##gff-version 3 Q53GD3 UniProtKB Chain 1 710 . . . ID=PRO_0000191723;Note=Choline transporter-like protein 4 Q53GD3 UniProtKB Topological domain 1 34 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 35 55 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 56 229 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 230 250 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 251 252 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 253 273 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 274 309 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 310 330 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 331 358 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 359 379 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 380 455 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 456 476 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 477 501 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 502 522 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 523 560 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 561 581 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 582 597 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 598 618 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 619 638 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Transmembrane 639 659 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Topological domain 660 710 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Site 308 308 . . . Note=Breakpoint for translocation with NEU1 Q53GD3 UniProtKB Glycosylation 69 69 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Glycosylation 155 155 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Glycosylation 197 197 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Glycosylation 298 298 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Glycosylation 393 393 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Glycosylation 405 405 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q53GD3 UniProtKB Glycosylation 416 416 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Alternative sequence 1 422 . . . ID=VSP_030998;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 Q53GD3 UniProtKB Alternative sequence 1 76 . . . ID=VSP_046236;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q53GD3 UniProtKB Alternative sequence 115 156 . . . ID=VSP_046821;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q53GD3 UniProtKB Natural variant 6 6 . . . ID=VAR_023406;Note=No effect on thiamine pyrophosphate transporter activity. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26741288;Dbxref=dbSNP:rs2075798,PMID:26741288 Q53GD3 UniProtKB Natural variant 123 123 . . . ID=VAR_047020;Note=No effect on thiamine pyrophosphate transporter activity. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26741288;Dbxref=dbSNP:rs12661281,PMID:26741288 Q53GD3 UniProtKB Natural variant 128 128 . . . ID=VAR_047021;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17856465,PMID:15489334 Q53GD3 UniProtKB Natural variant 156 156 . . . ID=VAR_078848;Note=In DFNA72%3B decreases choline transmembrane transporter activity. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28013291;Dbxref=dbSNP:rs1135402753,PMID:28013291 Q53GD3 UniProtKB Natural variant 187 187 . . . ID=VAR_023407;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12067718,ECO:0000269|PubMed:14574404,ECO:0000269|PubMed:14656967,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26741288,ECO:0000269|Ref.3,ECO:0000269|Ref.5,ECO:0000269|Ref.7;Dbxref=dbSNP:rs2242665,PMID:12067718,PMID:14574404,PMID:14656967,PMID:14702039,PMID:15489334,PMID:26741288 Q53GD3 UniProtKB Natural variant 326 326 . . . ID=VAR_023408;Note=M->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14574404,ECO:0000269|PubMed:14656967,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:26741288,ECO:0000269|Ref.3,ECO:0000269|Ref.5,ECO:0000269|Ref.7;Dbxref=dbSNP:rs644827,PMID:14574404,PMID:14656967,PMID:14702039,PMID:15489334,PMID:26741288 Q53GD3 UniProtKB Natural variant 347 347 . . . ID=VAR_036210;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Q53GD3 UniProtKB Natural variant 397 397 . . . ID=VAR_078849;Note=No effect on thiamine pyrophosphate transporter activity. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26741288;Dbxref=dbSNP:rs116706632,PMID:26741288 Q53GD3 UniProtKB Natural variant 411 411 . . . ID=VAR_036211;Note=In a colorectal cancer sample%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs563426936,PMID:16959974 Q53GD3 UniProtKB Natural variant 493 493 . . . ID=VAR_023409;Note=R->C;Dbxref=dbSNP:rs6915800 Q53GD3 UniProtKB Mutagenesis 29 29 . . . Note=No effect on glycosylation. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Mutagenesis 69 69 . . . Note=Decreases glycosylation levels. Decreases thiamine pyrophosphate uptake. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Mutagenesis 155 155 . . . Note=Decreases glycosylation levels. Decreases thiamine pyrophosphate uptake. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Mutagenesis 197 197 . . . Note=Decreases glycosylation levels. No effect on thiamine pyrophosphate uptake. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Mutagenesis 298 298 . . . Note=No effect on glycosylation. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Mutagenesis 393 393 . . . Note=Decreases glycosylation levels. Decreases thiamine pyrophosphate uptake. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Mutagenesis 409 409 . . . Note=No effect on glycosylation. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Mutagenesis 416 416 . . . Note=Decreases glycosylation levels. No effect on thiamine pyrophosphate uptake. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26828122;Dbxref=PMID:26828122 Q53GD3 UniProtKB Sequence conflict 117 118 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53GD3 UniProtKB Sequence conflict 144 145 . . . Note=NR->SS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53GD3 UniProtKB Sequence conflict 379 386 . . . Note=LATSGQPQ->PLPTQPATLG;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q53GD3 UniProtKB Sequence conflict 636 636 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305