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Q53H76

- PLA1A_HUMAN

UniProt

Q53H76 - PLA1A_HUMAN

Protein

Phospholipase A1 member A

Gene

PLA1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661NucleophileBy similarity
    Active sitei190 – 1901Charge relay systemPROSITE-ProRule annotation
    Active sitei260 – 2601Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. phosphatidylcholine 1-acylhydrolase activity Source: ProtInc

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. lipid metabolic process Source: ProtInc
    3. phosphatidylserine metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipase A1 member A (EC:3.1.1.-)
    Alternative name(s):
    Phosphatidylserine-specific phospholipase A1
    Short name:
    PS-PLA1
    Gene namesi
    Name:PLA1A
    Synonyms:NMD, PSPLA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17661. PLA1A.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134955851.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 456431Phospholipase A1 member APRO_0000273330Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi245 ↔ 258By similarity
    Disulfide bondi282 ↔ 293By similarity
    Disulfide bondi296 ↔ 304By similarity
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ53H76.
    PRIDEiQ53H76.

    PTM databases

    PhosphoSiteiQ53H76.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ53H76.
    BgeeiQ53H76.
    CleanExiHS_PLA1A.
    GenevestigatoriQ53H76.

    Organism-specific databases

    HPAiHPA058981.

    Interactioni

    Protein-protein interaction databases

    BioGridi119500. 1 interaction.
    IntActiQ53H76. 1 interaction.
    STRINGi9606.ENSP00000273371.

    Structurei

    3D structure databases

    ProteinModelPortaliQ53H76.
    SMRiQ53H76. Positions 48-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni374 – 45683Involved in the recognition of diacyl-phospholipidsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39669.
    HOGENOMiHOG000059578.
    HOVERGENiHBG082148.
    InParanoidiQ53H76.
    KOiK13618.
    OMAiAPYCVHH.
    OrthoDBiEOG744T8X.
    PhylomeDBiQ53H76.
    TreeFamiTF324997.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSiPR00821. TAGLIPASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q53H76-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPGPWESCF WVGGLILWLS VGSSGDAPPT PQPKCADFQS ANLFEGTDLK    50
    VQFLLFVPSN PSCGQLVEGS SDLQNSGFNA TLGTKLIIHG FRVLGTKPSW 100
    IDTFIRTLLR ATNANVIAVD WIYGSTGVYF SAVKNVIKLS LEISLFLNKL 150
    LVLGVSESSI HIIGVSLGAH VGGMVGQLFG GQLGQITGLD PAGPEYTRAS 200
    VEERLDAGDA LFVEAIHTDT DNLGIRIPVG HVDYFVNGGQ DQPGCPTFFY 250
    AGYSYLICDH MRAVHLYISA LENSCPLMAF PCASYKAFLA GRCLDCFNPF 300
    LLSCPRIGLV EQGGVKIEPL PKEVKVYLLT TSSAPYCMHH SLVEFHLKEL 350
    RNKDTNIEVT FLSSNITSSS KITIPKQQRY GKGIIAHATP QCQINQVKFK 400
    FQSSNRVWKK DRTTIIGKFC TALLPVNDRE KMVCLPEPVN LQASVTVSCD 450
    LKIACV 456
    Length:456
    Mass (Da):49,715
    Last modified:January 23, 2007 - v2
    Checksum:iCF09D725FD75820B
    GO
    Isoform 2 (identifier: Q53H76-2) [UniParc]FASTAAdd to Basket

    Also known as: DeltaC

    The sequence of this isoform differs from the canonical sequence as follows:
         374-376: IPK → MYT
         377-456: Missing.

    Show »
    Length:376
    Mass (Da):40,784
    Checksum:iE4F6460C73D8F775
    GO
    Isoform 3 (identifier: Q53H76-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         136-151: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:440
    Mass (Da):47,890
    Checksum:i3F34DC5D33A8E8C9
    GO
    Isoform 4 (identifier: Q53H76-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-173: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:283
    Mass (Da):31,285
    Checksum:i1C9E49C66DE3EB7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti213 – 2131V → T in BAD96425. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231S → I.
    Corresponds to variant rs11929241 [ dbSNP | Ensembl ].
    VAR_030126
    Natural varianti110 – 1101R → H.1 Publication
    Corresponds to variant rs61733987 [ dbSNP | Ensembl ].
    VAR_030127
    Natural varianti284 – 2841S → N.
    Corresponds to variant rs2692622 [ dbSNP | Ensembl ].
    VAR_030128

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 173173Missing in isoform 4. 1 PublicationVSP_044944Add
    BLAST
    Alternative sequencei136 – 15116Missing in isoform 3. 1 PublicationVSP_022507Add
    BLAST
    Alternative sequencei374 – 3763IPK → MYT in isoform 2. 1 PublicationVSP_022508
    Alternative sequencei377 – 45680Missing in isoform 2. 1 PublicationVSP_022509Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37591 mRNA. Translation: AAC99994.1.
    AF035268 mRNA. Translation: AAC98921.1.
    AF035269 mRNA. Translation: AAC98922.1.
    AK301880 mRNA. Translation: BAG63314.1.
    AK313519 mRNA. Translation: BAG36299.1.
    AK222705 mRNA. Translation: BAD96425.1.
    AC073352 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79557.1.
    BC047703 mRNA. Translation: AAH47703.1.
    CCDSiCCDS2991.1. [Q53H76-1]
    CCDS56268.1. [Q53H76-3]
    CCDS56269.1. [Q53H76-4]
    RefSeqiNP_001193889.1. NM_001206960.1. [Q53H76-3]
    NP_001193890.1. NM_001206961.1. [Q53H76-4]
    NP_056984.1. NM_015900.3. [Q53H76-1]
    UniGeneiHs.437451.

    Genome annotation databases

    EnsembliENST00000273371; ENSP00000273371; ENSG00000144837. [Q53H76-1]
    ENST00000488919; ENSP00000420625; ENSG00000144837. [Q53H76-4]
    ENST00000495992; ENSP00000417326; ENSG00000144837. [Q53H76-3]
    GeneIDi51365.
    KEGGihsa:51365.
    UCSCiuc003ecu.3. human. [Q53H76-1]
    uc003ecv.3. human. [Q53H76-3]

    Polymorphism databases

    DMDMi124015212.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37591 mRNA. Translation: AAC99994.1 .
    AF035268 mRNA. Translation: AAC98921.1 .
    AF035269 mRNA. Translation: AAC98922.1 .
    AK301880 mRNA. Translation: BAG63314.1 .
    AK313519 mRNA. Translation: BAG36299.1 .
    AK222705 mRNA. Translation: BAD96425.1 .
    AC073352 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79557.1 .
    BC047703 mRNA. Translation: AAH47703.1 .
    CCDSi CCDS2991.1. [Q53H76-1 ]
    CCDS56268.1. [Q53H76-3 ]
    CCDS56269.1. [Q53H76-4 ]
    RefSeqi NP_001193889.1. NM_001206960.1. [Q53H76-3 ]
    NP_001193890.1. NM_001206961.1. [Q53H76-4 ]
    NP_056984.1. NM_015900.3. [Q53H76-1 ]
    UniGenei Hs.437451.

    3D structure databases

    ProteinModelPortali Q53H76.
    SMRi Q53H76. Positions 48-410.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119500. 1 interaction.
    IntActi Q53H76. 1 interaction.
    STRINGi 9606.ENSP00000273371.

    PTM databases

    PhosphoSitei Q53H76.

    Polymorphism databases

    DMDMi 124015212.

    Proteomic databases

    PaxDbi Q53H76.
    PRIDEi Q53H76.

    Protocols and materials databases

    DNASUi 51365.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273371 ; ENSP00000273371 ; ENSG00000144837 . [Q53H76-1 ]
    ENST00000488919 ; ENSP00000420625 ; ENSG00000144837 . [Q53H76-4 ]
    ENST00000495992 ; ENSP00000417326 ; ENSG00000144837 . [Q53H76-3 ]
    GeneIDi 51365.
    KEGGi hsa:51365.
    UCSCi uc003ecu.3. human. [Q53H76-1 ]
    uc003ecv.3. human. [Q53H76-3 ]

    Organism-specific databases

    CTDi 51365.
    GeneCardsi GC03P119316.
    HGNCi HGNC:17661. PLA1A.
    HPAi HPA058981.
    MIMi 607460. gene.
    neXtProti NX_Q53H76.
    PharmGKBi PA134955851.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39669.
    HOGENOMi HOG000059578.
    HOVERGENi HBG082148.
    InParanoidi Q53H76.
    KOi K13618.
    OMAi APYCVHH.
    OrthoDBi EOG744T8X.
    PhylomeDBi Q53H76.
    TreeFami TF324997.

    Miscellaneous databases

    GenomeRNAii 51365.
    NextBioi 54833.
    PROi Q53H76.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q53H76.
    Bgeei Q53H76.
    CleanExi HS_PLA1A.
    Genevestigatori Q53H76.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    IPR016272. Lipoprotein_lipase_LIPH.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSi PR00821. TAGLIPASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipases."
      van Groningen J.J.M., Egmond M.R., Bloemers H.P.J., Swart G.W.M.
      FEBS Lett. 404:82-86(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Melanoma.
    2. "An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans."
      Nagai Y., Aoki J., Sato T., Amano K., Matsuda Y., Arai H., Inoue K.
      J. Biol. Chem. 274:11053-11059(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Testis.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Skin.
    8. "Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 (PSPLA1)."
      Wang J., Wen X.-Y., Stewart A.K., Hegele R.A.
      J. Hum. Genet. 47:611-613(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-110.

    Entry informationi

    Entry nameiPLA1A_HUMAN
    AccessioniPrimary (citable) accession number: Q53H76
    Secondary accession number(s): B2R8V2
    , B4DXA2, O95991, Q86WX6, Q9UPD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3