Q53GL7 (PAR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 68.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Poly [ADP-ribose] polymerase 10 Short name=PARP-10 EC=2.4.2.30 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1025 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. Ref.4 Ref.5 |
| Catalytic activity | NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. |
| Subunit structure | Interacts with MYC. Ref.4 |
| Subcellular location | Nucleus › nucleolus. Cytoplasm. Note: Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase. Ref.4 |
| Tissue specificity | Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon. Ref.4 |
| Post-translational modification | Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. |
| Sequence similarities | Contains 1 PARP catalytic domain. |
| Sequence caution | The sequence BAC11498.1 differs from that shown. Reason: Frameshift at position 965. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Polymorphism |
| Ligand | NAD |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | Golgi apparatus Inferred from direct assay. Source: HPA nucleolusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1025 | 1025 | Poly [ADP-ribose] polymerase 10 | PRO_0000252435 | |||||||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||||||
| Domain | 806 – 1025 | 220 | PARP catalytic | ||||||||||||||||||||||||||||||||||||||||
| Region | 700 – 907 | 208 | Myc binding | ||||||||||||||||||||||||||||||||||||||||
| Motif | 650 – 667 | 18 | Ubiquitin-interacting | ||||||||||||||||||||||||||||||||||||||||
| Motif | 673 – 690 | 18 | Ubiquitin-interacting | ||||||||||||||||||||||||||||||||||||||||
| Compositional bias | 186 – 193 | 8 | Poly-Leu | ||||||||||||||||||||||||||||||||||||||||
| Compositional bias | 588 – 697 | 110 | Glu-rich | ||||||||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 101 | 1 | Phosphothreonine Ref.5 | ||||||||||||||||||||||||||||||||||||||||
| Modified residue | 916 | 1 | N6-acetyllysine Ref.6 | ||||||||||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 249 | 1 | I → V. Corresponds to variant rs11136344 [ dbSNP | Ensembl ]. | VAR_027859 | |||||||||||||||||||||||||||||||||||||||
| Natural variant | 395 | 1 | L → P. Corresponds to variant rs11136343 [ dbSNP | Ensembl ]. | VAR_027860 | |||||||||||||||||||||||||||||||||||||||
| Natural variant | 630 | 1 | V → A. Ref.3 Corresponds to variant rs11544989 [ dbSNP | Ensembl ]. | VAR_027861 | |||||||||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 813 | 1 | L → P in AAH14229. Ref.2 | ||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 1013 | 1 | D → G in BAD96634. Ref.1 | ||||||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 820 – 822 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Helix | 830 – 839 | 10 | |||||||||||||||||||||||||||||||||||||||||
| Helix | 842 – 846 | 5 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 848 – 856 | 9 | |||||||||||||||||||||||||||||||||||||||||
| Helix | 859 – 875 | 17 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 881 – 887 | 7 | |||||||||||||||||||||||||||||||||||||||||
| Helix | 891 – 893 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Helix | 894 – 899 | 6 | |||||||||||||||||||||||||||||||||||||||||
| Turn | 904 – 906 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 919 – 923 | 5 | |||||||||||||||||||||||||||||||||||||||||
| Helix | 924 – 927 | 4 | |||||||||||||||||||||||||||||||||||||||||
| Turn | 930 – 932 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 941 – 949 | 9 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 972 – 974 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 978 – 980 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 982 – 984 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 987 – 989 | 3 | |||||||||||||||||||||||||||||||||||||||||
| Beta strand | 995 – 1006 | 12 | |||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 357-1025. Tissue: Skin and Uterus. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-1025, VARIANT ALA-630. Tissue: Thyroid. |
| [4] | "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation." Yu M., Schreek S., Cerni C., Schamberger C., Lesniewicz K., Poreba E., Vervoorts J., Walsemann G., Groetzinger J., Kremmer E., Mehraein Y., Mertsching J., Kraft R., Austen M., Luescher-Firzlaff J., Luescher B. Oncogene 24:1982-1993(2005) [PubMed: 15674325] [Abstract] Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH MYC. |
| [5] | "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10)." Chou H.Y., Chou H.T., Lee S.C. J. Biol. Chem. 281:15201-15207(2006) [PubMed: 16455663] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION AT THR-101. |
| [6] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-916, MASS SPECTROMETRY. |
| [7] | "Solution structure of the RRM domain in the human poly (ADP-ribose) polymerase family, member 10 variant." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 7-101. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AK222914 mRNA. Translation: BAD96634.1. BC014229 mRNA. Translation: AAH14229.2. BC019030 mRNA. Translation: AAH19030.2. AK075250 mRNA. Translation: BAC11498.1. Sequence problems. | ||||||||||||||||||
| IPI | IPI00064457. | ||||||||||||||||||
| RefSeq | NP_116178.2. NM_032789.3. | ||||||||||||||||||
| UniGene | Hs.348609. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| ProteinModelPortal | Q53GL7. | ||||||||||||||||||
| SMR | Q53GL7. Positions 11-101, 817-1008. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| STRING | Q53GL7. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q53GL7. | ||||||||||||||||||
Polymorphism databases | |||||||||||||||||||
| DMDM | 116248563. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q53GL7. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000313028; ENSP00000325618; ENSG00000178685. | ||||||||||||||||||
| GeneID | 84875. | ||||||||||||||||||
| KEGG | hsa:84875. | ||||||||||||||||||
| UCSC | uc003zak.2. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 84875. | ||||||||||||||||||
| GeneCards | GC08M145051. | ||||||||||||||||||
| H-InvDB | HIX0201285. | ||||||||||||||||||
| HGNC | HGNC:25895. PARP10. | ||||||||||||||||||
| HPA | HPA028122. | ||||||||||||||||||
| MIM | 609564. gene. | ||||||||||||||||||
| neXtProt | NX_Q53GL7. | ||||||||||||||||||
| PharmGKB | PA134892853. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOVERGEN | HBG068843. | ||||||||||||||||||
| InParanoid | Q53GL7. | ||||||||||||||||||
| OMA | YFAKRAS. | ||||||||||||||||||
| OrthoDB | EOG4JWVD9. | ||||||||||||||||||
| PhylomeDB | Q53GL7. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q53GL7. | ||||||||||||||||||
| Bgee | Q53GL7. | ||||||||||||||||||
| CleanEx | HS_PARP10. | ||||||||||||||||||
| Genevestigator | Q53GL7. | ||||||||||||||||||
| GermOnline | ENSG00000178685. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR012677. Nucleotide-bd_a/b_plait. IPR012317. Poly(ADP-ribose)pol_cat_dom. IPR003903. Ubiquitin-int_motif. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. | ||||||||||||||||||
| KO | K15261. | ||||||||||||||||||
| Pfam | PF00644. PARP. 1 hit. [Graphical view] | ||||||||||||||||||
| SMART | SM00726. UIM. 3 hits. [Graphical view] | ||||||||||||||||||
| PROSITE | PS51059. PARP_CATALYTIC. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| NextBio | 75175. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | PAR10_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q53GL7 Secondary accession number(s): Q8N2I0, Q8WV05, Q96CH7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with