9UPD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.