##gff-version 3 Q53H47 UniProtKB Chain 1 684 . . . ID=PRO_0000259526;Note=Histone-lysine N-methyltransferase SETMAR Q53H47 UniProtKB Domain 73 136 . . . Note=Pre-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00157 Q53H47 UniProtKB Domain 139 263 . . . Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190 Q53H47 UniProtKB Domain 283 299 . . . Note=Post-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00155 Q53H47 UniProtKB DNA binding 364 395 . . . Note=H-T-H motif;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q53H47 UniProtKB DNA binding 428 448 . . . Note=H-T-H motif Q53H47 UniProtKB Region 1 345 . . . Note=Histone-lysine N-methyltransferase Q53H47 UniProtKB Region 346 684 . . . Note=Mariner transposase Hsmar1 Q53H47 UniProtKB Binding site 75 75 . . . . Q53H47 UniProtKB Binding site 75 75 . . . . Q53H47 UniProtKB Binding site 77 77 . . . . Q53H47 UniProtKB Binding site 82 82 . . . . Q53H47 UniProtKB Binding site 82 82 . . . . Q53H47 UniProtKB Binding site 87 87 . . . . Q53H47 UniProtKB Binding site 89 89 . . . . Q53H47 UniProtKB Binding site 118 118 . . . . Q53H47 UniProtKB Binding site 118 118 . . . . Q53H47 UniProtKB Binding site 122 122 . . . . Q53H47 UniProtKB Binding site 124 124 . . . . Q53H47 UniProtKB Binding site 128 128 . . . . Q53H47 UniProtKB Binding site 149 151 . . . . Q53H47 UniProtKB Binding site 192 192 . . . . Q53H47 UniProtKB Binding site 220 220 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190 Q53H47 UniProtKB Binding site 223 224 . . . . Q53H47 UniProtKB Binding site 226 226 . . . . Q53H47 UniProtKB Binding site 287 287 . . . . Q53H47 UniProtKB Binding site 289 289 . . . . Q53H47 UniProtKB Binding site 294 294 . . . . Q53H47 UniProtKB Binding site 496 496 . . . . Q53H47 UniProtKB Binding site 588 588 . . . . Q53H47 UniProtKB Modified residue 498 498 . . . Note=N6-methyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18790802;Dbxref=PMID:18790802 Q53H47 UniProtKB Modified residue 508 508 . . . Note=Phosphoserine%3B by CHEK1;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:22231448,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:22231448,PMID:23186163 Q53H47 UniProtKB Alternative sequence 163 301 . . . ID=VSP_054089;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Alternative sequence 341 365 . . . ID=VSP_021440;Note=In isoform 2. TMKMMLDKKQIRAIFLFEFKMGRKA->VSLFSDKQLAPPYSGRQWLASFTSA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q53H47 UniProtKB Alternative sequence 366 684 . . . ID=VSP_021441;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q53H47 UniProtKB Mutagenesis 223 223 . . . Note=Reduces activity in double-strand break repair. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16332963;Dbxref=PMID:16332963 Q53H47 UniProtKB Mutagenesis 261 261 . . . Note=Reduces activity in double-strand break repair. D->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16332963;Dbxref=PMID:16332963 Q53H47 UniProtKB Mutagenesis 445 445 . . . Note=Abolishes TIR-specific DNA-binding. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17877369;Dbxref=PMID:17877369 Q53H47 UniProtKB Mutagenesis 473 473 . . . Note=Abolishes homodimerization and DNA-binding and reduces cleavage of single-stranded DNA. F->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20521842;Dbxref=PMID:20521842 Q53H47 UniProtKB Mutagenesis 496 496 . . . Note=Abolishes DNA cleavage. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17877369;Dbxref=PMID:17877369 Q53H47 UniProtKB Mutagenesis 503 503 . . . Note=Reduces activity in double-strand break repair. D->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16332963;Dbxref=PMID:16332963 Q53H47 UniProtKB Mutagenesis 508 508 . . . Note=Prevents phosphorylation. Impairs recruitment to damaged DNA and double-strand break repair. Impairs interaction with histone H3 and its methylation. Allows replication fork restart. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22231448;Dbxref=PMID:22231448 Q53H47 UniProtKB Mutagenesis 623 623 . . . Note=Loss of function in DNA repair. Altered DNA-binding properties. N->D%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24573677;Dbxref=PMID:24573677 Q53H47 UniProtKB Sequence conflict 91 91 . . . Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 343 343 . . . Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 439 439 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 465 465 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 484 484 . . . Note=H->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 508 508 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 514 514 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 525 525 . . . Note=I->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 528 528 . . . Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 535 535 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 562 562 . . . Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 567 568 . . . Note=NQ->HR;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 575 575 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 620 620 . . . Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 623 623 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 626 626 . . . Note=V->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 631 631 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 656 656 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Sequence conflict 667 667 . . . Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53H47 UniProtKB Turn 30 33 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 35 37 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 40 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Turn 84 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Helix 88 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Helix 133 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 141 145 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 147 157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 164 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 170 173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Helix 175 182 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 194 198 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 206 216 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Helix 218 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 229 241 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 243 250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 257 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Beta strand 270 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BO5 Q53H47 UniProtKB Helix 348 360 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S03 Q53H47 UniProtKB Helix 365 376 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S03 Q53H47 UniProtKB Helix 383 394 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S03 Q53H47 UniProtKB Helix 414 423 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S03 Q53H47 UniProtKB Helix 429 436 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S03 Q53H47 UniProtKB Helix 440 449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7S03 Q53H47 UniProtKB Helix 466 485 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 489 491 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Beta strand 492 503 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Beta strand 530 538 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Beta strand 541 547 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 556 573 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 574 576 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3K9J Q53H47 UniProtKB Beta strand 584 586 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 591 594 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 598 605 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 617 619 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 621 624 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 626 634 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 642 654 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 660 666 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Helix 668 677 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K Q53H47 UniProtKB Turn 678 680 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3F2K