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Protein

Zinc finger protein 394

Gene

ZNF394

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri358 – 380C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 463C2H2-type 4PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri469 – 491C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 394
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 14
Gene namesi
Name:ZNF394
Synonyms:ZKSCAN14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000160908.14.
HGNCiHGNC:18832. ZNF394.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160908.
PharmGKBiPA38702.

Polymorphism and mutation databases

BioMutaiZNF394.
DMDMi81175102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475571 – 561Zinc finger protein 394Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki282Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki443Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ53GI3.
PaxDbiQ53GI3.
PeptideAtlasiQ53GI3.
PRIDEiQ53GI3.

PTM databases

iPTMnetiQ53GI3.
PhosphoSitePlusiQ53GI3.

Expressioni

Gene expression databases

BgeeiENSG00000160908.
CleanExiHS_ZNF394.
GenevisibleiQ53GI3. HS.

Organism-specific databases

HPAiHPA051421.
HPA054639.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123898. 8 interactors.
IntActiQ53GI3. 5 interactors.
STRINGi9606.ENSP00000337363.

Structurei

3D structure databases

ProteinModelPortaliQ53GI3.
SMRiQ53GI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 146SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini155 – 230KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri358 – 380C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 463C2H2-type 4PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri469 – 491C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ53GI3.
KOiK09229.
OMAiCGETCHI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ53GI3.
TreeFamiTF337913.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53GI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSSLTAQRR GSDAELGPWV MAARSKDAAP SQRDGLLPVK VEEDSPGSWE
60 70 80 90 100
PNYPAASPDP ETSRLHFRQL RYQEVAGPEE ALSRLRELCR RWLRPELLSK
110 120 130 140 150
EQILELLVLE QFLTILPEEL QAWVREHCPE SGEEAVAVVR ALQRALDGTS
160 170 180 190 200
SQGMVTFEDT AVSLTWEEWE RLDPARRDFC RESAQKDSGS TVPPSLESRV
210 220 230 240 250
ENKELIPMQQ ILEEAEPQGQ LQEAFQGKRP LFSKCGSTHE DRVEKQSGDP
260 270 280 290 300
LPLKLENSPE AEGLNSISDV NKNGSIEGED SKNNELQNSA RCSNLVLCQH
310 320 330 340 350
IPKAERPTDS EEHGNKCKQS FHMVTWHVLK PHKSDSGDSF HHSSLFETQR
360 370 380 390 400
QLHEERPYKC GNCGKSFKQR SDLFRHQRIH TGEKPYGCQE CGKSFSQSAA
410 420 430 440 450
LTKHQRTHTG EKPYTCLKCG ERFRQNSHLN RHQSTHSRDK HFKCEECGET
460 470 480 490 500
CHISNLFRHQ RLHKGERPYK CEECEKSFKQ RSDLFKHHRI HTGEKPYGCS
510 520 530 540 550
VCGKRFNQSA TLIKHQRIHT GEKPYKCLEC GERFRQSTHL IRHQRIHQNK
560
VLSAGRGGSR L
Length:561
Mass (Da):64,256
Last modified:November 8, 2005 - v2
Checksum:iD92AE5E58DEDAAA5
GO
Isoform 2 (identifier: Q53GI3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-162: GMVTFEDTAV → VWKAEWRTKS
     163-561: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,401
Checksum:iD12A4B279BA4681F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → C in BAB14021 (PubMed:14702039).Curated1
Sequence conflicti21M → T in BAD96668 (Ref. 3) Curated1
Sequence conflicti127H → Y (PubMed:8065901).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052816325T → M. Corresponds to variant dbSNP:rs3735454Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056547153 – 162GMVTFEDTAV → VWKAEWRTKS in isoform 2. 1 Publication10
Alternative sequenceiVSP_056548163 – 561Missing in isoform 2. 1 PublicationAdd BLAST399

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY642122 mRNA. Translation: AAT67053.1.
AK022360 mRNA. Translation: BAB14021.1.
AK222948 mRNA. Translation: BAD96668.1.
AC073063 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23874.1.
CH471091 Genomic DNA. Translation: EAW76659.1.
BC017051 mRNA. Translation: AAH17051.1.
BC025241 mRNA. Translation: AAH25241.1.
BC051847 mRNA. Translation: AAH51847.1.
CCDSiCCDS5666.1. [Q53GI3-1]
RefSeqiNP_001332896.1. NM_001345967.1. [Q53GI3-3]
NP_115540.2. NM_032164.3. [Q53GI3-1]
UniGeneiHs.386324.

Genome annotation databases

EnsembliENST00000337673; ENSP00000337363; ENSG00000160908. [Q53GI3-1]
ENST00000426306; ENSP00000409565; ENSG00000160908. [Q53GI3-3]
GeneIDi84124.
KEGGihsa:84124.
UCSCiuc003uqs.4. human. [Q53GI3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN394_HUMAN
AccessioniPrimary (citable) accession number: Q53GI3
Secondary accession number(s): A4D281
, Q05DA6, Q6P5X9, Q8TB27, Q9HA37, Q9UD51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 22, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families