Q53FR0 (Q53FR0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Serine/threonine-protein phosphatase RuleBase RU004273 EC=3.1.3.16 RuleBase RU004273
Organism	Homo sapiens (Human) EMBL BAD96942.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	499 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. RuleBase RU004273
Sequence similarities	Belongs to the PPP phosphatase family. RuleBase RU004273

Ontologies

Keywords
Domain	Repeat RuleBase RU003537 TPR repeat SAAS SAAS001440 RuleBase RU003339
Ligand	Iron PIRSR PIRSR033096-2 RuleBase RU004273 Metal-binding PIRSR PIRSR033096-2
Molecular function	Hydrolase RuleBase RU004273
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	304	1	Proton donor By similarity PIRSR PIRSR033096-1
	Metal binding	242	1	Iron By similarity PIRSR PIRSR033096-2
	Metal binding	244	1	Iron By similarity PIRSR PIRSR033096-2
	Metal binding	271	1	Iron By similarity PIRSR PIRSR033096-2
Experimental info
	Non-terminal residue	1	1	EMBL BAD96942.1

Sequences

	Sequence		Length	Mass (Da)
	Q53FR0 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: DB5E20D85465C33F	FASTA	499	56,907
	10 20 30 40 50 60 MAMAEGERTE CAEPPRDEPP ADGALRRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 70 80 90 100 110 120 NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 130 140 150 160 170 180 TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 190 200 210 220 230 240 LEDGKVTISF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 250 260 270 280 290 300 GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 310 320 330 340 350 360 RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 370 380 390 400 410 420 VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR GVSCQFGPDV TKAFLEENNL 430 440 450 460 470 480 DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 490 HPNVKPMAYA NTLLQLGMM

References

[1]	"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides." Maruyama K., Sugano S. Gene 138:171-174(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Stomach mucosa EMBL BAD96942.1.
[2]	"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library." Suzuki Y., Yoshitomo K., Maruyama K., Suyama A., Sugano S. Gene 200:149-156(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Stomach mucosa EMBL BAD96942.1.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Stomach mucosa EMBL BAD96942.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK223222 mRNA. Translation: BAD96942.1.
IPI	IPI00019812.
UniGene	Hs.654604.
3D structure databases
ProteinModelPortal	Q53FR0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q53FR0.
Proteomic databases
PRIDE	Q53FR0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000216.
Gene expression databases
ArrayExpress	Q53FR0.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR004843. Metallo_PEstase_dom. IPR013235. PPP_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. IPR011236. Ser/Thr_PPase_5. IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PANTHER	PTHR11668:SF12. PTHR11668:SF12. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. PF08321. PPP5. 1 hit. PF00515. TPR_1. 1 hit. [Graphical view]
PIRSF	PIRSF033096. PPPtase_5. 1 hit.
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. SM00028. TPR. 3 hits. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q53FR0_HUMAN

Accession

Primary (citable) accession number: Q53FR0

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.