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Protein

Poly [ADP-ribose] polymerase 10

Gene

PARP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.2 Publications

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

  • K63-linked polyubiquitin binding Source: UniProtKB
  • NAD+ ADP-ribosyltransferase activity Source: UniProtKB

GO - Biological processi

  • negative regulation of fibroblast proliferation Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of protein import into nucleus, translocation Source: UniProtKB
  • negative regulation of protein K63-linked ubiquitination Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • protein ADP-ribosylation Source: UniProtKB
  • protein auto-ADP-ribosylation Source: UniProtKB
  • protein poly-ADP-ribosylation Source: UniProtKB
  • regulation of chromatin assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciZFISH:HS17104-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 10 (EC:2.4.2.30)
Short name:
PARP-10
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 10
Short name:
ARTD10
Gene namesi
Name:PARP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25895. PARP10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: HPA
  • nucleolus Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178685.
PharmGKBiPA134892853.

Chemistry databases

ChEMBLiCHEMBL2429708.

Polymorphism and mutation databases

BioMutaiPARP10.
DMDMi116248563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524351 – 1025Poly [ADP-ribose] polymerase 10Add BLAST1025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101Phosphothreonine1 Publication1
Modified residuei378PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei663PhosphoserineCombined sources1
Modified residuei916N6-acetyllysineCombined sources1
Modified residuei1011PhosphoserineCombined sources1

Post-translational modificationi

Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ53GL7.
MaxQBiQ53GL7.
PaxDbiQ53GL7.
PeptideAtlasiQ53GL7.
PRIDEiQ53GL7.

PTM databases

iPTMnetiQ53GL7.
PhosphoSitePlusiQ53GL7.

Expressioni

Tissue specificityi

Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.1 Publication

Gene expression databases

BgeeiENSG00000178685.
CleanExiHS_PARP10.
ExpressionAtlasiQ53GL7. baseline and differential.
GenevisibleiQ53GL7. HS.

Organism-specific databases

HPAiHPA028122.

Interactioni

Subunit structurei

Interacts with MYC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
OARD1Q9Y5303EBI-2857573,EBI-8502288

GO - Molecular functioni

  • K63-linked polyubiquitin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124320. 17 interactors.
IntActiQ53GL7. 4 interactors.
MINTiMINT-8408778.
STRINGi9606.ENSP00000325618.

Chemistry databases

BindingDBiQ53GL7.

Structurei

Secondary structure

11025
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 17Combined sources6
Helixi24 – 32Combined sources9
Turni34 – 37Combined sources4
Beta strandi43 – 48Combined sources6
Beta strandi51 – 55Combined sources5
Helixi59 – 66Combined sources8
Beta strandi72 – 77Combined sources6
Beta strandi79 – 82Combined sources4
Beta strandi820 – 822Combined sources3
Beta strandi825 – 827Combined sources3
Helixi828 – 839Combined sources12
Helixi842 – 846Combined sources5
Beta strandi848 – 856Combined sources9
Helixi859 – 875Combined sources17
Beta strandi881 – 889Combined sources9
Helixi891 – 893Combined sources3
Helixi894 – 900Combined sources7
Turni904 – 906Combined sources3
Beta strandi916 – 923Combined sources8
Helixi924 – 927Combined sources4
Turni930 – 932Combined sources3
Beta strandi939 – 949Combined sources11
Beta strandi952 – 955Combined sources4
Beta strandi961 – 963Combined sources3
Beta strandi971 – 974Combined sources4
Beta strandi976 – 980Combined sources5
Beta strandi982 – 984Combined sources3
Beta strandi987 – 990Combined sources4
Beta strandi995 – 1006Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DHXNMR-A10-100[»]
3HKVX-ray2.10A/B809-1017[»]
ProteinModelPortaliQ53GL7.
SMRiQ53GL7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53GL7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini806 – 1025PARP catalyticPROSITE-ProRule annotationAdd BLAST220

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni700 – 907Myc bindingAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi650 – 667Ubiquitin-interactingAdd BLAST18
Motifi673 – 690Ubiquitin-interactingAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 193Poly-Leu8
Compositional biasi588 – 697Glu-richAdd BLAST110

Sequence similaritiesi

Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH3S. Eukaryota.
ENOG411034Y. LUCA.
GeneTreeiENSGT00760000119084.
HOVERGENiHBG068843.
InParanoidiQ53GL7.
KOiK15261.
PhylomeDBiQ53GL7.
TreeFamiTF328965.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53GL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAMAEAEAG VAVEVRGLPP AVPDELLTLY FENRRRSGGG PVLSWQRLGC
60 70 80 90 100
GGVLTFREPA DAERVLAQAD HELHGAQLSL RPAPPRAPAR LLLQGLPPGT
110 120 130 140 150
TPQRLEQHVQ ALLRASGLPV QPCCALASPR PDRALVQLPK PLSEADVRVL
160 170 180 190 200
EEQAQNLGLE GTLVSLARVP QARAVRVVGD GASVDLLLLE LYLENERRSG
210 220 230 240 250
GGPLEDLQRL PGPLGTVASF QQWQVAERVL QQEHRLQGSE LSLVPHYDIL
260 270 280 290 300
EPEELAENTS GGDHPSTQGP RATKHALLRT GGLVTALQGA GTVTMGSGEE
310 320 330 340 350
PGQSGASLRT GPMVQGRGIM TTGSGQEPGQ SGTSLRTGPM GSLGQAEQVS
360 370 380 390 400
SMPMGSLEHE GLVSLRPVGL QEQEGPMSLG PVGSAGPVET SKGLLGQEGL
410 420 430 440 450
VEIAMDSPEQ EGLVGPMEIT MGSLEKAGPV SPGCVKLAGQ EGLVEMVLLM
460 470 480 490 500
EPGAMRFLQL YHEDLLAGLG DVALLPLEGP DMTGFRLCGA QASCQAAEEF
510 520 530 540 550
LRSLLGSISC HVLCLEHPGS ARFLLGPEGQ HLLQGLEAQF QCVFGTERLA
560 570 580 590 600
TATLDTGLEE VDPTEALPVL PGNAHTLWTP DSTGGDQEDV SLEEVRELLA
610 620 630 640 650
TLEGLDLDGE DWLPRELEEE GPQEQPEEEV TPGHEEEEPV APSTVAPRWL
660 670 680 690 700
EEEAALQLAL HRSLEPQGQV AEQEEAAALR QALTLSLLEQ PPLEAEEPPD
710 720 730 740 750
GGTDGKAQLV VHSAFEQDVE ELDRALRAAL EVHVQEETVG PWRRTLPAEL
760 770 780 790 800
RARLERCHGV SVALRGDCTI LRGFGAHPAR AARHLVALLA GPWDQSLAFP
810 820 830 840 850
LAASGPTLAG QTLKGPWNNL ERLAENTGEF QEVVRAFYDT LDAARSSIRV
860 870 880 890 900
VRVERVSHPL LQQQYELYRE RLLQRCERRP VEQVLYHGTT APAVPDICAH
910 920 930 940 950
GFNRSFCGRN ATVYGKGVYF ARRASLSVQD RYSPPNADGH KAVFVARVLT
960 970 980 990 1000
GDYGQGRRGL RAPPLRGPGH VLLRYDSAVD CICQPSIFVI FHDTQALPTH
1010 1020
LITCEHVPRA SPDDPSGLPG RSPDT
Length:1,025
Mass (Da):109,998
Last modified:October 17, 2006 - v2
Checksum:iAC9CCFCF9B83A989
GO

Sequence cautioni

The sequence BAC11498 differs from that shown. Reason: Frameshift at position 965.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313M → I in BAB55067 (PubMed:14702039).Curated1
Sequence conflicti518P → S in BAB55067 (PubMed:14702039).Curated1
Sequence conflicti813L → P in AAH14229 (PubMed:15489334).Curated1
Sequence conflicti922R → K in BAB55067 (PubMed:14702039).Curated1
Sequence conflicti1013D → G in BAD96634 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027859249I → V.Corresponds to variant rs11136344dbSNPEnsembl.1
Natural variantiVAR_027860395L → P.Corresponds to variant rs11136343dbSNPEnsembl.1
Natural variantiVAR_027861630V → A.1 PublicationCorresponds to variant rs11544989dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027370 mRNA. Translation: BAB55067.1.
AK075250 mRNA. Translation: BAC11498.1. Sequence problems.
AK222914 mRNA. Translation: BAD96634.1.
BC014229 mRNA. Translation: AAH14229.2.
BC019030 mRNA. Translation: AAH19030.2.
CCDSiCCDS34960.1.
RefSeqiNP_116178.2. NM_032789.4.
UniGeneiHs.348609.

Genome annotation databases

EnsembliENST00000313028; ENSP00000325618; ENSG00000178685.
GeneIDi84875.
KEGGihsa:84875.
UCSCiuc003zal.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027370 mRNA. Translation: BAB55067.1.
AK075250 mRNA. Translation: BAC11498.1. Sequence problems.
AK222914 mRNA. Translation: BAD96634.1.
BC014229 mRNA. Translation: AAH14229.2.
BC019030 mRNA. Translation: AAH19030.2.
CCDSiCCDS34960.1.
RefSeqiNP_116178.2. NM_032789.4.
UniGeneiHs.348609.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DHXNMR-A10-100[»]
3HKVX-ray2.10A/B809-1017[»]
ProteinModelPortaliQ53GL7.
SMRiQ53GL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124320. 17 interactors.
IntActiQ53GL7. 4 interactors.
MINTiMINT-8408778.
STRINGi9606.ENSP00000325618.

Chemistry databases

BindingDBiQ53GL7.
ChEMBLiCHEMBL2429708.

PTM databases

iPTMnetiQ53GL7.
PhosphoSitePlusiQ53GL7.

Polymorphism and mutation databases

BioMutaiPARP10.
DMDMi116248563.

Proteomic databases

EPDiQ53GL7.
MaxQBiQ53GL7.
PaxDbiQ53GL7.
PeptideAtlasiQ53GL7.
PRIDEiQ53GL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313028; ENSP00000325618; ENSG00000178685.
GeneIDi84875.
KEGGihsa:84875.
UCSCiuc003zal.5. human.

Organism-specific databases

CTDi84875.
GeneCardsiPARP10.
H-InvDBHIX0201285.
HGNCiHGNC:25895. PARP10.
HPAiHPA028122.
MIMi609564. gene.
neXtProtiNX_Q53GL7.
OpenTargetsiENSG00000178685.
PharmGKBiPA134892853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3S. Eukaryota.
ENOG411034Y. LUCA.
GeneTreeiENSGT00760000119084.
HOVERGENiHBG068843.
InParanoidiQ53GL7.
KOiK15261.
PhylomeDBiQ53GL7.
TreeFamiTF328965.

Enzyme and pathway databases

BioCyciZFISH:HS17104-MONOMER.

Miscellaneous databases

ChiTaRSiPARP10. human.
EvolutionaryTraceiQ53GL7.
GeneWikiiPARP10.
GenomeRNAii84875.
PROiQ53GL7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178685.
CleanExiHS_PARP10.
ExpressionAtlasiQ53GL7. baseline and differential.
GenevisibleiQ53GL7. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR10_HUMAN
AccessioniPrimary (citable) accession number: Q53GL7
Secondary accession number(s): Q8N2I0
, Q8WV05, Q96CH7, Q96K72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.