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Q53GD3

- CTL4_HUMAN

UniProt

Q53GD3 - CTL4_HUMAN

Protein

Choline transporter-like protein 4

Gene

SLC44A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei308 – 3081Breakpoint for translocation with NEU1

    GO - Biological processi

    1. acetylcholine biosynthetic process Source: UniProt
    2. acetylcholine secretion Source: UniProt
    3. glycerophospholipid biosynthetic process Source: Reactome
    4. phosphatidylcholine biosynthetic process Source: Reactome
    5. phospholipid metabolic process Source: Reactome
    6. positive regulation of cell growth Source: UniProt
    7. small molecule metabolic process Source: Reactome
    8. transmembrane transport Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_121238. Synthesis of PC.
    REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Protein family/group databases

    TCDBi2.A.92.1.7. the choline transporter-like (ctl) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline transporter-like protein 4
    Alternative name(s):
    Solute carrier family 44 member 4
    Gene namesi
    Name:SLC44A4
    Synonyms:C6orf29, CTL4, NG22
    ORF Names:UNQ441/PRO874
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13941. SLC44A4.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    An interstitial deletion causing the fusion of exon 10 of CTL4 with the 3'-UTR of NEU has been detected in two patients affected by sialidosis.

    Organism-specific databases

    PharmGKBiPA25930.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 710710Choline transporter-like protein 4PRO_0000191723Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ53GD3.
    PaxDbiQ53GD3.
    PRIDEiQ53GD3.

    PTM databases

    PhosphoSiteiQ53GD3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ53GD3.
    BgeeiQ53GD3.
    GenevestigatoriQ53GD3.

    Organism-specific databases

    HPAiHPA046977.
    HPA054176.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000229729.

    Structurei

    3D structure databases

    ProteinModelPortaliQ53GD3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini56 – 229174ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 2522CytoplasmicSequence Analysis
    Topological domaini274 – 30936ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini331 – 35828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini380 – 45576ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini477 – 50125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini523 – 56038ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini582 – 59716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini619 – 63820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini660 – 71051CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei502 – 52221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei561 – 58121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei598 – 61821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei639 – 65921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310633.
    HOVERGENiHBG062155.
    InParanoidiQ53GD3.
    KOiK15377.
    OMAiPITGCKT.
    OrthoDBiEOG7FR7G4.
    PhylomeDBiQ53GD3.
    TreeFamiTF313325.

    Family and domain databases

    InterProiIPR007603. Choline_transptr-like.
    [Graphical view]
    PANTHERiPTHR12385. PTHR12385. 1 hit.
    PfamiPF04515. Choline_transpo. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q53GD3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGKQRDEDD EAYGKPVKYD PSFRGPIKNR SCTDVICCVL FLLFILGYIV    50
    VGIVAWLYGD PRQVLYPRNS TGAYCGMGEN KDKPYLLYFN IFSCILSSNI 100
    ISVAENGLQC PTPQVCVSSC PEDPWTVGKN EFSQTVGEVF YTKNRNFCLP 150
    GVPWNMTVIT SLQQELCPSF LLPSAPALGR CFPWTNVTPP ALPGITNDTT 200
    IQQGISGLID SLNARDISVK IFEDFAQSWY WILVALGVAL VLSLLFILLL 250
    RLVAGPLVLV LILGVLGVLA YGIYYCWEEY RVLRDKGASI SQLGFTTNLS 300
    AYQSVQETWL AALIVLAVLE AILLLMLIFL RQRIRIAIAL LKEASKAVGQ 350
    MMSTMFYPLV TFVLLLICIA YWAMTALYLA TSGQPQYVLW ASNISSPGCE 400
    KVPINTSCNP TAHLVNSSCP GLMCVFQGYS SKGLIQRSVF NLQIYGVLGL 450
    FWTLNWVLAL GQCVLAGAFA SFYWAFHKPQ DIPTFPLISA FIRTLRYHTG 500
    SLAFGALILT LVQIARVILE YIDHKLRGVQ NPVARCIMCC FKCCLWCLEK 550
    FIKFLNRNAY IMIAIYGKNF CVSAKNAFML LMRNIVRVVV LDKVTDLLLF 600
    FGKLLVVGGV GVLSFFFFSG RIPGLGKDFK SPHLNYYWLP IMTSILGAYV 650
    IASGFFSVFG MCVDTLFLCF LEDLERNNGS LDRPYYMSKS LLKILGKKNE 700
    APPDNKKRKK 710
    Length:710
    Mass (Da):79,254
    Last modified:November 2, 2010 - v2
    Checksum:i4DE5B45574C408AD
    GO
    Isoform 2 (identifier: Q53GD3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-422: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:288
    Mass (Da):32,729
    Checksum:i6A1ACC9313FB9A3F
    GO
    Isoform 3 (identifier: Q53GD3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:634
    Mass (Da):70,762
    Checksum:iABBB965DD14DB114
    GO
    Isoform 4 (identifier: Q53GD3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-156: Missing.

    Show »
    Length:668
    Mass (Da):74,504
    Checksum:iBC10838F8AC3C6DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1182Missing in CAH56275. (PubMed:17974005)Curated
    Sequence conflicti144 – 1452NR → SS in BAB55083. (PubMed:14702039)Curated
    Sequence conflicti379 – 3868LATSGQPQ → PLPTQPATLG in AAD21813. (PubMed:14656967)Curated
    Sequence conflicti379 – 3868LATSGQPQ → PLPTQPATLG in BAB63296. 1 PublicationCurated
    Sequence conflicti636 – 6361Missing in AAH14659. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61R → L.
    Corresponds to variant rs2075798 [ dbSNP | Ensembl ].
    VAR_023406
    Natural varianti123 – 1231D → V.
    Corresponds to variant rs12661281 [ dbSNP | Ensembl ].
    VAR_047020
    Natural varianti128 – 1281G → E.1 Publication
    Corresponds to variant rs17856465 [ dbSNP | Ensembl ].
    VAR_047021
    Natural varianti187 – 1871V → I.8 Publications
    Corresponds to variant rs2242665 [ dbSNP | Ensembl ].
    VAR_023407
    Natural varianti326 – 3261M → V.7 Publications
    Corresponds to variant rs644827 [ dbSNP | Ensembl ].
    VAR_023408
    Natural varianti347 – 3471A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036210
    Natural varianti411 – 4111T → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036211
    Natural varianti493 – 4931R → C.
    Corresponds to variant rs6915800 [ dbSNP | Ensembl ].
    VAR_023409

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 422422Missing in isoform 2. 1 PublicationVSP_030998Add
    BLAST
    Alternative sequencei1 – 7676Missing in isoform 3. 1 PublicationVSP_046236Add
    BLAST
    Alternative sequencei115 – 15642Missing in isoform 4. 1 PublicationVSP_046821Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027397 mRNA. Translation: BAB55083.1.
    AK300550 mRNA. Translation: BAG62256.1.
    AK301596 mRNA. Translation: BAG63084.1.
    AY358457 mRNA. Translation: AAQ88822.1.
    AK222998 mRNA. Translation: BAD96718.1.
    AF134726 Genomic DNA. Translation: AAD21813.1.
    BA000025 Genomic DNA. Translation: BAB63296.1.
    AL662834 Genomic DNA. Translation: CAI17744.1.
    AL671762 Genomic DNA. Translation: CAI18223.2.
    AL844853 Genomic DNA. Translation: CAI41851.1.
    BX005460 Genomic DNA. Translation: CAM26148.1.
    CR936237 Genomic DNA. Translation: CAQ09154.1.
    CR759784 Genomic DNA. Translation: CAQ09306.1.
    CR388202 Genomic DNA. Translation: CAQ09513.1.
    CH471081 Genomic DNA. Translation: EAX03538.1.
    BC014659 mRNA. Translation: AAH14659.1.
    AF466766 mRNA. Translation: AAL75992.1.
    AL833009 mRNA. Translation: CAH56275.1.
    CCDSiCCDS4724.2. [Q53GD3-1]
    CCDS54989.1. [Q53GD3-3]
    CCDS54990.1. [Q53GD3-4]
    RefSeqiNP_001171515.1. NM_001178044.1. [Q53GD3-4]
    NP_001171516.1. NM_001178045.1. [Q53GD3-3]
    NP_079533.2. NM_025257.2. [Q53GD3-1]
    UniGeneiHs.335355.

    Genome annotation databases

    EnsembliENST00000229729; ENSP00000229729; ENSG00000204385. [Q53GD3-1]
    ENST00000375562; ENSP00000364712; ENSG00000204385. [Q53GD3-4]
    ENST00000383379; ENSP00000372870; ENSG00000206378. [Q53GD3-1]
    ENST00000415517; ENSP00000414120; ENSG00000229077.
    ENST00000417894; ENSP00000389244; ENSG00000235336.
    ENST00000425238; ENSP00000399161; ENSG00000228263. [Q53GD3-1]
    ENST00000442152; ENSP00000398852; ENSG00000232180.
    ENST00000453831; ENSP00000393939; ENSG00000231479. [Q53GD3-1]
    ENST00000544672; ENSP00000444109; ENSG00000204385. [Q53GD3-3]
    ENST00000546461; ENSP00000449039; ENSG00000231479. [Q53GD3-3]
    ENST00000547493; ENSP00000449232; ENSG00000229077.
    ENST00000547684; ENSP00000449180; ENSG00000206378. [Q53GD3-3]
    ENST00000548188; ENSP00000447560; ENSG00000228263. [Q53GD3-3]
    ENST00000549663; ENSP00000449642; ENSG00000228263. [Q53GD3-4]
    ENST00000549677; ENSP00000449518; ENSG00000206378. [Q53GD3-4]
    ENST00000550401; ENSP00000448474; ENSG00000235336.
    ENST00000551168; ENSP00000448088; ENSG00000231479. [Q53GD3-4]
    ENST00000553121; ENSP00000447704; ENSG00000232180.
    GeneIDi80736.
    KEGGihsa:80736.
    UCSCiuc010jti.3. human. [Q53GD3-1]

    Polymorphism databases

    DMDMi311033368.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027397 mRNA. Translation: BAB55083.1 .
    AK300550 mRNA. Translation: BAG62256.1 .
    AK301596 mRNA. Translation: BAG63084.1 .
    AY358457 mRNA. Translation: AAQ88822.1 .
    AK222998 mRNA. Translation: BAD96718.1 .
    AF134726 Genomic DNA. Translation: AAD21813.1 .
    BA000025 Genomic DNA. Translation: BAB63296.1 .
    AL662834 Genomic DNA. Translation: CAI17744.1 .
    AL671762 Genomic DNA. Translation: CAI18223.2 .
    AL844853 Genomic DNA. Translation: CAI41851.1 .
    BX005460 Genomic DNA. Translation: CAM26148.1 .
    CR936237 Genomic DNA. Translation: CAQ09154.1 .
    CR759784 Genomic DNA. Translation: CAQ09306.1 .
    CR388202 Genomic DNA. Translation: CAQ09513.1 .
    CH471081 Genomic DNA. Translation: EAX03538.1 .
    BC014659 mRNA. Translation: AAH14659.1 .
    AF466766 mRNA. Translation: AAL75992.1 .
    AL833009 mRNA. Translation: CAH56275.1 .
    CCDSi CCDS4724.2. [Q53GD3-1 ]
    CCDS54989.1. [Q53GD3-3 ]
    CCDS54990.1. [Q53GD3-4 ]
    RefSeqi NP_001171515.1. NM_001178044.1. [Q53GD3-4 ]
    NP_001171516.1. NM_001178045.1. [Q53GD3-3 ]
    NP_079533.2. NM_025257.2. [Q53GD3-1 ]
    UniGenei Hs.335355.

    3D structure databases

    ProteinModelPortali Q53GD3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000229729.

    Chemistry

    DrugBanki DB00122. Choline.

    Protein family/group databases

    TCDBi 2.A.92.1.7. the choline transporter-like (ctl) family.

    PTM databases

    PhosphoSitei Q53GD3.

    Polymorphism databases

    DMDMi 311033368.

    Proteomic databases

    MaxQBi Q53GD3.
    PaxDbi Q53GD3.
    PRIDEi Q53GD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229729 ; ENSP00000229729 ; ENSG00000204385 . [Q53GD3-1 ]
    ENST00000375562 ; ENSP00000364712 ; ENSG00000204385 . [Q53GD3-4 ]
    ENST00000383379 ; ENSP00000372870 ; ENSG00000206378 . [Q53GD3-1 ]
    ENST00000415517 ; ENSP00000414120 ; ENSG00000229077 .
    ENST00000417894 ; ENSP00000389244 ; ENSG00000235336 .
    ENST00000425238 ; ENSP00000399161 ; ENSG00000228263 . [Q53GD3-1 ]
    ENST00000442152 ; ENSP00000398852 ; ENSG00000232180 .
    ENST00000453831 ; ENSP00000393939 ; ENSG00000231479 . [Q53GD3-1 ]
    ENST00000544672 ; ENSP00000444109 ; ENSG00000204385 . [Q53GD3-3 ]
    ENST00000546461 ; ENSP00000449039 ; ENSG00000231479 . [Q53GD3-3 ]
    ENST00000547493 ; ENSP00000449232 ; ENSG00000229077 .
    ENST00000547684 ; ENSP00000449180 ; ENSG00000206378 . [Q53GD3-3 ]
    ENST00000548188 ; ENSP00000447560 ; ENSG00000228263 . [Q53GD3-3 ]
    ENST00000549663 ; ENSP00000449642 ; ENSG00000228263 . [Q53GD3-4 ]
    ENST00000549677 ; ENSP00000449518 ; ENSG00000206378 . [Q53GD3-4 ]
    ENST00000550401 ; ENSP00000448474 ; ENSG00000235336 .
    ENST00000551168 ; ENSP00000448088 ; ENSG00000231479 . [Q53GD3-4 ]
    ENST00000553121 ; ENSP00000447704 ; ENSG00000232180 .
    GeneIDi 80736.
    KEGGi hsa:80736.
    UCSCi uc010jti.3. human. [Q53GD3-1 ]

    Organism-specific databases

    CTDi 80736.
    GeneCardsi GC06M031830.
    GC06Mi31842.
    GC06Mj31818.
    GC06Mk31813.
    GC06Mm31907.
    GC06Mn31822.
    GC06Mo31822.
    H-InvDB HIX0166072.
    HIX0166339.
    HIX0167126.
    HIX0184154.
    HGNCi HGNC:13941. SLC44A4.
    HPAi HPA046977.
    HPA054176.
    MIMi 606107. gene.
    neXtProti NX_Q53GD3.
    PharmGKBi PA25930.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310633.
    HOVERGENi HBG062155.
    InParanoidi Q53GD3.
    KOi K15377.
    OMAi PITGCKT.
    OrthoDBi EOG7FR7G4.
    PhylomeDBi Q53GD3.
    TreeFami TF313325.

    Enzyme and pathway databases

    Reactomei REACT_121238. Synthesis of PC.
    REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    ChiTaRSi SLC44A4. human.
    GeneWikii SLC44A4.
    GenomeRNAii 80736.
    NextBioi 71058.
    PROi Q53GD3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q53GD3.
    Bgeei Q53GD3.
    Genevestigatori Q53GD3.

    Family and domain databases

    InterProi IPR007603. Choline_transptr-like.
    [Graphical view ]
    PANTHERi PTHR12385. PTHR12385. 1 hit.
    Pfami PF04515. Choline_transpo. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS ILE-187 AND VAL-326.
      Tissue: Mammary gland and Prostate.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-187 AND VAL-326.
      Tissue: Small intestine.
    4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
    5. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-128; ILE-187 AND VAL-326.
      Tissue: Colon.
    9. "Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient."
      Uhl J., Penzel R., Sergi C., Kopitz J., Otto H.F., Cantz M.
      FEBS Lett. 521:19-23(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-308 (ISOFORM 1), CHROMOSOMAL REARRANGEMENT WITH NEU1, VARIANT ILE-187.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-710 (ISOFORMS 1/3).
      Tissue: Stomach.
    11. "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
      O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.
      Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.
    12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-347 AND MET-411.

    Entry informationi

    Entry nameiCTL4_HUMAN
    AccessioniPrimary (citable) accession number: Q53GD3
    Secondary accession number(s): A2BED3
    , B0UXX8, B0UZY8, B4DU94, B4DWM2, E9PEK7, Q5JP84, Q5JQ93, Q658S8, Q6UX89, Q8TEW4, Q96C58, Q96K59, Q9Y332
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3