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Q53GD3

- CTL4_HUMAN

UniProt

Q53GD3 - CTL4_HUMAN

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Protein

Choline transporter-like protein 4

Gene

SLC44A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei308 – 3081Breakpoint for translocation with NEU1

GO - Biological processi

  1. acetylcholine biosynthetic process Source: UniProt
  2. acetylcholine secretion Source: UniProt
  3. glycerophospholipid biosynthetic process Source: Reactome
  4. phosphatidylcholine biosynthetic process Source: Reactome
  5. phospholipid metabolic process Source: Reactome
  6. positive regulation of cell growth Source: UniProt
  7. small molecule metabolic process Source: Reactome
  8. transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.92.1.7. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 4
Alternative name(s):
Solute carrier family 44 member 4
Gene namesi
Name:SLC44A4
Synonyms:C6orf29, CTL4, NG22
ORF Names:UNQ441/PRO874
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13941. SLC44A4.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

An interstitial deletion causing the fusion of exon 10 of CTL4 with the 3'-UTR of NEU has been detected in two patients affected by sialidosis.

Organism-specific databases

PharmGKBiPA25930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Choline transporter-like protein 4PRO_0000191723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ53GD3.
PaxDbiQ53GD3.
PRIDEiQ53GD3.

PTM databases

PhosphoSiteiQ53GD3.

Expressioni

Gene expression databases

BgeeiQ53GD3.
GenevestigatoriQ53GD3.

Organism-specific databases

HPAiHPA046977.
HPA054176.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000229729.

Structurei

3D structure databases

ProteinModelPortaliQ53GD3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini56 – 229174ExtracellularSequence AnalysisAdd
BLAST
Topological domaini251 – 2522CytoplasmicSequence Analysis
Topological domaini274 – 30936ExtracellularSequence AnalysisAdd
BLAST
Topological domaini331 – 35828CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini380 – 45576ExtracellularSequence AnalysisAdd
BLAST
Topological domaini477 – 50125CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini523 – 56038ExtracellularSequence AnalysisAdd
BLAST
Topological domaini582 – 59716CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini619 – 63820ExtracellularSequence AnalysisAdd
BLAST
Topological domaini660 – 71051CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST
Transmembranei502 – 52221HelicalSequence AnalysisAdd
BLAST
Transmembranei561 – 58121HelicalSequence AnalysisAdd
BLAST
Transmembranei598 – 61821HelicalSequence AnalysisAdd
BLAST
Transmembranei639 – 65921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOVERGENiHBG062155.
InParanoidiQ53GD3.
KOiK15377.
OMAiPITGCKT.
OrthoDBiEOG7FR7G4.
PhylomeDBiQ53GD3.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q53GD3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGKQRDEDD EAYGKPVKYD PSFRGPIKNR SCTDVICCVL FLLFILGYIV
60 70 80 90 100
VGIVAWLYGD PRQVLYPRNS TGAYCGMGEN KDKPYLLYFN IFSCILSSNI
110 120 130 140 150
ISVAENGLQC PTPQVCVSSC PEDPWTVGKN EFSQTVGEVF YTKNRNFCLP
160 170 180 190 200
GVPWNMTVIT SLQQELCPSF LLPSAPALGR CFPWTNVTPP ALPGITNDTT
210 220 230 240 250
IQQGISGLID SLNARDISVK IFEDFAQSWY WILVALGVAL VLSLLFILLL
260 270 280 290 300
RLVAGPLVLV LILGVLGVLA YGIYYCWEEY RVLRDKGASI SQLGFTTNLS
310 320 330 340 350
AYQSVQETWL AALIVLAVLE AILLLMLIFL RQRIRIAIAL LKEASKAVGQ
360 370 380 390 400
MMSTMFYPLV TFVLLLICIA YWAMTALYLA TSGQPQYVLW ASNISSPGCE
410 420 430 440 450
KVPINTSCNP TAHLVNSSCP GLMCVFQGYS SKGLIQRSVF NLQIYGVLGL
460 470 480 490 500
FWTLNWVLAL GQCVLAGAFA SFYWAFHKPQ DIPTFPLISA FIRTLRYHTG
510 520 530 540 550
SLAFGALILT LVQIARVILE YIDHKLRGVQ NPVARCIMCC FKCCLWCLEK
560 570 580 590 600
FIKFLNRNAY IMIAIYGKNF CVSAKNAFML LMRNIVRVVV LDKVTDLLLF
610 620 630 640 650
FGKLLVVGGV GVLSFFFFSG RIPGLGKDFK SPHLNYYWLP IMTSILGAYV
660 670 680 690 700
IASGFFSVFG MCVDTLFLCF LEDLERNNGS LDRPYYMSKS LLKILGKKNE
710
APPDNKKRKK
Length:710
Mass (Da):79,254
Last modified:November 2, 2010 - v2
Checksum:i4DE5B45574C408AD
GO
Isoform 2 (identifier: Q53GD3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-422: Missing.

Note: No experimental confirmation available.

Show »
Length:288
Mass (Da):32,729
Checksum:i6A1ACC9313FB9A3F
GO
Isoform 3 (identifier: Q53GD3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.

Show »
Length:634
Mass (Da):70,762
Checksum:iABBB965DD14DB114
GO
Isoform 4 (identifier: Q53GD3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-156: Missing.

Show »
Length:668
Mass (Da):74,504
Checksum:iBC10838F8AC3C6DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1182Missing in CAH56275. (PubMed:17974005)Curated
Sequence conflicti144 – 1452NR → SS in BAB55083. (PubMed:14702039)Curated
Sequence conflicti379 – 3868LATSGQPQ → PLPTQPATLG in AAD21813. (PubMed:14656967)Curated
Sequence conflicti379 – 3868LATSGQPQ → PLPTQPATLG in BAB63296. 1 PublicationCurated
Sequence conflicti636 – 6361Missing in AAH14659. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → L.
Corresponds to variant rs2075798 [ dbSNP | Ensembl ].
VAR_023406
Natural varianti123 – 1231D → V.
Corresponds to variant rs12661281 [ dbSNP | Ensembl ].
VAR_047020
Natural varianti128 – 1281G → E.1 Publication
Corresponds to variant rs17856465 [ dbSNP | Ensembl ].
VAR_047021
Natural varianti187 – 1871V → I.8 Publications
Corresponds to variant rs2242665 [ dbSNP | Ensembl ].
VAR_023407
Natural varianti326 – 3261M → V.7 Publications
Corresponds to variant rs644827 [ dbSNP | Ensembl ].
VAR_023408
Natural varianti347 – 3471A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036210
Natural varianti411 – 4111T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036211
Natural varianti493 – 4931R → C.
Corresponds to variant rs6915800 [ dbSNP | Ensembl ].
VAR_023409

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 422422Missing in isoform 2. 1 PublicationVSP_030998Add
BLAST
Alternative sequencei1 – 7676Missing in isoform 3. 1 PublicationVSP_046236Add
BLAST
Alternative sequencei115 – 15642Missing in isoform 4. 1 PublicationVSP_046821Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027397 mRNA. Translation: BAB55083.1.
AK300550 mRNA. Translation: BAG62256.1.
AK301596 mRNA. Translation: BAG63084.1.
AY358457 mRNA. Translation: AAQ88822.1.
AK222998 mRNA. Translation: BAD96718.1.
AF134726 Genomic DNA. Translation: AAD21813.1.
BA000025 Genomic DNA. Translation: BAB63296.1.
AL662834 Genomic DNA. Translation: CAI17744.1.
AL671762 Genomic DNA. Translation: CAI18223.2.
AL844853 Genomic DNA. Translation: CAI41851.1.
BX005460 Genomic DNA. Translation: CAM26148.1.
CR936237 Genomic DNA. Translation: CAQ09154.1.
CR759784 Genomic DNA. Translation: CAQ09306.1.
CR388202 Genomic DNA. Translation: CAQ09513.1.
CH471081 Genomic DNA. Translation: EAX03538.1.
BC014659 mRNA. Translation: AAH14659.1.
AF466766 mRNA. Translation: AAL75992.1.
AL833009 mRNA. Translation: CAH56275.1.
CCDSiCCDS4724.2. [Q53GD3-1]
CCDS54989.1. [Q53GD3-3]
CCDS54990.1. [Q53GD3-4]
RefSeqiNP_001171515.1. NM_001178044.1. [Q53GD3-4]
NP_001171516.1. NM_001178045.1. [Q53GD3-3]
NP_079533.2. NM_025257.2. [Q53GD3-1]
UniGeneiHs.335355.

Genome annotation databases

EnsembliENST00000229729; ENSP00000229729; ENSG00000204385. [Q53GD3-1]
ENST00000375562; ENSP00000364712; ENSG00000204385. [Q53GD3-4]
ENST00000383379; ENSP00000372870; ENSG00000206378. [Q53GD3-1]
ENST00000415517; ENSP00000414120; ENSG00000229077.
ENST00000417894; ENSP00000389244; ENSG00000235336.
ENST00000425238; ENSP00000399161; ENSG00000228263. [Q53GD3-1]
ENST00000442152; ENSP00000398852; ENSG00000232180.
ENST00000453831; ENSP00000393939; ENSG00000231479. [Q53GD3-1]
ENST00000544672; ENSP00000444109; ENSG00000204385. [Q53GD3-3]
ENST00000546461; ENSP00000449039; ENSG00000231479. [Q53GD3-3]
ENST00000547493; ENSP00000449232; ENSG00000229077.
ENST00000547684; ENSP00000449180; ENSG00000206378. [Q53GD3-3]
ENST00000548188; ENSP00000447560; ENSG00000228263. [Q53GD3-3]
ENST00000549663; ENSP00000449642; ENSG00000228263. [Q53GD3-4]
ENST00000549677; ENSP00000449518; ENSG00000206378. [Q53GD3-4]
ENST00000550401; ENSP00000448474; ENSG00000235336.
ENST00000551168; ENSP00000448088; ENSG00000231479. [Q53GD3-4]
ENST00000553121; ENSP00000447704; ENSG00000232180.
GeneIDi80736.
KEGGihsa:80736.
UCSCiuc010jti.3. human. [Q53GD3-1]

Polymorphism databases

DMDMi311033368.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027397 mRNA. Translation: BAB55083.1 .
AK300550 mRNA. Translation: BAG62256.1 .
AK301596 mRNA. Translation: BAG63084.1 .
AY358457 mRNA. Translation: AAQ88822.1 .
AK222998 mRNA. Translation: BAD96718.1 .
AF134726 Genomic DNA. Translation: AAD21813.1 .
BA000025 Genomic DNA. Translation: BAB63296.1 .
AL662834 Genomic DNA. Translation: CAI17744.1 .
AL671762 Genomic DNA. Translation: CAI18223.2 .
AL844853 Genomic DNA. Translation: CAI41851.1 .
BX005460 Genomic DNA. Translation: CAM26148.1 .
CR936237 Genomic DNA. Translation: CAQ09154.1 .
CR759784 Genomic DNA. Translation: CAQ09306.1 .
CR388202 Genomic DNA. Translation: CAQ09513.1 .
CH471081 Genomic DNA. Translation: EAX03538.1 .
BC014659 mRNA. Translation: AAH14659.1 .
AF466766 mRNA. Translation: AAL75992.1 .
AL833009 mRNA. Translation: CAH56275.1 .
CCDSi CCDS4724.2. [Q53GD3-1 ]
CCDS54989.1. [Q53GD3-3 ]
CCDS54990.1. [Q53GD3-4 ]
RefSeqi NP_001171515.1. NM_001178044.1. [Q53GD3-4 ]
NP_001171516.1. NM_001178045.1. [Q53GD3-3 ]
NP_079533.2. NM_025257.2. [Q53GD3-1 ]
UniGenei Hs.335355.

3D structure databases

ProteinModelPortali Q53GD3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000229729.

Chemistry

DrugBanki DB00122. Choline.

Protein family/group databases

TCDBi 2.A.92.1.7. the choline transporter-like (ctl) family.

PTM databases

PhosphoSitei Q53GD3.

Polymorphism databases

DMDMi 311033368.

Proteomic databases

MaxQBi Q53GD3.
PaxDbi Q53GD3.
PRIDEi Q53GD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229729 ; ENSP00000229729 ; ENSG00000204385 . [Q53GD3-1 ]
ENST00000375562 ; ENSP00000364712 ; ENSG00000204385 . [Q53GD3-4 ]
ENST00000383379 ; ENSP00000372870 ; ENSG00000206378 . [Q53GD3-1 ]
ENST00000415517 ; ENSP00000414120 ; ENSG00000229077 .
ENST00000417894 ; ENSP00000389244 ; ENSG00000235336 .
ENST00000425238 ; ENSP00000399161 ; ENSG00000228263 . [Q53GD3-1 ]
ENST00000442152 ; ENSP00000398852 ; ENSG00000232180 .
ENST00000453831 ; ENSP00000393939 ; ENSG00000231479 . [Q53GD3-1 ]
ENST00000544672 ; ENSP00000444109 ; ENSG00000204385 . [Q53GD3-3 ]
ENST00000546461 ; ENSP00000449039 ; ENSG00000231479 . [Q53GD3-3 ]
ENST00000547493 ; ENSP00000449232 ; ENSG00000229077 .
ENST00000547684 ; ENSP00000449180 ; ENSG00000206378 . [Q53GD3-3 ]
ENST00000548188 ; ENSP00000447560 ; ENSG00000228263 . [Q53GD3-3 ]
ENST00000549663 ; ENSP00000449642 ; ENSG00000228263 . [Q53GD3-4 ]
ENST00000549677 ; ENSP00000449518 ; ENSG00000206378 . [Q53GD3-4 ]
ENST00000550401 ; ENSP00000448474 ; ENSG00000235336 .
ENST00000551168 ; ENSP00000448088 ; ENSG00000231479 . [Q53GD3-4 ]
ENST00000553121 ; ENSP00000447704 ; ENSG00000232180 .
GeneIDi 80736.
KEGGi hsa:80736.
UCSCi uc010jti.3. human. [Q53GD3-1 ]

Organism-specific databases

CTDi 80736.
GeneCardsi GC06M031830.
GC06Mi31842.
GC06Mj31818.
GC06Mk31813.
GC06Mm31907.
GC06Mn31822.
GC06Mo31822.
H-InvDB HIX0166072.
HIX0166339.
HIX0167126.
HIX0184154.
HGNCi HGNC:13941. SLC44A4.
HPAi HPA046977.
HPA054176.
MIMi 606107. gene.
neXtProti NX_Q53GD3.
PharmGKBi PA25930.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310633.
GeneTreei ENSGT00550000074521.
HOVERGENi HBG062155.
InParanoidi Q53GD3.
KOi K15377.
OMAi PITGCKT.
OrthoDBi EOG7FR7G4.
PhylomeDBi Q53GD3.
TreeFami TF313325.

Enzyme and pathway databases

Reactomei REACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSi SLC44A4. human.
GeneWikii SLC44A4.
GenomeRNAii 80736.
NextBioi 71058.
PROi Q53GD3.
SOURCEi Search...

Gene expression databases

Bgeei Q53GD3.
Genevestigatori Q53GD3.

Family and domain databases

InterProi IPR007603. Choline_transptr-like.
[Graphical view ]
PANTHERi PTHR12385. PTHR12385. 1 hit.
Pfami PF04515. Choline_transpo. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS ILE-187 AND VAL-326.
    Tissue: Mammary gland and Prostate.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-187 AND VAL-326.
    Tissue: Small intestine.
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
  5. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-128; ILE-187 AND VAL-326.
    Tissue: Colon.
  9. "Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient."
    Uhl J., Penzel R., Sergi C., Kopitz J., Otto H.F., Cantz M.
    FEBS Lett. 521:19-23(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-308 (ISOFORM 1), CHROMOSOMAL REARRANGEMENT WITH NEU1, VARIANT ILE-187.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-710 (ISOFORMS 1/3).
    Tissue: Stomach.
  11. "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
    O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.
    Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.
  12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-347 AND MET-411.

Entry informationi

Entry nameiCTL4_HUMAN
AccessioniPrimary (citable) accession number: Q53GD3
Secondary accession number(s): A2BED3
, B0UXX8, B0UZY8, B4DU94, B4DWM2, E9PEK7, Q5JP84, Q5JQ93, Q658S8, Q6UX89, Q8TEW4, Q96C58, Q96K59, Q9Y332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3