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Protein
Submitted name:

Connector enhancer of kinase suppressor of Ras 1 variant

Gene

CNKSR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Connector enhancer of kinase suppressor of Ras 1 variantImported
Submitted name:
Connector enhancer of kinase suppressor of Ras 1, isoform CRA_bImported
Gene namesi
Name:CNKSR1Imported
ORF Names:hCG_40691Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000142675.17

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901167

Expressioni

Gene expression databases

BgeeiENSG00000142675
ExpressionAtlasiQ53GM7 baseline and differential

Structurei

3D structure databases

SMRiQ53GM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 70SAMInterPro annotationAdd BLAST64
Domaini78 – 164CRICInterPro annotationAdd BLAST87
Domaini196 – 278PDZInterPro annotationAdd BLAST83
Domaini396 – 495PHInterPro annotationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili616 – 636Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1738 Eukaryota
ENOG41104C7 LUCA
HOVERGENiHBG051039

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR017874 CRIC_domain
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF10534 CRIC_ras_sig, 1 hit
PF00169 PH, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51290 CRIC, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Fragment.

Q53GM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVETWTPG KVATWLRGLD DSLQDYPFED WQLPGKNLLQ LCPQSLEALA
60 70 80 90 100
VRSLGHQELI LGGVEQLQAL SSRLQTENLQ SLTEGLLGAT HDFQSIVQGC
110 120 130 140 150
LGDCAKTPID VLCAAVELLH EADALLFWLS RYLFSHLNDF SACQEIRDLL
160 170 180 190 200
EELSQVLHED GPAAEKEGTV LRICSHVAGI CHNILVCCPK ELLEQKAVLE
210 220 230 240 250
QVQLDSPLGL EIHTTSNCQH FVSQVDTQVP TDSRLQIQPG DEVVQINEQV
260 270 280 290 300
VVGWPRKNMV RELLREPAGL SLVLKKIPIP ETPPQTPPQV LDSPHQRSPS
310 320 330 340 350
LSLAPLSPRA PSEDVFAFDL SSNPSPGPSP AWTDSASLGP EPLPIPPEPP
360 370 380 390 400
AILPAGVAGT PGLPESPDKS PVGRKKSKGL ATRLSRRRVS CRELGRPDCD
410 420 430 440 450
GWLLLRKAPG GFMGPRWRRR WFVLKGHTLY WYRQPQDEKA EGLINVSNYS
460 470 480 490 500
LESGHDQKKK YVFQLTHDVY KPFIFAADTL TDLSMWVRHL ITCISKYQSP
510 520 530 540 550
GRAPPPREED CYSETEAEDP DDEAGSHSAS PSPAQAGSPL HGDTSPAATP
560 570 580 590 600
TQRSPRTSFG SLTDSSEEAL EGMVRGLRQG GVSLLGQPQP LTQEQWRSSF
610 620 630 640 650
MRRNRDPQLN ERVHRVRALQ STLKAKLQEL QVLEEVLGDP ELTGEKFRQW
660 670 680 690 700
KEQNRELYSE GLGAWGVAQA EGSSHILTSD STEQSPHSLP SDPEEHSHLC
710
PLTSESSLRP PDL
Length:713
Mass (Da):78,790
Last modified:February 5, 2008 - v1
Checksum:iBF7383CCDA911E7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222904 mRNA Translation: BAD96624.1
CH471059 Genomic DNA Translation: EAX07841.1
RefSeqiNP_006305.2, NM_006314.2
UniGeneiHs.16232

Genome annotation databases

GeneIDi10256

Similar proteinsi

Entry informationi

Entry nameiQ53GM7_HUMAN
AccessioniPrimary (citable) accession number: Q53GM7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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