Unreviewed, UniProtKB/TrEMBL Q53FV8 (Q53FV8_HUMAN)

Names and origin

Protein names	Submitted name:     Presenilin 1 isoform I-463 variant EMBL BAD96893.1
Organism	Homo sapiens (Human) EMBL BAD96893.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	463 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD96893.1

Sequences

	Sequence		Length	Mass (Da)
	Q53FV8-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: F4171D9BC28CBE04	FASTA	463	52,066
	10 20 30 40 50 60 MTELPAPLSY FQNAQMSEDN HLSNTNDNRE RQEHNDRRSL GHPEPLSNGR PQGNSRQVVE 70 80 90 100 110 120 QDEEEDEELT LKYGAKHVIM LFVPVTLCMV VVVATIKSVS FYTPKDGQLI YTPFTEDTET 130 140 150 160 170 180 VGQRALHSIL NAAIMISVIV VMTILLVVLY KYRCYKVIHA WLIISSLLLL FFFSFIYLGE 190 200 210 220 230 240 VFKTYNVAVD YITVALLIWN FGVVGMISIH WKGPLRLQQA YLIMISALMA LVFIKYLPEW 250 260 270 280 290 300 TAWLILAVIS VYDLVAVLCP KGPLRMLVET AQERNETLFP ALIYSSTMVW LVNMAEGDPG 310 320 330 340 350 360 AQRRVSKNSK YNAESTERES QDTVAENDDG GFSEEWEAQR DSHLGPHRST PESRAAVQEL 370 380 390 400 410 420 SSSILAGEDP EERGVKLGLG DFIFYSVLVG KASATASGDW NTTIACFVAI LIGLCLTLLL 430 440 450 460 LAIFKKALPA LPISITFGLV FYFATDYLVQ PFMDQLAFHQ FYI

References

[1]	"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides." Maruyama K., Sugano S. Gene 138:171-174(1994) [PubMed: 8125298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Human lung EMBL BAD96893.1.
[2]	"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library." Suzuki Y., Yoshitomo K., Maruyama K., Suyama A., Sugano S. Gene 200:149-156(1997) [PubMed: 9373149] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Human lung EMBL BAD96893.1.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Human lung EMBL BAD96893.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK223173 mRNA. Translation: BAD96893.1.
IPI	IPI00028077.
UniGene	Hs.3260
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q53FV8.
Genome annotation databases
Ensembl	ENST00000357710; ENSP00000350342; ENSG00000080815; Homo sapiens. [Genome view] ENST00000394164; ENSP00000377719; ENSG00000080815; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:9508. PSEN1.
Phylogenomic databases
HOVERGEN	Q53FV8.
Gene expression databases
ArrayExpress	Q53FV8.
Bgee	Q53FV8.
Family and domain databases
InterPro	IPR002031. Pept_A22A_PS1. IPR006639. Peptidase_A22. IPR001108. Peptidase_A22A. [Graphical view]
PANTHER	PTHR10202:SF7. Pept_A22A_PS1. 1 hit. PTHR10202. Peptidase_A22A. 1 hit.
Pfam	PF01080. Presenilin. 1 hit. [Graphical view]
PRINTS	PR01072. PRESENILIN. PR01073. PRESENILIN1.
SMART	SM00730. PSN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q53FV8_HUMAN

Accession

Primary (citable) accession number: Q53FV8

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	November 24, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.