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Protein

Cellular tumor antigen p53

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

ApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36679.

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PaxDbiQ53GA5.

PTM databases

iPTMnetiQ53GA5.

Expressioni

Gene expression databases

GenevisibleiQ53GA5. HS.

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000269305.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5353P53InterPro annotationAdd
BLAST
Domaini84 – 12239P53_tetramerInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IITK. Eukaryota.
ENOG410ZSWV. LUCA.
HOVERGENiHBG005201.
KOiK04451.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q53GA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YMCNSSCMGG MNGRPILTII TLEDSSGNLL GRNSFEVRVC ACPGRDRRTE
60 70 80 90 100
EENLRKKGEP HHELPPGSTK RALPNNTSSS PQPKKKPLDG EYFTLQIRGR
110 120 130 140 150
ERFEMFRELN EALELKDAQA GKEPGGSRAH SSHLKSKKGQ STSRHKKLMF

KTEGPDSD
Length:158
Mass (Da):17,656
Last modified:May 24, 2005 - v1
Checksum:i5C1AD3B95EB611D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223026 mRNA. Translation: BAD96746.1.
RefSeqiNP_000537.3. NM_000546.5.
NP_001119584.1. NM_001126112.2.
NP_001119585.1. NM_001126113.2.
NP_001119586.1. NM_001126114.2.
NP_001119587.1. NM_001126115.1.
NP_001119588.1. NM_001126116.1.
NP_001119589.1. NM_001126117.1.
NP_001119590.1. NM_001126118.1.
NP_001263624.1. NM_001276695.1.
NP_001263625.1. NM_001276696.1.
NP_001263626.1. NM_001276697.1.
NP_001263627.1. NM_001276698.1.
NP_001263628.1. NM_001276699.1.
NP_001263689.1. NM_001276760.1.
NP_001263690.1. NM_001276761.1.
UniGeneiHs.437460.
Hs.740601.

Genome annotation databases

GeneIDi7157.
KEGGihsa:7157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223026 mRNA. Translation: BAD96746.1.
RefSeqiNP_000537.3. NM_000546.5.
NP_001119584.1. NM_001126112.2.
NP_001119585.1. NM_001126113.2.
NP_001119586.1. NM_001126114.2.
NP_001119587.1. NM_001126115.1.
NP_001119588.1. NM_001126116.1.
NP_001119589.1. NM_001126117.1.
NP_001119590.1. NM_001126118.1.
NP_001263624.1. NM_001276695.1.
NP_001263625.1. NM_001276696.1.
NP_001263626.1. NM_001276697.1.
NP_001263627.1. NM_001276698.1.
NP_001263628.1. NM_001276699.1.
NP_001263689.1. NM_001276760.1.
NP_001263690.1. NM_001276761.1.
UniGeneiHs.437460.
Hs.740601.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269305.

PTM databases

iPTMnetiQ53GA5.

Proteomic databases

PaxDbiQ53GA5.

Protocols and materials databases

DNASUi7157.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7157.
KEGGihsa:7157.

Organism-specific databases

CTDi7157.
PharmGKBiPA36679.

Phylogenomic databases

eggNOGiENOG410IITK. Eukaryota.
ENOG410ZSWV. LUCA.
HOVERGENiHBG005201.
KOiK04451.

Miscellaneous databases

GenomeRNAii7157.
NextBioi28006.

Gene expression databases

GenevisibleiQ53GA5. HS.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides."
    Maruyama K., Sugano S.
    Gene 138:171-174(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThyroidImported.
  2. "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library."
    Suzuki Y., Yoshitomo K., Maruyama K., Suyama A., Sugano S.
    Gene 200:149-156(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThyroidImported.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThyroidImported.

Entry informationi

Entry nameiQ53GA5_HUMAN
AccessioniPrimary (citable) accession number: Q53GA5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: March 16, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.