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Protein

PDZ and LIM domain protein 3

Gene

PDLIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the organization of actin filament arrays within muscle cells.By similarity

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 3
Alternative name(s):
Actinin-associated LIM protein
Alpha-actinin-2-associated LIM protein
Gene namesi
Name:PDLIM3
Synonyms:ALP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000154553.13
HGNCiHGNC:20767 PDLIM3
MIMi605889 gene
neXtProtiNX_Q53GG5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27295
OpenTargetsiENSG00000154553
PharmGKBiPA134970631

Polymorphism and mutation databases

BioMutaiPDLIM3
DMDMi74740479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758671 – 364PDZ and LIM domain protein 3Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei93PhosphoserineCombined sources1
Modified residuei264PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ53GG5
MaxQBiQ53GG5
PaxDbiQ53GG5
PeptideAtlasiQ53GG5
PRIDEiQ53GG5

PTM databases

iPTMnetiQ53GG5
PhosphoSitePlusiQ53GG5

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.1 Publication

Gene expression databases

BgeeiENSG00000154553
CleanExiHS_PDLIM3
ExpressionAtlasiQ53GG5 baseline and differential
GenevisibleiQ53GG5 HS

Organism-specific databases

HPAiHPA004749

Interactioni

Subunit structurei

Interacts with ACTN2 (By similarity). Forms a heterodimer with PDLIM4 (via LIM domain) (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118119, 5 interactors
IntActiQ53GG5, 9 interactors
STRINGi9606.ENSP00000284770

Structurei

3D structure databases

ProteinModelPortaliQ53GG5
SMRiQ53GG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84PDZPROSITE-ProRule annotationAdd BLAST84
Domaini292 – 351LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00590000082980
HOVERGENiHBG061371
InParanoidiQ53GG5
OMAiSMSEPTA
OrthoDBiEOG091G0A6C
PhylomeDBiQ53GG5
TreeFamiTF106408

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR001478 PDZ
IPR036034 PDZ_sf
IPR006643 Zasp-like_motif
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SM00735 ZM, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53GG5-1) [UniParc]FASTAAdd to basket
Also known as: ALP-SK

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQTVILPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL
60 70 80 90 100
AIDGFGTESM THADAQDRIK AAAHQLCLKI DRGETHLWSP QVSEDGKAHP
110 120 130 140 150
FKINLESEPQ DGNYFEHKHN IRPKPFVIPG RSSGCSTPSG IDCGSGRSTP
160 170 180 190 200
SSVSTVSTIC PGDLKVAAKL APNIPLEMEL PGVKIVHAQF NTPMQLYSDD
210 220 230 240 250
NIMETLQGQV STALGETPLM SEPTASVPPE SDVYRMLHDN RNEPTQPRQS
260 270 280 290 300
GSFRVLQGMV DDGSDDRPAG TRSVRAPVTK VHGGSGGAQR MPLCDKCGSG
310 320 330 340 350
IVGAVVKARD KYRHPECFVC ADCNLNLKQK GYFFIEGELY CETHARARTK
360
PPEGYDTVTL YPKA
Length:364
Mass (Da):39,232
Last modified:May 24, 2005 - v1
Checksum:i083802DF22D7A237
GO
Isoform 2 (identifier: Q53GG5-2) [UniParc]FASTAAdd to basket
Also known as: ALP-H

The sequence of this isoform differs from the canonical sequence as follows:
     111-224: DGNYFEHKHN...GETPLMSEPT → EFKPIGTAHN...IPSSPQNEPT

Show »
Length:316
Mass (Da):34,280
Checksum:i99FB41E90188ED8A
GO
Isoform 3 (identifier: Q53GG5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-233: DGNYFEHKHN...TASVPPESDV → EFKPIGTAHN...TSIIFGPNLS
     234-364: Missing.

Show »
Length:189
Mass (Da):20,214
Checksum:i4DB3477EA08C336E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → A in AAC16670 (PubMed:9334352).Curated1
Sequence conflicti12P → A in AAC16672 (PubMed:9334352).Curated1
Sequence conflicti40A → G in AAC16670 (PubMed:9334352).Curated1
Sequence conflicti40A → G in AAC16672 (PubMed:9334352).Curated1
Sequence conflicti217T → I in AAC16670 (PubMed:9334352).Curated1
Sequence conflicti221S → N in AAB96665 (PubMed:10063829).Curated1
Sequence conflicti353E → R in AAC16670 (PubMed:9334352).Curated1
Sequence conflicti353E → R in AAC16672 (PubMed:9334352).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050166127V → M. Corresponds to variant dbSNP:rs11944325Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016500111 – 233DGNYF…PESDV → EFKPIGTAHNRRAQPFVAAA NIDDKRQVVSASYNSPIGLY STSNIQDALHGQLRGLIPSS PQKTGTTLNTSIIFGPNLS in isoform 3. 2 PublicationsAdd BLAST123
Alternative sequenceiVSP_016501111 – 224DGNYF…MSEPT → EFKPIGTAHNRRAQPFVAAA NIDDKRQVVSASYNSPIGLY STSNIQDALHGQLRGLIPSS PQNEPT in isoform 2. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_016502234 – 364Missing in isoform 3. 2 PublicationsAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002280 mRNA Translation: AAC16670.1
AF002282 mRNA Translation: AAC16672.1
AF039018 mRNA Translation: AAB96665.1
AK313253 mRNA Translation: BAG36063.1
BT007341 mRNA Translation: AAP36005.1
AK222966 mRNA Translation: BAD96686.1
CH471056 Genomic DNA Translation: EAX04641.1
BC001017 mRNA No translation available.
BC027870 mRNA Translation: AAH27870.1
CCDSiCCDS3844.1 [Q53GG5-1]
CCDS47172.1 [Q53GG5-2]
RefSeqiNP_001107579.1, NM_001114107.4 [Q53GG5-2]
NP_055291.2, NM_014476.5 [Q53GG5-1]
UniGeneiHs.701364

Genome annotation databases

EnsembliENST00000284770; ENSP00000284770; ENSG00000154553 [Q53GG5-1]
ENST00000284771; ENSP00000284771; ENSG00000154553 [Q53GG5-2]
GeneIDi27295
KEGGihsa:27295
UCSCiuc003ixw.5 human [Q53GG5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPDLI3_HUMAN
AccessioniPrimary (citable) accession number: Q53GG5
Secondary accession number(s): B2R866
, O43590, O60439, O60440, Q8N6Y6, Q9BVP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health