UDP-glucuronosyltransferase

Functionⁱ

Catalytic activityⁱ

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functionⁱ

glucuronosyltransferase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	GlycosyltransferaseUniRule annotation, Transferase

Molecular function

GlycosyltransferaseUniRule annotation, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU362059
; Single-pass membrane protein
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU362059

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	492 – 516	HelicalUniRule annotationAdd BLAST		25

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-UniRule

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA37186.

PharmGKBⁱ

PA37186.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	UniRule annotationAdd BLAST		22
ChainⁱPRO_5005143461	23 – 528	UDP-glucuronosyltransferaseUniRule annotationAdd BLAST		506

Proteomic databases

PaxDbⁱ	Q53GU2.
PeptideAtlas More...PeptideAtlasⁱ	Q53GU2.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the UDP-glycosyltransferase family.UniRule annotation

Keywords - Domainⁱ

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1192. Eukaryota. COG1819. LUCA.
HOVERGENⁱ	HBG004033.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002213. UDP_glucos_trans.
PANTHERⁱ	PTHR11926. PTHR11926. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00201. UDPGT. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00375. UDPGT. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q53GU2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH 
        60         70         80         90        100
EVTVLASSAS ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ 
       110        120        130        140        150
KDTFWLPFSR EQEILWAIND IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD 
       160        170        180        190        200
AYLPCGELLA ELFNIPFVYS HSFSPGYSFE RHSGGFIFPP SYVPVVMSKL 
       210        220        230        240        250
SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG RPTTLSETMR 
       260        270        280        290        300
KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE 
       310        320        330        340        350
NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT 
       360        370        380        390        400
RLYKWIPQND LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD 
       410        420        430        440        450
NIAHMKAKGA AVRVDFNTMS STDLLNALKT VINDPSYKEN IMKLSRIQHD 
       460        470        480        490        500
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH NLTWFQYHSL DVIGFLLACV 
       510        520 
ATVLFIITKC CLFCFWKFAR KGKKGKRD

Length:528

Mass (Da):60,802

Last modified:May 24, 2005 - v1

Checksum:ⁱ301ACD2ADF64B1B9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK222839 mRNA. Translation: BAD96559.1.
UniGeneⁱ	Hs.201634.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK222839 mRNA. Translation: BAD96559.1.
UniGeneⁱ	Hs.201634.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q53GU2.
PeptideAtlas More...PeptideAtlasⁱ	Q53GU2.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7365.
Structural Biology Knowledgebase	Search...

Organism-specific databases

PharmGKBⁱ	PA37186.

PharmGKBⁱ

PA37186.

Phylogenomic databases

eggNOGⁱ	KOG1192. Eukaryota. COG1819. LUCA.
HOVERGENⁱ	HBG004033.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002213. UDP_glucos_trans.
PANTHERⁱ	PTHR11926. PTHR11926. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00201. UDPGT. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00375. UDPGT. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q53GU2_HUMAN
Accessionⁱ	Q53GU2Primary (citable) accession number: Q53GU2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 24, 2005
	Last sequence update:	May 24, 2005
	Last modified:	July 5, 2017
	This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q53GU2 (Q53GU2_HUMAN)

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Molecule processing

Proteomic databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q53GU2 (Q53GU2_HUMAN)

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UDP-glucuronosyltransferase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ