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Protein
Submitted name:

Matrix metalloproteinase 1 preproprotein variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseSAAS annotation, Protease

Keywords - Ligandi

CalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metalloproteinase 1 preproprotein variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30867.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ53G95.
PeptideAtlasiQ53G95.

Expressioni

Gene expression databases

GenevisibleiQ53G95. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322788.

Structurei

3D structure databases

ProteinModelPortaliQ53G95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 131ZnMcInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOVERGENiHBG052484.
KOiK01388.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q53G95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HAIEKAFQLW SNVTPLTFTK VSEGQADIMI SFVRGDHRDN SPFDGPGGNL
60 70 80 90 100
AHAFQPGPGI GGDAHFDEDE RWTNNFREYN LHRVAAHELG HSLGLSHSTD
110 120 130 140 150
IGALMYPSYT FSGDVQLAQD DIDGIQAIYG RSQNPVQPIG PQTPKACDSK
160 170 180 190 200
LTFDAITTIR GEVMFFKDRF YMRTNPFYPE VELNFISVFW PQLPNGLEAA
210 220 230 240 250
YESADRDEVR FFKGNKYWAV QGQNVLHGYP KDIYSSFGFP RTVKHIDAAL
260 270 280 290 300
SEENTGKTYF FVANKYWRYD EYKRSMDPGY PKMIAHDFPG IGHKVDAVFM
310 320 330
KDGFFYFFHG TRQYKFDPKT KRILTLQKAN SWFNCRKN
Length:338
Mass (Da):38,745
Last modified:May 24, 2005 - v1
Checksum:i00757969533BD994
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223036 mRNA. Translation: BAD96756.1.
RefSeqiNP_002412.1. NM_002421.3.
UniGeneiHs.83169.

Genome annotation databases

GeneIDi4312.
KEGGihsa:4312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223036 mRNA. Translation: BAD96756.1.
RefSeqiNP_002412.1. NM_002421.3.
UniGeneiHs.83169.

3D structure databases

ProteinModelPortaliQ53G95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322788.

Proteomic databases

PaxDbiQ53G95.
PeptideAtlasiQ53G95.

Protocols and materials databases

DNASUi4312.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4312.
KEGGihsa:4312.

Organism-specific databases

CTDi4312.
PharmGKBiPA30867.

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
HOVERGENiHBG052484.
KOiK01388.

Miscellaneous databases

GenomeRNAii4312.

Gene expression databases

GenevisibleiQ53G95. HS.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ53G95_HUMAN
AccessioniPrimary (citable) accession number: Q53G95
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.