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Protein
Submitted name:

Connector enhancer of kinase suppressor of Ras 1 variant

Gene

CNKSR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Connector enhancer of kinase suppressor of Ras 1 variantImported
Submitted name:
Connector enhancer of kinase suppressor of Ras 1, isoform CRA_bImported
Gene namesi
Name:CNKSR1Imported
ORF Names:hCG_40691Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901167.

Expressioni

Gene expression databases

BgeeiENSG00000142675.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 70SAM (sterile alpha motif)InterPro annotationAdd BLAST64
Domaini78 – 164CRICInterPro annotationAdd BLAST87
Domaini196 – 278PDZ (DHR)InterPro annotationAdd BLAST83
Domaini396 – 495PHInterPro annotationAdd BLAST100

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1738. Eukaryota.
ENOG41104C7. LUCA.
HOVERGENiHBG051039.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR017874. CRIC_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF10534. CRIC_ras_sig. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51290. CRIC. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53GM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVETWTPG KVATWLRGLD DSLQDYPFED WQLPGKNLLQ LCPQSLEALA
60 70 80 90 100
VRSLGHQELI LGGVEQLQAL SSRLQTENLQ SLTEGLLGAT HDFQSIVQGC
110 120 130 140 150
LGDCAKTPID VLCAAVELLH EADALLFWLS RYLFSHLNDF SACQEIRDLL
160 170 180 190 200
EELSQVLHED GPAAEKEGTV LRICSHVAGI CHNILVCCPK ELLEQKAVLE
210 220 230 240 250
QVQLDSPLGL EIHTTSNCQH FVSQVDTQVP TDSRLQIQPG DEVVQINEQV
260 270 280 290 300
VVGWPRKNMV RELLREPAGL SLVLKKIPIP ETPPQTPPQV LDSPHQRSPS
310 320 330 340 350
LSLAPLSPRA PSEDVFAFDL SSNPSPGPSP AWTDSASLGP EPLPIPPEPP
360 370 380 390 400
AILPAGVAGT PGLPESPDKS PVGRKKSKGL ATRLSRRRVS CRELGRPDCD
410 420 430 440 450
GWLLLRKAPG GFMGPRWRRR WFVLKGHTLY WYRQPQDEKA EGLINVSNYS
460 470 480 490 500
LESGHDQKKK YVFQLTHDVY KPFIFAADTL TDLSMWVRHL ITCISKYQSP
510 520 530 540 550
GRAPPPREED CYSETEAEDP DDEAGSHSAS PSPAQAGSPL HGDTSPAATP
560 570 580 590 600
TQRSPRTSFG SLTDSSEEAL EGMVRGLRQG GVSLLGQPQP LTQEQWRSSF
610 620 630 640 650
MRRNRDPQLN ERVHRVRALQ STLKAKLQEL QVLEEVLGDP ELTGEKFRQW
660 670 680 690 700
KEQNRELYSE GLGAWGVAQA EGSSHILTSD STEQSPHSLP SDPEEHSHLC
710
PLTSESSLRP PDL
Length:713
Mass (Da):78,790
Last modified:February 5, 2008 - v1
Checksum:iBF7383CCDA911E7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222904 mRNA. Translation: BAD96624.1.
CH471059 Genomic DNA. Translation: EAX07841.1.
RefSeqiNP_006305.2. NM_006314.2.
UniGeneiHs.16232.

Genome annotation databases

GeneIDi10256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222904 mRNA. Translation: BAD96624.1.
CH471059 Genomic DNA. Translation: EAX07841.1.
RefSeqiNP_006305.2. NM_006314.2.
UniGeneiHs.16232.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354609.

Protocols and materials databases

DNASUi10256.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10256.

Organism-specific databases

CTDi10256.
PharmGKBiPA134901167.

Phylogenomic databases

eggNOGiKOG1738. Eukaryota.
ENOG41104C7. LUCA.
HOVERGENiHBG051039.

Miscellaneous databases

ChiTaRSiCNKSR1. human.
GenomeRNAii10256.

Gene expression databases

BgeeiENSG00000142675.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR017874. CRIC_domain.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF10534. CRIC_ras_sig. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51290. CRIC. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53GM7_HUMAN
AccessioniPrimary (citable) accession number: Q53GM7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.