Q53G44 (IF44L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon-induced protein 44-like

Gene names

Name:	IFI44L
Synonyms:	C1orf29
ORF Names:	GS3686

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Exhibits a low antiviral activity against hepatitis C virus. Ref.6
Subcellular location	Cytoplasm Potential.
Induction	By type I interferons. Ref.6
Sequence similarities	Belongs to the IFI44 family.
Sequence caution	The sequence AAH15932.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA19056.1 differs from that shown. Reason: Frameshift at position 18. The sequence BAD96807.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to virus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q53G44-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q53G44-2)

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: I → M
     162-452: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 452	452	Interferon-induced protein 44-like		PRO_0000337845
Natural variations
	Alternative sequence	161	1	I → M in isoform 2.		VSP_036554
	Alternative sequence	162 – 452	291	Missing in isoform 2.		VSP_036555
	Natural variant	73	1	H → R. Ref.1 Ref.2 Ref.3 Corresponds to variant rs273259 [ dbSNP | Ensembl ].		VAR_054648
	Natural variant	104	1	A → T. Corresponds to variant rs34932081 [ dbSNP | Ensembl ].		VAR_054649
	Natural variant	148	1	R → C. Corresponds to variant rs273258 [ dbSNP | Ensembl ].		VAR_054650
	Natural variant	217	1	V → I. Ref.2 Corresponds to variant rs3820093 [ dbSNP | Ensembl ].		VAR_054651
	Natural variant	235	1	I → T. Ref.1 Corresponds to variant rs987495 [ dbSNP | Ensembl ].		VAR_054652
	Natural variant	296	1	R → C. Ref.2 Corresponds to variant rs1981071 [ dbSNP | Ensembl ].		VAR_054653
	Natural variant	390	1	M → I. Corresponds to variant rs35466823 [ dbSNP | Ensembl ].		VAR_043726
Experimental info
	Sequence conflict	54	1	A → V in CAD90004. Ref.3
	Sequence conflict	154	1	E → G in CAD90004. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 3, 2009. Version 3. Checksum: E12E2DAF00547D7F	FASTA	452	51,322
	10 20 30 40 50 60 MEVTTRLTWN DENHLRKLLG NVSLSLLYKS SVHGGSIEDM VERCSRQGCT ITMAYIDYNM 70 80 90 100 110 120 IVAFMLGNYI NLHESSTEPN DSLWFSLQKK NDTTEIETLL LNTAPKIIDE QLVCRLSKTD 130 140 150 160 170 180 IFIICRDNKI YLDKMITRNL KLRFYGHRQY LECEVFRVEG IKDNLDDIKR IIKAREHRNR 190 200 210 220 230 240 LLADIRDYRP YADLVSEIRI LLVGPVGSGK SSFFNSVKSI FHGHVTGQAV VGSDITSITE 250 260 270 280 290 300 RYRIYSVKDG KNGKSLPFML CDTMGLDGAE GAGLCMDDIP HILKGCMPDR YQFNSRKPIT 310 320 330 340 350 360 PEHSTFITSP SLKDRIHCVA YVLDINSIDN LYSKMLAKVK QVHKEVLNCG IAYVALLTKV 370 380 390 400 410 420 DDCSEVLQDN FLNMSRSMTS QSRVMNVHKM LGIPISNILM VGNYASDLEL DPMKDILILS 430 440 450 ALRQMLRAAD DFLEDLPLEE TGAIERALQP CI
	Isoform 2 [UniParc]. Checksum: 9E67486F73BA8786	FASTA	161	18,825
	10 20 30 40 50 60 MEVTTRLTWN DENHLRKLLG NVSLSLLYKS SVHGGSIEDM VERCSRQGCT ITMAYIDYNM 70 80 90 100 110 120 IVAFMLGNYI NLHESSTEPN DSLWFSLQKK NDTTEIETLL LNTAPKIIDE QLVCRLSKTD 130 140 150 160 IFIICRDNKI YLDKMITRNL KLRFYGHRQY LECEVFRVEG M

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning of a cDNA for novel genes expressed in human osteoblast." Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-73 AND THR-235. Tissue: Cancellous bone.
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-73; ILE-217 AND CYS-296.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-73. Tissue: Spinal cord.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[6]	"A diverse range of gene products are effectors of the type I interferon antiviral response." Schoggins J.W., Wilson S.J., Panis M., Murphy M.Y., Jones C.T., Bieniasz P., Rice C.M. Nature 472:481-485(2011) [PubMed: 21478870] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB000115 mRNA. Translation: BAA19056.1. Frameshift. AK223087 mRNA. Translation: BAD96807.1. Different initiation. AL832618 mRNA. Translation: CAD90004.1. AC104837 Genomic DNA. No translation available. BC015932 mRNA. Translation: AAH15932.1. Different initiation.
IPI	IPI00303276. IPI00894388.
RefSeq	NP_006811.2. NM_006820.2.
UniGene	Hs.724492.
3D structure databases
ProteinModelPortal	Q53G44.
SMR	Q53G44. Positions 178-237.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53G44.
PTM databases
PhosphoSite	Q53G44.
Polymorphism databases
DMDM	224471886.
Proteomic databases
PRIDE	Q53G44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370751; ENSP00000359787; ENSG00000137959.
GeneID	10964.
KEGG	hsa:10964.
UCSC	uc001dio.2. human.
Organism-specific databases
CTD	10964.
GeneCards	GC01P079085.
H-InvDB	HIX0000722.
HGNC	HGNC:17817. IFI44L.
MIM	613975. gene.
neXtProt	NX_Q53G44.
PharmGKB	PA25615.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09332.
GeneTree	ENSGT00390000017981.
HOGENOM	HBG446001.
HOVERGEN	HBG052085.
InParanoid	Q53G44.
OMA	KSIFHGH.
Gene expression databases
ArrayExpress	Q53G44.
Bgee	Q53G44.
CleanEx	HS_IFI44L.
Genevestigator	Q53G44.
Family and domain databases
InterPro	IPR024644. IFI44. [Graphical view]
PANTHER	PTHR14241. PTHR14241. 1 hit.
ProtoNet	Search...
Other
NextBio	41666.
SOURCE	Search...

Entry information

Entry name

IF44L_HUMAN

Accession

Primary (citable) accession number: Q53G44
Secondary accession number(s): Q86TE1, Q96B64, Q99984

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.