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Q53G02

- Q53G02_HUMAN

UniProt

Q53G02 - Q53G02_HUMAN

Protein

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.UniRule annotation

    Catalytic activityi

    Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-diphosphooligosaccharide-protein glycotransferase activity Source: InterPro

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1UniRule annotation (EC:2.4.99.18UniRule annotation)
    Short name:
    Oligosaccharyl transferase subunit DAD1UniRule annotation
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. oligosaccharyltransferase complex Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulumUniRule annotation, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27136.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ53G02.

    Interactioni

    Subunit structurei

    Component of the oligosaccharyltransferase (OST) complex.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DAD/OST2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG004452.
    KOiK12668.

    Family and domain databases

    InterProiIPR003038. DAD/Ost2.
    [Graphical view]
    PANTHERiPTHR10705. PTHR10705. 1 hit.
    PfamiPF02109. DAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005588. DAD. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q53G02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASVVSVIS RFLEEYLSST PQRLKLLDAY LLYILLTGAL QFGYCLLVGT    50
    FPFNSFLSGF ISCVGSFILA VCLRIQINPQ NKADFQGISP GRAFADFLFA 100
    STILHLVVMN FVG 113
    Length:113
    Mass (Da):12,425
    Last modified:May 24, 2005 - v1
    Checksum:iCA1983CADCEB20F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK223129 mRNA. Translation: BAD96849.1.
    RefSeqiNP_001335.1. NM_001344.3.
    UniGeneiHs.82890.

    Genome annotation databases

    GeneIDi1603.
    KEGGihsa:1603.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK223129 mRNA. Translation: BAD96849.1 .
    RefSeqi NP_001335.1. NM_001344.3.
    UniGenei Hs.82890.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q53G02.

    Protocols and materials databases

    DNASUi 1603.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1603.
    KEGGi hsa:1603.

    Organism-specific databases

    CTDi 1603.
    PharmGKBi PA27136.

    Phylogenomic databases

    HOVERGENi HBG004452.
    KOi K12668.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    GenomeRNAii 1603.
    NextBioi 6578.

    Family and domain databases

    InterProi IPR003038. DAD/Ost2.
    [Graphical view ]
    PANTHERi PTHR10705. PTHR10705. 1 hit.
    Pfami PF02109. DAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005588. DAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides."
      Maruyama K., Sugano S.
      Gene 138:171-174(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library."
      Suzuki Y., Yoshitomo K., Maruyama K., Suyama A., Sugano S.
      Gene 200:149-156(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ53G02_HUMAN
    AccessioniPrimary (citable) accession number: Q53G02
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.