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Protein

Interferon-induced protein 44-like

Gene

IFI44L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits a low antiviral activity against hepatitis C virus.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein 44-like
Gene namesi
Name:IFI44L
Synonyms:C1orf29
ORF Names:GS3686
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17817. IFI44L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25615.

Polymorphism and mutation databases

BioMutaiIFI44L.
DMDMi224471886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Interferon-induced protein 44-likePRO_0000337845Add
BLAST

Proteomic databases

PaxDbiQ53G44.
PRIDEiQ53G44.

PTM databases

PhosphoSiteiQ53G44.

Expressioni

Inductioni

By type I interferons.1 Publication

Gene expression databases

BgeeiQ53G44.
CleanExiHS_IFI44L.
ExpressionAtlasiQ53G44. baseline and differential.
GenevisibleiQ53G44. HS.

Organism-specific databases

HPAiHPA053247.
HPA060372.

Interactioni

Protein-protein interaction databases

BioGridi116163. 2 interactions.
STRINGi9606.ENSP00000359787.

Structurei

3D structure databases

ProteinModelPortaliQ53G44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFI44 family.Curated

Phylogenomic databases

eggNOGiENOG410IDX3. Eukaryota.
ENOG410XP4J. LUCA.
GeneTreeiENSGT00390000017981.
HOGENOMiHOG000035123.
HOVERGENiHBG052085.
InParanoidiQ53G44.
OMAiYLECEVF.
PhylomeDBiQ53G44.
TreeFamiTF328728.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006073. GTP_binding_domain.
IPR024644. IFI44_fam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR14241:SF2. PTHR14241:SF2. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53G44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVTTRLTWN DENHLRKLLG NVSLSLLYKS SVHGGSIEDM VERCSRQGCT
60 70 80 90 100
ITMAYIDYNM IVAFMLGNYI NLHESSTEPN DSLWFSLQKK NDTTEIETLL
110 120 130 140 150
LNTAPKIIDE QLVCRLSKTD IFIICRDNKI YLDKMITRNL KLRFYGHRQY
160 170 180 190 200
LECEVFRVEG IKDNLDDIKR IIKAREHRNR LLADIRDYRP YADLVSEIRI
210 220 230 240 250
LLVGPVGSGK SSFFNSVKSI FHGHVTGQAV VGSDITSITE RYRIYSVKDG
260 270 280 290 300
KNGKSLPFML CDTMGLDGAE GAGLCMDDIP HILKGCMPDR YQFNSRKPIT
310 320 330 340 350
PEHSTFITSP SLKDRIHCVA YVLDINSIDN LYSKMLAKVK QVHKEVLNCG
360 370 380 390 400
IAYVALLTKV DDCSEVLQDN FLNMSRSMTS QSRVMNVHKM LGIPISNILM
410 420 430 440 450
VGNYASDLEL DPMKDILILS ALRQMLRAAD DFLEDLPLEE TGAIERALQP

CI
Length:452
Mass (Da):51,322
Last modified:March 3, 2009 - v3
Checksum:iE12E2DAF00547D7F
GO
Isoform 2 (identifier: Q53G44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: I → M
     162-452: Missing.

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):18,825
Checksum:i9E67486F73BA8786
GO

Sequence cautioni

The sequence AAH15932.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA19056.1 differs from that shown. Reason: Frameshift at position 18. Curated
The sequence BAD96807.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541A → V in CAD90004 (PubMed:17974005).Curated
Sequence conflicti154 – 1541E → G in CAD90004 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731H → R.3 Publications
Corresponds to variant rs273259 [ dbSNP | Ensembl ].
VAR_054648
Natural varianti104 – 1041A → T.
Corresponds to variant rs34932081 [ dbSNP | Ensembl ].
VAR_054649
Natural varianti148 – 1481R → C.
Corresponds to variant rs273258 [ dbSNP | Ensembl ].
VAR_054650
Natural varianti217 – 2171V → I.1 Publication
Corresponds to variant rs3820093 [ dbSNP | Ensembl ].
VAR_054651
Natural varianti235 – 2351I → T.1 Publication
Corresponds to variant rs987495 [ dbSNP | Ensembl ].
VAR_054652
Natural varianti296 – 2961R → C.1 Publication
Corresponds to variant rs1981071 [ dbSNP | Ensembl ].
VAR_054653
Natural varianti390 – 3901M → I.
Corresponds to variant rs35466823 [ dbSNP | Ensembl ].
VAR_043726

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 1611I → M in isoform 2. 1 PublicationVSP_036554
Alternative sequencei162 – 452291Missing in isoform 2. 1 PublicationVSP_036555Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000115 mRNA. Translation: BAA19056.1. Frameshift.
AK223087 mRNA. Translation: BAD96807.1. Different initiation.
AL832618 mRNA. Translation: CAD90004.1.
AC104837 Genomic DNA. No translation available.
BC015932 mRNA. Translation: AAH15932.1. Different initiation.
CCDSiCCDS687.2. [Q53G44-1]
RefSeqiNP_006811.2. NM_006820.3. [Q53G44-1]
XP_011538841.1. XM_011540539.1. [Q53G44-1]
UniGeneiHs.744918.

Genome annotation databases

EnsembliENST00000370751; ENSP00000359787; ENSG00000137959. [Q53G44-1]
GeneIDi10964.
KEGGihsa:10964.
UCSCiuc010oro.2. human. [Q53G44-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000115 mRNA. Translation: BAA19056.1. Frameshift.
AK223087 mRNA. Translation: BAD96807.1. Different initiation.
AL832618 mRNA. Translation: CAD90004.1.
AC104837 Genomic DNA. No translation available.
BC015932 mRNA. Translation: AAH15932.1. Different initiation.
CCDSiCCDS687.2. [Q53G44-1]
RefSeqiNP_006811.2. NM_006820.3. [Q53G44-1]
XP_011538841.1. XM_011540539.1. [Q53G44-1]
UniGeneiHs.744918.

3D structure databases

ProteinModelPortaliQ53G44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116163. 2 interactions.
STRINGi9606.ENSP00000359787.

PTM databases

PhosphoSiteiQ53G44.

Polymorphism and mutation databases

BioMutaiIFI44L.
DMDMi224471886.

Proteomic databases

PaxDbiQ53G44.
PRIDEiQ53G44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370751; ENSP00000359787; ENSG00000137959. [Q53G44-1]
GeneIDi10964.
KEGGihsa:10964.
UCSCiuc010oro.2. human. [Q53G44-1]

Organism-specific databases

CTDi10964.
GeneCardsiIFI44L.
H-InvDBHIX0000722.
HGNCiHGNC:17817. IFI44L.
HPAiHPA053247.
HPA060372.
MIMi613975. gene.
neXtProtiNX_Q53G44.
PharmGKBiPA25615.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDX3. Eukaryota.
ENOG410XP4J. LUCA.
GeneTreeiENSGT00390000017981.
HOGENOMiHOG000035123.
HOVERGENiHBG052085.
InParanoidiQ53G44.
OMAiYLECEVF.
PhylomeDBiQ53G44.
TreeFamiTF328728.

Miscellaneous databases

ChiTaRSiIFI44L. human.
GenomeRNAii10964.
NextBioi41666.
PROiQ53G44.
SOURCEiSearch...

Gene expression databases

BgeeiQ53G44.
CleanExiHS_IFI44L.
ExpressionAtlasiQ53G44. baseline and differential.
GenevisibleiQ53G44. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006073. GTP_binding_domain.
IPR024644. IFI44_fam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR14241:SF2. PTHR14241:SF2. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of a cDNA for novel genes expressed in human osteoblast."
    Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-73 AND THR-235.
    Tissue: Cancellous bone.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-73; ILE-217 AND CYS-296.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-73.
    Tissue: Spinal cord.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  6. "A diverse range of gene products are effectors of the type I interferon antiviral response."
    Schoggins J.W., Wilson S.J., Panis M., Murphy M.Y., Jones C.T., Bieniasz P., Rice C.M.
    Nature 472:481-485(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiIF44L_HUMAN
AccessioniPrimary (citable) accession number: Q53G44
Secondary accession number(s): Q86TE1, Q96B64, Q99984
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.