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Q53GS7

- GLE1_HUMAN

UniProt

Q53GS7 - GLE1_HUMAN

Protein

Nucleoporin GLE1

Gene

GLE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).3 Publications

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct

    GO - Biological processi

    1. mRNA export from nucleus Source: ProtInc
    2. poly(A)+ mRNA export from nucleus Source: InterPro
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Protein family/group databases

    TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoporin GLE1
    Short name:
    hGLE1
    Alternative name(s):
    GLE1-like protein
    Gene namesi
    Name:GLE1
    Synonyms:GLE1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:4315. GLE1.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function.
    Isoform 1 : Cytoplasm. Nucleusnuclear pore complex
    Note: Shuttles between the nucleus and the cytoplasm. In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular space Source: UniProt
    3. membrane Source: UniProtKB
    4. nuclear pore Source: ProtInc
    5. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nuclear pore complex, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Lethal congenital contracture syndrome 1 (LCCS1) [MIM:253310]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS1 patients manifest early fetal hydrops and akinesia, micrognathia, pulmonary hypoplasia, pterygia, and multiple joint contractures. It leads to prenatal death.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441T → TPFQ in LCCS1; allele Fin(Major); does not affect subcellular localization.
    VAR_043874
    Natural varianti569 – 5691R → H in LCCS1. 1 Publication
    VAR_043875
    Lethal arthrogryposis with anterior horn cell disease (LAAHD) [MIM:611890]: A disorder characterized by fetal akinesia, arthrogryposis and motor neuron loss. The fetus often survives delivery, but dies early as a result of respiratory failure. Neuropathological findings resemble those of lethal congenital contracture syndrome type 1, but are less severe.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti617 – 6171V → M in LAAHD. 1 Publication
    VAR_043876
    Natural varianti684 – 6841I → T in LAAHD. 1 Publication
    VAR_043877

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi253310. phenotype.
    611890. phenotype.
    Orphaneti53696. Lethal arthrogryposis - anterior horn cell disease.
    1486. Lethal congenital contracture syndrome type 1.
    PharmGKBiPA28718.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 698698Nucleoporin GLE1PRO_0000204822Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei88 – 881Phosphoserine2 Publications
    Modified residuei99 – 991Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ53GS7.
    PaxDbiQ53GS7.
    PRIDEiQ53GS7.

    PTM databases

    PhosphoSiteiQ53GS7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ53GS7.
    BgeeiQ53GS7.
    CleanExiHS_GLE1.
    GenevestigatoriQ53GS7.

    Organism-specific databases

    HPAiHPA041689.
    HPA043538.

    Interactioni

    Subunit structurei

    Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2. Isoform 2 does not interact with NUPL2. Able to form a heterotrimer with NUP155 and NUPL2 in vitro.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself5EBI-1955541,EBI-1955541
    EIF3FO003032EBI-1955541,EBI-711990

    Protein-protein interaction databases

    BioGridi108995. 8 interactions.
    IntActiQ53GS7. 4 interactions.
    MINTiMINT-4535009.
    STRINGi9606.ENSP00000308622.

    Structurei

    3D structure databases

    ProteinModelPortaliQ53GS7.
    SMRiQ53GS7. Positions 480-656.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929Interaction with NUP155Add
    BLAST
    Regioni444 – 48340Mediates the shuttling between the nucleus and the cytoplasmAdd
    BLAST
    Regioni656 – 69843Interaction with NUPL2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili151 – 277127Sequence AnalysisAdd
    BLAST
    Coiled coili305 – 35652Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GLE1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG330485.
    HOGENOMiHOG000246966.
    HOVERGENiHBG081558.
    InParanoidiQ53GS7.
    OMAiSQHTESM.
    OrthoDBiEOG7FFMRB.
    PhylomeDBiQ53GS7.
    TreeFamiTF324158.

    Family and domain databases

    InterProiIPR012476. GLE1.
    [Graphical view]
    PANTHERiPTHR12960. PTHR12960. 1 hit.
    PfamiPF07817. GLE1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q53GS7-1) [UniParc]FASTAAdd to Basket

    Also known as: hGle1B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPSEGRCWET LKALRSSDKG RLCYYRDWLL RREDVLEECM SLPKLSSYSG    50
    WVVEHVLPHM QENQPLSETS PSSTSASALD QPSFVPKSPD ASSAFSPASP 100
    ATPNGTKGKD ESQHTESMVL QSSRGIKVEG CVRMYELVHR MKGTEGLRLW 150
    QEEQERKVQA LSEMASEQLK RFDEWKELKQ HKEFQDLREV MEKSSREALG 200
    HQEKLKAEHR HRAKILNLKL REAEQQRVKQ AEQERLRKEE GQIRLRALYA 250
    LQEEMLQLSQ QLDASEQHKA LLKVDLAAFQ TRGNQLCSLI SGIIRASSES 300
    SYPTAESQAE AERALREMRD LLMNLGQEIT RACEDKRRQD EEEAQVKLQE 350
    AQMQQGPEAH KEPPAPSQGP GGKQNEDLQV KVQDITMQWY QQLQDASMQC 400
    VLTFEGLTNS KDSQAKKIKM DLQKAATIPV SQISTIAGSK LKEIFDKIHS 450
    LLSGKPVQSG GRSVSVTLNP QGLDFVQYKL AEKFVKQGEE EVASHHEAAF 500
    PIAVVASGIW ELHPRVGDLI LAHLHKKCPY SVPFYPTFKE GMALEDYQRM 550
    LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGNR QEIHPHGLNH 600
    GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMLILIKE 650
    DYFPRIEAIT SSGQMGSFIR LKQFLEKCLQ HKDIPVPKGF LTSSFWRS 698

    Note: Major isoform.

    Length:698
    Mass (Da):79,836
    Last modified:December 6, 2005 - v2
    Checksum:iF9FC04683BCCDBB2
    GO
    Isoform 2 (identifier: Q53GS7-2) [UniParc]FASTAAdd to Basket

    Also known as: hGle1A

    The sequence of this isoform differs from the canonical sequence as follows:
         656-659: IEAI → YQAC
         660-698: Missing.

    Show »
    Length:659
    Mass (Da):75,407
    Checksum:iC97A3FFE7E7581B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831S → P in BAD96574. 1 PublicationCurated
    Sequence conflicti172 – 1721F → S in BAD96562. 1 PublicationCurated
    Sequence conflicti549 – 5491R → G in BAD96562. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301G → D.1 Publication
    Corresponds to variant rs17852725 [ dbSNP | Ensembl ].
    VAR_024056
    Natural varianti144 – 1441T → TPFQ in LCCS1; allele Fin(Major); does not affect subcellular localization.
    VAR_043874
    Natural varianti243 – 2431I → V.
    Corresponds to variant rs2275260 [ dbSNP | Ensembl ].
    VAR_024057
    Natural varianti569 – 5691R → H in LCCS1. 1 Publication
    VAR_043875
    Natural varianti590 – 5901R → Q.1 Publication
    Corresponds to variant rs17856852 [ dbSNP | Ensembl ].
    VAR_024058
    Natural varianti617 – 6171V → M in LAAHD. 1 Publication
    VAR_043876
    Natural varianti684 – 6841I → T in LAAHD. 1 Publication
    VAR_043877

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei656 – 6594IEAI → YQAC in isoform 2. 2 PublicationsVSP_016486
    Alternative sequencei660 – 69839Missing in isoform 2. 2 PublicationsVSP_016487Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058922 mRNA. Translation: AAC25561.1.
    AK222842 mRNA. Translation: BAD96562.1.
    AK222854 mRNA. Translation: BAD96574.1.
    AL445287, AL356481 Genomic DNA. Translation: CAH71064.1.
    AL445287, AL356481 Genomic DNA. Translation: CAH71065.1.
    AL356481, AL445287 Genomic DNA. Translation: CAH71402.1.
    AL356481, AL445287 Genomic DNA. Translation: CAH71403.1.
    BC030012 mRNA. Translation: AAH30012.1.
    AL117584 mRNA. Translation: CAB56006.1.
    CCDSiCCDS35154.1. [Q53GS7-1]
    CCDS6904.1. [Q53GS7-2]
    PIRiT17316.
    RefSeqiNP_001003722.1. NM_001003722.1. [Q53GS7-1]
    NP_001490.1. NM_001499.2. [Q53GS7-2]
    UniGeneiHs.522418.

    Genome annotation databases

    EnsembliENST00000309971; ENSP00000308622; ENSG00000119392. [Q53GS7-1]
    ENST00000372770; ENSP00000361856; ENSG00000119392. [Q53GS7-2]
    GeneIDi2733.
    KEGGihsa:2733.
    UCSCiuc004bvi.3. human. [Q53GS7-2]
    uc004bvj.3. human. [Q53GS7-1]

    Polymorphism databases

    DMDMi83288218.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058922 mRNA. Translation: AAC25561.1 .
    AK222842 mRNA. Translation: BAD96562.1 .
    AK222854 mRNA. Translation: BAD96574.1 .
    AL445287 , AL356481 Genomic DNA. Translation: CAH71064.1 .
    AL445287 , AL356481 Genomic DNA. Translation: CAH71065.1 .
    AL356481 , AL445287 Genomic DNA. Translation: CAH71402.1 .
    AL356481 , AL445287 Genomic DNA. Translation: CAH71403.1 .
    BC030012 mRNA. Translation: AAH30012.1 .
    AL117584 mRNA. Translation: CAB56006.1 .
    CCDSi CCDS35154.1. [Q53GS7-1 ]
    CCDS6904.1. [Q53GS7-2 ]
    PIRi T17316.
    RefSeqi NP_001003722.1. NM_001003722.1. [Q53GS7-1 ]
    NP_001490.1. NM_001499.2. [Q53GS7-2 ]
    UniGenei Hs.522418.

    3D structure databases

    ProteinModelPortali Q53GS7.
    SMRi Q53GS7. Positions 480-656.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108995. 8 interactions.
    IntActi Q53GS7. 4 interactions.
    MINTi MINT-4535009.
    STRINGi 9606.ENSP00000308622.

    Protein family/group databases

    TCDBi 3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

    PTM databases

    PhosphoSitei Q53GS7.

    Polymorphism databases

    DMDMi 83288218.

    Proteomic databases

    MaxQBi Q53GS7.
    PaxDbi Q53GS7.
    PRIDEi Q53GS7.

    Protocols and materials databases

    DNASUi 2733.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309971 ; ENSP00000308622 ; ENSG00000119392 . [Q53GS7-1 ]
    ENST00000372770 ; ENSP00000361856 ; ENSG00000119392 . [Q53GS7-2 ]
    GeneIDi 2733.
    KEGGi hsa:2733.
    UCSCi uc004bvi.3. human. [Q53GS7-2 ]
    uc004bvj.3. human. [Q53GS7-1 ]

    Organism-specific databases

    CTDi 2733.
    GeneCardsi GC09P131266.
    HGNCi HGNC:4315. GLE1.
    HPAi HPA041689.
    HPA043538.
    MIMi 253310. phenotype.
    603371. gene.
    611890. phenotype.
    neXtProti NX_Q53GS7.
    Orphaneti 53696. Lethal arthrogryposis - anterior horn cell disease.
    1486. Lethal congenital contracture syndrome type 1.
    PharmGKBi PA28718.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330485.
    HOGENOMi HOG000246966.
    HOVERGENi HBG081558.
    InParanoidi Q53GS7.
    OMAi SQHTESM.
    OrthoDBi EOG7FFMRB.
    PhylomeDBi Q53GS7.
    TreeFami TF324158.

    Miscellaneous databases

    GeneWikii GLE1L.
    GenomeRNAii 2733.
    NextBioi 10770.
    PROi Q53GS7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q53GS7.
    Bgeei Q53GS7.
    CleanExi HS_GLE1.
    Genevestigatori Q53GS7.

    Family and domain databases

    InterProi IPR012476. GLE1.
    [Graphical view ]
    PANTHERi PTHR12960. PTHR12960. 1 hit.
    Pfami PF07817. GLE1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export."
      Watkins J.L., Murphy R., Emtage J.L.T., Wente S.R.
      Proc. Natl. Acad. Sci. U.S.A. 95:6779-6784(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
      Tissue: Brain.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Liver.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-130 AND GLN-590.
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-698 (ISOFORM 1).
    6. "An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export."
      Kendirgi F., Barry D.M., Griffis E.R., Powers M.A., Wente S.R.
      J. Cell Biol. 160:1029-1040(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
    7. "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155."
      Rayala H.J., Kendirgi F., Barry D.M., Majerus P.W., Wente S.R.
      Mol. Cell. Proteomics 3:145-155(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NUP155.
    8. "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA."
      Kendirgi F., Rexer D.J., Alcazar-Roman A.R., Onishko H.M., Wente S.R.
      Mol. Biol. Cell 16:4304-4315(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NUPL2 AND NUP155.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: VARIANTS LCCS1 PRO-PHE-GLN-144 INS AND HIS-569, VARIANTS LAAHD MET-617 AND THR-684, CHARACTERIZATION OF VARIANT LCCS1 PRO-PHE-GLN-144 INS.

    Entry informationi

    Entry nameiGLE1_HUMAN
    AccessioniPrimary (citable) accession number: Q53GS7
    Secondary accession number(s): O75458
    , Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3