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Q53GL7

- PAR10_HUMAN

UniProt

Q53GL7 - PAR10_HUMAN

Protein

Poly [ADP-ribose] polymerase 10

Gene

PARP10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.2 Publications

    Catalytic activityi

    NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. K63-linked polyubiquitin binding Source: UniProt
    2. NAD+ ADP-ribosyltransferase activity Source: UniProt
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of fibroblast proliferation Source: UniProtKB
    2. negative regulation of gene expression Source: UniProt
    3. negative regulation of NF-kappaB transcription factor activity Source: UniProt
    4. negative regulation of protein import into nucleus, translocation Source: UniProt
    5. negative regulation of protein K63-linked ubiquitination Source: UniProt
    6. negative regulation of viral genome replication Source: UniProt
    7. protein ADP-ribosylation Source: UniProt
    8. protein auto-ADP-ribosylation Source: UniProt
    9. protein poly-ADP-ribosylation Source: UniProtKB
    10. regulation of chromatin assembly Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly [ADP-ribose] polymerase 10 (EC:2.4.2.30)
    Short name:
    PARP-10
    Alternative name(s):
    ADP-ribosyltransferase diphtheria toxin-like 10
    Short name:
    ARTD10
    Gene namesi
    Name:PARP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:25895. PARP10.

    Subcellular locationi

    Nucleusnucleolus 1 Publication. Cytoplasm 1 Publication
    Note: Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. Golgi apparatus Source: HPA
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134892853.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10251025Poly [ADP-ribose] polymerase 10PRO_0000252435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei101 – 1011Phosphothreonine1 Publication
    Modified residuei916 – 9161N6-acetyllysine1 Publication

    Post-translational modificationi

    Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ53GL7.
    PaxDbiQ53GL7.
    PRIDEiQ53GL7.

    PTM databases

    PhosphoSiteiQ53GL7.

    Expressioni

    Tissue specificityi

    Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.1 Publication

    Gene expression databases

    ArrayExpressiQ53GL7.
    BgeeiQ53GL7.
    CleanExiHS_PARP10.
    GenevestigatoriQ53GL7.

    Organism-specific databases

    HPAiHPA028122.

    Interactioni

    Subunit structurei

    Interacts with MYC.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    OARD1Q9Y5303EBI-2857573,EBI-8502288

    Protein-protein interaction databases

    BioGridi124320. 9 interactions.
    IntActiQ53GL7. 4 interactions.
    MINTiMINT-8408778.
    STRINGi9606.ENSP00000325618.

    Structurei

    Secondary structure

    1
    1025
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi12 – 176
    Helixi24 – 329
    Turni34 – 374
    Beta strandi43 – 486
    Beta strandi51 – 555
    Helixi59 – 668
    Beta strandi72 – 776
    Beta strandi79 – 824
    Beta strandi820 – 8223
    Beta strandi825 – 8273
    Helixi828 – 83912
    Helixi842 – 8465
    Beta strandi848 – 8569
    Helixi859 – 87517
    Beta strandi881 – 8899
    Helixi891 – 8933
    Helixi894 – 9007
    Turni904 – 9063
    Beta strandi916 – 9238
    Helixi924 – 9274
    Turni930 – 9323
    Beta strandi939 – 94911
    Beta strandi952 – 9554
    Beta strandi961 – 9633
    Beta strandi971 – 9744
    Beta strandi976 – 9805
    Beta strandi982 – 9843
    Beta strandi987 – 9904
    Beta strandi995 – 100612

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DHXNMR-A10-100[»]
    3HKVX-ray2.10A/B809-1017[»]
    ProteinModelPortaliQ53GL7.
    SMRiQ53GL7. Positions 11-101, 817-1008.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ53GL7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini806 – 1025220PARP catalyticPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni700 – 907208Myc bindingAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi650 – 66718Ubiquitin-interactingAdd
    BLAST
    Motifi673 – 69018Ubiquitin-interactingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi186 – 1938Poly-Leu
    Compositional biasi588 – 697110Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG42948.
    HOVERGENiHBG068843.
    InParanoidiQ53GL7.
    KOiK15261.
    PhylomeDBiQ53GL7.
    TreeFamiTF328965.

    Family and domain databases

    Gene3Di3.90.228.10. 1 hit.
    InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view]
    PfamiPF00644. PARP. 1 hit.
    [Graphical view]
    SMARTiSM00726. UIM. 3 hits.
    [Graphical view]
    PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q53GL7-1 [UniParc]FASTAAdd to Basket

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    MVAMAEAEAG VAVEVRGLPP AVPDELLTLY FENRRRSGGG PVLSWQRLGC     50
    GGVLTFREPA DAERVLAQAD HELHGAQLSL RPAPPRAPAR LLLQGLPPGT 100
    TPQRLEQHVQ ALLRASGLPV QPCCALASPR PDRALVQLPK PLSEADVRVL 150
    EEQAQNLGLE GTLVSLARVP QARAVRVVGD GASVDLLLLE LYLENERRSG 200
    GGPLEDLQRL PGPLGTVASF QQWQVAERVL QQEHRLQGSE LSLVPHYDIL 250
    EPEELAENTS GGDHPSTQGP RATKHALLRT GGLVTALQGA GTVTMGSGEE 300
    PGQSGASLRT GPMVQGRGIM TTGSGQEPGQ SGTSLRTGPM GSLGQAEQVS 350
    SMPMGSLEHE GLVSLRPVGL QEQEGPMSLG PVGSAGPVET SKGLLGQEGL 400
    VEIAMDSPEQ EGLVGPMEIT MGSLEKAGPV SPGCVKLAGQ EGLVEMVLLM 450
    EPGAMRFLQL YHEDLLAGLG DVALLPLEGP DMTGFRLCGA QASCQAAEEF 500
    LRSLLGSISC HVLCLEHPGS ARFLLGPEGQ HLLQGLEAQF QCVFGTERLA 550
    TATLDTGLEE VDPTEALPVL PGNAHTLWTP DSTGGDQEDV SLEEVRELLA 600
    TLEGLDLDGE DWLPRELEEE GPQEQPEEEV TPGHEEEEPV APSTVAPRWL 650
    EEEAALQLAL HRSLEPQGQV AEQEEAAALR QALTLSLLEQ PPLEAEEPPD 700
    GGTDGKAQLV VHSAFEQDVE ELDRALRAAL EVHVQEETVG PWRRTLPAEL 750
    RARLERCHGV SVALRGDCTI LRGFGAHPAR AARHLVALLA GPWDQSLAFP 800
    LAASGPTLAG QTLKGPWNNL ERLAENTGEF QEVVRAFYDT LDAARSSIRV 850
    VRVERVSHPL LQQQYELYRE RLLQRCERRP VEQVLYHGTT APAVPDICAH 900
    GFNRSFCGRN ATVYGKGVYF ARRASLSVQD RYSPPNADGH KAVFVARVLT 950
    GDYGQGRRGL RAPPLRGPGH VLLRYDSAVD CICQPSIFVI FHDTQALPTH 1000
    LITCEHVPRA SPDDPSGLPG RSPDT 1025
    Length:1,025
    Mass (Da):109,998
    Last modified:October 17, 2006 - v2
    Checksum:iAC9CCFCF9B83A989
    GO

    Sequence cautioni

    The sequence BAC11498.1 differs from that shown. Reason: Frameshift at position 965.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131M → I in BAB55067. (PubMed:14702039)Curated
    Sequence conflicti518 – 5181P → S in BAB55067. (PubMed:14702039)Curated
    Sequence conflicti813 – 8131L → P in AAH14229. (PubMed:15489334)Curated
    Sequence conflicti922 – 9221R → K in BAB55067. (PubMed:14702039)Curated
    Sequence conflicti1013 – 10131D → G in BAD96634. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491I → V.
    Corresponds to variant rs11136344 [ dbSNP | Ensembl ].
    VAR_027859
    Natural varianti395 – 3951L → P.
    Corresponds to variant rs11136343 [ dbSNP | Ensembl ].
    VAR_027860
    Natural varianti630 – 6301V → A.1 Publication
    Corresponds to variant rs11544989 [ dbSNP | Ensembl ].
    VAR_027861

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027370 mRNA. Translation: BAB55067.1.
    AK075250 mRNA. Translation: BAC11498.1. Sequence problems.
    AK222914 mRNA. Translation: BAD96634.1.
    BC014229 mRNA. Translation: AAH14229.2.
    BC019030 mRNA. Translation: AAH19030.2.
    CCDSiCCDS34960.1.
    RefSeqiNP_116178.2. NM_032789.3.
    UniGeneiHs.348609.

    Genome annotation databases

    EnsembliENST00000313028; ENSP00000325618; ENSG00000178685.
    GeneIDi84875.
    KEGGihsa:84875.
    UCSCiuc003zal.4. human.

    Polymorphism databases

    DMDMi116248563.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027370 mRNA. Translation: BAB55067.1 .
    AK075250 mRNA. Translation: BAC11498.1 . Sequence problems.
    AK222914 mRNA. Translation: BAD96634.1 .
    BC014229 mRNA. Translation: AAH14229.2 .
    BC019030 mRNA. Translation: AAH19030.2 .
    CCDSi CCDS34960.1.
    RefSeqi NP_116178.2. NM_032789.3.
    UniGenei Hs.348609.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DHX NMR - A 10-100 [» ]
    3HKV X-ray 2.10 A/B 809-1017 [» ]
    ProteinModelPortali Q53GL7.
    SMRi Q53GL7. Positions 11-101, 817-1008.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124320. 9 interactions.
    IntActi Q53GL7. 4 interactions.
    MINTi MINT-8408778.
    STRINGi 9606.ENSP00000325618.

    Chemistry

    ChEMBLi CHEMBL2429708.

    PTM databases

    PhosphoSitei Q53GL7.

    Polymorphism databases

    DMDMi 116248563.

    Proteomic databases

    MaxQBi Q53GL7.
    PaxDbi Q53GL7.
    PRIDEi Q53GL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313028 ; ENSP00000325618 ; ENSG00000178685 .
    GeneIDi 84875.
    KEGGi hsa:84875.
    UCSCi uc003zal.4. human.

    Organism-specific databases

    CTDi 84875.
    GeneCardsi GC08M145051.
    H-InvDB HIX0201285.
    HGNCi HGNC:25895. PARP10.
    HPAi HPA028122.
    MIMi 609564. gene.
    neXtProti NX_Q53GL7.
    PharmGKBi PA134892853.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42948.
    HOVERGENi HBG068843.
    InParanoidi Q53GL7.
    KOi K15261.
    PhylomeDBi Q53GL7.
    TreeFami TF328965.

    Miscellaneous databases

    EvolutionaryTracei Q53GL7.
    GeneWikii PARP10.
    GenomeRNAii 84875.
    NextBioi 75175.
    PROi Q53GL7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q53GL7.
    Bgeei Q53GL7.
    CleanExi HS_PARP10.
    Genevestigatori Q53GL7.

    Family and domain databases

    Gene3Di 3.90.228.10. 1 hit.
    InterProi IPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view ]
    Pfami PF00644. PARP. 1 hit.
    [Graphical view ]
    SMARTi SM00726. UIM. 3 hits.
    [Graphical view ]
    PROSITEi PS51059. PARP_CATALYTIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-630.
      Tissue: Mammary gland and Thyroid.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 357-1025.
      Tissue: Skin and Uterus.
    4. Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH MYC.
    5. "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10)."
      Chou H.Y., Chou H.T., Lee S.C.
      J. Biol. Chem. 281:15201-15207(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT THR-101.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-916, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
      Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
      Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    8. "Solution structure of the RRM domain in the human poly (ADP-ribose) polymerase family, member 10 variant."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 7-101.
    9. "Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide."
      Structural genomics consortium (SGC)
      Submitted (JUN-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 809-1017.

    Entry informationi

    Entry nameiPAR10_HUMAN
    AccessioniPrimary (citable) accession number: Q53GL7
    Secondary accession number(s): Q8N2I0
    , Q8WV05, Q96CH7, Q96K72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3