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Protein

Cellular tumor antigen p53

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36679

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PeptideAtlasiQ53GA5
PRIDEiQ53GA5

Expressioni

Gene expression databases

GenevisibleiQ53GA5 HS

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 53P53InterPro annotationAdd BLAST53
Domaini84 – 122P53_tetramerInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IITK Eukaryota
ENOG410ZSWV LUCA
HOVERGENiHBG005201
KOiK04451

Family and domain databases

Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
PANTHERiPTHR11447 PTHR11447, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SUPFAMiSSF47719 SSF47719, 1 hit
SSF49417 SSF49417, 1 hit

Sequencei

Sequence statusi: Fragment.

Q53GA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YMCNSSCMGG MNGRPILTII TLEDSSGNLL GRNSFEVRVC ACPGRDRRTE
60 70 80 90 100
EENLRKKGEP HHELPPGSTK RALPNNTSSS PQPKKKPLDG EYFTLQIRGR
110 120 130 140 150
ERFEMFRELN EALELKDAQA GKEPGGSRAH SSHLKSKKGQ STSRHKKLMF

KTEGPDSD
Length:158
Mass (Da):17,656
Last modified:May 24, 2005 - v1
Checksum:i5C1AD3B95EB611D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223026 mRNA Translation: BAD96746.1
RefSeqiNP_000537.3, NM_000546.5
NP_001119584.1, NM_001126112.2
NP_001119585.1, NM_001126113.2
NP_001119586.1, NM_001126114.2
NP_001119587.1, NM_001126115.1
NP_001119588.1, NM_001126116.1
NP_001119589.1, NM_001126117.1
NP_001119590.1, NM_001126118.1
NP_001263624.1, NM_001276695.1
NP_001263625.1, NM_001276696.1
NP_001263626.1, NM_001276697.1
NP_001263627.1, NM_001276698.1
NP_001263628.1, NM_001276699.1
NP_001263689.1, NM_001276760.1
NP_001263690.1, NM_001276761.1
UniGeneiHs.437460
Hs.740601

Genome annotation databases

GeneIDi7157
KEGGihsa:7157

Similar proteinsi

Entry informationi

Entry nameiQ53GA5_HUMAN
AccessioniPrimary (citable) accession number: Q53GA5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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