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Protein

Zinc finger protein 394

Gene

ZNF394

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri358 – 38023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46322C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 394
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 14
Gene namesi
Name:ZNF394
Synonyms:ZKSCAN14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18832. ZNF394.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38702.

Polymorphism and mutation databases

BioMutaiZNF394.
DMDMi81175102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Zinc finger protein 394PRO_0000047557Add
BLAST

Proteomic databases

MaxQBiQ53GI3.
PaxDbiQ53GI3.
PRIDEiQ53GI3.

PTM databases

iPTMnetiQ53GI3.
PhosphoSiteiQ53GI3.

Expressioni

Gene expression databases

BgeeiQ53GI3.
CleanExiHS_ZNF394.
GenevisibleiQ53GI3. HS.

Organism-specific databases

HPAiHPA051421.
HPA054639.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10211248,EBI-748961
CLK2P497603EBI-10211248,EBI-750020

Protein-protein interaction databases

BioGridi123898. 8 interactions.
IntActiQ53GI3. 2 interactions.
STRINGi9606.ENSP00000337363.

Structurei

3D structure databases

ProteinModelPortaliQ53GI3.
SMRiQ53GI3. Positions 56-147, 322-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 14683SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini155 – 23076KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri358 – 38023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46322C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ53GI3.
KOiK09229.
OMAiNKELIPM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ53GI3.
TreeFamiTF337913.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53GI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSSLTAQRR GSDAELGPWV MAARSKDAAP SQRDGLLPVK VEEDSPGSWE
60 70 80 90 100
PNYPAASPDP ETSRLHFRQL RYQEVAGPEE ALSRLRELCR RWLRPELLSK
110 120 130 140 150
EQILELLVLE QFLTILPEEL QAWVREHCPE SGEEAVAVVR ALQRALDGTS
160 170 180 190 200
SQGMVTFEDT AVSLTWEEWE RLDPARRDFC RESAQKDSGS TVPPSLESRV
210 220 230 240 250
ENKELIPMQQ ILEEAEPQGQ LQEAFQGKRP LFSKCGSTHE DRVEKQSGDP
260 270 280 290 300
LPLKLENSPE AEGLNSISDV NKNGSIEGED SKNNELQNSA RCSNLVLCQH
310 320 330 340 350
IPKAERPTDS EEHGNKCKQS FHMVTWHVLK PHKSDSGDSF HHSSLFETQR
360 370 380 390 400
QLHEERPYKC GNCGKSFKQR SDLFRHQRIH TGEKPYGCQE CGKSFSQSAA
410 420 430 440 450
LTKHQRTHTG EKPYTCLKCG ERFRQNSHLN RHQSTHSRDK HFKCEECGET
460 470 480 490 500
CHISNLFRHQ RLHKGERPYK CEECEKSFKQ RSDLFKHHRI HTGEKPYGCS
510 520 530 540 550
VCGKRFNQSA TLIKHQRIHT GEKPYKCLEC GERFRQSTHL IRHQRIHQNK
560
VLSAGRGGSR L
Length:561
Mass (Da):64,256
Last modified:November 8, 2005 - v2
Checksum:iD92AE5E58DEDAAA5
GO
Isoform 2 (identifier: Q53GI3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-162: GMVTFEDTAV → VWKAEWRTKS
     163-561: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,401
Checksum:iD12A4B279BA4681F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → C in BAB14021 (PubMed:14702039).Curated
Sequence conflicti21 – 211M → T in BAD96668 (Ref. 3) Curated
Sequence conflicti127 – 1271H → Y (PubMed:8065901).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti325 – 3251T → M.
Corresponds to variant rs3735454 [ dbSNP | Ensembl ].
VAR_052816

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei153 – 16210GMVTFEDTAV → VWKAEWRTKS in isoform 2. 1 PublicationVSP_056547
Alternative sequencei163 – 561399Missing in isoform 2. 1 PublicationVSP_056548Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY642122 mRNA. Translation: AAT67053.1.
AK022360 mRNA. Translation: BAB14021.1.
AK222948 mRNA. Translation: BAD96668.1.
AC073063 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23874.1.
CH471091 Genomic DNA. Translation: EAW76659.1.
BC017051 mRNA. Translation: AAH17051.1.
BC025241 mRNA. Translation: AAH25241.1.
BC051847 mRNA. Translation: AAH51847.1.
CCDSiCCDS5666.1. [Q53GI3-1]
RefSeqiNP_115540.2. NM_032164.2. [Q53GI3-1]
UniGeneiHs.386324.

Genome annotation databases

EnsembliENST00000337673; ENSP00000337363; ENSG00000160908. [Q53GI3-1]
ENST00000426306; ENSP00000409565; ENSG00000160908. [Q53GI3-3]
GeneIDi84124.
KEGGihsa:84124.
UCSCiuc003uqs.4. human. [Q53GI3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY642122 mRNA. Translation: AAT67053.1.
AK022360 mRNA. Translation: BAB14021.1.
AK222948 mRNA. Translation: BAD96668.1.
AC073063 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23874.1.
CH471091 Genomic DNA. Translation: EAW76659.1.
BC017051 mRNA. Translation: AAH17051.1.
BC025241 mRNA. Translation: AAH25241.1.
BC051847 mRNA. Translation: AAH51847.1.
CCDSiCCDS5666.1. [Q53GI3-1]
RefSeqiNP_115540.2. NM_032164.2. [Q53GI3-1]
UniGeneiHs.386324.

3D structure databases

ProteinModelPortaliQ53GI3.
SMRiQ53GI3. Positions 56-147, 322-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123898. 8 interactions.
IntActiQ53GI3. 2 interactions.
STRINGi9606.ENSP00000337363.

PTM databases

iPTMnetiQ53GI3.
PhosphoSiteiQ53GI3.

Polymorphism and mutation databases

BioMutaiZNF394.
DMDMi81175102.

Proteomic databases

MaxQBiQ53GI3.
PaxDbiQ53GI3.
PRIDEiQ53GI3.

Protocols and materials databases

DNASUi84124.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337673; ENSP00000337363; ENSG00000160908. [Q53GI3-1]
ENST00000426306; ENSP00000409565; ENSG00000160908. [Q53GI3-3]
GeneIDi84124.
KEGGihsa:84124.
UCSCiuc003uqs.4. human. [Q53GI3-1]

Organism-specific databases

CTDi84124.
GeneCardsiZNF394.
HGNCiHGNC:18832. ZNF394.
HPAiHPA051421.
HPA054639.
neXtProtiNX_Q53GI3.
PharmGKBiPA38702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ53GI3.
KOiK09229.
OMAiNKELIPM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ53GI3.
TreeFamiTF337913.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF394. human.
GenomeRNAii84124.
PROiQ53GI3.

Gene expression databases

BgeeiQ53GI3.
CleanExiHS_ZNF394.
GenevisibleiQ53GI3. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394."
    Huang C., Wang Y., Li D., Li Y., Luo J., Yuan W., Ou Y., Zhu C., Zhang Y., Wang Z., Liu M., Wu X.
    Biochem. Biophys. Res. Commun. 320:1298-1305(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon, Lung and Skin.
  8. "Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins."
    Pengue G., Calabro V., Bartoli P.C., Pagliuca A., Lania L.
    Nucleic Acids Res. 22:2908-2914(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-143 (ISOFORM 1/2).

Entry informationi

Entry nameiZN394_HUMAN
AccessioniPrimary (citable) accession number: Q53GI3
Secondary accession number(s): A4D281
, Q05DA6, Q6P5X9, Q8TB27, Q9HA37, Q9UD51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.