Q53GD3 (CTL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline transporter-like protein 4

Alternative name(s):
Solute carrier family 44 member 4

Gene names

Name:	SLC44A4
Synonyms:	C6orf29, CTL4, NG22
ORF Names:	UNQ441/PRO874

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	710 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Involvement in disease	An interstitial deletion causing the fusion of exon 10 of CTL4 with the 3'-UTR of NEU has been detected in two patients affected by sialidosis.
Sequence similarities	Belongs to the CTL (choline transporter-like) family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylcholine biosynthetic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q53GD3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q53GD3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-422: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q53GD3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 710	710	Choline transporter-like protein 4		PRO_0000191723
Regions
	Topological domain	1 – 34	34	Cytoplasmic Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Topological domain	56 – 229	174	Extracellular Potential
	Transmembrane	230 – 250	21	Helical; Potential
	Topological domain	251 – 252	2	Cytoplasmic Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Topological domain	274 – 309	36	Extracellular Potential
	Transmembrane	310 – 330	21	Helical; Potential
	Topological domain	331 – 358	28	Cytoplasmic Potential
	Transmembrane	359 – 379	21	Helical; Potential
	Topological domain	380 – 455	76	Extracellular Potential
	Transmembrane	456 – 476	21	Helical; Potential
	Topological domain	477 – 501	25	Cytoplasmic Potential
	Transmembrane	502 – 522	21	Helical; Potential
	Topological domain	523 – 560	38	Extracellular Potential
	Transmembrane	561 – 581	21	Helical; Potential
	Topological domain	582 – 597	16	Cytoplasmic Potential
	Transmembrane	598 – 618	21	Helical; Potential
	Topological domain	619 – 638	20	Extracellular Potential
	Transmembrane	639 – 659	21	Helical; Potential
	Topological domain	660 – 710	51	Cytoplasmic Potential
Sites
	Site	308	1	Breakpoint for translocation with NEU1
Amino acid modifications
	Glycosylation	69	1	N-linked (GlcNAc...) Potential
	Glycosylation	155	1	N-linked (GlcNAc...) Potential
	Glycosylation	197	1	N-linked (GlcNAc...) Potential
	Glycosylation	298	1	N-linked (GlcNAc...) Potential
	Glycosylation	393	1	N-linked (GlcNAc...) Potential
	Glycosylation	405	1	N-linked (GlcNAc...) Potential
	Glycosylation	416	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 422	422	Missing in isoform 2.		VSP_030998
	Alternative sequence	1 – 76	76	Missing in isoform 3.		VSP_046236
	Natural variant	6	1	R → L. Corresponds to variant rs2075798 [ dbSNP | Ensembl ].		VAR_023406
	Natural variant	123	1	D → V. Corresponds to variant rs12661281 [ dbSNP | Ensembl ].		VAR_047020
	Natural variant	128	1	G → E. Ref.8 Corresponds to variant rs17856465 [ dbSNP | Ensembl ].		VAR_047021
	Natural variant	187	1	V → I. Ref.1 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Corresponds to variant rs2242665 [ dbSNP | Ensembl ].		VAR_023407
	Natural variant	326	1	M → V. Ref.1 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Corresponds to variant rs644827 [ dbSNP | Ensembl ].		VAR_023408
	Natural variant	347	1	A → T in a colorectal cancer sample; somatic mutation. Ref.12		VAR_036210
	Natural variant	411	1	T → M in a colorectal cancer sample; somatic mutation. Ref.12		VAR_036211
	Natural variant	493	1	R → C. Corresponds to variant rs6915800 [ dbSNP | Ensembl ].		VAR_023409
Experimental info
	Sequence conflict	117 – 118	2	Missing in CAH56275. Ref.10
	Sequence conflict	144 – 145	2	NR → SS in BAB55083. Ref.1
	Sequence conflict	379 – 386	8	LATSGQPQ → PLPTQPATLG in AAD21813. Ref.4
	Sequence conflict	379 – 386	8	LATSGQPQ → PLPTQPATLG in BAB63296. Ref.5
	Sequence conflict	636	1	Missing in AAH14659. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: 4DE5B45574C408AD	FASTA	710	79,254
	10 20 30 40 50 60 MGGKQRDEDD EAYGKPVKYD PSFRGPIKNR SCTDVICCVL FLLFILGYIV VGIVAWLYGD 70 80 90 100 110 120 PRQVLYPRNS TGAYCGMGEN KDKPYLLYFN IFSCILSSNI ISVAENGLQC PTPQVCVSSC 130 140 150 160 170 180 PEDPWTVGKN EFSQTVGEVF YTKNRNFCLP GVPWNMTVIT SLQQELCPSF LLPSAPALGR 190 200 210 220 230 240 CFPWTNVTPP ALPGITNDTT IQQGISGLID SLNARDISVK IFEDFAQSWY WILVALGVAL 250 260 270 280 290 300 VLSLLFILLL RLVAGPLVLV LILGVLGVLA YGIYYCWEEY RVLRDKGASI SQLGFTTNLS 310 320 330 340 350 360 AYQSVQETWL AALIVLAVLE AILLLMLIFL RQRIRIAIAL LKEASKAVGQ MMSTMFYPLV 370 380 390 400 410 420 TFVLLLICIA YWAMTALYLA TSGQPQYVLW ASNISSPGCE KVPINTSCNP TAHLVNSSCP 430 440 450 460 470 480 GLMCVFQGYS SKGLIQRSVF NLQIYGVLGL FWTLNWVLAL GQCVLAGAFA SFYWAFHKPQ 490 500 510 520 530 540 DIPTFPLISA FIRTLRYHTG SLAFGALILT LVQIARVILE YIDHKLRGVQ NPVARCIMCC 550 560 570 580 590 600 FKCCLWCLEK FIKFLNRNAY IMIAIYGKNF CVSAKNAFML LMRNIVRVVV LDKVTDLLLF 610 620 630 640 650 660 FGKLLVVGGV GVLSFFFFSG RIPGLGKDFK SPHLNYYWLP IMTSILGAYV IASGFFSVFG 670 680 690 700 710 MCVDTLFLCF LEDLERNNGS LDRPYYMSKS LLKILGKKNE APPDNKKRKK
	Isoform 2 [UniParc]. Checksum: 6A1ACC9313FB9A3F	FASTA	288	32,729
	10 20 30 40 50 60 MCVFQGYSSK GLIQRSVFNL QIYGVLGLFW TLNWVLALGQ CVLAGAFASF YWAFHKPQDI 70 80 90 100 110 120 PTFPLISAFI RTLRYHTGSL AFGALILTLV QIARVILEYI DHKLRGVQNP VARCIMCCFK 130 140 150 160 170 180 CCLWCLEKFI KFLNRNAYIM IAIYGKNFCV SAKNAFMLLM RNIVRVVVLD KVTDLLLFFG 190 200 210 220 230 240 KLLVVGGVGV LSFFFFSGRI PGLGKDFKSP HLNYYWLPIM TSILGAYVIA SGFFSVFGMC 250 260 270 280 VDTLFLCFLE DLERNNGSLD RPYYMSKSLL KILGKKNEAP PDNKKRKK
	Isoform 3 [UniParc]. Checksum: ABBB965DD14DB114	FASTA	634	70,762
	10 20 30 40 50 60 MGENKDKPYL LYFNIFSCIL SSNIISVAEN GLQCPTPQVC VSSCPEDPWT VGKNEFSQTV 70 80 90 100 110 120 GEVFYTKNRN FCLPGVPWNM TVITSLQQEL CPSFLLPSAP ALGRCFPWTN VTPPALPGIT 130 140 150 160 170 180 NDTTIQQGIS GLIDSLNARD ISVKIFEDFA QSWYWILVAL GVALVLSLLF ILLLRLVAGP 190 200 210 220 230 240 LVLVLILGVL GVLAYGIYYC WEEYRVLRDK GASISQLGFT TNLSAYQSVQ ETWLAALIVL 250 260 270 280 290 300 AVLEAILLLM LIFLRQRIRI AIALLKEASK AVGQMMSTMF YPLVTFVLLL ICIAYWAMTA 310 320 330 340 350 360 LYLATSGQPQ YVLWASNISS PGCEKVPINT SCNPTAHLVN SSCPGLMCVF QGYSSKGLIQ 370 380 390 400 410 420 RSVFNLQIYG VLGLFWTLNW VLALGQCVLA GAFASFYWAF HKPQDIPTFP LISAFIRTLR 430 440 450 460 470 480 YHTGSLAFGA LILTLVQIAR VILEYIDHKL RGVQNPVARC IMCCFKCCLW CLEKFIKFLN 490 500 510 520 530 540 RNAYIMIAIY GKNFCVSAKN AFMLLMRNIV RVVVLDKVTD LLLFFGKLLV VGGVGVLSFF 550 560 570 580 590 600 FFSGRIPGLG KDFKSPHLNY YWLPIMTSIL GAYVIASGFF SVFGMCVDTL FLCFLEDLER 610 620 630 NNGSLDRPYY MSKSLLKILG KKNEAPPDNK KRKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS ILE-187 AND VAL-326. Tissue: Mammary gland and Prostate.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-187 AND VAL-326. Tissue: Small intestine.
[4]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
[5]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-187 AND VAL-326.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-128; ILE-187 AND VAL-326. Tissue: Colon.
[9]	"Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient." Uhl J., Penzel R., Sergi C., Kopitz J., Otto H.F., Cantz M. FEBS Lett. 521:19-23(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-308 (ISOFORM 1), CHROMOSOMAL REARRANGEMENT WITH NEU1, VARIANT ILE-187.
[10]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-710 (ISOFORMS 1/3). Tissue: Stomach.
[11]	"An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins." O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M. Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-347 AND MET-411.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027397 mRNA. Translation: BAB55083.1. AK300550 mRNA. Translation: BAG62256.1. AY358457 mRNA. Translation: AAQ88822.1. AK222998 mRNA. Translation: BAD96718.1. AF134726 Genomic DNA. Translation: AAD21813.1. BA000025 Genomic DNA. Translation: BAB63296.1. AL662834 Genomic DNA. Translation: CAI17744.1. AL671762 Genomic DNA. Translation: CAI18223.2. AL844853 Genomic DNA. Translation: CAI41851.1. BX005460 Genomic DNA. Translation: CAM26148.1. CR936237 Genomic DNA. Translation: CAQ09154.1. CR759784 Genomic DNA. Translation: CAQ09306.1. CR388202 Genomic DNA. Translation: CAQ09513.1. CH471081 Genomic DNA. Translation: EAX03538.1. BC014659 mRNA. Translation: AAH14659.1. AF466766 mRNA. Translation: AAL75992.1. AL833009 mRNA. Translation: CAH56275.1.
IPI	IPI00893953. IPI01020767. IPI01021535.
RefSeq	NP_001171515.1. NM_001178044.1. NP_001171516.1. NM_001178045.1. NP_079533.2. NM_025257.2.
UniGene	Hs.335355.
3D structure databases
ProteinModelPortal	Q53GD3.
ModBase	Search...
PTM databases
PhosphoSite	Q53GD3.
Polymorphism databases
DMDM	311033368.
Proteomic databases
PaxDb	Q53GD3.
PRIDE	Q53GD3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229729; ENSP00000229729; ENSG00000204385. ENST00000383379; ENSP00000372870; ENSG00000206378. ENST00000415517; ENSP00000414120; ENSG00000229077. ENST00000417894; ENSP00000389244; ENSG00000235336. ENST00000425238; ENSP00000399161; ENSG00000228263. ENST00000442152; ENSP00000398852; ENSG00000232180. ENST00000453831; ENSP00000393939; ENSG00000231479. ENST00000544672; ENSP00000444109; ENSG00000204385. ENST00000546461; ENSP00000449039; ENSG00000231479. ENST00000547684; ENSP00000449180; ENSG00000206378. ENST00000548188; ENSP00000447560; ENSG00000228263.
GeneID	80736.
KEGG	hsa:80736.
UCSC	uc010jti.3. human.
Organism-specific databases
CTD	80736.
GeneCards	GC06M031830.
H-InvDB	HIX0166072. HIX0166339. HIX0167126. HIX0184154.
HGNC	HGNC:13941. SLC44A4.
MIM	606107. gene.
neXtProt	NX_Q53GD3.
Orphanet	93400. Congenital sialidosis type 2. 93399. Juvenile sialidosis type 2. 812. Sialidosis type 1.
PharmGKB	PA25930.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG310633.
HOVERGEN	HBG062155.
InParanoid	Q53GD3.
KO	K15377.
OMA	QLGFTTN.
OrthoDB	EOG43JC47.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules. REACT_20679. Amine compound SLC transporters.
Gene expression databases
ArrayExpress	Q53GD3.
Bgee	Q53GD3.
Genevestigator	Q53GD3.
GermOnline	ENSG00000204385. Homo sapiens.
Family and domain databases
InterPro	IPR007603. Choline_transptr-like. [Graphical view]
PANTHER	PTHR12385. PTHR12385. 1 hit.
Pfam	PF04515. Choline_transpo. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC44A4. human.
DrugBank	DB00122. Choline.
GenomeRNAi	80736.
NextBio	71058.
SOURCE	Search...

Entry information

Entry name

CTL4_HUMAN

Accession

Primary (citable) accession number: Q53GD3
Secondary accession number(s): A2BED3 , B0UXX8, B0UZY8, B4DU94, Q5JP84, Q5JQ93, Q658S8, Q6UX89, Q8TEW4, Q96C58, Q96K59, Q9Y332

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.